检索结果-南通市图书馆

中国生化药物杂志 2003年第5期24卷 262-264页

作者：侯骏骥张天民牛桂珍山东省生物药物研究院山东济南250014 山东大学药学院山东济南250012 吉林市医院吉林吉林132001

玻璃酸存在于人体的诸多组织器官内 ,对其生理功能已经了解 ,在临床眼科以及外科已使用多年 ,并积累了一些成功的经验。

关键词：玻璃酸妇产科术后粘连药物媒介

Black soldier fly:A new vista for livestock and poultry manure management

在线全文

学校读者我要写书评

暂无评论

Journal of Integrative Agriculture 2021年第5期20卷 1167-1179页

作者： zhang ji-bin zhang jia LI jia-hui Jeffery KTOMERLIN XIAO Xiao-peng Kashif ur REHMAN CAI Min-min ZHENG Long-yu YU Zi-niu State Key Laboratory of Agricultural Microbiology/National Engineering Research Center of Microbial Pesticides/College of Life Science and Technology Huazhong Agricultural UniversityWuhan 430070P.R.China Department of Entomology Texas A&M UniversityTX 77843USA Livestock and Dairy Development Department Poultry Research InstituteRawalpindi 46000Pakistan

The number of intensive livestock and poultry farms is expected to increase substantially in future because of consumer ***,such demand also results in a great deal of manure being generated,which threatens the environment if it is not properly *** developments in biotransformation of these wastes with the black soldier fly(BSF),Hermetia illucens(L.)(Diptera:Stratiomydiae),demonstrates such concerns can be abated,while also producing products(e.g.,protein,chitin,biodiesel,and fertilizer)of *** this review,we analyzed the factors influencing black soldier fly larvae(BSFL)conversion processes,the role of microorganisms,and the mechanisms used by BSFL when converting livestock and poultry manure into these valuable *** effects of BSFL conversion technology on reducing the hazards of such materials and their associated pathogens are reviewed,and the economics of livestock and poultry manure conversion by BSF larvae is discussed.

关键词： black soldier fly livestock and poultry manure conversion mechanism resource utilization

Insights into wing dimorphism in worldwide agricultural pest and hostalternating aphid Aphis gossypii

在线全文

学校读者我要写书评

暂无评论

Journal of Cotton Research 2021年第1期4卷 38-49页

作者： ji jichao HUANGFU Ningbo LUO Junyu GAO Xueke {2. Lin {3. Shuai CUI jinjie State Key Laboratory of Cotton Biology/Institute of Cotton Research(ICR) Chinese Academy of Agricultural Sciences(CAAS)Anyang 455000HenanChina Zhengzhou Research Base of ICR CAAS/State Key Laboratory of Cotton

Background:The worldwide pest Aphis gossypii has three-winged morphs in its life cycle,namely,winged parthenogenetic female(WPF),winged gynopara(GP),and winged male,which are all produced by a wingless parthenogenetic female(WLPF).Most studies on *** have focused on WPF,while few have investigated GP and *** shared molecular mechanism underlying the wing differentiation in the three wing morphs of *** remains *** wing differentiation of WPF was explored in a previous ***,GP and male were induced *** characters of the body,internal genitals,wing veins,and fecundity of GP and male were compared with those of WPF or *** with WLPF,the shared and separate differentially expressed genes(DEGs)were identified in these three-wing ***:Newly-born nymphs reared in short photoperiod condition(8 L:16D,18°C)exclusively produced gynoparae(GPe)and males in adulthood successively,in which the sex ratio was GP biased.A total of 14 GPe and 9 males were produced by one mother *** with WLPF,the three-wing morphs exhibited similar morphology and wing vein patterns but were obviously discriminated in the length of fore-and underwings,reproductive system,and fecundity.A total of 3.090 annotated unigenes were obtained from libraries constructed using the four morphs via RNA sequencing(RNA-Seq).In addition,10867 and 193.4 DEGs were identified in the pairwise comparison of GP versus WLPF and male versus WLPF,*** with WLPF,the winged morphs demonstrated 2.3. shared DEGs(1658 upregulated and 677 downregulated).The 1658 shared upregulated DEGs were enriched in multiple signaling pathways,including insulin,FoxO,MAPK,starch and sucrose metabolism,fatty acid biosynthesis,and degradation,suggesting their key roles in the regulation of wing plasticity in the cotton ***-four genes that spanned the range of differential expression were chosen to validate statistical analysis based on RNA-Seq through the

关键词： Cotton aphid Wing differentiation Wing plasticity Winged parthenogenetic female Gynopara Male

基于人脐静脉内皮细胞的OGD/R模型研究当归-川芎药对中7个活性成分对VEGF-PI3.-AKT/NF-κB信号通路的影响

在线全文

学校读者我要写书评

暂无评论

世界科学技术-中医药现代化 2024年第3期26卷 691-703页

作者：纪秋如泥文娟王晓艳张书琦吴娅丽牛璐李琨李伟霞唐进法河南中医药大学药学院郑州450046 河南中医药大学第一附属医院河南省中药临床应用、评价与转化工程研究中心河南省中药临床药学中医药重点实验室河南省中药安全评价与风险防控工程研究中心郑州450000

目的探讨当归-川芎药对中7个活性成分(绿原酸、阿魏酸、咖啡酸、丁烯基苯酞、洋川芎内酯H、洋川芎内酯A、藁本内酯)对VEGF-PI3.-AKT/NF-κB信号通路关键蛋白及其上下游血管活性物质、黏附因子和炎症因子的调控作用。方法构建人脐静脉内... 详细信息

目的探讨当归-川芎药对中7个活性成分(绿原酸、阿魏酸、咖啡酸、丁烯基苯酞、洋川芎内酯H、洋川芎内酯A、藁本内酯)对VEGF-PI3.-AKT/NF-κB信号通路关键蛋白及其上下游血管活性物质、黏附因子和炎症因子的调控作用。方法构建人脐静脉内皮细胞(HUVEC)的氧糖剥夺/复氧(OGD/R)模型,采用细胞增殖试剂盒(CCK-8法)检测细胞活力,探索7个成分的最佳造模时间;通过检测乳酸脱氢酶(LDH)释放探索最佳给药浓度;采用酶联免疫吸附法(ELISA)检测7个成分对VEGF、VCAM-1、PAI-1、NF-κB、IL-1和IL-6表达的影响;采用逆转录-聚合酶链式反应(RT-PCR)法检测7个成分对VEGF-PI3.-AKT/NF-κB信号通路关键蛋白mRNA表达的影响。结果HUVEC氧糖剥夺6 h再复氧为最佳造模时间。高剂量绿原酸组、阿魏酸组、洋川芎内酯H组,低、中剂量丁烯基苯酞组,中、高剂量洋川芎内酯A、藁本内酯组显著降低LDH漏出率(P1);绿原酸、阿魏酸、洋川芎内酯H部分剂量组细胞中VEGF、ICAM-1、VCAM-1的表达显著降低,绿原酸、阿魏酸、洋川芎内酯H、藁本内酯部分剂量组细胞NF-κB的表达显著下降,绿原酸、咖啡酸、丁烯基苯酞、洋川芎内酯H、洋川芎内酯A部分剂量组细胞中IL-6的表达显著增加,绿原酸、阿魏酸、洋川芎内酯A部分剂量组细胞IL-1表达显著减少,阿魏酸、洋川芎内酯H部分剂量组细胞中PAI-1的表达量显著下降(P1);绿原酸、阿魏酸、咖啡酸、丁烯基苯酞和洋川芎内酯A部分剂量组细胞中ERK、VEGF、NF-κB、VEGFR2.MMP9的mRNA相对表达量显著下调,洋川芎内酯H和洋川芎内酯A部分剂量组细胞中AKT的mRNA相对表达量均显著上调(P1)。结论当归-川芎中的药效成分可能通过抑制黏附因子、炎症因子和VEGF-PI3.-AKT/NF-κB信号通路关键蛋白mRNA的表达,从而发挥抗缺血性中风的作用。

关键词：当归-川芎药对人脐静脉内皮细胞药效成分缺糖缺氧/复氧 VEGF-PI3.-AKT/NF-κB信号通路

Pulse electrochemical synaptic transistor for supersensitive and ultrafast biosensors

在线全文

学校读者我要写书评

暂无评论

InfoMat 2023年第11期5卷 25-39页

作者： jianlong ji Zhenxing Wang Fan {2. Bin Wang Yan {3. Xiaoning jiang Zeng-ying Qiao Tian-ling Ren Wendong {2. Shengbo Sang Zhengdong Cheng Qijun Sun College of Electronics Information and Optical Engineering Taiyuan University of TechnologyTaiyuanthe People’s Republic of China Beijing Institute of Nanoenergy and Nanosystems Chinese Academy of SciencesBeijingthe People’s Republic of China Department of Mechanical and Aerospace Engineering North Carolina State UniversityRaleighNorth CarolinaUSA D Artificial Intelligence Biomedical Research Institute Taiyuanthe People’s Republic of China CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety CAS Center for Excellence in NanoscienceNational Center for Nanoscience and Technology(NCNST)Beijingthe People’s Republic of China Institute of Microelectronics Tsinghua UniversityBeijingthe People’s Republic of China College of Chemical and Biological Engineering Zhejiang UniversityHangzhouthe People’s Republic of China

High sensitivity and fast response are the figures of merit for benchmarking commercial *** to the advantages of intrinsic signal amplification,bionic ability,and mechanical flexibility,electrochemical transistors(ECTs)have recently gained increasing popularity in constructing various *** the current work,we have proposed a pulse-driven synaptic ECT for supersensitive and ultrafast *** pulsing the presynaptic input(drain bias,VD)and setting the modulation potential(gate bias)near transconductance intersection(VG,i),the synaptic ECT-based pH sensor can achieve a record high sensitivity up to 12. mV pH^(-1)(almost twice the Nernstian limit,59.2.mV pH^(-1))and an ultrafast response time as low as 8.75 ms(7169 times faster than the potentiostatic sensors,62.73.s).The proposed synaptic sensing strategy can effectively eliminate the transconductance fluctuation issue during the calibration process of the pH sensor and significantly reduce power ***,the most sensitive working point at VG,i has been elaborately figured out through a series of detailed mathematical derivations,which is of great significance to provide higher sensitivity with quasi-nonfluctuating amplification *** proposed electrochemical synaptic transistor paired with an optimized operating gate offers a new paradigm for standardizing and commercializing high-performance biosensors.

关键词： fast response pH sensor pulse electrochemical transistor supersensitive synaptic transistor

清热解毒汤联合维A酸乳膏哈西奈德溶液治疗血热型寻常型银屑病的效果及对患者皮损情况和炎症反应的影响

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

当代医学 2024年第9期30卷 25-29页

作者：王庆华张芳牛明红济南市钢城区人民医院皮肤科山东济南271104

目的探讨清热解毒汤联合维A酸乳膏哈西奈德溶液治疗血热型寻常型银屑病的效果及对患者皮损情况、炎症反应的影响。方法选取2.2.年1月至2.2.年3.于济南市钢城区人民医院就诊的61例寻常型银屑病患者作为研究对象,采用随机信封法分为观察... 详细信息

目的探讨清热解毒汤联合维A酸乳膏哈西奈德溶液治疗血热型寻常型银屑病的效果及对患者皮损情况、炎症反应的影响。方法选取2.2.年1月至2.2.年3.于济南市钢城区人民医院就诊的61例寻常型银屑病患者作为研究对象,采用随机信封法分为观察组(n=3.)与对照组(n=3.)。对照组采用维A酸乳膏哈西奈德溶液治疗,观察组在对照组的基础上联合清热解毒汤治疗。比较两组治疗前后中医证候积分、皮损面积和严重程度指数(PASI)评分、临床疗效及炎症因子[白细胞介素(IL)-2.IL-10、IL-4、IL-17及肿瘤坏死因子-α(TNF-α)]水平。结果治疗后,两组鳞屑、乏力困倦、红斑、瘙痒评分均低于治疗前,且观察组低于对照组,差异有统计学意义(P17、IL-2.IL-10水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05)。治疗后,两组经表皮水分丢失量少于治疗前,角质层含水量及皮脂含量均多于治疗前,且观察组经表皮水分丢失量少于对照组,角质层含水量及皮脂含量均多于对照组,差异有统计学意义(P<0.05)。结论清热解毒汤联合维A酸乳膏哈西奈德溶液能进一步增强血热型寻常型银屑病患者的治疗效果,改善患者皮损情况及皮肤屏障功能,抑制患者炎症因子表达水平,值得临床推广应用。

关键词：清热解毒汤维A酸乳膏哈西奈德寻常型银屑病炎症反应

Gastrointestinal-type chemotherapy prolongs survival in an atypical primary ovarian mucinous carcinoma: A case report

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2021年第11期9卷 2533-2541页

作者： Qi Wang Xiao-Yan niu Hui Feng jie Wu Wen Gao Zai-Xian {2. Yu-Wei Zou Bi-Yuan {2. Hai-ji Wang Department of Radiation Oncology The Affiliated Hospital of Qingdao UniversityQingdao 266000Shandong ProvinceChina Department of Ultrasound The Affiliated Hospital of Qingdao UniversityQingdao 266000Shandong ProvinceChina Department of Pathology The Affiliated Hospital of Qingdao UniversityQingdao 266000Shandong ProvinceChina Department of Radiology The Affiliated Hospital of Qingdao UniversityQingdao 266000Shandong ProvinceChina

BACKGROUND Primary ovarian mucinous carcinoma is a rare histologic subtype of epithelial ovarian carcinoma and exhibits considerable morphologic overlap with secondary *** is hard to differentiate primary from metastatic ovarian mucinous carcinoma by morphological and immunohistochemical *** of the histologic similarity between primary ovarian mucinous carcinoma and metastatic gastrointestinal carcinoma,it has been hypothesized that ovarian mucinous carcinomas might respond better to non-gynecologic ***,the standard treatment of advanced ovarian mucinous carcinoma has not reached a *** SUMMARY A 56-year-old postmenopausal woman presented with repeated pain attacks in the right lower quadrant abdomen,accompanied by diarrhoea,anorexia,and weight loss for about 3.*** patient initially misdiagnosed as having gastrointestinal carcinoma because of similar pathological *** on the physical examination,tumour markers,imaging tests,and genetic tests,the patient was clinically diagnosed with ovary mucinous *** gastrointestinal-type chemotherapy or gynecologic chemotherapy was a favourable choice for patients with advanced ovarian mucinous cancer had not been *** patient received a chemotherapy regimen based on the histologic characteristics rather than the tumour *** patient received nine cycles of FOLFOX and *** was followed by seven cycles of bevacizumab maintenance therapy for 9 *** therapeutic efficacy was *** The genetic analysis might be used in the differential diagnosis of primary ovarian mucinous carcinoma and non-gynecologic mucinous ***,primary ovarian mucinous carcinoma patients could benefit from gastrointestinal-type chemotherapy.

关键词： Ovarian mucinous cancer Chemotherapy Pathology Next-generation sequencing Case report

Key design parameters and optimum method of medium- and high-velocity synchronous induction coilgun based on orthogonal experimental design

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Physics B 2019年第2期28卷 202-209页

作者： Kai-Pei Liu Xiao-Bo niu Ya-Dong zhang Zeng-Chao {2. {2.an-Yuan Feng Wen-Qi Li School of Electrical Engineering Wuhan University Electronic Information School Wuhan University College of Electrical and Electronic Engineering Shandong University of Technology

The energy conversion efficiency of a multistage synchronous induction coilgun(MSSICG) has become one of the key factors that restricts its industrialization. To improve the launch efficiency of medium-and high-velocity MSSICG,we propose an optimization design scheme combining orthogonal experimental design(OED) and self-consistent design method in this paper. The OED is introduced to reduce the number of iterations and improve the identification accuracy and efficiency. A self-consistent design model is established to overcome a defect that the parameters that need to be optimized will multiply as the number of coil stages increases. The influence of six factors(radial thickness of armature, axial length of armature, axial length of coil, capacitance, wire diameter, and slip speed) on the launch efficiency are then evaluated by range analysis. This work presents a valuable reference for optimizing medium-and high-velocity MSSICG.

关键词： multistage synchronous induction coilgun(MSSICG) self-consistent design orthogonal experimental design(OED) range analysis

基于MOF骨架Fe-W碳化物用于硝基芳烃选择性加氢的研究

在线全文

学校读者我要写书评

暂无评论

现代化工 2017年第8期37卷 109-112页

作者：裴慧霞高睿杰潘伦牛洪岭邹吉军张香文山西潞安煤基合成油有限公司山西长治046103 天津大学化工学院先进燃料与化学推进剂教育部重点实验室天津300072

基于金属-有机骨架材料(MOF)制备了一类新型双金属碳化物催化剂。将磷钨酸(PTA)包覆在铁-MOF中,通过惰性气氛高温焙烧得到了双金属碳化物,并研究了其催化加氢性能。其中,900℃高温焙烧得到的Fe6W6C晶体在加氢反应中起到了关键的作用。PT... 详细信息

基于金属-有机骨架材料(MOF)制备了一类新型双金属碳化物催化剂。将磷钨酸(PTA)包覆在铁-MOF中,通过惰性气氛高温焙烧得到了双金属碳化物,并研究了其催化加氢性能。其中,900℃高温焙烧得到的Fe6W6C晶体在加氢反应中起到了关键的作用。PTA@MOF-900表现出很高的硝基芳烃和苯乙炔的加氢活性(>86%),且其加氢选择性接近100%,对于不同反应底物均具有较好的普适性。该催化剂循环使用5次,催化活性仍能维持在70%左右。

关键词：非均相催化硝基芳烃加氢 MOF 金属碳化物

Influence of Surface Change of Substrate Due to Impacting Behavior of Plasma Spraying Particles

在线全文

学校读者我要写书评

暂无评论

Journal of Iron and Steel Research International 2012年第S2期19卷 800-804页

作者： niu Li-ping zhang Ting-an SHI Guan-yong HE {2.-cheng School of Materials and Metallurgy Northeastern University Key Laboratory for Ecological Utilization of Multimetallic Mineral(Ministry of Education)

In this paper,the process of many particles hitting the same point of the substrate has been studied and an approximated formula to estimate maximum number of impact on the same point has been obtained through analytical *** number of impacting on the same point of substrate;ust be small than this critical number to prevent substrate *** calculation results shows that for 45 steel,it is 2. when initial velocity is 40m/s,15 when initial velocity is 60 m/s,12.when initial velocity is 80 m/s and 4 when initial velocity is 2.0 m/*** the increase of the particles initial velocity,the maximum number of speculation by the analytical model becomes *** we can deduce that this treatment does not cause the damage of substrate material.

关键词： plasma spraying maximum number of particles analytical model substrate