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World Journal of Clinical Oncology 2025年第2期16卷 18-28页

作者： Zhong-Yuan Hu Ding Ding Yu Song Ya-Feng Deng Cheng-ming zhang Tao Yu First School of Clinical Medicine Shaanxi University of Chinese MedicineXianyang 712000Shaanxi ProvinceChina College of Acupuncture and Massage Shaanxi University of Chinese MedicineXianyang 712000Shaanxi ProvinceChina Graduate School Guangzhou University of Chinese MedicineGuangzhou 510000Guangdong ProvinceChina Digestive Department I Shaanxi Provincial Hospital of Traditional Chinese MedicineXi’an 710000Shaanxi ProvinceChina

Pancreatic ductal adenocarcinoma stands out as an exceptionally fatal cancer owing to the complexities associated with its treatment and diagnosis,leading to a notably low five-year survival *** study offers a detailed exploration of epidemiological trends in pancreatic cancer and key molecular drivers,such as mutations in CDKN2A,KRAS,SMAD4,and TP53,along with the influence of cancer-associated fibroblasts(CAFs)on disease *** particular,we focused on the pivotal roles of signaling pathways such as the transforming growth factor-βand Wnt/β-catenin pathways in the development of pancreatic cancer and investigated their application in emerging therapeutic *** study provides new scientific perspectives on pancreatic cancer treatment,especially in the development of precision medicine and targeted therapeutic strategies,and demonstrates the importance of signaling pathway research in the development of effective therapeutic *** studies should explore the subtypes of CAFs and their specific roles in the tumor microenvironment to devise more effective therapeutic methods.

关键词： Pancreatic cancer Fibroblasts Signaling pathways Tumor microenvironment

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文明叙事:习近平文化思想的方法论审视

新疆师范大学学报（哲学社会科学版） 2025年第1期46卷 34-42页

作者：张明谷生秀南京大学马克思主义学院江苏南京210023

文明是中国共产党百余年推进马克思主义中国化时代化的核心线索,文明叙事是中国共产党历史叙事的重要维度,也是习近平文化思想的重要方法论。习近平文化思想的深厚文明意蕴体现在四个方面:一是从历史纵深出发把握“走自己的路”的文明基... 详细信息

文明是中国共产党百余年推进马克思主义中国化时代化的核心线索,文明叙事是中国共产党历史叙事的重要维度,也是习近平文化思想的重要方法论。习近平文化思想的深厚文明意蕴体现在四个方面:一是从历史纵深出发把握“走自己的路”的文明基因,即从中华5000多年文明的历史传承中把握中国道路的来龙去脉及其内在逻辑必然;二是以“第二个结合”为根本方法,重塑发展中华文明的使命担当,不断推动建设中华民族现代文明实现传统文明的现代新生;三是坚守文明超越理念,将新文明的建构与中国式现代化的现实实践相互关联,以中国式现代化创造人类文明新形态,打破西方以资本逻辑为核心的形而上学抽象文明观的历史困境;四是坚持文明交流互鉴,推动落实全球文明倡议,构建人类文明交往新范式。

关键词：习近平文化思想文明叙事 “走自己的路” “第二个结合” 文明交流互鉴

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矿山采空区边坡动态稳定性评价方法

工程科学学报 2025年第2期47卷 215-223页

作者：杜岩张洪达谢谟文蒋宇静张明贾北凝北京科技大学城市地下空间工程北京市重点实验室山东科技大学矿山灾害预防控制省部共建国家重点实验室培育基地安徽理工大学深部煤矿采动响应与灾害防控国家重点实验室北京综建科技有限公司

矿山边坡因采空区沉降引发的斜面岩土体崩塌破坏，是一种破坏力极强的地质灾害.由于传统的稳定性评价方法未考虑采空区沉降造成的应力场变异，难以实现矿山边坡的动态稳定性评价，因而在矿山地质灾害预警预防方面存在诸多限制.基于此，... 详细信息

矿山边坡因采空区沉降引发的斜面岩土体崩塌破坏，是一种破坏力极强的地质灾害.由于传统的稳定性评价方法未考虑采空区沉降造成的应力场变异，难以实现矿山边坡的动态稳定性评价，因而在矿山地质灾害预警预防方面存在诸多限制.基于此，本研究针对矿山采空区滑坡的成因机制，建立了一套适用于矿山边坡的动态稳定性评价方法.首先通过构建采空区沉降分析模型，计算采空区上方岩体的沉降范围及其产生的冲击作用力，分析沉降对坡体应力场的影响，并在此基础上对传统不平衡推力法进行修正.案例分析结果显示，传统方法未考虑采空区沉降作用和锁固段的破坏情况，导致稳定性系数计算偏大，为1.355.而改进方法通过考虑采空区沉降信息，计算得出锁固段稳定性系数为0.667，整体稳定性系数为0.979，与矿山采空区边坡实际破坏情况一致.当沉降位移比（SHDR）大于0.73时，采空区边坡稳定性会发生明显变异，因而会在相对安全的工况下发生失稳破坏.改进方法通过考虑采空区沉降作用和锁固段的破坏情况，可以更好地实现矿山边坡稳定性的评价，为矿区更好地应对类似地质灾害提供有效参考.

关键词：采空区边坡动态稳定性评价采空区沉降锁固段沉降位移比

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不同热处理蛋黄脂质对小鼠学习认知能力下降的缓解能力

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食品工业科技 2025年第1期46卷 367-376页

作者：吴瑶刘铭坤方冰张明合肥工业大学食品与生物工程学院安徽合肥230061 中国农业大学营养与健康系北京100083 北京工商大学食品与健康学院北京100048

为探讨不同温度处理下蛋黄脂质对小鼠学习认知能力下降的缓解能力的差异。本研究利用小鼠认知障碍模型,比较95℃(水浴30 min)和121℃(灭菌锅加热30 min)热处理蛋黄脂质组分改善小鼠学习认知能力的差异。研究结果表明,相较于121℃热处理... 详细信息

为探讨不同温度处理下蛋黄脂质对小鼠学习认知能力下降的缓解能力的差异。本研究利用小鼠认知障碍模型,比较95℃(水浴30 min)和121℃(灭菌锅加热30 min)热处理蛋黄脂质组分改善小鼠学习认知能力的差异。研究结果表明,相较于121℃热处理的蛋黄脂质,95℃热处理的蛋黄脂质更有效地降低了Tau蛋白的磷酸化和Aβ1-40、GSK-3β表达,下调了促炎因子的表达,其提升小鼠的学习记忆能力的效果更好。95℃热处理蛋黄脂质中的多不饱和脂肪酸以及DHA较121℃热处理的蛋黄脂质显著增加(P<0.05)。因此,过度的加热条件,会破坏蛋品中DHA等多不饱和脂肪酸,削弱蛋黄脂质的改善认知的生物活性。本研究为蛋制品的热加工工艺的优化提供参考依据。

关键词：蛋黄脂质热处理学习和记忆

Achievements and problems of geotechnical engineering investigation in China

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2011年第2期12卷 87-102页

作者： Zai-ming zhang Beijing Geotechnical Institute (BGI) Engineering Consultants Ltd. Beijing 100038 China College of Architecture and Civil Engineering Beijing University of Technology Beijing 100124 China

As an industry and a discipline,geotechnical investigation in China differs from that in the USA and European countries in its course of emergence and evolution. For over half a century,Chinese geotechnical investigation professionals witnessed continuous technical advances as they undertook independently almost all of China's large-scale construction projects. Based on projects that won the "National Outstanding Engineering Investigation" Gold Medal Awards since the year 2000,this paper discusses the achievements of geotechnical investigation in the context of comprehensive technical ability,project evaluation and analysis,hi-tech applications and engineering monitoring,and analyzes several factors that have hindered the industry's further development and alignment with international practice. Finally,some suggestions are given for future improvement.

关键词： Geotechnical engineering Engineering investigation Technical advance

Sectorization Model of Terminal Airspace with Arrival and Departure Separation

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Transactions of Nanjing University of Aeronautics and Astronautics 2016年第4期33卷 442-450页

作者： zhang ming Yu Hui zhang ming College of Civil Aviation Nanjing University of Aeronautics and Astronautics

Terminal airspace(TMA)is the airspace centering several military and civil aviation airports with complex route structure,limited airspace resources,traffic flow,difficult management and considerable airspace complexity.A scientific and rational sectorization of TMA can optimize airspace resources,and sufficiently utilize the control of human resources to ensure the safety of *** functional sectorization model was established based on the route structure of arriving and departing aircraft as well as controlling *** on principles of sectorization and topological relations within a network,the arrival and departure sectorization model was established,using tree based ant colony algorithm(ACO)*** TMA was taken as an example to be sectorizaed,and the result showed that this model was superior to traditional ones when arrival and departure routes were separated at dense airport terminal airspace.

关键词： air traffic management arrival and departure sectorization model controller′s workload route structure of arriving and departing aircraft Ant colony algorithm

BASIC HYDRODYNAMICS CHARACTERISTICS OF CAVITY SPIRAL FLOW IN A LARGE SIZE LEVEL PIPE

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Journal of Hydrodynamics 2005年第4期17卷 503-513页

作者： NIU Zheng-ming zhang ming-yuan School of Energy and Power Engineering Xi＇an Jiaotong University Xi＇an 710048 China

Based on the observation of a model test and in combination with some theoretical analysis, the researches of some basic hydrodynamics characteristics of cavity spiral flow in a large size level pipe with a shaft-inlet is presented in the paper, which include the basic flow pattern, formation condition of the cavity spiral flow, discharge Q, cavity diameter d0, wall pressure coefficient Cpw, velocity distribution, total energy dissipation rate η etc. The results show that the basic flow patterns can be divided into three zones according to the variations in amount of ventilation Ф, cavity diameter d0 and gas pressure p0 within cavity spiral flow when the upstream and downstream water level changes and that the basic hydrodynamics characteristics change with the flow pattern and have the different behaviour.

关键词： hydrodynamics characteristics flow pattern zoning change cavity spiral flow large size level pipe

Ni-Ag双原子团簇催化甲烷干法重整反应的理论研究

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原子与分子物理学报 2025年第3期42卷 13-20页

作者：刘佳慕红梅张明明李文雅李东东张建辉兰州资源环境职业技术大学黄河流域生态环境产教融合研究院兰州730021 贵州民族大学化学工程学院贵阳550025

甲烷干重整制合成气是将温室气体转换为合成气的有效途径,兼具环境效益和经济效益.本文采用密度泛函理论方法对Ni-Ag双原子团簇催化甲烷干重整反应的体系进行理论研究,对势能面上各驻点进行了全几何参数优化,通过频率分析确认了过渡态,... 详细信息

甲烷干重整制合成气是将温室气体转换为合成气的有效途径,兼具环境效益和经济效益.本文采用密度泛函理论方法对Ni-Ag双原子团簇催化甲烷干重整反应的体系进行理论研究,对势能面上各驻点进行了全几何参数优化,通过频率分析确认了过渡态,并通过内禀反应坐标方法进行了验证,得出各基元反应的能量最低路径.研究结果对于理解在Ni上引入第二种金属Ag形成双原子团簇催化甲烷干法重整的理论研究有一定的意义,并为下一步实验研究提供理论基础.

关键词：甲烷干重整 Ni-Ag双原子团簇密度泛函理论活化能

Dominance-based fuzzy rough approach to an interval-valued decision system

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Frontiers of Computer Science 2011年第2期5卷 195-204页

作者： Xibei YANG ming zhang School of Computer Science and Engineering Jiangsu University of Science and Technology Zhenjiang 212003 China School of Computer Science and Technology Nanjing University of Science and Technology Nanjing 210094 China

Though the dominance-based rough set approach has been applied to interval-valued information systems for knowledge discovery, the traditional dominance relation cannot be used to describe the degree of dominance principle in terms of pairs of objects. In this paper, a ranking method of interval-valued data is used to describe the degree of dominance in the interval-valued information system. Therefore, the fuzzy rough technique is employed to construct the rough approximations of upward and downward unions of decision classes, from which one can induce at least and at most decision rules with certainty factors from the interval-valued decision system. Some numerical examples are employed to substantiate the conceptual arguments.

关键词： certainty factor decision rule dominance relation interval-valued information system intervalvalued decision system fuzzy rough approximation

Strong Cosmic Censorship in accelerating spacetime

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Science China(Physics,Mechanics & Astronomy) 2023年第8期66卷 51-56页

作者： ming zhang Jie Jiang Department of Physics Jiangxi Normal UniversityNanchang 330022China College of Education for the Future Beijing Normal UniversityZhuhai 519087China

It has been established that Strong Cosmic Censorship Conjecture(SCCC)is respected by an asymptotically flat black hole with charge,but violated by a charged asymptotically de Sitter black *** studied the instability of the Cauchy horizon for an accelerating black hole in Einstein theory conformally coupled with a scalar *** black hole is uncharged while having inner,outer,and acceleration *** the limit of vanishing acceleration,denoted by A→0,it becomes asymptotically flat and extremal,with its acceleration horizon vanishing as *** exploring the perturbation of the massless scalar field upon the accelerating black hole,whose decay rate is governed by the quasinormal mode spectra,we show that the SCCC is violated in the near-extremal regime and also in the A→0+*** result is the first observation of a black hole violating the SCCC in an almost asymptotically Minkowskian flat regime,as well as the first example of a black hole violating the SCCC with neither charge nor rotation.

关键词： Strong Cosmic Censorship accelerating black hole Cauchy horizon

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