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Chinese Chemical Letters 2024年第7期35卷 428-432页

作者： Yiyue Ding qiuxiang zhang Lei zhang Qilu Yao Gang Feng zhang-Hui Lu Key Laboratory of Energy Catalysis and Conversion of Nanchang College of Chemistry and Chemical EngineeringJiangxi Normal UniversityNanchang 330022China School of Chemistry and Chemical Engineering Nanchang UniversityNanchang 330031China

Formic acid(FA),which is obtainable through CO_(2)hydrogenation with green hydrogen or biomass conversion,has been used as a prospective liquid organic hydrogen carrier(LOHC)because of the abundant advantages of renewability,wide availability,stability,and high volumetric capacity(53 g H_(2)/L).The development of highly efficient catalytic systems to achieve enhanced catalytic activity is attractive but still ***,ultrafine and highly dispersed PdAu nanoclusters(NCs)anchored on amino-modified reduced graphene oxide(ArGO)were successfully synthesized via a facile impregnation-reduction method and applied as a catalyst toward formic acid dehydrogenation(FAD).Benefiting from the promoting effect of amino groups,the strain and ligand effect in the alloy,and the Mott–Schottky effect between PdAu NCs and ArGO,the resultant PdAu/ArGO affords an ultrahigh activity under visible light irradiation with an exceptional turnover frequency value of 10,699.5 h^(-1)at 298 K without any additives,more than 2.6times improvement than that under dark,which is the highest among all reported catalysts under the same *** study provides a green and convenient strategy for developing more efficient and sustainable FAD catalysts and promotes the effective utilization of FA as a prospective renewable LOHC.

关键词： Visible-light-enhanced Hydrogen production Formic acid Pd-Au Heterogeneous catalyst

Blautia producta displays potential probiotic properties against dextran sulfate sodium-induced colitis in mice

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Food Science and Human Wellness 2024年第2期13卷 709-720页

作者： Bingyong Mao Weiling Guo Shumao Cui qiuxiang zhang Jianxin Zhao Xin Tang Hao zhang State Key Laboratory of Food Science and Resources Jiangnan UniversityWuxi 214122China School of Food Science and Technology Jiangnan UniversityWuxi 214122China National Engineering Research Center for Functional Food Jiangnan UniversityWuxi 214122China

Blautia has attracted attention because of its potential efficacy in ameliorating host energy metabolism and *** study aims to investigate the influences of Blautia producta D4 on colitis induced by dextran sulfate sodium(DSS)and to reveal the underlying *** showed that *** D4 intervention significantly relieved body weight loss,and suppressed the elevation of pro-inflammatory cytokines(including interleukin-6(IL-6),tumor necrosis factor-α(TNF-α),and interleukin-1β(IL-1β))and excessive oxidative stress(myeloperoxidease(MPO)activity,superoxide dismutase(SOD)activity,glutathione peroxidase(GSH-Px)activity,and malondialdehyde(MDA)level)in colitis ***,the concentrations of tight junction proteins(occludin,claudin-1,and ZO-1)related to the intestinal barrier were obviously elevated,and colitis-related TLR4/NF-κB pathway activation was remarkably inhibited after *** D4 *** intestinal microbial disorder was evidently ameliorated by increasing the relative abundance of Clostridium sensu stricto 1,Bifidobacterium,GCA-900066225,Enterorhabdus,and reducing the relative abundance of Lachnospiraceae NK4A136 *** conclusion,oral administration of *** D4 could ameliorate DSS-induced colitis by suppressing inflammatory responses,maintaining the intestinal barrier,inhibiting TLR4/NF-κB pathway,and regulating intestinal microbiota *** results are conducive to accelerate the development of *** D4 as a functional probiotic for colitis.

关键词： Blautia producta D4 Colitis Intestinal mechanical barrier TLR4/NF-κB pathway Intestinal microbiot

Prognostic ability of the neoadjuvant rectal(NAR)score in long-course concurrent chemoradiotherapy for patients with locally advanced rectal cancer:a retrospective cohort study

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Malignancy Spectrum 2024年第1期1卷 53-63页

作者： Siyi Lu Ran Peng Xianan Li Zhaoyu Chen Yi Zhou Ruize Qu Xin Zhou qiuxiang zhang Yuxia Wang Xuemin Li Tao Sun Hao Wang Wei Fu Cancer Center Peking University Third HospitalBeijingChina Department of General Surgery Peking University Third HospitalBeijingChina Department of Radiation Oncology Peking University Third HospitalBeijingChina Department of Radiation Oncology Peking University People's HospitalBeijingChina Department of Basic Medical Sciences Peking University Health Science CenterBeijingChina Shenzhen Health Development Research and Data Management Center ShenzhenChina Department of Clinical Nutrition Peking University Third HospitalBeijingChina

Background:The aims of this study were to evaluate the prognostic ability of the neoadjuvant rectal(NAR)score and to develop and validate a nomogram based on the NAR for patients with locally advanced rectal cancer(LARC)treated with neoadjuvant chemoradiotherapy(nCRT).Methods:In total,307 patients,including 230 patients from the primary cohort and 77 from the external cohort,were enrolled across the two *** associations of the NAR score with the tumor response,tumor control,and clinicopathological parameters were *** analysis was performed in the primary and external cohorts using Kaplan‒Meier *** and multivariate analyses were performed to evaluate the prognostic *** NAR-based nomogram was developed in the primary cohort and validated in the external cohort using the concordance index(C-index),calibration plots,and decision curve analyses(DCAs).Results:Kaplan‒Meier survival analysis revealed that the disease-free survival(DFS)and overall survival(OS)of the NAR>16 group were significantly lower than those of the NAR≤16 group(p<0.001).Multivariate Cox regression analysis identified the NAR score as an independent prognostic factor for both DFS(hazard ratio[HR]=2.484,95%confidence interval[CI]:1.159−5.323,p=0.019)and OS(HR=4.633,95%CI:1.076−19.941,p=0.04).Calibration plots and DCAs showed that NARbased nomograms for DFS and OS were consistent and useful in clinical ***,the C-indexes of the NAR-based nomograms were better than those of the other variables in both the primary and external ***:Our study validates the prognostic role of the NAR score for DFS and *** NAR-based nomogram for OS could accurately predict the outcome of LARC patients by stratifying the risk score accordingly.

关键词： NAR score rectal cancer prognosis nomogram

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耐高渗青春双歧杆菌的筛选及发酵工艺优化

食品与发酵工业 2024年第3期50卷 30-37页

作者：潘子怡毛丙永唐鑫张秋香赵建新崔树茂江南大学食品学院江苏无锡214122

为解决青春双歧杆菌在生产中发酵密度低的问题,该文测定了94株青春双歧杆菌的耐渗能力,同时评价了耐高渗菌株耐渗能力的遗传稳定性,最后通过解析培养基底物和发酵工艺探究了耐高渗菌株的最适发酵条件,从而提高其生产中的发酵活菌数。筛... 详细信息

为解决青春双歧杆菌在生产中发酵密度低的问题,该文测定了94株青春双歧杆菌的耐渗能力,同时评价了耐高渗菌株耐渗能力的遗传稳定性,最后通过解析培养基底物和发酵工艺探究了耐高渗菌株的最适发酵条件,从而提高其生产中的发酵活菌数。筛选得到两株最高可耐受1400 mOsm/kg的菌株CCFM1302和CCFM1066,其最优氮源为复合氮源(胰酪蛋白胨和酵母浸粉FM528以质量比1∶1复合),最优碳氮比分别为(2.71±0.23)∶1和(2.53±0.11)∶1。以达到完全抑制渗透压为发酵终点推算底物最适浓度,进一步优化微量元素的添加量,得到最优培养基:复合氮源21.0 g/L、葡萄糖57.0 g/L(CCFM1302),复合氮源22.4 g/L、葡萄糖56.5 g/L(CCFM1066);此外添加MgSO_(4)·7H_(2)O 0.25 g/L,半胱氨酸1 g/L、吐温801 mL/L。恒pH 5.5培养至稳定期发酵液活菌数可达(1.82±0.08)×10^(10)CFU/mL和(1.70±0.03)×10^(10)CFU/mL。该文筛选到可产业化的两株青春双歧杆菌,并优化其高密度发酵工艺,对生产和应用都具有重要意义。

关键词：青春双歧杆菌渗透压高密度培养碳氮比活菌数

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统计假设检验的模糊集描述

宁夏师范学院学报 2024年第1期45卷 18-26页

作者：章秋香魏立力宁夏大学数学统计学院宁夏银川750021

基于p值函数给出了零假设显著性检验的模糊集描述,为模糊集理论提供实际背景的同时,给p值一个新的解释.其中样本数据对零假设的支持程度用一个模糊集的隶属度函数表示,检验的拒绝域表示为该模糊集的截集,截集的水平表示显著性水平.具体... 详细信息

基于p值函数给出了零假设显著性检验的模糊集描述,为模糊集理论提供实际背景的同时,给p值一个新的解释.其中样本数据对零假设的支持程度用一个模糊集的隶属度函数表示,检验的拒绝域表示为该模糊集的截集,截集的水平表示显著性水平.具体例子表明此方法的可行性和有效性.

关键词：假设检验 p值函数模糊集

智能版MoCA评估系统在轻度认知功能障碍诊断中的应用价值研究

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中华老年医学杂志 2024年第8期43卷 1019-1024页

作者：汤观秀张秋香刘倩曾晖周可怡颜萍平中南大学湘雅三医院老年病科长沙410013

目的探讨智能版蒙特利尔认知量表(MoCA)评估系统在老年住院患者中识别轻度认知功能障碍(MCI)的价值。方法选取2020年7月至2022年12月期间在中南大学湘雅三医院神经内科和老年病科诊断为MCI的75例患者(MCI组)和195例认知功能正常的患者(... 详细信息

目的探讨智能版蒙特利尔认知量表(MoCA)评估系统在老年住院患者中识别轻度认知功能障碍(MCI)的价值。方法选取2020年7月至2022年12月期间在中南大学湘雅三医院神经内科和老年病科诊断为MCI的75例患者(MCI组)和195例认知功能正常的患者(正常对照组),分别给予智能版MoCA系统评估和简易智能状态检查量表(MMSE)评估,并分析评估结果。结果MCI组MoCA总评分及MMSE总分[(19.73±2.42)分和(24.81±2.33)分]均低于正常对照组[(24.47±2.02)分和(26.50±1.65)分],差异有统计学意义(P<0.01)。智能版MoCA最佳截断值为23.5分,其诊断MCI的灵敏度、特异度、Kappa值(96.0%、82.1%、0.690)均高于MMSE量表(90.0%、62.6%、0.428)。结论智能版对老年MCI具有较高的筛查价值,该系统诊断MCI的敏感性和特异性均高于MMSE。

关键词：轻度认知功能障碍电子化评估蒙特利尔认知评估量表简易智能状态检查量表诊断价值

不同剂量长双歧杆菌联合西兰花种子水提物对结肠炎的缓解作用

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食品与发酵工业 2024年第12期50卷 92-100页

作者：徐何颖邬佳颖唐鑫张秋香崔树茂赵建新毛丙永江南大学食品学院江苏无锡214122

长双歧杆菌CCFM1206分离自健康成人粪便,可将萝卜硫苷转化成萝卜硫素(sulforaphane,SFN),该文研究了西兰花种子水提物(broccoli seed extract,BSE)以及其联合不同剂量的长双歧杆菌CCFM1206(10^(8)、10^(9)和10^(10)CFU)对小鼠肠内SFN水平的调控以及对右旋糖酐硫酸酯钠(dextran sulfate sodium,DSS)诱导结肠炎的缓解作用。研究发现,与BSE组相比,补充10^(9)和10^(10)CFU长双歧杆菌CCFM1206后,小鼠粪便中SFN和N-乙酰萝卜硫素(sulforaphane N-acetyl-L-cysteine,SFN-NAC)总量由30.84μmol/g分别提高至45.48和49.32μmol/g(P<0.05);仅摄入BSE(200 mg/kg小鼠体重),能有效缓解小鼠结肠缩短、降低炎症因子水平(IL-6、IL-1β和TNF-α)、增强抗氧化酶活力(GSH、SOD)、上调紧密连接蛋白的基因转录水平和蛋白表达水平,激活Nrf2信号通路并抑制NF-κB信号通路;补充10^(8)CFU长双歧杆菌CCFM1206效果与BSE无显著差异,而补充10^(9)和10^(10)CFU长双歧杆菌CCFM1206在激活Nrf2和抑制NF-κB信号通路方面更加优异,这可能与产生更多SFN有关。该研究可为开发缓解结肠炎的膳食制剂提供理论依据和剂量参考。

关键词：萝卜硫素长双歧杆菌西兰花种子水提物结肠炎紧密连接蛋白

乳酸菌发酵对花生衣抗糖化缓解皮肤衰老功能的影响

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上海理工大学学报 2024年第4期46卷 364-374页

作者：岳开妍毛丙永唐鑫张秋香赵建新崔树茂江南大学食品学院无锡214122

糖化会导致晚期糖基化终末产物(AGEs)形成并在体内积累,引起皮肤衰老。体外实验表明花生衣具有抗糖化作用,乳酸菌发酵能否提升花生衣的抗糖能力尚不清楚。本研究采用体外AGEs生成模型和丙酮醛损伤皮肤成纤维细胞(HSF)模型,从10株乳酸菌... 详细信息

糖化会导致晚期糖基化终末产物(AGEs)形成并在体内积累,引起皮肤衰老。体外实验表明花生衣具有抗糖化作用,乳酸菌发酵能否提升花生衣的抗糖能力尚不清楚。本研究采用体外AGEs生成模型和丙酮醛损伤皮肤成纤维细胞(HSF)模型,从10株乳酸菌中筛出植物乳植杆菌CCFM1354,该菌具有很好的抑制AGEs生成能力,能缓解HSF细胞的糖化损伤。高糖细胞模型实验发现,CCFM1354发酵花生衣能显著降低HSF细胞中BAX和NFKB1的mRNA的相对表达量;D-半乳糖诱导的衰老小鼠实验结果表明,口服植物乳植杆菌CCFM1354发酵花生衣能显著降低小鼠血清AGEs含量,提高小鼠皮肤弹性,改善小鼠皮肤萎缩状况,且效果优于未发酵花生衣。由此可见,植物乳植杆菌CCFM1354发酵能显著提升花生衣的抗糖化功能,缓解皮肤衰老。

关键词：抗糖化晚期糖基化终末产物(AGEs) 乳酸菌发酵花生衣皮肤衰老

新型简易移送垫在手术室围手术期过床转运的应用效果

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中国当代医药 2024年第13期31卷 127-130,134页

作者：郭小菊张秋香涂平花南昌市第一医院手术室江西南昌330008

目的探讨新型简易移送垫在手术室围手术期过床转运的应用效果。方法选取2022年8月至2023年2月南昌市第一医院100例手术患者为研究对象,按随机数字表法分为对照组(50例)和观察组(50例)。对照组使用传统搬运方法,观察组使用新型简易转运... 详细信息

目的探讨新型简易移送垫在手术室围手术期过床转运的应用效果。方法选取2022年8月至2023年2月南昌市第一医院100例手术患者为研究对象,按随机数字表法分为对照组(50例)和观察组(50例)。对照组使用传统搬运方法,观察组使用新型简易转运移送垫搬运,比较两组的不良事件发生率、患者舒适满意度、过床搬运时间及医护人员腰肌损伤发生率。结果观察组的不良事件总发生率低于对照组,差异有统计学意义(P<0.05);观察组患者舒适度高于对照组,差异有统计学意义(P<0.05);观察组过床搬运时间短于对照组,差异有统计学意义(P<0.05);观察组医护人员腰肌损伤总发生率低于对照组,差异有统计学意义(P<0.05)。结论通过新型简易转运移送垫在术后手术室与临床科室过床搬运的应用,从而避免搬运过程中坠落、管道脱落或牵扯等不良事件发生,给患者增加舒适及安全感,提高患者舒适满意度,降低临床医护人员搬运时导致的腰肌劳损的发生率,值得临床推广。

关键词：移送垫过床转运围手术期安全护理

New‑Generation Ferroelectric AlScN Materials

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Nano-Micro Letters 2024年第11期16卷 88-118页

作者： Yalong zhang qiuxiang Zhu Bobo Tian Chungang Duan Key Laboratory of Polar Materials and Devices Ministry of EducationShanghai Center of Brain‑Inspired Intelligent Materials and DevicesDepartment of ElectronicsEast China Normal UniversityShanghai 200241People’s Republic of China Collaborative Innovation Center of Extreme Optics Shanxi UniversityTaiyuan 030006ShanxiPeople’s Republic of China

Ferroelectrics have great potential in the field of nonvolatile memory due to programmable polarization states by external electric field in nonvolatile ***,complementary metal oxide semiconductor compatibility and uniformity of ferroelectric performance after size scaling have always been two thorny issues hindering practical application of ferroelectric memory *** emerging ferroelectricity of wurtzite structure nitride offers opportunities to circumvent the *** review covers the mechanism of ferroelectricity and domain dynamics in ferroelectric AlScN *** performance optimization of AlScN films grown by different techniques is summarized and their applications for memories and emerging in-memory computing are ***,the challenges and perspectives regarding the commercial avenue of ferroelectric AlScN are discussed.

关键词： AlScN Ferroelectrics Nonvolatile memory In-memory computing