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Cancer metastasis: issues and challenges

Chinese Journal of Cancer 2017年第3期36卷 108-111页

作者： Chao-nan qian Yan Mei Jian zhang State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine Sun Yat-sen University Cancer Center Guangzhou 510060 Guangdong P. R. China Center for Translational Medicine Guangxi Medical University and Key Laboratory of Longevity and Aging.related Diseases Ministry of Education Nanning 530021 Guangxi P. R. China Department of Biology Southern University of Science and Technology School of Medicine Shenzhen 518055 Guangdong P. R.China Department of Urology University of Pittsburgh School of MedicinePittsburgh PA 15232 USA

Metastasis is the major cause of treatment failure in cancer patients and of cancer?related *** editorial discusses how cancer metastasis may be better perceived and *** on big?data analyses,a collection of150 important pro?metastatic genes was *** The Cancer Genome Atlas datasets to re?analyze the effect of some previously reported metastatic genes—e.g.,JAM2,PPARGC1A,SIK2,and TRAF6—on overall survival of patients with renal and liver cancers,we found that these genes are actually protective factors for patients with *** role of epithelial–mesenchymal transition(EMT)in single?cell metastasis has been well?***,in metastasis caused by cancer cell clusters,EMT may not be necessary.A novel role of epithelial marker E?cadherin,as a sensitizer for chemoresistant prostate cancer cells by inhibiting Notch signaling,has been *** editorial also discusses the obstacles for developing anti?metastatic drugs,including the lack of high?throughput technologies for identifying metastasis inhibitors,less application of animal models in the pre?clinical evaluation of the leading com?pounds,and the need for adjustments in clinical trial design to better reflect the anti?metastatic efficacy of new *** are confident that by developing more effective high?throughput technologies to identify metastasis inhibitors,we can better predict,prevent,and treat cancer metastasis.

关键词： Metastasis E-cadherin EMT JAM2 PPARGC1A SIK2 TRAF6

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环糊精基的金属有机骨架的合成及负载5-氟尿嘧啶的研究

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分子科学学报 2016年第3期32卷 205-209页

作者：朱培培孙龙江杨小宁杨西亚沙靖全吴连贺张倩男佳木斯大学药学院黑龙江佳木斯154007 济宁学院化学与化工系山东曲阜273155

用溶剂热法合成了基于环糊精的金属有机骨架化合物(Na-CD-MOF),采用X-射线单晶衍射、红外光谱和元素分析进行了结构表征.以5-氟尿嘧啶(5-FU)为模型药物,研究了Na-CD-MOF的细胞毒性和载药及体外释药的能力.研究结果表明,新合成的Na-CD-MO... 详细信息

用溶剂热法合成了基于环糊精的金属有机骨架化合物(Na-CD-MOF),采用X-射线单晶衍射、红外光谱和元素分析进行了结构表征.以5-氟尿嘧啶(5-FU)为模型药物,研究了Na-CD-MOF的细胞毒性和载药及体外释药的能力.研究结果表明,新合成的Na-CD-MOF对5-FU的负载量最大为1.18g/g,且具有明显的缓释作用.体外细胞毒性实验表明,Na-CD-MOF具有良好的生物相容性,有望成为一种绿色的药物载体.

关键词：金属有机骨架环糊精 5-氟尿嘧啶载药量药物缓释

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QoS Routing Optimization Based on Deep Reinforcement Learning in SDN

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Computers, Materials & Continua 2024年第5期79卷 3007-3021页

作者： Yu Song Xusheng qian nan zhang Wei Wang Ao Xiong State Key Laboratory of Networking and Switching Technology Beijing University of Posts and TelecommunicationsBeijing100876China Marketing Service Center State Grid Jiangsu Electric Power Co.Ltd.Nanjing220000China Customer Service Center State Grid Co.Ltd.Nanjing211161China

To enhance the efficiency and expediency of issuing e-licenses within the power sector, we must confront thechallenge of managing the surging demand for data traffic. Within this realm, the network imposes stringentQuality of Service (QoS) requirements, revealing the inadequacies of traditional routing allocation mechanismsin accommodating such extensive data flows. In response to the imperative of handling a substantial influx of datarequests promptly and alleviating the constraints of existing technologies and network congestion, we present anarchitecture forQoS routing optimizationwith in SoftwareDefinedNetwork (SDN), leveraging deep reinforcementlearning. This innovative approach entails the separation of SDN control and transmission functionalities, centralizingcontrol over data forwardingwhile integrating deep reinforcement learning for informed routing decisions. Byfactoring in considerations such as delay, bandwidth, jitter rate, and packet loss rate, we design a reward function toguide theDeepDeterministic PolicyGradient (DDPG) algorithmin learning the optimal routing strategy to furnishsuperior QoS provision. In our empirical investigations, we juxtapose the performance of Deep ReinforcementLearning (DRL) against that of Shortest Path (SP) algorithms in terms of data packet transmission delay. Theexperimental simulation results show that our proposed algorithm has significant efficacy in reducing networkdelay and improving the overall transmission efficiency, which is superior to the traditional methods.

关键词： Deep reinforcement learning SDN route optimization QoS

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Tunable perpendicular anisotropic magnetoresistance in CoO/Co/Pt heterostructures

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Rare Metals 2023年第2期42卷 579-584页

作者： qian-qian Liu Guang Yang Jing-Yan zhang Guo-nan Feng Chun Feng qian Zhan Ming-Hua Li Guang-Hua Yu Department of Materials Physics and Chemistry University of Science and Technology BeijingBeijing100083China

Transport properties of magnetron-sputtered CoO/Co/Pt heterostructures were investigated by physical property measurement *** types of magnetoresistance are observed in the heterostructures,including isotropic anisotropic magnetoresistance(AMR),AMR with geometric size effect,and interfacial effect.A reversal in sign of perpendicular AMR is found in the film CoO(3 nm)/Co(3 nm)/Pt(3 nm)compared to the film CoO(3 nm)/Co(3 nm)/CoO(3 nm),which is associated with ***,perpendicular AMR is tunable in the films CoO(3 nm)/Co(3 nm)/CoO(t)/Pt(3 nm)and CoO(3 nm)/Co(3 nm)/Pt(t)/CoO(3 nm)at will,with either positive or negative value,by varying the inserting layer *** electronic structure information of the samples was measured by X-ray photoelectron spectroscopy(XPS).The spin-related transport and XPS results manifest that magnetic proximity effect,surface scattering,together with oxygen migration contribute to the tunable function of Pt.

关键词： Perpendicular anisotropic magnetoresistance Magnetic proximity effect Surface scattering X-ray photoelectron spectroscopy

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Aggregation-Induced Emission:A Rising Star in Chemistry and Materials Science

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Chinese Journal of Chemistry 2021年第3期39卷 677-689页

作者： Ting Han Dingyuan Yan qian Wu nan Song Haoke zhang Dong Wang Center for AIE Research Shenzhen Key Laboratory of Polymer Science and TechnologyGuangdong Research Center for Interfacial Engineering of Functional MaterialsCollege of Materials Science and EngineeringShenzhen UniversityShenzhenGuangdong 518060China College of Physics and Optoelectronic Engineering Shenzhen UniversityShenzhenGuangdong 518060China Department of Chemistry The Hong Kong University of Science and TechnologyClear Water BayKowloonHong KongChina

Aggregation-induced emission(AIE)refers to a photophysical effect that the luminescence of aggregates is stronger than that of the dispersed *** the concept of AIE was coined by Professor Ben Zhong Tang and co-workers in 2001,AIE has evolved from a simple luminescent phenomenon to a multidisciplinary research field with a widespread *** has changed people's way of thinking about chromophore aggregation and greatly promoted the development of advanced luminescent *** the 20-year development,diverse AIE luminogens(AlEgens)with attractive functionalities have been developed and remarkable achievements have been made in the mechanistic study and high-tech applications of *** this review,we provide an overview of the historical development and representative achievements of AIE *** on the application of AIE in aggregate science are also briefly discussed to guide the future development in this field.

关键词： Aggregation-induced emission Fluorescence Materials science Structures Mechanisms

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Colorimetric and fluorimetric detection of cysteine: Unexpected Michael addition–elimination reaction

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Chinese Chemical Letters 2015年第10期26卷 1249-1254页

作者： Hao-Ran Qu Zi-You zhang nan Wang qian Sun Shan-Shan Liu Wei-Bing zhang Jun-Hong qian Shanghai Key Laboratory of Functional Materials Chemistry School of Chemistry and Molecular Engineering East China University of Science and Technology Shanghai Key Laboratory of Chemical Biology School of Pharmacy East China University of Science and Technology

The synthesis of three isomers based on Michael addition mechanism for the detection of sulfurcontaining species in aqueous solution is described. These compounds are constructed by conjugating an enone to a coumarin fluorophore. A substituted-phenyl（o, m, or p-） was appended at the carbonyl carbon to adjust the reactivity. The experimental results showed that（E）-7-（diethylamino）-3-（3-（3-hydroxyphenyl）-3-oxoprop-1-en-1-yl）-2H-chromen-2-one（m-QPS） and（E）-7-（diethylamino）-3-（3-（4-hydroxyphenyl）-3-oxoprop-1-en-1-yl）-2H-chromen-2-one（p-QPS） barely react with sulfur-containing nucleophiles, while（E）-7-（diethylamino）-3-（3-（2-hydroxyphenyl）-3-oxoprop-1-en-1-yl）-2H-chromen-2-one（o-QPS） exhibited a fast response toward sulfite, sulfide and thiols in DMSO/phosphate buffer（2：1）. The above results are probably due to the intramolecular H-bonding activated Michael *** interestingly, cysteine triggered unusual photophysical responses of o-QPS： the original absorption（488 nm） and emission peaks（573 nm） underwent significant blue shifts initially and then recovered,which might be caused by the Michael addition and elimination reaction, respectively.

关键词： Michael addition Sulfur-containing compounds Cysteine Fluorescent probe

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Fabrication and shape detection of a catheter using fiber Bragg grating

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Advances in Manufacturing 2020年第1期8卷 107-118页

作者： Xiang-Yan Chen Ya-nan zhang Lin-Yong Shen Jin-Wu qian Jia-Ying Fan Department of Mechatronics Engineering and Automation Shanghai UniversityShanghai 200444People's Republic of China

Considering the spatial position and shape detection properties of the fiber Bragg grating(FBG)curve sensor used in the human body,the positioning accuracy of the FBG curve sensor plays a major role in the pre-diagnosis and treatment of *** present a new type of shape-sensing catheter(diameter of 2.0 mm and length of 810 mm)that is integrated with an array of four optical fibers,where each contains five nodes,to track the ***,the distribution of the four orthogonal fiber gratings is wound around a nitinol wire using novel packaging technology,and the spatial curve shape is rebuilt based on the positioning of discrete points in *** experimental platform is built,and then a reconstruction algorithm for coordinate point fitting of the Frenet frame is used to perform the reconstruction experiment on millimeter *** results show that,compared with those in previous studies,in 2D test,the maximum relative error for the end position is reduced to 2.74%,and in 3D reconstruction experiment,the maximum shape error is 3.43%,which verifies both the applicability of the sensor and the feasibility of the proposed *** results reported here will provide an academic foundation and the key technologies required for navigation and positioning of noninvasive and minimally invasive surgical robots,intelligent structural health detection,and search and rescue operations in debris.

关键词： Fiber Bragg grating(FBG) Thin diameter Encapsulation positioning Shape detection

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Box-Behnken优化红景天中红景天苷和酪醇的提取工艺

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中国现代中药 2022年第5期24卷 854-860页

作者：李杰左想想张南茜刘江齐朱艳平刘耀河南科技大学基础医学院河南洛阳471023 南召县林业局河南南阳474650

目的:优化红景天中红景天苷和酪醇的超声辅助低共熔溶剂提取工艺。方法:采用单因素试验研究提取时间、含水量及液料比对红景天苷和酪醇提取率的影响,并在此基础上运用Box-Behnken响应面法对该提取条件进行预测分析。结果:超声辅助低共... 详细信息

目的:优化红景天中红景天苷和酪醇的超声辅助低共熔溶剂提取工艺。方法:采用单因素试验研究提取时间、含水量及液料比对红景天苷和酪醇提取率的影响,并在此基础上运用Box-Behnken响应面法对该提取条件进行预测分析。结果:超声辅助低共熔溶剂法提取的最佳条件为提取时间30 min,含水量26%,液料比38∶1,在此条件下,红景天苷和酪醇的提取率分别为11.64、2.02 mg·g^(-1),与模型预测值吻合。结论:利用Box-Behnken响应面法优选的超声辅助低共熔溶剂法提取稳定可靠、切实可行,可为红景天的开发利用提供参考。

关键词：红景天超声辅助提取低共熔溶剂 Box-Behnken响应面法

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At-home cancer screening:a solution for China and other developing countries with a large population and limited number of healthcare practitioners

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Chinese Journal of Cancer 2017年第8期36卷 339-341页

作者： Chao-nan qian Department of Nasopharyngeal Carcinoma State Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineSun Yat-sen University Cancer CenterGuangzhou 510060GuangdongP.R.China

Five-year survival rate for patients with all cancers combined, in China, is only 30.9%, which is much lower than those in developed countries. The three main reasons for the low cancer curative rates in China include differences in the spectrum of cancer types, in early detection rates, and in the percentage of cancer patients receiving standardized treatment between China and developed *** most important mechanism for improving the curative rate is to improve early detection rates of major cancers in China using novel and affordable technologies that can be operated at home by the patients *** attempt could be helpful in setting up a practical example for other developing countries with limited medical resources and a limited number of healthcare practitioners.

关键词： The spectrum of cancer types At-home cancer screening Early detection rate Standardized treatment Lung cancer Cervical cancer Gastric cancer Colorectal cancer Breast cancer HPV Stool DNA

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Kinetic model of chromium release from argon oxygen decarburisation(AOD)slag in a neutral leachate

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Journal of Iron and Steel Research International 2020年第11期27卷 1303-1310页

作者： Ya-nan Zeng qian-qian Ren Bao Liu Jun-guo Li School of Metallurgy and Energy North China University of Science and TechnologyTangshan 063200HebeiChina

Valorisation of argon oxygen decarburisation(AOD)slag,a suitable recycling resource,is limited by the release of a notable amount of heavy metals,such as *** mineralogical component of AOD slag was characterised by X-ray diffraction and scanning electron microscopy-energy-dispersive X-ray *** explore the release kinetics of chromium from AOD slag,neutral leaching tests were performed at various *** results indicated the existence of two leaching stages:quick and slow leaching *** 2 h,the chromium release fraction increased sharply as the leaching time *** the leaching time in creased,the chromium release rate gradually *** on the shrinking core model,chromium release kinetic models for the quick and slow leaching stages from the AOD slag were independently *** chromium release was controlled by solid product diffusion during the quick leaching stage and a complicated process in the slow leaching *** activation energy of chromium leaching was calculated based on the Arrhenius *** product diffusion was the velocity-determining step during the 2 h leaching *** the slow leaching stage,chromium release was controlled by complicated hybrid control dominated by solid product diffusion.

关键词： Kinetic model Chromium release Shrinking core model-AOD slag

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