检索结果-南通市图书馆

Unraveling the mechanism of action of Shangxia Liangji formula for treating insomnia:a metabolomics and network pharmacology approach

引用

Traditional Medicine Research 2025年第2期10卷 16-29页

作者： Xia-Jie quan Hao Liang Yong-Hong Tang Li Jiang Xiong-Ying Ji Feng-Ying zhang Ping zhang Bo Ouyang Department of Information The Affiliated Nanhua HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421002China Department of Neurology The Affiliated Nanhua HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421002China Department of Gastroscopy The Affiliated Nanhua HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421002China Department of Traditional Chinese Medicine The Affiliated Nanhua HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421002China

Background:Insomnia is a prevalent clinical condition and Shangxia Liangji formula(SXLJF)is a well-established method of ***,the specific mechanism of action of SXLJF remains ***:The mouse model of insomnia was established by intraperitoneal injection of ***-two mice were randomly divided into a negative control group,model group,SXLJF group(18.72 g/kg/day),and positive control group(diazepam,2 mg/kg)and treated with the corresponding drugs for 7 consecutive *** open field test and pentobarbital-induced sleeping test were ***-MS-based untargeted metabolomics and network pharmacology were applied to explore the potential targets of SXLJF for treating ***,key targets were validated using ***:Behavioral tests demonstrated that SXLJF reduced the total distance,average velocity,central distance,and sleep latency,and prolonged sleep *** and network pharmacology revealed potential targets,signaling pathways,metabolic pathways,and metabolites associated with the anti-insomnia effects of ***,tyrosine hydroxylase(TH)and tyrosine metabolism emerged as crucial metabolic pathways and targets,***-qPCR results supported the role of TH in the mechanism of SXLJF in treating ***:In conclusion,TH and tyrosine metabolism may represent significant targets and pathways for SXLJF in treating insomnia.

关键词： Shangxia Liangji formula insomnia metabolomics network pharmacology tyrosine hydroxylase tyrosine metabolism

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Influence of diet intake on liver function test

引用

World Journal of Gastroenterology 1997年第4期3卷 52-52页

作者： CHENG Shu quan, zhang Ji fang, zhang Zi Fu, QIAN Mei Yan, GUO Xiao Ling, SHANG Wen zhang and LI Duo Jing Department of Medical Laboratory, The Central Hospital of Jiaozuo Coal Mine Administration, Jiaozuo 454150, Henan Province, China

AIM To study the influence of diet intake on the result of liver function test. METHODS Blood samples from liver diseases ( n =100) and non liver diseases ( n =100) were taken at 07:00 in the morning (fasting state) and two hours after meal. Using Hitach 7150 automatic biochemistry analyser, ten liver function indexes (SB, TTT, ALT, AST, ALP, LDH, γ-GT, SP, A and G) were examined. RESULTS According to the SAS software system the differences were not significant between fasting state and after meal ( P =0 476-0 978). CONCLUSION Liver function test can be performed after meal.

关键词： dietary proteins dietary fats liver function tests

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

基于K-Factor GARMA模型的网络流量预测

引用

江南大学学报（自然科学版） 2008年第2期7卷 166-169页

作者：周丹琪乔国平张泉方浙江大学计算机科学与技术学院浙江杭州310027 江南计算技术研究所江苏无锡214083

为衡量网络运行负荷和运行状态,在对目前网络流量预测模型进行研究的基础上,结合GARMA,对网络进行合理规划,使之能过较好描述长相关和短相关流量的特征,并且提出一个拥有简单参数改进的k-factor GARMA预测模型.仿真结果验证了所提方法... 详细信息

为衡量网络运行负荷和运行状态,在对目前网络流量预测模型进行研究的基础上,结合GARMA,对网络进行合理规划,使之能过较好描述长相关和短相关流量的特征,并且提出一个拥有简单参数改进的k-factor GARMA预测模型.仿真结果验证了所提方法的有效性.

关键词：网络流量预测 GARMA模型极大似然估计

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Electrode/Electrolyte Optimization-Induced Double-Layered Architecture for High-Performance Aqueous Zinc-(Dual) Halogen Batteries

引用

NANO-MICRO LETTERS 2025年第1期17卷 1-17页

作者： Zhou, Chengwang Ding, Zhezheng Ying, Shengzhe Jiang, Hao Wang, Yan fang, Timing zhang, You Sun, Bing Tang, Xiao Liu, Xiaomin Qingdao Univ Sch Text & Clothing Sch Chem & Chem Engn Qingdao 266071 Shandong Peoples R China Univ Technol Sydney Fac Sci Ctr Clean Energy Technol Sch Math & Phys Sci Ultimo NSW 2007 Australia Henan Normal Univ Sch Chem & Chem Engn Xinxiang 453007 Henan Peoples R China

A double-layered protective film based on zinc-based coordination compound and ZnF2-rich solid electrolyte interphase layer has been successfully fabricated on the zinc metal anode via electrode/electrolyte synergistic *** double-layered architecture can effectively modulate Zn2+ flux and suppress the zinc dendrite growth, thus facilitating the uniform zinc *** as-developed zinc-(dual) halogen batteries based on double-layered protective film can present high areal capacity and satisfactory cycling stability. Aqueous zinc-halogen batteries are promising candidates for large-scale energy storage due to their abundant resources, intrinsic safety, and high theoretical capacity. Nevertheless, the uncontrollable zinc dendrite growth and spontaneous shuttle effect of active species have prohibited their practical implementation. Herein, a double-layered protective film based on zinc-ethylenediamine tetramethylene phosphonic acid (ZEA) artificial film and ZnF2-rich solid electrolyte interphase (SEI) layer has been successfully fabricated on the zinc metal anode via electrode/electrolyte synergistic optimization. The ZEA-based artificial film shows strong affinity for the ZnF2-rich SEI layer, therefore effectively suppressing the SEI breakage and facilitating the construction of double-layered protective film on the zinc metal anode. Such double-layered architecture not only modulates Zn2+ flux and suppresses the zinc dendrite growth, but also blocks the direct contact between the metal anode and electrolyte, thus mitigating the corrosion from the active species. When employing optimized metal anodes and electrolytes, the as-developed zinc-(dual) halogen batteries present high areal capacity and satisfactory cycling stability. This work provides a new avenue for developing aqueous zinc-(dual) halogen batteries.

关键词： Zn metal anodes Double-layered protective film Electrode/electrolyte optimization Aqueous zinc-(dual) halogen batteries

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chronic toxicity and cytotoxicity of synthetic pyrethroid insecticide cis-bifenthrin

引用

Journal of Environmental Sciences 2009年第12期21卷 1710-1715页

作者： WANG Cui CHEN fang zhang quan fang Zhuo College of Biological and Environmental Engineering Zhejiang University of Technology Hangzhou 310032 China College of Environmental Science and Engineering Zhejiang Gongshang University Hangzhou 310035 China

With the increasing use of synthetic pyrethroids （SPs）, the significance of ecological safety and health risk is an emerging concern, In this study, we evaluated the chronic aquatic toxicity of eis-bifenthrin （cis-BF） in Daphnia magna and its cytotoxicity in Chinese hamster ovary （CHO） cells as well as human cervical carcinoma （Hela） ceils. Chronic aquatic toxicity tests showed that cis-BF could significantly affect the reproduction of D. magna. The lowest observed effective concentration and the non-observed effective concentration of cis-BF to D. magna were 0.02 and 0.01 μg/L, respectively, and the chronic value was 0.014 μg/L. The intrinsic rate of natural increase was significantly decreased （p 〈 0.05） to 0.02 μg/L. The cytotoxicity assay demonstrated that cis-BF decreased cell viability in CHO and Hela cells in a concentration- and time-dependent manner. The IC50 values for Hela and CHO cells were 4.0 × 10^-5 and 3.2 × 10^-5 mol/L, respectively. Together, these results indicated that cis-BF induced chronic toxicity in both aquatic invertebrate animals and mammalian cells. These findings assist in understanding the impact of SPs on health and environmental safety. Considering the wide spectrum of SPs, a more comprehensive understanding of the negative effects is indispensible for planning future application and regulation of these pesticides.

关键词： cis-bifenthrin Daphnia magna chronic toxicity cytotoxicity

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Nitrogen addition promotes soil carbon accumulation globally

引用

Science China Life Sciences 2025年第1期 284-293页

作者： Xuemei Yang Suhui Ma Erhan Huang Danhua zhang Guoping Chen Jiangling Zhu Chengjun Ji Biao Zhu Lingli Liu Jingyun fang Institute of Ecology College of Urban and Environmental Sciencesand Key Laboratory for Earth Surface Processes of the Ministry of EducationPeking University Ministry of Education Key Laboratory for Transboundary Ecosecurity of Southwest China School of Ecology and Environmental ScienceYunnan University State Key Laboratory of Vegetation and Environmental Change Institute of BotanyChinese Academy of Sciences

Soil is the largest carbon(C) reservoir in terrestrial ecosystems and plays a crucial role in regulating the global C cycle and climate *** nitrogen(N) deposition has been widely considered as a critical factor affecting soil organic carbon(SOC) storage, but its effect on SOC components with different stability remains unclear. Here, we analyzed extensive empirical data from 304 sites worldwide to investigate how SOC and its components respond to N addition. Our analysis showed that N addition led to a significant increase in bulk SOC(6.7%), with greater increases in croplands(10.6%) and forests(6.0%) compared to grasslands(2.1%). Regarding SOC components, N addition promoted the accumulation of plant-derived C(9.7%–28.5%) over microbial-derived C(0.2%), as well as labile(5.7%) over recalcitrant components(–1.2%), resulting in a shift towards increased accumulation of plant-derived labile C. Consistently, N addition led to a greater increase in particulate organic C(11.9%) than mineral-associated organic C(3.6%), suggesting that N addition promotes C accumulation across all pools, with more increase in unstable than stable pools. The responses of SOC and its components were best predicted by the N addition rate and net primary productivity. Overall, our findings suggest that N enrichment could promote the accumulation of plant-derived and non-mineral associated C and a subsequent decrease in the overall stability of soil C pool, which underscores the importance of considering the effects of N enrichment on SOC components for a better understanding of C dynamics in soils.

关键词：

来源：

同方期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Inhibition of the NLRP3 inflammasome attenuates spiral ganglion neuron degeneration in aminoglycoside-induced hearing loss

引用

Neural Regeneration Research 2025年第10期20卷 3025-3039页

作者： Jia fang Zhuangzhuang Li Pengjun Wang Xiaoxu zhang Song Mao Yini Li Dongzhen Yu Xiaoyan Li Yazhi Xing Haibo Shi Shankai Yin Department of Otolaryngology Head and Neck Surgery Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of MedicineOtolaryngology Institute of Shanghai Jiao Tong UniversityShanghai Key Laboratory of Sleep Disordered BreathingShanghaiChina Department of Otorhinolaryngology-Head and Neck Surgery Shanghai Children’s HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina

Aminoglycosides are a widely used class of antibacterials renowned for their effectiveness and broad antimicrobial ***,their use leads to irreversible hearing damage by causing apoptosis of hair cells as their direct *** addition,the hearing damage caused by aminoglycosides involves damage of spiral ganglion neurons upon *** investigate the mechanisms underlying spiral ganglion neuron degeneration induced by aminoglycosides,we used a C57BL/6J mouse model treated with *** found that the mice exhibited auditory deficits following the acute loss of outer hair *** ganglion neurons displayed hallmarks of pyroptosis and exhibited progressive degeneration over *** profiling of these neurons showed significant upregulation of genes associated with inflammation and immune response,particularly those related to the NLRP3 *** of the canonical pyroptotic pathway in spiral ganglion neurons was observed,accompanied by infiltration of macrophages and the release of proinflammatory *** intervention targeting NLRP3 using Mcc950 and genetic intervention using NLRP3 knockout ameliorated spiral ganglion neuron degeneration in the injury *** findings suggest that NLRP3 inflammasome-mediated pyroptosis plays a role in aminoglycoside-induced spiral ganglion neuron *** of this pathway may offer a potential therapeutic strategy for treating sensorineural hearing loss by reducing spiral ganglion neuron degeneration.

关键词： degeneration hearing loss macrophages Mcc950 neuroinflammation NLRP3 inflammasome ototoxicity pyroptosis sensorineural hearing loss spiral ganglion neuron

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

空心圆柱扭剪仪重塑样击实器的研制

引用

实验室研究与探索 2008年第5期27卷 42-44,84页

作者：张泉芳赵宇黄博吴刚兵浙江大学建筑工程学院岩土工程研究所浙江杭州310027 浙江大学建筑工程学院土木水利工程实验中心浙江杭州310027

动态空心圆柱扭剪仪(HCA)是目前国内外公认的最复杂、最尖端的室内土动力学试验设备。为了配合空心圆柱扭剪仪重塑样的制样,依据传统三轴重塑样击实器的原理,研制了空心圆柱重塑试样的击实器,来控制重塑样的相对密度和均匀度。实践证明... 详细信息

动态空心圆柱扭剪仪(HCA)是目前国内外公认的最复杂、最尖端的室内土动力学试验设备。为了配合空心圆柱扭剪仪重塑样的制样,依据传统三轴重塑样击实器的原理,研制了空心圆柱重塑试样的击实器,来控制重塑样的相对密度和均匀度。实践证明,击实器可以满足重塑样制样的需要。

关键词：空心圆柱扭剪仪重塑样击实器

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

一种鉴定西红花和红花源性成分的实时荧光PCR方法

引用

中国中药杂志 2018年第23期43卷 4575-4581页

作者：张全芳刘艳艳谭晴晴姜欣欣陈雪燕葛付存步迅张永清山东农业科学院生物技术研究中心应用生命科学实验室山东济南250100 山东省百味堂中药饮片有限公司山东济南250108 山东中医药大学药学院天然药物研究所山东济南250355

该研究根据GenBank中的ITS2序列设计引物,基于SYBRGreen荧光PCR技术建立了一种能快速、灵敏和特异的鉴别西红花和红花源性的实时荧光定量PCR检测体系。与中草药DNA条形码技术相比,该方法检测时间短、特异性强、灵敏度高。利用该方法检... 详细信息

该研究根据GenBank中的ITS2序列设计引物,基于SYBRGreen荧光PCR技术建立了一种能快速、灵敏和特异的鉴别西红花和红花源性的实时荧光定量PCR检测体系。与中草药DNA条形码技术相比,该方法检测时间短、特异性强、灵敏度高。利用该方法检测15份样品,其中4份为红花,8份样品为西红花,3份为其他源性,与中草药DNA条形码检测结果一致。该方法为药材中西红花与红花源性的快速鉴定奠定了基础。

关键词： sYBRGreen实时荧光定量PCR 西红花红花源性鉴定

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

基于蕴涵算子族L-λ-G的FMP模型反向三I支持算法

引用

聊城大学学报（自然科学版） 2007年第3期20卷 8-11,36页

作者：王大全张兴芳聊城大学数学科学学院山东聊城252059

提出了基于蕴涵算子族L-λ-G的模糊推理的思想,这将有助于提高推理结果的可靠性.针对蕴涵算子族L-λ-G给出了模糊推理的FMP模型的反向三I支持算法、α-反向三I支持算法.

关键词：模糊推理反向三Ⅰ支持算法反向α-三Ⅰ支持算法蕴涵算子族L-λ-G

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：