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Untreated Prior Pulmonary Tuberculosis Adversely Affects Pregnancy Outcomes in Infertile Women Undergoing in vitro Fertilization and Embryo Transfer: A Large Retrospective Cohort Study

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Biomedical and Environmental Sciences 2021年第2期34卷 130-138页

作者： GAI xiao Yan CHI hong Bin ZENG Lin CAO Wen Li CHEN Li xue zhang Chen LU Ming ning Lan Ding CHANG Chun zhang Wei xia LIU Ping LI Rong SUN Yong Chang QIAO Jie Department of Respiratory and Critical Care Medicine Peking University Third HospitalBeijing 100191China Center for Reproductive Medicine Department of Obstetrics and GynecologyPeking University Third HospitalBeijing 100191China National Clinical Research Center for Obstetrics and Gynecology Beijing 100191China Research Center of Clinical Epidemiology Peking University Third HospitalBeijing 100191China Tuberculosis Department Beijing Geriatric HospitalBeijing 102699China Information Center Peking University Third HospitalBeijing 100191China

Objective Prior pulmonary tuberculosis(PTB) on chest X-ray(CXR) was commonly found in infertile patients receiving examinations before in vitro fertilization and embryo transfer(IVF-ET). It was unclear whether untreated PTB would affect pregnancy outcomes after *** We conducted a retrospective cohort study of 14,254 infertile patients who had received IVFET at Peking University Third Hospital in 2017. Prior PTB was defined as the presence of signs suggestive of old or inactive PTB on CXR, with or without a clinical TB history. Patients who had prior PTB on CXR but had not received a clinical diagnosis and anti-TB therapy were included for analysis. Live birth,clinical pregnancy, and miscarriage rates were compared between the untreated PTB and non-PTB *** The untreated PTB group had significantly lower clinical pregnancy(31.7% vs. 38.1%) and live birth(23.8% vs. 30.6%) rates than the non-PTB group(both P < 0.001). Multivariate analysis revealed that untreated PTB was a risk factor for decreased live birth rate [odds ratio(OR), 0.80;95% confidence interval(CI), 0.66–0.98;P = 0.028] in all patients and for increased miscarriage(OR, 4.19;95% CI,1.69–10.39;P = 0.002) and decreased live birth(OR, 0.45;95% CI, 0.24–0.83;P = 0.011) rates in patients with unexplained *** Untreated PTB was associated with adverse pregnancy outcomes after IVF-ET, especially in patients with unexplained infertility, highlighting the clinical significance of PTB in this specific patient population.

关键词： Tuberculosis Embryo transfer In vitro fertilization Infertility Pregnancy outcome

Activation-induced pyroptosis contributes to the loss of MAIT cells in chronic HIV-1 infected patients

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Military Medical Research 2023年第1期10卷 45-63页

作者： Peng xia Xu-dong Xing cui-xian Yang xue-Jiao Liao Fu-hua Liu Hui-huang huang Chao zhang Jin-Wen Song Yan-Mei Jiao Ming Shi Tian-Jun Jiang Chun-Bao Zhou Xi-Cheng Wang Qing He Qing-Lei Zeng Fu-Sheng Wang Ji-Yuan zhang Senior Department of Infectious Diseases the Fifth Medical Center of Chi‑nese PLA General HospitalNational Clinical Research Center for Infectious DiseasesSavaid Medical SchoolUniversity of Chinese Academy of SciencesBeijing 100039China Department of Infectious Diseases and Hepatology the First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China Biomedical Pioneering Innovation Center(BIOPIC) School of Life SciencesPeking UniversityBeijing 100871China Yunnan Infectious Disease Hospital Kunming 650301China The Third People’s Hospital of Shenzhen School of MedicineSouthern University of Science and TechnologyShenz‑hen 518112GuangzhouChina

Background: Mucosal-associated invariant T(MAIT) cells are systemically depleted in human immunodeficiency virus type 1(HIV-1) infected patients and are not replenished even after successful combined antiretroviral therapy(cART).This study aimed to identify the mechanism underlying MAIT cell ***: In the present study, we applied flow cytometry, single-cell RNA sequencing and immunohistochemical staining to evaluate the characteristics of pyroptotic MAIT cells in a total of 127 HIV-1 infected individuals, including 69 treatment-naive patients, 28 complete responders, 15 immunological non-responders, and 15 elite controllers, at the Fifth Medical Center of Chinese PLA General Hospital, Beijing, ***: Single-cell transcriptomic profiles revealed that circulating MAIT cells from HIV-1 infected subjects were highly activated, with upregulation of pyroptosis-related genes. Further analysis revealed that increased frequencies of pyroptotic MAIT cells correlated with markers of systemic T-cell activation, microbial translocation, and intestinal damage in cART-naive patients and poor CD4+ T-cell recovery in long-term cART patients. Immunohistochemical staining revealed that MAIT cells in the gut mucosa of HIV-1 infected patients exhibited a strong active gasdermin-D(GSDMD, marker of pyroptosis) signal near the cavity side, suggesting that these MAIT cells underwent active pyroptosis in the colorectal mucosa. Increased levels of the proinflammatory cytokines interleukin-12(IL-12) and IL-18 were observed in HIV-1 infected patients. In addition, activated MAIT cells exhibited an increased pyroptotic phenotype after being triggered by HIV-1 virions, T-cell receptor signals, IL-12 plus IL-18, and combinations of these factors, in ***: Activation-induced MAIT cell pyroptosis contributes to the loss of MAIT cells in HIV-1 infected patients,which could potentiate disease progression and poor immune reconstitution.

关键词： Acquired immune deficiency syndrome Human immunodeficiency virus Mucosal-associated invariant T cells Pyroptosis Immune reconstitution

Phonon lasing enhanced mass sensor with zeptogram resolution under ambient conditions

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Chip 2023年第3期2卷 1-6页

作者： Fei Pan Kaiyu cui Yidong huang Ziming Chen ning Wu Guoren Bai Zhilei huang xue Feng Fang Liu &Wei zhang Department of Electronic Engineering Tsinghua UniversityBeijing 100084China Beijing National Research Center for Information Science and Tech-nology(BNRist) Beijing 100084China

High-sensitivity mass sensors under ambient conditions are essential in various fields such as biological research,gas sensing and environ-mental *** the current work,a phonon lasing enhanced mass sensor was proposed based on an optomechanical crystal cav-ity under ambient *** phonon lasing was harnessed to achieve ultra-high resolution since it resulted in an extremely nar-row mechanical linewidth(less than 10 kHz).Masses with different weights were deposited on the cavity,it is predicted that the maxi-mum resolution for mass sensing can be 65±19 zg,which approaches the mass order of a protein and an *** implies the potential application of the proposed method in the biomedical fields such as oligonucleotide drug delivery area and the Human Proteome Project.

关键词： Mass sensing Optomechanical crystal cavity Phonon lasing

局部冷却布置对航空铝合金蒙皮化铣温度场的影响研究

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南昌航空大学学报（自然科学版） 2024年第1期38卷 10-16页

作者：黄梅吴宁李旭勇张东升李丰潘龙腾邹康鑫欧阳德来崔霞南昌航空大学材料科学与工程学院南昌330063 江西洪都航空工业集团有限责任公司南昌330096

为优化某航空铝合金蒙皮化铣过程中局部冷却布置,利用Fluent软件对局部冷却时蒙皮化铣温度场进行有限元数值模拟,研究局部冷却布置对航空铝合金蒙皮化铣温度场的影响。结果表明:随化铣时间增加,蒙皮表面温度增加,且存在较大温度差,化铣7... 详细信息

为优化某航空铝合金蒙皮化铣过程中局部冷却布置,利用Fluent软件对局部冷却时蒙皮化铣温度场进行有限元数值模拟,研究局部冷却布置对航空铝合金蒙皮化铣温度场的影响。结果表明:随化铣时间增加,蒙皮表面温度增加,且存在较大温度差,化铣760 s后温度差超过4℃;单冷却喷口局部冷却效果较差,底部化铣面冷却不足;下方加装一个喷口会改善底部化铣面冷却效果;上方加装一个喷口使化铣面右上部分高温区域消失,能够明显改善化铣面温度均匀性;但过多冷却喷口(5喷口)会使冷却液相互干扰,化铣面温度均匀性变差。喷口流速低于2 m/s时,化铣面降温速度较慢;高于3 m/s时,化铣面降温速度较快,但温度均匀性变差。从冷却效果考虑,采用纵向三冷却喷口布置、喷口流速3 m/s的方案最佳,此时化铣面最低温度冷却至85℃所需时间为51 s,化铣面最高温度为89.3℃,平均温度为87.5℃。

关键词：航空铝合金蒙皮化铣局部冷却温度场有限元模拟

Genetic dissection of the grain-filling rate and related traits through linkage analysis and genome-wide association study in bread wheat

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Journal of Integrative Agriculture 2022年第10期21卷 2805-2817页

作者： YU Hai-xia DUAN Xi-xian SUN Ai-qing SUN xiao-xiao zhang Jing-juan SUN hua-qing SUN Yan-yan ning Tang-yuan TIAN Ji-chun WANG dong-xue LI Hao FAN Ke-xin WANG Ai-ping MA Wu-jun CHEN Jian-sheng State Key Laboratory of Crop Biology/Key Laboratory of Crop Water Physiology and Drought-tolerance Germplasm Improvement Minstry of Agriculture and Rural Affairs/Group of Wheat Quality BreedingCollege of AgronomyShandong Agricultural UniversityTai’an 271018P.R.China Dezhou Agricultural Protection and Technological Extension Center Dezhou 253000P.R.China Zhongnong Tiantai Seed Co. Ltd.Pingyi 273300P.R.China School of Veterinary and Life Sciences Murdoch UniversityMurdochWA 6150Australia

Wheat grain yield is generally sink-limited during grain *** grain-filling rate(GFR)plays a vital role but is poorly studied due to the difficulty of phenotype *** study explored the grain-filling traits in a recombinant inbred population and wheat collection using two highly saturated genetic maps for linkage analysis and genome-wide association study(GWAS).Seventeen stable additive quantitative trait loci(QTLs)were identified on chromosomes 1B,4B,and *** linkage interval between IWB19555 and IWB56078 showed pleiotropic effects on GFR_(1),GFR_(max),kernel length(KL),kernel width(KW),kernel thickness(KT),and thousand kernel weight(TKW),with the phenotypic variation explained(PVE)ranging from 13.38%(KW)to 33.69%(TKW).198 significant marker-trait associations(MTAs)were distributed across most chromosomes except for 3D and *** major associated sites for GFR included IWB44469(11.27%),IWB8156(12.56%)and IWB24812(14.46%).Linkage analysis suggested that IWB35850,identified through GWAS,was located in approximately the same region as QGFR_(max)2B.3-11,where two high-confidence candidate genes were *** important grain weight(GW)-related QTLs colocalized with grain-filling *** findings contribute to understanding the genetic architecture of the GFR and provide a basic approach to predict candidate genes for grain yield trait QTLs.

关键词： wheat grain-filling rate linkage analysis genome-wide association study

Design biodegradable Zn alloys: Second phases and their significant influences on alloy properties

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Bioactive Materials 2020年第2期5卷 210-218页

作者： zhang-Zhi Shi Xi-xian Gao Hai-Jun zhang xue-Feng Liu Hui-Yan Li Chao Zhou Yu-xia Yin Lu-ning Wang Beijing Advanced Innovation Center for Materials Genome Engineering Beijing Laboratory of Metallic Materials and Processing for Modern TransportationKey Laboratory for Advanced Materials Processing of Ministry of EducationSchool of Materials Science and EngineeringUniversity of Science and Technology BeijingBeijing100083China Department of Interventional and Vascular Surgery The Tenth People's Hospital of ShanghaiTongji UniversityShanghai200072China National United Engineering Laboratory for Biomedical Material Modification Branden Industrial ParkDezhou CityShandong251100China

Alloying combined with plastic deformation processing is widely used to improve mechanical properties of pure ***-cast Zn and its alloys are *** plastic deformation processing,no effective method has yet been found to eliminate the brittleness and even endow room temperature *** phase,induced by alloying,not only largely determines the ability of plastic deformation,but also influences strength,corrosion rate and *** second phase is important for designing biodegradable Zn *** this review,knowledge related to second phases in biodegradable Zn alloys has been analyzed and summarized,including characteristics of binary phase diagrams,volume fraction of second phase in function of atomic percentage of an alloying element,and so *** about second phases in Zn-Li,Zn-Cu and Zn-Fe systems have been settled down,which benefits future *** effects of alloying elements and second phases on microstructure,strength,ductility,corrosion rate and cytotoxicity have been neatly ***,Mn,Li,Cu and Ag are recommended as the major alloying elements,owing to their prominent beneficial effects on at least one of the above *** future,synergistic effects of these elements should be more thoroughly *** other nutritional elements,such as Fe and Ca,refining second phase is a matter of vital concern.

关键词： Biodegradable Zn alloys Alloy design Second phase Microstructure Comprehensive properties

288例山东省牙膏不良反应监测数据回顾分析

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日用化学品科学 2024年第9期47卷 22-25页

作者：刘文文王昌媛崔小康刘宁张华琦高文政路长飞李霞山东省药品不良反应监测中心山东济南250014 青岛市市立医院山东青岛266001

分析山东省牙膏不良反应监测现状和不良反应特征,为牙膏安全监管和不良反应监测提供数据支持,保障公众牙膏使用安全。采用回顾性研究法,对2017年-2023年山东省药品不良反应监测中心收集的288例牙膏不良反应报告进行统计和分析。与化妆... 详细信息

分析山东省牙膏不良反应监测现状和不良反应特征,为牙膏安全监管和不良反应监测提供数据支持,保障公众牙膏使用安全。采用回顾性研究法,对2017年-2023年山东省药品不良反应监测中心收集的288例牙膏不良反应报告进行统计和分析。与化妆品不良反应监测总体数据相比,牙膏不良反应报告男女性别比例差异不明显,儿童占比较高。牙膏不良反应除疼痛、瘙痒、红斑、水肿等常见的化妆品不良反应自觉症状和皮损形态外,还有口腔发麻、发涩、恶心、牙龈或口腔黏膜充血、出血、肿胀、溃疡等特异性表现。牙膏不良反应报告并用牙膏(或化妆品)的比例较低,产品来源主要为网购。建议进一步加强牙膏不良反应收集力度,完善牙膏不良反应监测技术体系,做好牙膏不良反应科普宣传,重点关注儿童牙膏不良反应。

关键词：牙膏不良反应监测回顾分析

Clinical effect and antiviral mechanism of T-705 in treating severe fever with thrombocytopenia syndrome

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Signal Transduction and Targeted Therapy 2021年第5期6卷 1546-1558页

作者： Hao Li xia-Ming Jiang ning cui Chun Yuan Shao-Fei zhang Qing-Bin Lu Zhen-dong Yang Qin-Lin Xin Ya-Bin Song xiao-Ai zhang Hai-Zhou Liu Juan Du xue-Juan Fan Lan Yuan Yi-Mei Yuan Zhen Wang Juan Wang Lan zhang dong-Na zhang Zhi-Bo Wang Ke Dai Jie-Ying Bai Zhao-Nian Hao Hang Fan Li-Qun Fang Gengfu xiao Yang Yang Ke Peng hong-Quan Wang Jian-Xiong Li Lei-Ke zhang Wei Liu Beijing Institute of Microbiology and Epidemiology State Key Laboratory of Pathogen and BiosecurityBeijingP.R.China State Key Laboratory of Virology Wuhan Institute of VirologyCenter for Biosafety Mega-ScienceChinese Academy of SciencesWuhanHubeiP.R.China The 154 Hospital Peopled Liberation ArmyXinyangHenanP.R.China School of Public Health Peking UniversityBeijingP.R.China lnstitute of Molecular Medicine Peking UniversityBeijingP.R.China Rongji Medical College Huazhong University of Science and TechnologyWuhanP.R.China Department of Biostatistics and Emerging Pathogens Institute University of FloridaGainesvilleFLUSA Department of Cancer People's Liberation Army General HospitalBeijingP.R.China Beijing Key Laboratory of Vector Borne and Natural Focus Infectious Diseases BeijingP.R.China

Severe fever with thrombocytopenia syndrome(SFTS)virus(SFTSV)is an emerging tick-borne virus with high fatality and an expanding ***,effective anti-SFTSV intervention remains ***(T-705)was recently reported to show in vitro and in animal model antiviral efficacy against ***,we conducted a single-blind,randomized controlled trial to assess the efficacy and safety of T-705 in treating SFTS(Chinese Clinical Trial Registry website,number ChiCTR1900023350).From May to August 2018,laboratory-confirmed SFTS patients were recruited from a designated hospital and randomly assigned to receive oral T-705 in combination with supportive care or supportive care *** outcome occurred in 9.5%(7/74)of T-705 treated patients and 18.3%(13/71)of controls(odds ratio,0.466,95%Cl,0.174-1.247).Cox regression showed a significant reduction in case fatality rate(CFR)with an adjusted hazard ratio of 0.366(95%Cl,0.142-0.944).Among the low-viral load subgroup(RT-PCR cycle threshold>26),T-705 treatment significantly reduced CFR from 11.5 to 1.6%(P=0.029),while no between-arm difference was observed in the high-viral load subgroup(RT-PCR cycle threshold<26).The T-705-treated group showed shorter viral clearance,lower incidence of hemorrhagic signs,and faster recovery of laboratory abnormities compared with the *** in vitro and animal experiments demonstrated that the antiviral efficacies of T-705 were proportionally induced by SFTSV mutation rates,particularly from two transition mutation *** mutation analyses on T-705-treated serum samples disclosed a partially consistent mutagenesis pattern as those of the in vitro or animal experiments in reducing the SFTSV viral loads,further supporting the anti-SFTSV effect of T-705,especially for the low-viral loads.

关键词： effect faster supporting

王素梅运用上焦宣痹汤治疗儿童发声性抽动经验

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现代中医临床 2024年第4期31卷 79-82页

作者：白雪崔霞张雯王倩胡利军于文静王素梅(指导) 北京中医药大学第三附属医院北京100029

发声性抽动是抽动障碍的一种表现形式,以咽部发声、不自主重复及模仿他人语言甚至秽语为主要表现。王素梅教授认为发声性抽动病位在咽喉,位处上焦,多条经脉所过;主要病机为痰饮内停、气失宣降、郁而化火,治疗采用上焦宣痹汤,重在清轻宣... 详细信息

发声性抽动是抽动障碍的一种表现形式,以咽部发声、不自主重复及模仿他人语言甚至秽语为主要表现。王素梅教授认为发声性抽动病位在咽喉,位处上焦,多条经脉所过;主要病机为痰饮内停、气失宣降、郁而化火,治疗采用上焦宣痹汤,重在清轻宣散、畅达气机,以发散郁热和黏滞之痰。并结合临床病案阐述王教授运用上焦宣痹汤治疗儿童发声性抽动的经验。

关键词：发声性抽动抽动障碍上焦宣痹汤金木交互