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Ferroptosis regulating lipid peroxidation metabolism in the occurrence and development of gastric cancer

World Journal of Gastrointestinal Oncology 2024年第6期16卷 2781-2792页

作者： lan-Mei Wang Wei-Wei zhang Ying-Yang qiu Fang Wang Department of Clinical Laboratory Anqiu People's HospitalWeifang 262123Shandong ProvinceChina Department of Gastroenterology Feicheng People's HospitalTai’an 271600Shandong ProvinceChina Yong Loo Lin School of Medicine National University of Singapore119077Singapore Department of Gastroenterology Central Hospital Affiliated to Shandong First Medical UniversityJinan 250013Shandong ProvinceChina

BACKGROUND Gastric cancer is one of the most common malignant tumors in the world,and its occurrence and development involve complex biological *** death,as a new cell death mode,has attracted wide attention in recent ***,the regulatory mechanism of iron death in gastric cancer and its effect on lipid peroxidation metabolism remain *** To explore the role of iron death in the development of gastric cancer,reveal its relationship with lipid peroxidation,and provide a new theoretical basis for revealing the molecular mechanism of the occurrence and development of gastric *** The process of iron death in gastric cancer cells was simulated by cell culture model,and the occurrence of iron death was detected by fluorescence microscopy and flow *** changes of gene expression related to iron death and lipid peroxidation metabolism were analyzed by high-throughput sequencing *** addition,a mouse model of gastric cancer was established,and the role of iron death in vivo was studied by histology and immunohistochemistry,and the level of lipid peroxidation was *** methods comprehensively and deeply reveal the regulatory mechanism of iron death on lipid peroxidation metabolism in the occurrence and development of gastric *** Iron death was significantly activated in gastric cancer cells,and at the same time,associated lipid peroxidation levels increased *** high-throughput sequencing analysis,it was found that iron death regulated the expression of several genes related to lipid *** vivo experiments demonstrated that increased iron death in gastric cancer mice was accompanied by a significant increase in lipid *** This study confirmed the important role of iron death in regulating lipid peroxidation metabolism in the occurrence and development of gastric *** activation of iron death significantly increased lipid peroxidation levels,revealing it

关键词： Ferroptosis Lipid peroxidation Gastric cancer Lipid metabolism Systematic review

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Surrogate modeling for unsaturated infiltration via the physics and equality-constrained artificial neural networks

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第6期16卷 2282-2295页

作者： Peng lan Jingjing Su Sheng zhang School of Civil Engineering Central South UniversityChangsha410075China Discipline of Civil Surveying and Environmental EngineeringPriority Research Centre for Geotechnical Science and EngineeringThe University of NewcastleCallaghanNSW2308Australia Qinghai University Qinghai810016China

Machine learning(ML)provides a new surrogate method for investigating groundwater flow dynamics in unsaturated *** pure data-driven methods(*** neural network,DNN)can provide rapid predictions,but they do require sufficient on-site data for accurate training,and lack interpretability to the physical processes within the *** this paper,we provide a physics and equalityconstrained artificial neural network(PECANN),to derive unsaturated infiltration solutions with a small amount of initial and boundary *** takes the physics-informed neural network(PINN)as a foundation,encodes the unsaturated infiltration physical laws(*** equation,RE)into the loss function,and uses the augmented Lagrangian method to constrain the learning process of the solutions of RE by adding stronger penalty for the initial and boundary *** unsaturated infiltration cases are designed to test the training performance of PECANN,***-dimensional(1D)steady-state unsaturated infiltration,1D transient-state infiltration,two-dimensional(2D)transient-state infiltration,and 1D coupled unsaturated infiltration and *** predicted results of PECANN are compared with the finite difference solutions or analytical *** results indicate that PECANN can accurately capture the variations of pressure head during the unsaturated infiltration,and present higher precision and robustness than DNN and *** is also revealed that PECANN can achieve the same accuracy as the finite difference method with fewer initial and boundary training ***,we investigate the effect of the hyperparameters of PECANN on solving RE *** provides an effective tool for simulating unsaturated infiltration.

关键词： Richards equation(RE) Unsaturated infiltration Data-driven solutions Numerical modeling Machine learning(ML)

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Taphonomy and Paleoecology of Lycoptera: A Case Study from the Lower Jehol Group in Western Liaoning, Northeastern China

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Journal of Earth Science 2024年第3期35卷 737-746页

作者： Zhongwu lan Rong Cao Shujing zhang State Key Laboratory of Lithospheric Evolution Institute of Geology and GeophysicsChinese Academy of SciencesBeijing 100029China State Key Laboratory of Palaeobiology and Stratigraphy Nanjing Institute of Geology and PalaeontologyChinese Academy of SciencesNanjing 210008China State Key Laboratory of Geological Processes and Mineral Resources China University of GeosciencesWuhan 430078China College of Earth and Planetary Sciences University of Chinese Academy of SciencesBeijing 100049China Department of Geology Trinity CollegeDublin 999015Ireland

Taphonomy and paleoecology(biological behavior)of the Early Cretaceous fish fossils are poorly *** study reports for the first time a detailed taphonomical and paleoecological study on Lycoptera in the Mesozoic strata of western Liaoning Province,NE *** XRD analysis shows that gismondine is the dominant clay minerals that could have contributed to the preservation of Lycoptera fossils and microbial mat fragments in the fossil-bearing *** may have formed under volcanism-related hydrothermal regime that was transformed from crystal and lithic ***μ-XRF imaging analysis shows a dominant chemical composition of Al,Si,P,S,Rh,K,Ca,Ti,C,Cr,Mn,Fe,Ni,among which P,Ca,C and S are enriched in the fish skeleton in comparison to the *** suggests a dominant apatite composition for the fish *** influence did not smear off these organic signals probably because of protection of *** coexistance of C and S with Ni is assumed to represent recovered primary productivity following volcanic explosions and toxic gas *** head of juvenile fish stays close to the body of adult *** further discoveries,such phenomenon is interpreted to suggest that adult fish actively protected juvenile fish in the presence of environmental pressures such as anoxia and deterioration of water quality induced by *** acidification and hypoxia in association with volcanism created a harmful environment causing mass extinction of *** adult Lycoptera protected their juveniles by its body at the moment before *** biological behavior will be increasingly reported given the wide occurrence of Lycoptera in Mesozoic strata.

关键词： Lycoptera taphonomy paleoecology fish Jehol Group NE China.

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Two-dimensional bifunctional electrocatalyst(Mo-NiFe-LDH)with multilevel structure for highly efficient overall water splitting

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Rare Metals 2024年第6期43卷 2613-2622页

作者： Bao-Jie zhang Bin Chang Shi-Peng qiu Gang Zhao Xiao Wang Xi-Jin Xu lan Mu Wen-Bo Liao Xiao-Jing Dong School of Physics and Technology University of JinanJinan 250000China KAUST Catalysis Center(KCC) King Abdullah University of Science and Technology(KAUST)Thuwal 23955-6900Kingdomof SaudiArabia School of Chemical Engineering and Technology Tianjin UniversityTianjin 300072China School of Physics and Physical Engineering Qufu Normal UniversityQufu273100China

To effectively address energy challenges,it is crucial to explore efficient and stable bifunctional nonprecious metal *** this study,a Mo-doped nickeliron layered double hydroxide with flower-cluster architecture was successfully prepared by a one-step hydrothermal method,which demonstrated a good water splitting *** an appropriate amount of Mo doping,some lattice distortions in the material provided reactive sites for the adsorption and conversion of intermediates,thus optimising the charge distribution of the ***,the multidimensional void structures formed after doping had a larger specific surface area and accelerated the penetration of the electrolyte,which significantly improved the activity of the catalyst in alkaline *** 10 mA·cm^(-2),the hydrogen and oxygen evolution overpotentials of Mo-doped nickel-iron double hydroxides(Mo-NiFe LDH/NF-0.2)were 167 and 220 mV,respectively,with an excellent durability up to 24 *** the Mo-NiFe LDH/NF-0,2 catalyst was used as the cathode and anode of an electrolytic cell,the catalyst achieved a current density of 10 mA·cm^(-2)at an applied voltage of 1.643 *** study provides a novel approach for designing excellent bifunctional electrocatalysts containing nonprecious metals.

关键词： Bifunctional electrocatalysts 2D multilevel structure Overall water splitting Mo-doped Ni-Fe LDH

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Body-force modeling considering induced upstream effects for a transonic compressor with total temperature distortion

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Chinese Journal of Aeronautics 2024年第6期37卷 7-19页

作者： Jiahui qiu Chen YANG Wenqiang zhang Min zhang Juan DU Digital Twin Research Center Institute of Engineering ThermophysicsChinese Academy of SciencesBeijing 100190China School of Engineering and Science University of Chinese Academy of SciencesBeijing 100190China National Key Laboratory of Science and Technology on Advanced Light-duty Gas-turbine Chinese Academy of SciencesBeijing 100190China School of Mechatronical Engineering Beijing Institute of TechnologyBeijing 100081China

To numerically study the impact of total temperature distortion on a transonic compressor with reduced computational costs,a Body-Force Model(BFM)is ***,the interactions between the distorted flow and the compressor are analyzed using full-annulus Unsteady Reynolds-Averaged Navier-Stokes(URANS)results and the orbit *** is found that the induced swirl distortion and the mass flux nonuniformity are intensified in the compressor upstream flow field.A correction factor is thus added to the BFM to account for the effect of the induced swirl,which is crucial for the accurate representation of distortion transfer in the ***,steady simulations with large-amplitude 180circumferential total temperature distortion are performed using the developed *** is shown that the distorted compressor map simulated with the BFM matches well with URANS *** circumferential phase shift of total temperature and the generation of the additional total pressure distortion across the rotor are in line with the time-averaged URANS flow *** compressor upstream effects on the distorted inflow can also be exactly *** above-mentioned results demonstrate the BFM developed in this paper can effectively capture the distorted flow features inside the compressor,and significantly reduce the computational costs by five orders of magnitude compared with URANS.

关键词： Upstream effect Orbit method Induced swirl distortion Body force model Correction factor Time-averaged URANS

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Oligodendrocytes in central nervous system diseases:the effect of cytokine regulation

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Neural Regeneration Research 2024年第10期19卷 2132-2143页

作者： Chengfu zhang Mengsheng qiu Hui Fu Center for Cognition and Brain Disorders The Affiliated Hospital of Hangzhou Normal UniversityHangzhouZhejiang ProvinceChina Department of Psychiatry National Clinical Research Center for Mental Disordersand National Center for Mental DisordersThe Second Xiangya Hospital of Central South UniversityChangshaHunan ProvinceChina Institute of Life Sciences Key Laboratory of Organ Development and Regeneration of Zhejiang ProvinceCollege of Life and Environment SciencesHangzhou Normal UniversityHangzhouZhejiang ProvinceChina Key Laboratory of Aging and Cancer Biology of Zhejiang Province School of Basic Medical SciencesHangzhou Normal UniversityHangzhouZhejiang ProvinceChina

Cytokines including tumor necrosis factor, interleukins, interferons, and chemokines are abundantly produced in various diseases. As pleiotropic factors, cytokines are involved in nearly every aspect of cellular functions such as migration, survival, proliferation, and differentiation. Oligodendrocytes are the myelin-forming cells in the central nervous system and play critical roles in the conduction of action potentials, supply of metabolic components for axons, and other functions. Emerging evidence suggests that both oligodendrocytes and oligodendrocyte precursor cells are vulnerable to cytokines released under pathological conditions. This review mainly summarizes the effects of cytokines on oligodendrocyte lineage cells in central nervous system diseases. A comprehensive understanding of the effects of cytokines on oligodendrocyte lineage cells contributes to our understanding of central nervous system diseases and offers insights into treatment strategies.

关键词： astrocyte central nervous system disease CXC chemokine cytokine interferonγ interleukin microglia oligodendrocyte oligodendrocyte precursor cell tumor necrosis factorα

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Distributed Source-Load-Storage Cooperative Low-Carbon Scheduling Strategy Considering Vehicle-to-Grid Aggregators

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Journal of Modern Power Systems and Clean Energy 2024年第2期12卷 440-453页

作者： Xiao Xu Ziwen qiu Teng zhang Hui Gao School of Automation Nanjing University of Posts and TelecommunicationsNanjing210023China

The vehicle-to-grid(V2G)technology enables the bidirectional power flow between electric vehicle(EV)batteries and the power grid,making EV-based mobile energy storage an appealing supplement to stationary energy storage ***,the stochastic and volatile charging behaviors pose a challenge for EV fleets to engage directly in multi-agent *** unlock the scheduling potential of EVs,this paper proposes a source-load-storage cooperative low-carbon scheduling strategy considering V2G *** uncertainty of EV charging patterns is managed through a rolling-horizon control framework,where the scheduling and control horizons are adaptively adjusted according to the availability periods of ***,a Minkowski-sum based aggregation method is employed to evaluate the scheduling potential of aggregated EV fleets within a given scheduling *** method effectively reduces the variable dimension while preserving the charging and discharging constraints of individual ***,a Nash bargaining based cooperative scheduling model involving a distribution system operator(DSO),an EV aggregator(EVA),and a load aggregator(LA)is established to maximize the social welfare and improve the low-carbon performance of the *** model is solved by the alternating direction method of multipliers(ADMM)algorithm in a distributed manner,with privacy of participants fully *** proposed strategy is proven to achieve the objective of low-carbon economic operation.

关键词： Electric vehicle(EV) low-carbon scheduling mobile storage system Nash bargaining power flexibility alternating direction method of multipliers(ADMM).

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Decouple charge transfer reactions in the Li-ion battery

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Journal of Energy Chemistry 2024年第5期92卷 759-798页

作者： Yuxuan Bai qiu-An Huang Kai Wu Jiujun zhang Institute for Sustainable Energy/College of Sciences Shanghai UniversityShanghai 200444China Ningde Contemporary Innovation Laboratory Contemporary Amperex Technology Co.LimitedNingde 352100FujianChina

In the development of Li-ion batteries(LIBs)with high energy/power density,long cycle-life,fast charging,and high safety,an insight into charge transfer reactions is *** electrochemical impedance spectroscopy(EIS)is regarded as a powerful diagnosis tool,it is not a direct but an indirect *** respect to this,some critical questions need to be answered:(i)why EIS can reflect the kinetics of charge transfer reactions;(ii)what the inherent logical relationship between impedance models under different physical scenes is;(iii)how charge transfer reactions compete with each other at multiple *** work aims at answering these questions via developing a theory framework so as to mitigate the blindness and uncertainty in unveiling charge transfer reactions in *** systematically answer the above questions,this article is organized into a three-in-one(review,tutorial,and research)type and the following contributions are made:(i)a brief review is given for impedance model development of the LIBs over the past half century;(ii)an open source code toolbox is developed based on the unified impedance model;(iii)the competive mechanisms of charge transfer reactions are unveiled based on the developed EIS-Toolbox@*** work not only clarifies theoretical fundamentals,but also provides an easy-to-use open source code for EIS-Toolbox@LIB to optimize fast charge/discharge,mitigate cycle aging,and improve energy/power density.

关键词： Electrochemical impedance spectroscopy Unified impedance model Charge transfer reactions Solid/electrolyte diffusion Porous electrode EIS-Toolbox@LIB

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Seismicity changes and numerical simulation of coseismic deformation following the 2022 M_(s)6.8 Luding earthquake in Sichuan,China

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Science China Earth Sciences 2024年第8期67卷 2507-2521页

作者： qiu MENG Zitao WANG Huai zhang Key Laboratory of Computational Geodynamics of Chinese Academy of Sciences College of Earth and Planetary SciencesUniversity of Chinese Academy of SciencesBeijing 100049China Institute of Earthquake Forecasting China Earthquake AdministrationBeijing 100036China Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai) Zhuhai 519080China Beijing Yanshan Earth Critical Zone National Research Station Beijing 101408China

The Xianshuihe fault is a major tectonic boundary between the Sichuan-Yunnan rhombic and Bayanhar blocks in Southwest *** an average left-lateral strike-slip movement of 10–15 mm/yr,it is a fast-moving strike-slip continental *** September 5,2022,the Ms6.8 Luding earthquake occurred along the Moxi segment of the Xianshuihe fault,reaching a maximum intensity of IX and resulting in a significant number of casualties and severe property *** earthquake broke the long-standing seismic quiescence of the Xianshuihe fault,which lasted for more than 40 years,and was followed by a significant number of *** outstanding question is how the behavior of the Xianshuihe fault and major earthquakes changed following this *** this study,we examined the changes in regional seismicity following the Luding earthquake and identified the potential for future strong earthquakes along the Xianshuihe *** used a finite element numerical method to simulate the environment of the seismogenic fault and its adjacent *** addition,we used the coseismic slip model of the Luding earthquake with the split-node method to calculate how the stress and strain fields in the surrounding area were affected by the2022 *** stress changes were resolved in the main faults,and the seismicity of adjacent faults was analyzed in conjunction with the observed seismic *** results indicate that regional tectonic movement primarily occurred to the southeast along the Moxi *** stress field is approximately north-south in tension and east-west in *** in the stress field in the epicentral region of the Luding earthquake exceeded 1 *** maximum displacement of the coseismic deformation field was concentrated between Moxi town and Tuanjie village,and the Coulomb stress of the fault zone in this region experienced the largest ***,the b-value of the Gutenberg-Richter magnitude-frequency relationship at the epicenter a

关键词： Luding earthquake Seismicity Coulomb failure stress change Finite element numerical simulation

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Experimental and numerical flutter analysis of a folding fin with multiple asymmetric free-plays

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Chinese Journal of Aeronautics 2024年第5期37卷 332-348页

作者： Chenyu LIU Chao AN Changchuan XIE Xin zhang lan YANG School of Aeronautic Science and Engineering Beihang UniversityBeijing 100191China Beijing Institute of Electronic System Engineering Beijing 100854China Beijing Institute of Astronautical Systems Engineering Beijing 100076China

Experimental folding fin models with an adjustable free-play are tested in a wind *** fin structure is modeled using the free-interface component mode synthesis method,and its free-play is modeled as four independent nonlinear springs with asymmetric stiffness.A nonplanar unsteady vortex-lattice method considering compressibility is employed to address nonlinear deformation and high subsonic *** spline interpolation is improved through projection and *** aeroelastic characteristics of folding fins with different free-play magnitudes,initial conditions and elastic-axis positions are analyzed using an established time-marching method because of its relatively small computation scale and high *** results show good consistency among the presented method,the wind tunnel test and the harmonic balance *** is a negative correlation between the critical speed of divergent motion and the ratio of the initial condition to the free-play *** either the free-play magnitude or the initial condition is extreme(tiny or vast),the system nonlinearity degenerates to ***,the flutter prevention design of a linear model can be applied to a nonlinear model,such as moving the elastic-axis position *** presented fin configuration exhibits an unstable limit cycle oscillation because the orders of coupled flutter modes do not change with variations in equivalent linear stiffness.

关键词： Free-play Limit cycle oscillation Flutter Component mode synthesis Vortex-lattice method

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