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Galvanic replacement reaction for in situ fabrication of litchi-shaped heterogeneous liquid metal-Au nano-composite for radio-photothermal cancer therapy

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Bioactive Materials 2021年第3期6卷 602-612页

作者： Zhenhu Guo Jingsong Lu Dan Wang Wensheng Xie Yongjie Chi jianzhong xu Nonaka Takuya Junxin zhang Wanling xu Fei Gao Hong Wu Lingyun Zhao State Key Laboratory of Powder Metallurgy Powder Metallurgy Research InstituteCentral South UniversityChangshaHunan410083China Key Laboratory of Advanced Materials Ministry of Education of ChinaSchool of Materials Science and EngineeringTsinghua UniversityBeijing100084China State Key Laboratory of New Ceramics and Fine Processing School of Materials Science and EngineeringTsinghua UniversityBeijing100084China Research Center of Magnetic and Electronic Materials College of Materials Science and EngineeringZhejiang University of TechnologyHangzhouZhejiang310014China Department of Nanoengineering Chemical Engineering Programand Moores Cancer CenterUniversity of California San DiegoLa JollaCA92093United States The Key Laboratory of Bioorganic Phosphorus Chemistry&Chemical Biology(Ministry of Education) Department of ChemistryTsinghua UniversityBeijing100084China School of Earth sciences and Resources China University of Geosciences(Beijing)Beijing100083China Shaanxi University of chinese Medicine Xi'anShanxi712046China

With tremendous research advances in biomedical application,liquid metals(LM)also offer fantastic chemistry for synthesis of novel ***,as a pioneering trial,litchi-shaped heterogeneous eutectic gallium indium-Au nanoparticles(EGaIn-Au NPs),served as effective radiosensitizer and photothermal agent for radio-photothermal cancer therapy,have been successfully prepared using in situ interfacial galvanic replacement *** enhanced photothermal conversion efficiency and boosted radio-sensitization effect could be achieved with the reduction of Au nanodots onto the eutectic gallium indium(EGaIn)NPs *** importantly,the growth of tumor could be effectively inhibited under the combined radio-photothermal therapy mediated by EGaIn-Au *** by this approach,in situ interfacial galvanic replacement reaction may open a novel strategy to fabricate LM-based nano-composite with advanced multi-functionalities.

关键词： Au nanodots Gallium Galvanic replacement reaction Indium Radio-photothermal therapy

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Restoration of electrical microenvironment enhances bone regeneration under diabetic conditions by modulating macrophage polarization

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Bioactive Materials 2021年第7期6卷 2029-2038页

作者： Xiaohan Dai Boon Chin Heng Yunyang Bai Fuping You Xiaowen Sun Yiping Li zhangui Tang mingming xu xuehui zhang xuliang Deng Hunan Key Laboratory of Oral Health Research&Hunan 3. Printing engineering Research Center of Oral Care&Hunan Clinical Research Center of Oral Major Diseases and Oral Health&Xiangya Stomatological Hospital&Xiangya School of Stomatology Central South UniversityChangsha410008PR China Department of Dental Materials&Dental Medical Devices Testing Center Peking University School and Hospital of StomatologyBeijing100081PR China Department of Geriatric Dentistry Peking University School and Hospital of StomatologyBeijing100081PR China Central Laboratory Peking University School and Hospital of StomatologyBeijing100081PR China institute of Systems Biomedicine Department of ImmunologySchool of Basic Medical SciencesBeijing Key Laboratory of Tumor Systems BiologyPeking University Health Science CenterBeijing100191PR China National engineering Laboratory for Digital and Material Technology of Stomatology NMPA Key Laboratory for Dental MaterialsBeijing Laboratory of Biomedical Materials&Beijing Key Laboratory of Digital StomatologyPeking University School and Hospital of StomatologyBeijing100081PR China

Macrophage-mediated inflammation compromises bone repair in diabetic *** signaling cues are known to regulate macrophage ***,the biological effects of electrical microenvironment from charged biomaterials on the immune response for regulating osteogenesis under diabetic conditions remain to be *** the endogeneous electrical microenvironment of native bone tissue was recapitulated by fabricating a ferroelectric BaTiO_(3./poly(vinylidene fluoridetrifluoroethylene)(BTO/P(VDF-TrFE))nanocomposite *** vitro,the polarized BaTiO_(3./poly(vinylidene fluoridetrifluoroethylene)(BTO/P(VDF-TrFE))nanocomposite membranes inhibited high glucose-induced M1-type inflammation,by effecting changes in cell morphology,M1 marker expression and pro-inflammatory cytokine secretion in *** led to enhanced osteogenic differentiation of human bone marrow mesenchymal stem cells(BM-MSCs).In vivo,the biomimetic electrical microenvironment recapitulated by the polarized nanocomposite membranes switched macrophage phenotype from the pro-inflammatory(M1)into the pro-healing(M2)phenotype,which in turn enhanced bone regeneration in rats with type 2 diabetes *** studies revealed that the biomimetic electrical microenvironment attenuated pro-inflammatory M1 macrophage polarization under hyperglycemic conditions by suppressing expression of AKT2 and IRF5 within the PI3.-AKT signaling pathway,thereby inducing favorable osteo-immunomodulatory *** study thus provides fundamental insights into the biological effects of restoring the electrical microenvironment conducive for osteogenesis under DM conditions,and offers an effective strategy to design functionalized biomaterials for bone regeneration therapy in diabetic patients.

关键词： Electrical microenvironment Diabetes Ferroelectric nanocomposites Bone regeneration Macrophage polarization

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Reactivation of PPARαalleviates myocardial lipid accumulation and cardiac dysfunction by improving fatty acidβ-oxidation in Dsg2-deficient arrhythmogenic cardiomyopathy

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Acta Pharmaceutica Sinica B 2023年第1期13卷 192-203页

作者： Yubi Lin Ruonan Liu Yanling Huang Zhe Yang jianzhong Xian Jingmin Huang Zirui Qiu Xiufang Lin Mengzhen zhang Hui Chen Huadong Wang Jiana Huang Geyang xu Department of Physiology School of MedicineJinan UniversityGuangzhou 510632China The First Dongguan Affiliated Hospital Guangdong Medical University Dongguan 523710China The Cardiovascular Center Department of CardiologyInterventional Medical CenterGuangdong Provincial Key Laboratory of Biomedical Imaging and Guangdong Provincial Engineering Research Center of Molecular Imagingthe Fifth Affiliated HospitalSun Yat-sen UniversityZhuhai 519000China Guangdong Provincial Cardiovascular institute Guangdong Provincial People's HospitalGuangzhou 510080China Biotherapy Center Cell-gene Therapy Translational Medicine Research Centerthe Third Affiliated HospitalSun Yat-sen UniversityGuangzhou 510630China Department of Pathophysiology School of MedicineJinan UniversityGuangzhou 510632China Reproductive Medicine Center the Six Affiliated HospitalSun Yat-sen UniversityGuangzhou 51000China

Arrhythmogenic cardiomyopathy(ACM),a fatal heart disease characterized by fibroadipocytic replacement of cardiac myocytes,accounts for 20%of sudden cardiac death and lacks effective *** is often caused by mutations in desmosome proteins,with Desmoglein-2(DSG2)mutations as a common ***,the mechanism underlying the accumulation of fibrofatty in ACM remains unknown,which impedes the development of curative *** we investigated the fat accumulation and the underlying mechanism in a mouse model of ACM induced by cardiac-specific knockout of Dsg2(CS-Dsg2^(-/-)).Heart failure and cardiac lipid accumulation were observed in CSDsg2^(-/-)*** demonstrated that these phenotypes were caused by decline of fatty acid(FA)β-oxidation resulted from impaired mammalian target of rapamycin(m TOR)*** worsened while overexpression of m TOR and 4EBP1 rescued the FAβ-oxidation pathway in CS-Dsg2^(-/-)*** of PPARa by fenofibrate or AAV9-Ppara significantly alleviated the lipid accumulation and restored cardiac *** results suggest that impaired m TOR-4EBP1-PPARa-dependent FAβ-oxidation contributes to myocardial lipid accumulation in ACM and PPARa may be a potential target for curative treatment of ACM.

关键词： Arrhythmogenic cardiomyopathy Desmosome Desmoglein2 Heart failure Lipid accumulation mTOR PPARa FA oxidation

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复杂地形条件下大型风电叶片先进设计技术研究

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中国科学：技术科学 2020年第10期50卷 1391-1403页

作者：张明明廖猜猜张磊武广兴徐建中中国科学院工程热物理研究所北京100190 国家能源风电叶片研发(实验)中心北京100190 中国科学院风能利用重点实验室北京100190 中国科学院大学北京100049

近年来,我国内陆复杂地形条件下风力发电迅速发展,但相关风电机组核心设计技术水平仍然偏低.为此,在中国科学院工程热物理所过去近15年的成果和经验基础上,本文重点围绕对机组效率、可靠性和度电成本起决定性作用的关键部件——风电叶片... 详细信息

近年来,我国内陆复杂地形条件下风力发电迅速发展,但相关风电机组核心设计技术水平仍然偏低.为此,在中国科学院工程热物理所过去近15年的成果和经验基础上,本文重点围绕对机组效率、可靠性和度电成本起决定性作用的关键部件——风电叶片,开展了复杂地形条件下气动增效、被动耦合降载、轻量化设计等新一代关键技术研究,以构建一体化优化设计技术体系.在填补国内行业空白的同时,力争使我国大型风电叶片的设计水平达到国际先进水平,对解决国家能源安全和环境污染问题具有重要意义.

关键词：复杂地形风电叶片降载轻量化优化设计

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Microelement analysis of source of raw materials of terracotta warriors and horses of Qin's Mausoleum in pits No.1 and No.2

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chinese Science Bulletin 2002年第16期47卷 1337-1340页

作者： Weijuan Zhao Aijun xu Rongwu Li Zhengyao Gao Guoxia Li jianzhong Xie Guohe Han Songlin Feng Dongyu Fan Ying zhang et al. Faculty of Physical engineering Zhengzhou University Zhengzhou China Department of Physics Beijing Normal University Beijing China High Energy Physics institute The Chinese Academy of Sciences Beijing China Museum of the Terracotta Warriors and Horses of Qin Shihuang’s Mausoleum Xi’an China

In order to search for sources of the raw material of the Qin’s terracotta warriors and horses, we selected 20 samples of pottery warriors and pottery horses of the Qin’s Mausoleum from pit No. 1,19 samples of pottery warriors and brick from pit No. 2, 20 samples of clays near the Qin’s Mausoleum and 2 samples of Yaozhou porcelain bodies. The 3. kinds of element content of each sample were measured by neutron activation analysis (NAA). These data were analyzed by fuzzy cluster analysis, the trend cluster analysis diagram was obtained. The results showed that samples of terracotta warriors and horses from pits No.1 and No. 2 were closely related to the loam layer near Qin’s Mausoleum, but their relations with the loess layers were not so close, and they were out of all relation to Yaozhou porcelain bodies. Thus, it could be deduced that the Li Mountain clay may be considered as the original place of the raw materials of the terracotta warriors and horses, the kiln sites might be located nearby the Qin’s

关键词： fuzzy cluster analysis terracotta warriors and horses of Qin’s Mausoleum the original place of raw material neutron acti-vation analysis microelement analysis.

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Characterization of contemporary aeolian dust deposition on mountain glaciers of western china

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Research in Cold and Arid Regions 2016年第1期8卷 9-21页

作者： jianzhong xu ShiChang Kang ShuGui Hou QiangGong zhang Jie Huang CunDe Xiao JiaWen Ren DaHe Qin .State Key Laboratory of Cryospheric sciences(SKLCS) Cold and Arid Regions Environmental and Engineering Research InstituteChinese Academy of Sciences(CAS)LanzhouGansu 730000China institute of Tibetan Plateau Research(ITP) Chinese Academy of Sciences(CAS)Beijing 100086China MOE Key Laboratory for Coast and Island Development School of Geographic and Oceanographic Sciences(SGOS)Nanjing UniversityNanjingJiangsu 210093China

From 2008 to 2010, a total of 15 snow pit samples were collected from 13.mountain glaciers in western china. In this study these samples are used to determine the spatial distribution of insoluble particle concentrations and dust deposition fluxes in western china. The results show that the mass concentrations of insoluble particles exhibit high spatial variation and strongly decrease （by a factor of approximately 50） from the north （Tienshan Mountains） to the south （Himalayas）. However, the insoluble particles concentrations at the southeastern Tibetan Plateau （TP） sites are also high and ap- proximately 3. times greater than those in the Himalayas. The spatial distribution of the dust flux is similar to that of the mass concentrations; however, the high dust deposition rate in the southeastern TP is very significant as a result of the extensive snow accumulation （precipitation） in this region. The average sizes of the insoluble particles at each site generally exhibit bimodal distributions with peaks at approximately 5 μm and 10 μm, which can be explained as re- sulting from dust emissions from regional and local sources, respectively. The enrichment factors for most of the elements measured in insoluble particles are less than 10 at all of the study sites, indicating primarily crustal sources. However, the sites located in the peripheral mountains of western china, such as the Tienshan Mountains and the Himalayas, are characterized by high levels of certain enrichment elements （e.g., Cu, Zn, Cr, and V） indicative of sources related to the long-range transport of pollutants.

关键词： snow pit dust insoluble particle Tibetan Plateau

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新概念兆瓦级风热机组性能预测与分析研究

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中国科学：技术科学 2020年第10期50卷 1404-1412页

作者：钟晓晖孙香宇张明明徐建中中国科学院工程热物理研究所国家能源风电叶片研发(实验)中心北京100190 中国科学院风能利用重点实验室北京100190 中国科学院大学北京100049

风能热利用是一种可以替代燃煤锅炉供暖的变革性洁净能源技术,是解决北方地区冬季雾霾问题的有效途径之一.风能热利用一方面可以解决燃煤供暖所带来的环境污染问题,另一方面还可以解决风能消纳问题.基于"温度对口、梯级利用"的科学用能... 详细信息

风能热利用是一种可以替代燃煤锅炉供暖的变革性洁净能源技术,是解决北方地区冬季雾霾问题的有效途径之一.风能热利用一方面可以解决燃煤供暖所带来的环境污染问题,另一方面还可以解决风能消纳问题.基于"温度对口、梯级利用"的科学用能原则,提出了"风热机组"首创概念,以MATLAB/Simulink仿真平台为基础,结合BEM理论和热泵循环模型,构建了风热机组仿真模型.搭建了风热机组性能测试实验平台,验证了仿真模型的可靠性.在此基础上,通过研究不同风况对兆瓦级风热机组的影响,获得了兆瓦级风热机组性能曲线和典型工况下的运行规律.研究结果可为拓展风能利用新方向,满足国家清洁供暖的重大需求提供新的技术方案和理论依据.

关键词：风热机组叶素动量理论(BEM)模型蒸汽压缩式热泵仿真

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风洞端壁对翼型气动特性的影响

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工程热物理学报 2023年第1期44卷 95-105页

作者：白井艳张磊杨科赵黛青张明明徐建中中国科学院广州能源研究所广州510650 中国科学院工程热物理研究所北京100190 中国科学院大学北京100049 中国科学院风能利用重点实验室北京100190 中国科学院洁净能源创新研究院大连116023

采用风洞实验和数值模拟相结合的方法,研究风洞端壁对翼型气动特性的影响。实验在IET低速回流风洞中实施,采用表面测压法。试验对象为三个不同尾缘厚度的翼型,分别为DU91-W2-250,DU91-W2-250_6和DU91-W2-250_10。实验雷诺数为2.62×10^(... 详细信息

采用风洞实验和数值模拟相结合的方法,研究风洞端壁对翼型气动特性的影响。实验在IET低速回流风洞中实施,采用表面测压法。试验对象为三个不同尾缘厚度的翼型,分别为DU91-W2-250,DU91-W2-250_6和DU91-W2-250_10。实验雷诺数为2.62×10^(5),数值模拟采用RANS方法。结果表明:DU91-W2-250翼型在流动发生失速之前,随攻角增加,风洞端壁与翼型连接处产生的角区分离涡不断增大。流动进入失速区后,翼型自身产生的三维失速胞与风洞端壁诱导的角区分离涡共同作用,随着三维失速胞的增大,角区分离涡变小;随尾缘厚度增大,风洞端壁对翼型绕流影响减小;风洞端壁诱导产生的角区分离涡对翼型绕流产生下洗作用,使得有效攻角和升力系数减小、阻力系数增加。同时风洞端壁延迟了翼型段中间截面的流动分离。

关键词：端壁效应钝尾缘风力机翼型

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Efficient expansion of rare human circulating hematopoietic stem/progenitor cells in steady-state blood using a polypeptide-forming 3. culture

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Protein & Cell 2022年第11期13卷 808-824页

作者： Yulin xu Xiangjun Zeng mingming zhang Binsheng Wang Xin Guo Wei Shan Shuyang Cai Qian Luo Honghu Li Xia Li xue Li Hao zhang Limengmeng Wang Yu Lin Lizhen Liu Yanwei Li Meng zhang Xiaohong Yu Pengxu Qian He Huang Bone Marrow Transplantation Center First Affiliated HospitalZhejiang University School of MedicineHangzhou 310012China Liangzhu Laboratory Zhejiang University Medical CenterHangzhou 311121China institute of Hematology Zhejiang UniversityHangzhou 310012China Zhejiang Province engineering Laboratory for Stem Cell and Immunity Therapy Hangzhou 310012China Core Facilities Zhejiang University School of MedicineHangzhou 310012China Dr.Li Dak Sum&Yip Yio Chin Center for Stem Cell and Regenerative Medicine Zhejiang UniversityHangzhou 310012China

Although widely applied in treating hematopoietic malignancies,transplantation of hematopoietic stem/progenitor cells(HSPCs)is impeded by HSPC *** circulating HSPCs(cHSPCs)in steady-state blood could be used as an alternative source remains largely *** we develop a three-dimensional culture system(3.CS)including arginine,glycine,aspartate,and a series of ***-day culture of peripheral blood mononuclear cells(PBMNCs)in 3.CS led to 125-and 70-fold increase of the frequency and number of CD3.+***,3.CS-expanded cHSPCs exhibited the similar reconstitution rate com-pared to CD3.+HSPCs in bone ***,3.CS fabricated an immunomodulatory niche,secreting cytokines as TNF to support cHSPC survival and ***,3.CS could also promote the expansion of cHSPCs in patients who failed in HSPC *** 3.CS successfully expands rare cHSPCs,providing an alternative source for the HSPC therapy,particularly for the patients/donors who have failed in HSPC mobilization.

关键词： hematopoietic stem/progenitor cell transplantation peripheral blood mononuclear cells expansion mobilization three-dimensional culture selfrenewal and multilineage differentiation

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Pyrene-tethered bismoviologens for visible light-induced C(sp^(3.)-P and C(sp^(2))-P bonds formation

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chinese Chemical Letters 2023年第6期34卷 329-335页

作者： Wenqiang Ma Sikun zhang Liang xu Bingjie zhang Guoping Li Bin Rao {3. zhang Gang He Key Laboratory of Thermo-Fluid Science and engineering of Ministry of Education School of Energy and Power EngineeringFrontier Institute of Science and TechnologyXi’an Jiaotong UniversityXi’an 710054China School of Chemistry Xi’an Key Laboratory of Sustainable Energy Materials ChemistryXi’an Jiaotong UniversityXi’an 710049China School of Materials Science and engineering Xi’an Jiaotong UniversityXi’an 710049China

Developing efficient photosensitizers for C-P bond construction is highly important and remains a challenge due to the urgently needed for the synthesis of modified nucleosides,nucleotides,and other phosphine-containing ***,two pyrene-tethered bismoviologen derivatives(Py-BiV^(2+))were designed and synthesized for visible-light-induced C-P bonds *** photochemical and electrochemical properties of Py-BiV^(2+)were studied systemically,certifying fine-tunable opto-electronic properties through the number of pyrene groups(4,n=1;6,n=2).The prepared Py-BiV^(2+)showed strong light absorption,while retaining good redox features and chromic response features that were inherent to viologens.4 exhibited accelerated photoinduced electron transfer in the presence of the electron donor(pyrene)and the generated 4(radical cation)showed higher ***,Py-BiV^(2+)directly served as photosensitizers for the first time in the visible-light-induced C(sp^(3.)-P and C(sp^(2))-P bonds *** expected,these novel viologen derivatives exhibited good catalytic performance and good substrate expansibility under ambient conditions.

关键词： Viologen Electrochromism C-P bonds Photocatalysis Bismuth

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