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恰当的白内障手术培训能够促进防盲工作的开展

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中华眼科杂志 2014年第3期50卷 164-166页

作者：张铭志香港中文大学联合汕头国际眼科中心 515041

白内障是全球也是我国主要的致盲眼病,然而由于各种原因,我国白内障手术率（CSR）远低于发达国家甚至某些发展中国家.对基层医院的眼科医师和年轻医师进行恰当的白内障手术规范化培训是提高我国CSR的关键之一.我们针对基层医院眼科医师... 详细信息

白内障是全球也是我国主要的致盲眼病,然而由于各种原因,我国白内障手术率（CSR）远低于发达国家甚至某些发展中国家.对基层医院的眼科医师和年轻医师进行恰当的白内障手术规范化培训是提高我国CSR的关键之一.我们针对基层医院眼科医师和年轻医师的白内障手术规范化培训进行了积极的探索,建立起恰当的、适宜的白内障手术培训模式,使基层眼科医师根据自身的条件为白内障患者提供优质的医疗服务,促进防盲工作持续地发展.

关键词：白内障白内障摘除术手术培训白内障手术率防盲

Fotemustine-based therapy in combination with rituximab as a first-line induction chemotherapy followed by WBRT for newly diagnosed primary central nervous system lymphoma: a prospective phase II trial

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Cancer Biology & Medicine 2022年第7期19卷 1089-1099页

作者： Jingjing Wu Fenghua Gao Wenhua Wang Xudong zhang Meng Dong Lei zhang Xin Li Ling Li Zhenchang Sun Xinhua Wang Xiaorui Fu Linan Zhu Mengjie Ding Songtao Niu Zhaoming Li Yu Chang Feifei Nan Jiaqian Yan Hui Yu Xiaolong Wu Zhiyuan Zhou Jieming zhang mingzhi zhang Cancer Research Institute Department of OncologyThe First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052HenanChina

Objective:This study aimed to evaluate the safety,efficacy,and feasibility of the rituximab,fotemustine,pemetrexed,and dexamethasone(R-FPD)regimen followed by whole-brain radiotherapy(WBRT)for patients with primary central nervous system lymphoma(PCNSL).Methods:A prospective,single-center phase II clinical trial was *** with PCNSL newly diagnosed at the First Affiliated Hospital of Zhengzhou University between July 2018 and July 2020 were *** R-FPD regimen consisted of rituximab(375 mg/m2 *** D0),fotemustine(100 mg/m2 *** D1),pemetrexed(600 mg/m2 *** D1),and dexamethasone(40 mg *** D1-5).Patients 60 years or younger who showed a complete response(CR)were treated with 23.4 Gy of WBRT after the end of chemotherapy;those older than 60 years with CR were treated with a wait-and-see approach;and those who did not show CR after the 4th cycle of chemotherapy were given salvage WBRT 30 Gy+local tumor field irradiation up to 45 Gy,regardless of ***:A total of 30 patients were *** 2 cycles,the objective response rate(ORR)was 96.5%(28/29,1 CR,27 PR,0 SD,and 1 PD).After 4 cycles,the ORR was 73.1%(19/26,11 CR,8 PR,4 SD,and 3 PD).After WBRT,the ORR was 90.9%(10/11,7 CR,3 PR,and 1 SD).The grade III and IV toxicity responses were mainly leukopenia(20.0%),thrombocytopenia(23.3%),and anemia(10.0%).Conclusions:Fotemustine-based therapy in combination with rituximab chemotherapy followed by WBRT can improve outcomes,providing ORR benefits and favorable tolerability in patients newly diagnosed with PCNSL.

关键词： Rituximab primary central nervous system lymphoma pemetrexed fotemustine WBRT

A multi-center,open-label,randomized,parallel-controlled phase II study comparing pharmacokinetic,pharmacodynamics and safety of ripertamab(SCT400)to rituximab(Mab Thera?)in patients with CD20-positive B-cell non-Hodgkin lymphoma

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Chinese Journal of Cancer Research 2022年第6期34卷 601-611页

作者： Xiaohong Han mingzhi zhang Huaqing Wang Qingyuan zhang Wei Li Miaowang Hao Yuhuan Gao Jie Jin Hanyun Ren Yun Tang Xiaonan Hong Xiaoyan Ke Hang Su Lin Gui Jianmin Luo Liangzhi Xie Wenlin Gai Yuankai Shi Clinical Pharmacology Research Center Peking Union Medical College HospitalState Key Laboratory of Complex Severe and Rare DiseasesNMPA Key Laboratory for Clinical Research and Evaluation of DrugBeijing Key Laboratory of Clinical PK&PD Investigation for Innovative DrugsChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China Department of Oncology the First Affliated Hospital of Zhengzhou UniversityZhengzhou 450052China Department of Medical Oncology Tianjin People's HospitalTianjin 300121China Department of Medical Oncology Harbin Medical University Cancer HospitalHarbin 150081China Oncology Department of Cancer Center the First Hospital of jilin UniversityChangchun 130021China Department of Hematology Tangdu HospitalAir Force Medical UniversityXi'an 710038China Department of Hematology the Fourth Hospital of Hebei Medical UniversityShijiazhuang 050011China Department of Hematology the First Affliated Hospital of Zhejiang UniversityHangzhou 310003China Department of Hematology Peking University First HospitalBeijing 100034China Department of Hematology West China HospitalSichuan UniversityChengdu 610041China Department of Medical Oncology Fudan University Shanghai Cancer CenterShanghai 2032China Department of Hematology Peking University Third HospitalBeijing 100191China Department of Lymphoma the Fifth Medical Center of PLA General HospitalBeijing 100071China Department of Medical Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing Key Laboratory of Clinical Study on Anticancer Molecular Targeted DrugsBeijing 100021China Department of Hematology the Second Hospital of Hebei Medical UniversityShijazhuang 050000China Beijing Engineering Research Center of Protein and Antibody Sinocelltech Ltd.Beijing 100176China

Objective:This multi-center,open-label,randomized,parallel-controlled phaseⅡstudy aimed to compare the pharmacokinetics(PK),pharmacodynamics(PD)and safety profile of ripertamab(SCT400),a recombinant antiCD20 monoclonal antibody,to rituximab(MabThera^(■))in patients with CD20-positive B-cell non-Hodgkin lymphoma(NHL).Methods:Patients with CD20-positive B-cell NHL who achieved complete remission or unconfirmed complete remission after standard treatment were randomly assigned at a 1:1 ratio to receive a single dose of ripertamab(375mg/m^(2))or rituximab(MabThera^(■),375 mg/m^(2)).PK was evaluated using area under the concentration-time curve(AUC)from time 0 to d 85(AUC_(0-85d)),AUC from time 0 to week 1(AUC0-1 w),AUC from time 0 to week 2(AUC_(0-2 w)),AUC from time 0 to week 3(AUC_(0-3 w)),AUC from time 0 to week 8(AUC_(0-8 w)),maximum serum concentration(C_(max)),terminal half-life(T_(1/2)),time to maximum serum concentration(T_(max))and clearance(CL).Bioequivalence was confirmed if the 90%confidence interval(90%CI)of the geometric mean ratio of ripertamab/rituximab was within the pre-defined bioequivalence range of 80.0%-125.0%.PD,immunogenicity,and safety were also ***:From December 30,2014 to November 24,2015,a total of 84 patients were randomized(ripertamab,n=42;rituximab,n=42)and the PK analysis was performed on 76 patients(ripertamab,n=38;rituximab,n=38).The geometric mean ratios of ripertamab/rituximab for AUC_(0-85d),ATC_(0-inf),and Cmaxwere 96.1%(90%CI:87.6%-105.5%),95.9%(90%CI:86.5%-106.4%)and 97.4%(90%CI:91.6%-103.6%),*** PK parameters met the pre-defined bioequivalence range of 80.0%-125.0%.For PD and safety evaluation,there was no statistical difference in peripheral CD 19-positive B-cell counts and CD20-positive B-cell counts at each visit,and no difference in the incidence of anti-drug antibodies was observed between the two *** incidences of treatment-emergent adverse events and treatment-related adverse events were a

关键词： Anti-CD20 monoclonal antibody non-Hodgkin lymphoma pharmacokinetics ripertamab rituximab safety

Percutaneous transhepatic biliary drainage for obstructive jaundice caused by metastatic gastric cancer： efficacy and complications

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The Chinese-German Journal of Clinical Oncology 2011年第3期10卷 157-161页

作者： Wenchang Yu Kongzhi zhang Shiguang Chen mingzhi Hao Department of Interventional Radiology Fujian Provincial Cancer Hospital Fuzhou 350014 China

Objective： The aim of our study was to evaluate the efficacy and incidence of complications of percutaneous transhepatic biliary drainage （PTBD） as palliative treatment of obstructive jaundice caused by metastatic gastric cancer. Methods： Hospital records were reviewed for 32 consecutive patients with biliary obstruction caused by metastatic gastric cancer who underwent PTBD at our institution between October 2004 and April 2010. Patients （23 males and 9 females） age ranged from 35 to 72 years. The indexes of hepatic function before PTBD and within one month after PTBD were compared. The incidence of complications and corresponding treatments were also documented. Results： The level of obstruction was defined as the distal bile duct （beyond the level of the liver hilum） in 22 patients （group 1） and the liver hilum in 10 patients （group 2）. Successful decompression of the biliary system after PTBD was defined by a total bilirubin decrease of more than 30% of the baseline value. Success rates were 100% （22/22） for group 1, 70% （7/10） for group 2, and 90.6% （29/32） for all patients. Differences in success rates between group 1 and group 2 were significant （P = 0.024）. Serum TBIL, ALT, and AST significantly decreased from （292.8 ± 179.9） μmol/L, （174.5 ± 107.4） IU/L, （159.9 ± 103.9） IU/L before PTBD to （111.5 ± 92.5） μmol/L, （58.5 ± 46.3） IU/L, （59.6 ± 48.9） IU/L, respectively within one month after PTBD （P 0.05）. Complications associated with PTBD included cholangitis in 13 patients （40.5%）, drainage tube displacement in 6 patients （18.8%）, hemobilia in 4 patients （12.5%）, tube occlusion in 2 patients （6.3%）, and pancreatitis in 1 patient （3.1%）. All complications were successfully treated with appropriate measures. Conclusion： Hepatic function can be improved by PTBD without serious complications in patients with obstructive jaundice caused by metastatic gastric cancer.

关键词： gastric cancer obstructive jaundice percutaneous transhepatic biliary drainage

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后危机时代中国企业的反周期跨国并购

世界经济与政治论坛 2009年第6期 4-10页

作者：张明之南京政治学院

跨国并购是强势国家通过其跨国公司打造全球生产体系的重要手段,在跨国公司的"中国攻略"逼迫下,我国民族企业普遍处于不利局面。跨国并购通常具有显著的周期性,通常与全球经济的活跃度保持同步。在金融危机导致全球公司并购行为急剧减... 详细信息

跨国并购是强势国家通过其跨国公司打造全球生产体系的重要手段,在跨国公司的"中国攻略"逼迫下,我国民族企业普遍处于不利局面。跨国并购通常具有显著的周期性,通常与全球经济的活跃度保持同步。在金融危机导致全球公司并购行为急剧减少情况下,2008年以来中国企业海外并购步伐明显加快。反周期的海外跨国并购,符合中国推行"走出去"战略,是培育与经济大国地位相称的跨国公司,维护产业安全的重要尝试。金融危机为民族企业低成本跨国并购海外战略性资产和资源类企业提供了重要的机遇。

关键词：跨国并购反周期定价权产业控制权国家利益

从发展理念到文明形态:中国式现代化的术语演进与知识生产

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马克思主义研究 2024年第3期 62-72页

作者：张明之国防大学政治学院上海200433

现代化道路总是具体历史条件下闪耀着具体民族国家的历史文化光辉的现代化。现代化和社会主义都意味着人类文明进步,中国式现代化以鲜明特征和独特优势开创了不同于西方现代化的新路径。中国式现代化实践新发展理念,推进文明形态的新发... 详细信息

现代化道路总是具体历史条件下闪耀着具体民族国家的历史文化光辉的现代化。现代化和社会主义都意味着人类文明进步,中国式现代化以鲜明特征和独特优势开创了不同于西方现代化的新路径。中国式现代化实践新发展理念,推进文明形态的新发展,体现了党团结领导人民开辟马克思主义中国化时代化的新境界。中国式现代化的内在基因是中华优秀传统文化,基本逻辑是马克思主义及其政党的领导,发展动力是人民对美好幸福生活的追求,历史方位是世界文明史的重要篇章。中国式现代化以其独具特色的术语表达与话语体系为世界文明进步生产全新的现代化知识,是对世界文明史知识体系的原创性贡献。

关键词：中国式现代化人类文明新形态新发展理念知识生产世界文明史

Policy　and　Profit　Allocation　for　the　Cooperative　Development　of　Natural　Gas　Resource　on　Chinese　Offshore　Continental　Shelf

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China Oil & Gas 1994年第2期1卷 54-56页

作者： Zhou Qingsong zhang mingzhi(China National Offshore Oil Corp.) China National Offshore Oil Corp.

China has a wide sea waters with their offshore continental shelf covering over 1 million km?.Rich oil-gas resources are lying under the sea *** accordance with the conventional international assessment method for oil and gas resources,it is expected that the gas reserve volume in China is approximately 14000 billion ***,the Yinggehai Basin,Qiongdo-ngnan Basin and Zhushan Depression in the Pearl River Mouth basin of the South China Sea are rapidly subsiding basins with more than 100 million km2 of prospects for exploration,where the geological conditions are favourable for generation of rich natural gas.

关键词： Offshore Continental shelf Natural gas Development Profit Allocation

Map Reduce框架下空间大数据的关联规则分析方法

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系统仿真学报 2018年第3期30卷 840-845页

作者：张明智李义国防大学信息作战与指挥训练教研部 66194部队

空间数据具有空间性、时间性、多维性、大数据量、空间关系复杂等特点,如何在空间大数据里面寻找模式、规律和特征知识,用于战场态势感知和战场空间管理,这需要利用和开发一些非传统的数据筛选工具进行分析、挖掘。针对现有Apriori算法... 详细信息

空间数据具有空间性、时间性、多维性、大数据量、空间关系复杂等特点,如何在空间大数据里面寻找模式、规律和特征知识,用于战场态势感知和战场空间管理,这需要利用和开发一些非传统的数据筛选工具进行分析、挖掘。针对现有Apriori算法扫描数据库过于频繁的问题,结合Map Reduce的工作原理,对Apriori算法进行了改进,提出基于Map Reduce的空间大数据快速分析思路和技术框架,初步搭建了验证原型,对关键技术进行实验。实例验证结果表明,利用该技术路线和框架,可以提升海量空间数据的处理分析速度。

关键词：空间数据大数据关联规则分析方法并行计算

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基于复杂网络的战争复杂体系建模研究进展

系统仿真学报 2015年第2期27卷 217-225,245页

作者：马力张明智国防大学信息作战与指挥训练教研部北京100091

战争复杂体系建模的关键是对体系组分间基于网络的耦合交互关系进行描述,复杂网络理论为战争复杂体系建模研究带来新的推动力。分析了复杂网络适用于体系建模的特点,归纳总结了体系复杂网络建模的两种一般性方法。从体系复杂网络建模所... 详细信息

战争复杂体系建模的关键是对体系组分间基于网络的耦合交互关系进行描述,复杂网络理论为战争复杂体系建模研究带来新的推动力。分析了复杂网络适用于体系建模的特点,归纳总结了体系复杂网络建模的两种一般性方法。从体系复杂网络建模所涉及的体系的网络化描述、体系复杂网络建模算法规则、基于复杂网络的体系测度与评价以及复杂网络与ABM相结合的研究4个方面详细论述了当前的研究进展情况,分别指出了存在的主要问题,并对下一步的研究趋势进行了预测分析,为基于复杂网络的战争复杂体系建模的进一步研究提供支持。

关键词：体系建模复杂网络战争复杂体系网络科学