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Shexiang Tongxin Dropping Pill Allieviates Heart Failure via Extracellula Matrix-Receptor Interaction Pathways Based on RNA-Seq Transcriptomics and Experimental Studies

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Chinese Journal of Integrative Medicine 2023年第7期29卷 600-607页

作者： TAN Ya-fang FU Yu-han zhang min-zhou Intensive Care Research Team of Traditional Chinese Medicine Guangdong Province Hospital of Chinese Medicinethe Second Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou510006China School of Life Sciences and Biopharmaceutics Guangdong Pharmaceutical UniversityGuangzhou510006China

Objective:To investigate the protective mechanisms of Chinese medicine Shexiang Tongxin Dropping Pills(STDP) on heart failure(HF).Methods:Isoproterenol(ISO)-induced HF rat model and angiotensin Ⅱ(Ang Ⅱ)-induced neonatal rat cardiac fibroblast(CFs) model were used in the present *** rats were treated with and without STDP(3 g/kg).RNA-seq was performed to identify differentially expressed genes(DEGs).Cardiac function was evaluated by *** and eosin and Masson’s stainings were taken to assess cardiac *** levels of collagen Ⅰ(Col Ⅰ) and collagen Ⅲ(Col Ⅲ) were detected by immunohistochemical ***8 kit and transwell assay were implemented to test the CFs’ proliferative and migratory activity,*** protein expressions of α-smooth muscle actin(α-SMA),matrix metalloproteinase-2(MMP-2),MMP-9,Col I,and Col Ⅲ were detected by Western ***:The results of RNA-seq analysis showed that STDP exerted its pharmacological effects on HF via multiple signaling pathways,such as the extracellular matrix(ECM)-receptor interaction,cell cycle,and B cell receptor *** from in vivo experiments demonstrated that STDP treatment reversed declines in cardiac function,inhibiting myocardial fibrosis,and reversing increases in Col Ⅰ and Col Ⅱ expression levels in the hearts of HF ***,STDP(6,9 mg/mL) inhibited the proliferation and migration of CFs exposed to Ang Ⅱin vitro(P<0.05).The activation of collagen synthesis and myofibroblast generation were markedly suppressed by STDP,also the synthesis of MMP-2 and MMR-9,as well as ECM components Col Ⅰ,Col Ⅲ,and α-SMA were decreased in Ang Ⅱ-induced neonatal rats’ ***:STDP had anti-fibrotic effects in HF,which might be caused by the modulation of ECM-receptor interaction *** the management of cardiac fibrosis,STOP may be a compelling candidate for improving prognosis of HF.

关键词： Shexiang Tongxin Dropping Pill heart failure RNA-seq extracellular matrix isoproterenol-induced

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Suxiao Jiuxin Pills Prevent Ventricular Fibrillation from Inhibiting L-type Calcium Currents CaV1.2 in vivo and in vitro

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Chinese Journal of Integrative Medicine 2023年第2期29卷 108-118页

作者： QI Jian-yong KANG Dong-yuan YU Juan zhang min-zhou Acute Myocardial Infarction Key Laboratory of Chinese Medicine in Guangzhou the 2nd Affiliated Hospital of Guangzhou University of Chinese MedicineGuangdong Province Hospital of Chinese MedicineGuangzhou 510006China Intensive Care Research Team of Traditional Chinese Medicine the 2nd Affiliated Hospital of Guangzhou University of Chinese MedicineGuangdong Province Hospital of Chinese MedicineGuangzhou 510006China Animal Center the 2nd Affiliated Hospital of Guangzhou University of Chinese MedicineGuangdong Province Hospital of Chinese MedicineGuangdong Province Academy of Chinese MedicineGuangzhou 510006China

Objective: To investigate whether Suxiao Jiuxin Pills(SJP), a Chinese herbal remedy, is an anti-ventricular fibrillation(VF) agent. Methods: VF was induced by isoproterenolol(ISO) intraperitoneal injection followed by electrical pacing in mice and rabbits. The effects of SJP on the L-type calcium channel current(CaV1.2), voltage-dependent sodium channel current(INa), rapid and slow delayed rectifier potassium channel current(IKr and IKs, respectively) were studied by whole-cell patch-clamp method. Computer simulation was implemented to incorporate the experimental data of SJP effects on the CaV1.2 current into the action potential(AP) and pseudo-electrocardiography(pseudo-ECG) models. Results: SJP prevented VF induction and reduced VF durations significantly in mice and rabbits. Patch-clamp experiments revealed that SJP decreased the peak amplitude of the CaV1.2 current with a half maximal concentration(IC50) value of 16.9 mg/L(SJP-30 mg/L, –32.8±6.1 pA;Verapamil, –16.2±1.8 pA;vs. control, –234.5±16.7 pA, P0.05). Computer simulation showed that SJP-reduced CaV1.2 current shortened the AP duration,transiting VF into sinus rhythm in pseudo-ECG. Conclusion: SJP reduced VF via inhibiting the CaV1.2 current with in vivo, in vitro, and in silico studies, which provide experimental basis for SJP anti-VF clinical application.

关键词： Suxiao Jiuxin Pills ventricular fibrillation patch clamp simulation CaV1.2

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A New High-Precision and Lightweight Detection Model for Illegal Construction Objects Based on Deep Learning

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Tsinghua Science and Technology 2024年第4期29卷 1002-1022页

作者： Wenjin Liu Lijuan zhou Shudong zhang Ning Luo min Xu School of Cyberspace Security(School of Cryptology) Hainan UniversityHaikou 570228China School of Information Engineering Capital Normal UniversityBeijing 100048China

Illegal construction has caused serious harm around the world. However, current methods are difficult to detect illegal construction activities in time, and the calculation complexity and the parameters of them are large. To solve these challenges, a new and unique detection method is proposed, which detects objects related to illegal buildings in time to discover illegal construction activities. Meanwhile, a new dataset and a high-precision and lightweight detector are proposed. The proposed detector is based on the algorithm You Only Look Once (YOLOv4). The use of DenseNet as the backbone of YDHNet enables better feature transfer and reuse, improves detection accuracy, and reduces computational costs. Meanwhile, depthwise separable convolution is employed to lightweight the neck and head to further reduce computational costs. Furthermore, H-swish is utilized to enhance non-linear feature extraction and improve detection accuracy. Experimental results illustrate that YDHNet realizes a mean average precision of 89.60% on the proposed dataset, which is 3.78% higher than YOLOv4. The computational cost and parameter count of YDHNet are 26.22 GFLOPs and 16.18 MB, respectively. Compared to YOLOv4 and other detectors, YDHNet not only has lower computational costs and higher detection accuracy, but also timely identifies illegal construction objects and automatically detects illegal construction activities.

关键词： object detection lightweight illegal buildings illegal construction objects high-precision

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SmartEagleEye:A Cloud-Oriented Webshell Detection System Based on Dynamic Gray-Box and Deep Learning

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Tsinghua Science and Technology 2024年第3期29卷 766-783页

作者： Xin Liu Yingli zhang Qingchen Yu Jiajun min Jun Shen Rui zhou Qingguo zhou School of Information Science and Engineering Lanzhou UniversityLanzhou 730000China College of Computer Science and Technology Zhejiang UniversityHangzhou 310058China School of Computing and Information Technology University of WollongongWollongong 2500Australia

Compared with traditional environments,the cloud environment exposes online services to additional vulnerabilities and threats of cyber attacks,and the cyber security of cloud platforms is becoming increasingly prominent.A piece of code,known as a Webshell,is usually uploaded to the target servers to achieve multiple *** Webshell attacks has become a hot spot in current ***,the traditional Webshell detectors are not built for the cloud,making it highly difficult to play a defensive role in the cloud ***,a Webshell detection system based on deep learning that is successfully applied in various scenarios,is proposed in this *** system contains two important components:gray-box and neural network *** gray-box analyzer defines a series of rules and algorithms for extracting static and dynamic behaviors from the code to make the decision *** neural network analyzer transforms suspicious code into Operation Code(OPCODE)sequences,turning the detection task into a classification *** experiment results show that SmartEagleEye achieves an encouraging high detection rate and an acceptable false-positive rate,which indicate its capability to provide good protection for the cloud environment.

关键词： Webshell detection cloud web security deep learning

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Controllable split polarization singularities for ultra-precise displacement sensing

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Photonics Research 2024年第7期12卷 1478-1484页

作者： JIAKANG zhou HAIXIANG MA SHUOSHUO zhang WU YUAN CHANGJUN min XIAOCONG YUAN YUQUAN zhang Nanophotonics Research Centre Institute of Microscale Optoelectronics&State Key Laboratory of Radio Frequency Heterogeneous IntegrationShenzhen UniversityShenzhen 518060China Research Center for Humanoid Sensing Research Institute of Intelligent SensingZhejiang LabHangzhou 311100China Department of Biomedical Engineering The Chinese University of Hong KongHong KongChina

The topic of optical precise displacement measurement has garnered significant attention and generated widespread interest recently. The use of optical singularity offers a potential solution for this purpose, although effectively manipulating the singularity in an ideal manner remains challenging. In this work, we propose a theoretical approach to achieve controllable position modulation of the C-point in the focal plane, whose spatial position can be easily modulated by adjusting the relative offset factor β and the offset angle α of an azimuthal polarization beam(APB), while the interval and orientation of the C-points can be flexibly regulated. Notably, the chiral polarization state undergoes a distinct reversal along the link-line connecting the two C-points, thereby providing a promising approach for accurate displacement sensing. To evaluate its sensing characteristics, the varying pattern of the scattered field intensity is monitored when sweeping a gold helix and nanoparticle along the link-line. The results of simulation quality index Q verify that the equilibrium factor of the scattering field possesses an obvious linear relationship with the displacement, signifying a precise sub-nanometric *** research introduces new methods for the flexible control of polarization singularities in tightly focused fields,thereby enhancing the utilization of circular polarization properties near C-points for displacement *** findings not only enrich the field of nanometer measurement technology but also pave the way for new avenues of research in this domain.

关键词： polarization displacement precise

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Unlock the full potential of carbon cloth-based scaffolds towards magnesium metal storage via regulation on magnesiophilicity and surface geometric structure

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Journal of Energy Chemistry 2024年第3期90卷 423-434,I0010页

作者： Jing Liu min Wang Zhonghua zhang Jinlei zhang Yitao He Zhenfang zhou Guicun Li College of Materials Science and Engineering Qingdao University of Science and TechnologyQingdao 266042ShandongChina Department of Pharmacy Jining Medical UniversityRizhao 276826ShandongChina Department of Energy and Power Engineering School of Energy and EnvironmentAnhui University of TechnologyMa’anshan 243000AnhuiChina

The development of rechargeable magnesium(Mg) batteries is of practical significance to upgrade the electric energy storage devices due to exceptional capacity and abundant resources of Mg-metal ***,the reversible Mg electrochemistry suffers from unsatisfied rate capability and lifespan,mainly caused by non-uniform distribution of *** this work,a fresh design concept of threedimensional carbon cloths scaffolds is proposed to overcome the uncontrollable Mg growth via homogenizing electric field and improving magnesiophilicity.A microscopic smooth and nitrogen-containing defective carbonaceous layer is constructed through a facile pyrolysis of ZIF8 on carbon *** revealed by finite element simulation and DFT calculation results,the smooth surface endows with uniform electric field distribution and simultaneously the nitrogen-doping species enable good magnesiophilicity of *** fine and uniform Mg nucleus as well as the inner electrodeposit behavior are also *** a result,an exceptional cycle life of 500 cycles at 4.0 mA cm^(-2) and 4.0 mA h cm^(-2) is firstly realized to our best ***,the functional scaffolds can be cycled for over 2200 h at 2.0 mA cm^(-2) under a normalized capacity of 5.0 mA h cm^(-2),far exceeding previous *** work offers an effective approach to enable the full potential of carbon cloths-based scaffolds towards metal storage for next generation battery applications.

关键词： Magnesium metal anodes Electrodeposition Heterogeneous nucleation

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Engineered stem cells by emerging biomedical stratagems

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Science Bulletin 2024年第2期69卷 248-279页

作者： Jinglin Wang Xiaoxuan zhang Hanxu Chen Haozhen Ren min zhou Yuanjin Zhao Department of Vascular Surgery.Nanjing Drum Tower Hospital Affliated Hospital of Medical SchoolNanjing UniversityNanjing 210008China Division of Hepatobiliary Surgery and Transplantation Surgery Department of General SurgeryNanjing Drum Tower HospitalSchool of Biological Science and Medical EngineeringSoutheast UniversityNanjing 210096China Shenzhen Research Institute Southeast UniversityShenzhen 518038China

Stem cell therapy holds immense potential as a viable treatment for a widespread range of intractable *** the safety of stem cell transplantation having been demonstrated in numerous clinical trials,various kinds of stem cells are currently utilized in medical *** the achievements,the therapeutic benefits of stem cells for diseases are limited,and the data of clinical researches are *** optimize tthe effectiveness of stem cells,engineering approaches have been developed to enhance their inherent abilities and impart them with new functionalities,paving the way for the next generation of stem cell *** review offers a detailed analysis of engineered stem cells,including their clinical applications and potential for future *** begin by briefly introducing the recent advances in the production of stem cells(induced pluripotent stem cells(ipsCs),embryonic stem cells(ESCs),mesenchymal stem cells(MSCs)and hematopoietic stem cells(HSCs).Furthermore,we present the latest developments of engineered strategies in stem cells,including engineered methods in molecular biology and biomaterial fields,and their application in biomedical ***,we summarize the current obstacles and suggest future prospects for engineered stem cells in clinical translations and biomedical applications.

关键词： Stem cells Genetic modification Biomaterials Microfluidics Organ-on-a-chip Bioprinting

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Realize ultralow-energy-consumption photo-synaptic device based on a single(Al,Ga)N nanowire for neuromorphic computing

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Nano Research 2024年第3期17卷 1933-1941页

作者： Xiushuo Gu min zhou Yukun Zhao Qianyi zhang Jianya zhang Yonglin Huang Shulong Lu College of Electronic and Optical Engineering&College of Flexible Electronics(Future Technology) Nanjing University of Posts and TelecommunicationsNanjing 210023China Key Lab of Nanodevices and Applications Suzhou Institute of Nano-Tech and Nano-Bionics(SINANO)Chinese Academy of Sciences(CAS)Suzhou 215123China School of Nano-Tech and Nano-Bionics University of Science and Technology of ChinaHefei 230026China Jiangsu Key Laboratory of Micro and Nano Heat Fluid Flow Technology and Energy Application School of Physical Science and TechnologySuzhou University of Science and TechnologySuzhou 215009China

The rapid development of artificial intelligence poses an urgent need for low-energy-consumption and small-sized artificial photonic ***,it is pretty novel to demonstrate a light-stimulated synaptic device based on a single(Al,Ga)N nanowire *** to the presence of vacancy defects in the single nanowire,the artificial synaptic device can simulate multiple functions of biological synapses under stimulation of both 310 and 365 nm light photons,including paired-pulse facilitation,spike timing dependent plasticity,and memory learning *** energy consumption of artificial synaptic device can be reduced as little as 5.58×10^(-13) J,which is close to that of the biological synapse in human ***,the synaptic device is demonstrated to have the high stability for both long-time stimulation and long-time *** on the experimental conductance of long-term potentiation and long-term depression,the simulated three-layer neural network can achieve a high recognition rate of 92%after only 10 training *** a brain-like behavior,the single-nanowire-based synaptic devices can promote the development of visual neuromorphic computing technology and artificial intelligence systems requiring ultralow energy consumption.

关键词： single(Al Ga)N nanowire light-stimulated synaptic device low-energy-consumption neural network

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High-power,electrically-driven continuous-wave 1.55-μm Si-based multi-quantum well lasers with a wide operating temperature range grown on wafer-scale InP-on-Si(100)heterogeneous substrate

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Light(Science & Applications) 2024年第8期13卷 1512-1523页

作者： Jialiang Sun Jiajie Lin min zhou Jianjun zhang Huiyun Liu Tiangui You Xin Ou National Key Laboratory of Materials for Integrated Circuits Shanghai Institute of Microsystem and Information TechnologyCASShanghai 200050China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of Sciences100049 BeijingChina College of Information Science and Engineering Jiaxing UniversityJiaxing 314001China Beijing National Laboratory for Condensed Matter Physics Institute of PhysicsChinese Academy of Sciences100190 BeijingChina Department of Electronic and Electrical Engineering University College LondonLondon WC1E 7JEUK

A reliable,efficient and electrically-pumped Si-based laser is considered as the main challenge to achieve the integration of all key building blocks with silicon *** the impressive advances that have been made in developing 1.3-μm Si-based quantum dot(QD)lasers,extending the wavelength window to the widely used 1.55-μm telecommunication region remains *** this study,we develop a novel photonic integration method of epitaxial growth of III-V on a wafer-scale InP-on-Si(100)(InPOS)heterogeneous substrate fabricated by the ion-cutting technique to realize integrated lasers on Si *** ion-cutting plus epitaxial growth approach decouples the correlated root causes of many detrimental dislocations during heteroepitaxial growth,namely lattice and domain *** this approach,we achieved state-of-the-art performance of the electrically-pumped,continuouswave(CW)1.55-μm Si-based laser with a room-temperature threshold current density of 0.65 kA/cm-2,and output power exceeding 155mW per facet without facet coating in CW *** lasing at 120℃ and pulsed lasing at over 130℃ were *** generic approach is also applied to other material systems to provide better performance and more functionalities for photonics and microelectronics.

关键词： pumped power quantum

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Role of CD36 in central nervous system diseases

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Neural Regeneration Research 2024年第3期19卷 512-518页

作者： min Feng Qiang zhou Huimin Xie Chang Liu Mengru Zheng Shuyu zhang Songlin zhou Jian Zhao School of Health Science and Engineering University of Shanghai for Science and TechnologyShanghaiChina Department of Orthopedic Oncology Second Affiliated Hospital of Naval Medical UniversityShanghaiChina Key Laboratory of Neuroregeneration of Jiangsu and ministry of Education NMPA Key Laboratory for Research and Evaluation of Tissue Engineering Technology ProductsJiangsu Clinical Medicine Center of Tissue Engineering and Nerve Injury RepairCo-Innovation Center of NeuroregenerationNantong UniversityNantongJiangsu ProvinceChina Department of Stomatology Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina Medical College of Nantong University NantongJiangsu ProvinceChina

CD36 is a highly glycosylated integral membrane protein that belongs to the scavenger receptor class B family and regulates the pathological progress of metabolic ***36 was recently found to be widely expressed in various cell types in the nervous system,including endothelial cells,pericytes,astrocytes,and ***36 mediates a number of regulatory processes,such as endothelial dysfunction,oxidative stress,mitochondrial dysfunction,and inflammatory responses,which are involved in many central nervous system diseases,such as stroke,Alzheimer’s disease,Parkinson’s disease,and spinal cord ***36 antagonists can suppress CD36 expression or prevent CD36 binding to its ligand,thereby achieving inhibition of CD36-mediated pathways or ***,we reviewed the mechanisms of action of CD36 antagonists,such as Salvianolic acid B,tanshinone IIA,curcumin,sulfosuccinimidyl oleate,antioxidants,and small-molecule ***,we predicted the structures of binding sites between CD36 and *** sites can provide targets for more efficient and safer CD36 antagonists for the treatment of central nervous system diseases.

关键词： animal experiments antagonists CD36 antagonist central nervous system diseases clinical trial curcumin microRNA salvianolic acid B small-molecule drugs sulfosuccinimidyl oleate

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