检索结果-南通市图书馆

Bazi Bushen alleviates reproductive aging in aged male mice

在线全文

学校读者我要写书评

暂无评论

chinese Journal of Natural Medicines 2024年第5期22卷 416-425页

作者： MA Kun LI Mengnan SONG Yahui MAO Xinjing zhang Shaolan zhang Yaping jiANG Yuning ji Chuanyuan niu Kunxu LI Hongrong HOU Yunlong WEI Cong graduate School Hebei University of Chinese MedicineShijiazhuang 050091China State Key Laboratory for Innovation and Transformation of Luobing Theory Shijiazhuang 050035China Key Laboratory of State Administration of TCM(Cardio-Cerebral Vessel Collateral Disease) Shijiazhuang 050035China College of Traditional chinese Medicine·College of Integrated Traditional chinese and Western Medicine Nanjing University of Chinese MedicineNanjing 210023China Hebei Provincial Key Laboratory of Luobing Shijiazhuang 050035China Key Disciplines of State Administration of TCM for Luobing Shijiazhuang 050035China

Bazi Bushen(BZBS),a traditional chinese medicine(TCM),has demonstrated therapeutic efficacy in testicular dysfunction within D-galactose and NaNO_(2.mouse *** study aimed to ascertain if BZBS could also mitigate the decline in testicular function associated with natural ***,male aged mice were employed to evaluate the preventive effects of BZBS on male reproductive *** was achieved by assessing sex hormone production,testicular histomorphology,and *** to the untreated aged control group,BZBS administration elevated the levels of sex hormones and spermatocyte populations and preserved normal testicular structure in aged ***,spermatogenesis was *** analyses,including malondialdehyde(MDA)assays and real-time PCR,indicated that BZBS diminished testicular oxidative stress and the inflammatory *** these findings,mice treated with BZBS exhibited reductions in the populations of senescent and apoptotic cells within the seminiferous tubules,suggesting alleviated cellular *** contrast,we observed that rapamycin,a drug known for its longevity benefits,induced excessive testicular apoptosis and did not decrease lipid ***,our results highlight BZBS’s promising clinical potential in counteracting male reproductive aging,underlining its mechanisms of action.

关键词： Traditional chinese medicine Male reproductive aging Spermatogenic cells Cell senescence Apoptosis

Variable phenotypes and outcomes associated with the MMACHC c.482.>A mutation:follow-up in a large CblC disease cohort

在线全文

学校读者我要写书评

暂无评论

World Journal of Pediatrics 2024年第8期20卷 848-858页

作者： Sheng-Nan Wu Hui-Shu E Yue Yu Shi-Ying Ling Li-Li Liang Wen-Juan Qiu Hui-Wen zhang Rui-Xue Shuai Hai-Yan Wei Chi-Ju Yang Peng Xu Xi-Gui Chen Hui Zou ji-Zhen Feng Ting-Ting {2. Hai-Li Hu Kai-Chuang zhang De-Yun Lu Zhu-Wen Gong Xia Zhan Wen-Jun ji Xue-Fan Gu Yong-Xing Chen Lian-Shu Han Department of Endocrinology and Metabolism Henan Key Laboratory of Children’s Genetics and Metabolic DiseasesChildren’s Hospital Affiliated to Zhengzhou UniversityHenan Children’s HospitalZhengzhou Children’s HospitalNo.255 Gangdu StreetZhengzhouChina Department of Pediatric Endocrinology and Genetics Fujian Children’s HospitalFuzhouChina The Center for Pediatric Liver Diseases Children’s HospitalFudan UniversityShanghaiChina Department of Pediatric Endocrinology/Genetics Shanghai Institute for Pediatric ResearchXinhua HospitalSchool of MedicineShanghai Jiao Tong UniversityNo.1665 Kongjiang RoadShanghaiChina Department of Pediatrics Second Affiliated Hospital of Naval Medical UniversityShanghaiChina Center of Neonatal Disease Screening Jining Maternal and Child Health Care HospitalJiningChina Center of Neonatal Disease Screening Jinan Maternal and Child Health Care HospitalJinanChina Center of Neonatal Disease Screening Shijiazhuang Maternal and Child Health Care HospitalShijiazhuangChina Center of Neonatal Disease Screening Shandong Maternal and Child Health Care HospitalJinanChina Center of Neonatal Disease Screening Hefei Maternal and Child Health Care HospitalHefeiChina

Background The aim of this study was to characterize the variable phenotypes and outcomes associated with the methylmalonic aciduria and homocystinuria type C protein gene(MMACHC)c.482.>A mutation in 195 chinese cases with CblC *** We carried out a national,retrospective multicenter study of 195 chinese patients with CblC disease attributable to the MMACHC c.482.>A variant either in a homozygous or compound heterozygous *** control group consisted of 2.0 patients diagnosed with CblC disease who did not possess the c.482.>A *** features,including disease onset,symptoms,biochemical metabolites,gene mutation,and follow-up outcomes were reviewed and analyzed in *** median follow-up period spanned 3 years and 8 months,with a range of 1 year and 2.months to 12.years and 10 *** Among 195 patients carrying the c.482.>A variant,12.(64.1%)cases were diagnosed by newborn screening(NBS),60(30.8%)cases were detected due to disease onset,and 10(5.1%)cases were identified from sibling *** hundred and seventeen(93.6%)individuals who were diagnosed by NBS,and nine patients who came from sibling diagnoses remained asymptomatic in this *** 69 symptomatic patients of the c.482.>A group,more patients presented with later onset,and the top six common clinical symptoms at disease onset were developmental delay(59.4%),lower limb weakness and poor exercise tolerance(50.7%),cognitive decline(37.7%),gait instability and abnormal posture(36.2.),seizures(2..1%),and psychiatric and behavioral disturbances(2..6%).In the 159 symptomatic patients lacking c.482.>A variants,the most frequently observed clinical manifestations at disease onset included developmental delay(81.8%),lethargy and feeding difficulty(62.9%),lower limb weakness and poor exercise tolerance(54.7%),prolonged neonatal jaundice(51.6%),vomiting(47.2.),and seizures(32.7%).Before treatment,the levels of blood propionylcarnitine,propionylcarnitine/acetylcarnitine ratio

关键词： c.482.>A CblC disease MMACHC gene Newborn screening Outcome Use our pre-submission checklist Avoid common mistakes on your manuscript.

Southeastern extension of the Red River fault zone (RRFZ) and its tectonic evolution significance in western South china Sea

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science china Earth sciences 2006年第8期49卷 839-850页

作者： LIU Baoming1,2.3, XIA Bin1, LI Xuxuan1,3, zhang Minqiang1,3, {2. Binhua2. ZHONG Lifeng1, jiN Qinghuan1,4 & ji Shaocheng1,5 1. Key Laboratory of Marginal Sea Geology and Resources, chinese academy of sciences,Guangzhou 510640, china 2. china university of Geosciences (Beijing), Beijing 100083, china 3. Research Center of Science & Technology Department, CNOOC, Beijing 10002., china 4. Guangzhou Marine Geological Survey, Ministry of Land & Resources, Guangzhou 510075, china 5. Ecole Polytechnique Montreal, H3C3A7, Canada Key Laboratory of Marginal Sea Geology and Resources Chinese Academy of Sciences Guangzhou China china university of Geo{2. (Beijing) Beijing China Research Center of Science & Technology Department CNOOC Beijing China Guangzhou Marine Geological Survey Ministry of Land & Resources Guangzhou China Ecole Polytechnique Montreal Canada

Recent geophysical surveys and basin modeling suggest that the No.1 fault in the Ying- gehai basin (YGHB) is the seaward elongation of the Red River fault zone (RRFZ) in the South china Sea (SCS). The RRFZ, which separates the South china and Indochina block, extends first along the Yuedong fault, offshore of Vietnam, and then continues southward and breaks off into two branches: the Lupar fault and the Tinjia fault. The southern extension of the Lupar fault dies out beneath the NW Borneo while the Tinjia fault extends southeast and reaches the Brunei-Sabah area. According to the gravity and geomagnetic data, and the tectonic evolution of the basins, there are different evolution histories between the Wan’an basin (WAB) and the basins in the Nansha block. The Tinjia fault may be the boundary between the Balingian block and the Nansha block. Hence, the line linking the Yue- dong fault and the Tinjia fault, which both are continental margin faults and strike-slip ones in the geological evolution histories, constitute the boundary between the Indochina and Nansha block. The Lupar fault, in contrast, is an intraplate fault within the Indochina block. The results provide new hints for reconstructing the tectonic evolution history of the RRFZ and the opening of the SCS, and also a framework for hydrocarbon prospecting in the region.

关键词： Red River fault zone, tectonic evolution, fault, extension, western South china Sea.

Synthesis and Biological Activity of Aspirin Eugenol Ester

在线全文

学校读者我要写书评

暂无评论

Synthesis and Biological Activity of Aspirin Eugenol Ester

淮河流域细颗粒物化学组分时空特征及驱动因素分析

2.11年全国药物化学学术会议——药物的源头创新

作者： jian-yong Li~(1*),Yuan-guang Yu~1,Qi-wen Wang~1ji-yu {2.~1,Ya-jun Yang~1,Bing Li~1,Xu-zheng Zhou~1 jian-rong niu~1,Xiao-juan Wei~1 and Zhi-qi Liu~2.1 Key Lab of New Animal Drug Project,Gansu Province,Key Lab of Veterinary Pharmaceutics Discovery,Ministry of Agriculture,Lanzhou Institute of Animal Science and Veterinary Pharmaceutics,chinese academy of Agricultural sciences,Lanzhou730050, china 2.The academy of Life Science and Engineering,university of Technology,china

Aspirin,as starting precursor,was reacted with SOCI to generate acyl chloride compound via esterifying eugenol to aspirin eugenol ester(AEE) with a yield of 65%.Tests of AEE for acute toxicity,anti-inflammatory,analgesic and antipyretic effects were carried out in mice and *** results showed that toxicity of AEE was significantly reduced, about 50 and 3.7 times lower than aspirin and eugenol,*** strength of anti-inflammation,analgesia and antipyresis was similar as aspirin and eugenol,but the effects lasted longer.

关键词： Aspirin Eugenol Ester toxicity anti-inflammation analgesic and antipyretic effects

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

环境科学 2024年第10期45卷 5650-5660页

作者：刘晓咏牛继强刘航张一丹颜俊闫军辉苏方成信阳师范大学地理科学学院信阳464000 信阳师范大学河南省水土环境污染协同防治重点实验室信阳464000 中国科学院大气物理研究所大气边界层物理和大气化学国家重点实验室北京100029 郑州大学化学学院郑州450001

基于淮河流域35个城市2.15~2.2.年的细颗粒物(PM_(2.5))及其组分数据集,分析了污染物的时空分布格局,利用随机森林模型考察了气象因子对PM_(2.5)浓度的影响.采用KZ(Kolmogorov-Zurbenko)滤波和多元线性回归(MLR)对PM_(2.5)、硫酸盐(SO_(... 详细信息

基于淮河流域35个城市2.15~2.2.年的细颗粒物(PM_(2.5))及其组分数据集,分析了污染物的时空分布格局,利用随机森林模型考察了气象因子对PM_(2.5)浓度的影响.采用KZ(Kolmogorov-Zurbenko)滤波和多元线性回归(MLR)对PM_(2.5)、硫酸盐(SO_(4)^(2.))、硝酸盐(NO_(3)^(-))、铵盐(NH_(4)^(+))、有机物(OM)和黑炭(BC)的原始序列进行气象调整,定量气象条件的影响.结果表明,2.15~2.2.年淮河流域PM_(2.5)、SO_(4)^(2.)、NO_(3)^(-)、NH_(4)^(+)、OM和BC的变化速率分别为-4.71、-0.99、-1.05、-0.77、-1.01和-0.19μg·(m^(3)·a)^(-1).PM_(2.5)及其组分浓度高值集中在淮河流域中部和西部区域,而沿海及南部城市的浓度较低.PM_(2.5)短期、季节和长期分量对35个城市PM_(2.5)原始序列总方差的贡献率分别为51.6%、35.9%和7.0%,沿海城市更受短期分量影响.2.15~2.18年气象条件不利于淮河流域PM_(2.5)浓度的降低,2.19~2.2.年气象条件有利于PM_(2.5)浓度的降低.2.15~2.2.年气象条件对淮河流域PM_(2.5)、SO_(4)^(2.)、NO_(3)^(-)、NH_(4)^(+)、OM和BC长期分量下降的贡献率分别为2..3%、2..1%、31.0%、2..3%、2..8%和2..6%.气象条件对安徽、山东、江苏和河南省淮河流域城市PM_(2.5)长期分量降低的贡献率分别为43.4%、2..6%、2..5%和2..6%.随着淮河流域PM_(2.5)浓度降低,硫氧化率(SOR)明显上升,而氮氧化率(NOR)变化不大.

关键词： PM_(2.5) 化学组分 KZ滤波时空分布气象影响

基于COSMO-SAC模型预测烟碱+醇二元体系汽-液相平衡

在线全文

学校读者我要写书评

暂无评论

过程工程学报 2024年第3期24卷 338-345页

作者：邓芙蓉季常征牛亚鹏冯晓民孟祥士张孟伟彭昌军华东理工大学化学与分子工程学院上海200237 河南中烟工业有限责任公司技术中心河南郑州450016

类导体屏蔽片段活度系数模型(COSMO-SAC)可直接通过量子化学计算实现相平衡等性质的预测。本工作结合COSMO-SAC模型预测了烟碱分别与一元醇(甲醇、乙醇、丙醇、异丙醇、丁醇、戊醇、己醇、庚醇、辛醇)和多元醇(乙二醇、1,2.丙二醇、1,3... 详细信息

类导体屏蔽片段活度系数模型(COSMO-SAC)可直接通过量子化学计算实现相平衡等性质的预测。本工作结合COSMO-SAC模型预测了烟碱分别与一元醇(甲醇、乙醇、丙醇、异丙醇、丁醇、戊醇、己醇、庚醇、辛醇)和多元醇(乙二醇、1,2.丙二醇、1,3-丙二醇、丙三醇)组成的二元体系的汽-液相平衡。结果表明,醇与烟碱的二元体系均为正偏差体系;其中,一元醇与烟碱的二元体系均为一般正偏差体系,相图轮廓类似,但随着醇类物质碳链数目增加,汽-液共存区的面积减小;烟碱与多元醇构成的二元体系均会出现恒沸现象,是一个具有最低恒沸点的系统。温度越高,恒沸混合物形成的压力和比例也越高。在101.3 kPa下,丙三醇/烟碱体系的恒沸温度和恒沸组成分别为511.4 K和0.2.1,1,2.丙二醇/烟碱的为459.5 K和0.857,1,3-丙二醇/烟碱的为483.0 K和0.72.,乙二醇/烟碱的为467.0 K和0.889。研究结果为指导烟碱的纯化分离以及认识烟碱的释放规律提供了理论数据。

关键词：烟碱醇 COSMO-SAC 汽-液相平衡预测

Melanin precursors mediated adaption to temperature changes in fungus and animal via inhibition of lipid-mediated ferroptosis

在线全文

学校读者我要写书评

暂无评论

Science china(Life sciences) 2023年第8期66卷 1800-1817页

作者： Xiaoyu Yang Yonghong Chen Longlong zhang jiangbo He Qunfu Wu Shuhong Li Donglou Wang {2. Gou Zhuang Wu Keqin zhang Shenghong Li Xuemei niu State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan and Key Laboratory for Southwest Microbial Diversity of the Ministry of EducationYunnan UniversityKunming 650032China State Key Laboratory of Phytochemistry and Plant Resources in West china Kunming Institute of BotanyChinese Academy of SciencesKunming 650201China Kunming Key Laboratory of Respiratory Disease Kunming UniversityKunming 650214China

The discovery of biological activities of natural products plays a vital part in drug *** mechanism by which organisms respond to temperature changes via biosynthesis of natural products remained largely cryptic.A thermophilic fungus under cold stress turned black and accumulated a polyketide metabolite 1 and lipid *** in 1 caused melanin loss and accumulated extra lipid mass,unexpectedly leading to seriously damaged mitochondria diagnostic for *** analysis revealed that lipid mass induced by cold stress intensively increased ferroptosis risk and 1 functioned as cell wall reinforcer against mass lipid accumulation and as reactive oxygen species scavenger against lipid *** also found that melanin in mice lowered lipid level but enhanced animal resistance to cold *** with melanin precursors significantly increased mouse cell survival rate under cold *** results unveiled a metabolite-lipid-ferroptosis-cold relationship,which provided mechanistic insights into the functions of most common metabolites and into diseases related to cold *** findings opened a perspective for developing anti-cold and anti-ferroptosis therapeutics and agents.

关键词： melanin precursor lipid ferroptosis temperature change anti-cold

近邻宜居行星巡天计划:利用空间天体测量法寻找下一个“地球”

在线全文

学校读者我要写书评

暂无评论

空间科学学报 2024年第2期44卷 193-214页

作者：季江徽李海涛张俊波李东方亮王素邓雷陈果李飞董瑶李保权高晓东鲜浩中国科学院紫金山天文台南京210023 中国科学技术大学天文与空间科学学院合肥230026 中国科学院行星科学重点实验室南京210023 中国科学院国家空间科学中心北京100190 中国科学院大学北京100049 中国科学院光电技术研究所成都610209 自适应光学全国重点实验室成都610209 中国科学院微小卫星创新研究院上海201306

近邻宜居行星巡天计划(Closeby Habitable Exoplanet Survey,CHES)采用空间微角秒级别的高精度天体测量技术,普查太阳系近邻(10 pc内)约100颗FGK等类型恒星,探测宜居带类地行星或超级地球;详细普查宜居行星的数目、真实质量和三维轨道... 详细信息

近邻宜居行星巡天计划(Closeby Habitable Exoplanet Survey,CHES)采用空间微角秒级别的高精度天体测量技术,普查太阳系近邻(10 pc内)约100颗FGK等类型恒星,探测宜居带类地行星或超级地球;详细普查宜居行星的数目、真实质量和三维轨道等信息,这将是国际上首次近邻宜居带类地行星的空间探测任务.CHES的有效载荷是一台口径为1.2.m,视场为0.44°×0.44°,焦距为36 m的高像质、低畸变、高稳定光学望远镜,采用同轴三反TMA光学成像系统.为实现宜居带类地行星探测,CHES任务中的测量精度为1μas,是目前国际测量精度最高的空间探测项目.在空间科学先导专项背景型号项目的支持下,CHES团队深入凝练和论证科学目标,成功突破了三项关键技术难题:实现了畸变大视场高像质空间望远镜光学系统技术的重要突破;突破了10–5 pixel级别星间距测量技术;实现了卫星系统高稳定度姿态控制精度及热控精度的创新.CHES预计发现50颗类地行星,引领中国空间科学探测技术的跨越式发展.

关键词：高精度天体测量法系外行星近邻宜居行星

Single-atom Pt promoted Mo_(2.C for electrochemical hydrogen evolution reaction

在线全文

学校读者我要写书评

暂无评论

Journal of Energy Chemistry 2021年第6期30卷 371-377,I0009页

作者： Shanshan niu ji Yang Haifeng Qi Yang Su Zhiyu Wang jieshan Qiu Aiqin Wang Tao zhang State Key Laboratory of Catalysis Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023LiaoningChina State Key Lab of Fine Chemicals Liaoning Key Lab for Energy Materials and Chemical EngineeringPSU-DUT Joint Center for Energy ResearchDalian University of TechnologyDalian 116024LiaoningChina College of Chemical Engineering Beijing University of Chemical TechnologyBeijing 100029China

Hydrogen generation from electrochemical water splitting powered by renewable energy is important to the sustainable society,but the prohibitive cost of current Pt electrocatalyst has impeded the large-scale production of hydrogen by water *** this contribution,a new low-Pt electrocatalyst for hydrogen evolution reaction(HER) has been fabricated by a facile one-pot synthesis approach,in which Pt^(2.)cations and phosphomolybdic acid confined in the metal-organic frameworks(MOFs) were submitted to pyrolysis to yield Pt single atoms dispersed into Mo_(2.C nanocrystals in 3 D porous carbon *** as-synthesized Pt_(1)-Mo_(2.C-C catalyst with Pt content of only 0.7 wt% exhibited remarkably enhanced activity for HER in 1 M KOH,with overpotential at 10 mA/cm^(2. lowered from 2.1 mV to 155 mV and 7-fold higher mass activity(7.14 A/mgpt) than the benchmark 2. wt% Pt/*** promoted activity can be attributed to the electronic interaction between Pt single atoms and Mo2. surface,which not only improved water activation but also strengthened hydrogen adsorption,as indicated by FTIR and microcalorimetric characterizations.

关键词： Metal carbide Pt single atom MOF Hydrogen evolution reaction