检索结果-南通市图书馆

N-acetylcysteine protects against cadmium-induced germ cell apoptosis by inhibiting endoplasmic reticulum stress in testes

在线全文

学校读者我要写书评

暂无评论

Asian Journal of Andrology 2013年第2期15卷 290-296,I0010页

作者： Yan-Li Ji hua Wang Cheng zhang Ying zhang mei Zhao Yuan-hua Chen De-Xiang Xu Department of Toxicology School of Public Health Anhui Medical University Hefei 230032 China

Cadmium （Cd） is a reproductive toxicant that induces germ cell apoptosis in the testes. Previous studies have demonstrated that endoplasmic reticulum （ER） stress is involved in Cd-induced germ cell apoptosis. The aim of the present study was to investigate the effects of N-acetylcysteine （NAC）, an antioxidant, on Cd-induced ER stress and germ cell apoptosis in the testes. Male CD-1 mice were intraperitoneally injected with CdCl2 （2.0 mg kg^-1）. As expected, acute Cd exposure induced germ cell apoptosis in the testes, as determined by terminal dUTP nick-end labelling （TUNEL）. However, the administration of NAC alleviated Cd-induced germ ceil apoptosis in the testes. Further analysis showed that NAC attenuated the Cd-induced upregulation of testicular glucose-regulated protein 78 （GRP78）, an important ER molecular chaperone. Moreover, NAC inhibited the Cd-induced phosphorylation of testicular eukaryotic translation initiation factor 2a （elF2a）, a downstream target of the double-stranded RNA-activated kinase-like ER kinase （PERK） pathway. In addition, NAC blocked the Cd-induced activation of testicular X binding protein （XBP）-1, indicating that NAC attenuates the Cd-induced ER stress and the unfolded protein response （UPR）. Interestingly, NAC almost completely prevented the Cd-induced elevation of C/EBP homologous protein （CHOP） and phosphorylation of c-Jun N-terminal kinase （.INK）, two components of the ER stress-mediated apoptotic pathway. In conclusion, NAC protects against Cd-induced germ cell apoptosis by inhibiting endoplasmic reticulum stress in the testes.

关键词： antioxidant apoptosis cadmium endoplasmic reticulum stress N-acetylcysteine (NAC) testis unfolded protein response

Removal of cadmium using MnO_2 loaded D301 resin

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Environmental Sciences 2007年第6期19卷 652-656页

作者： ZHU Zhi-liang MA Hong-mei zhang Rong-hua GE Yuan-xin ZHAO Jian-fu Key Laboratory of Yangtze Aquatic Environment of Ministry of Education State Key Laboratory of Pollution Control and Resource Reuse Tongji University Shanghai 200092 China

MnO2 loaded weak basic anion exchange resin D301 （Anion exchange resin, macroreticular weak basic styrene） as adsorbent has been prepared and applied to the removal of cadmium. The adsorption characteristics have been investigated with respect to effect of pH, equilibrium isotherms, removal kinetic data, and interference of the coexisting ions. The results indicated that the Cd^2＋ could be efficiently removed using MnO2 loaded D301 resin in the pH range of 3-8 from aqueous solutions with the co-existence of high concentration of alkali and alkaline-earth metals ions. The saturate adsorption capacity of the Cd^2＋ was 77.88 mg/g. The adsorption process followed the pseudo first-order kinetics. The equilibrium data obtained in this study accorded excellently with the Langmuir adsorption isotherm.

关键词： cadmium kinetics adsorption loaded resin removal

Luteolin prevents f MLP-induced neutrophils adhesion via suppression of LFA-1 and phosphodiesterase 4 activity

在线全文

学校读者我要写书评

暂无评论

Journal of Integrative Agriculture 2015年第1期14卷 140-147页

作者： JIANG Dai-xun LIU Shu-rong zhang mei-hua zhang Tao MA Wen-jing MU Xiang CHEN Wu Beijing Key Laboratory of Traditional Chinese Veterinary Medicine Beijing University of Agriculture

Luteolin is an active ingredient found early from Fofium perillae and Flos Ionicerae, and has a specific inhibition on phosphodiesterase 4 （PDE4） activity in vitro. Researches show luteolin has pharmacological effects of anti-inflammation, anti-anaphylaxis, antitumor, antioxidant, protection of nervous system and so on, and has mainly been used for the treatment of respiratory inflammatory diseases, cancer and cardiovascular disease in clinic. PDE4, specific to hydrolyze cyclic AMP （cAMP）, is considered to be a new anti-inflammatory target due to the decisive role on cAMP signal in inflammatory cells such as neutrophils. In order to explore the anti-inflammatory mechanism, we further studied the effects of luteolin on the activity and expression of PDE4, the expression of lymphocyte function-associated antigen-1 （LFA-1） and macrophage-1 （MAC-l） in neutrophils, and the adhesion of neutrophils and endothelial cells. The results showed that luteolin had a dose-dependent inhibition on both bare PDE4 activity and PDE4 in cultured neutrophils, and had an obviously promotive effect on gene expressions of PDE4A, 4B and 4D in later period. Luteolin had a significant inhibitory effect on neutrophils adhesion and LFA-1 expression in early stage, and had no obvious effect on MAC-1 expression. Therefore, luteolin can inhibit LFA-1 expression of neutrophils, then inhibit the adhesion of neutrophils and endothelial cells, and the mechanism is at least related with the inhibition of PDE4 activity.

关键词： luteolin neutrophils phosphodiesterase 4 LFA-1 MAC-1 adhesion swine

归肾丸合生化汤对人流术后子宫内膜修复的影响

在线全文

学校读者我要写书评

暂无评论

山西中医 2024年第10期40卷 26-27页

作者：陈倩倩张玫桦吴晓放洪璐卢晓露浙江省东阳市妇幼保健院东阳322100 浙江省武义县中医院

目的:观察归肾丸合生化汤对人流术后子宫内膜修复的临床疗效。方法:将200名人工流产患者随机分为两组各100例。对照组予戊酸雌二醇片及地屈孕酮片治疗,治疗组在对照组基础上予中药归肾丸合生化汤治疗,两组均治疗3个月经周期,观察两组患... 详细信息

目的:观察归肾丸合生化汤对人流术后子宫内膜修复的临床疗效。方法:将200名人工流产患者随机分为两组各100例。对照组予戊酸雌二醇片及地屈孕酮片治疗,治疗组在对照组基础上予中药归肾丸合生化汤治疗,两组均治疗3个月经周期,观察两组患者月经首次复潮时间、子宫内膜厚度及宫腔黏连的发生等情况。结果:患者月经首次复潮时间两组比较差异无统计学意义(P﹥0.05)。治疗组患者子宫内膜平均(7.23±1.57)mm,对照组(5.08±1.40)mm,差异具有统计学意义(P﹤0.05)。结论:归肾丸合生化汤对多次人工流产患者子宫内膜修复有促进作用,可刺激子宫内膜生长、增厚。

关键词：人工流产归肾丸生化汤子宫内膜修复中西医结合疗法

Fabrication and properties of lightweight zirconia with fine closed porosity

在线全文

学校读者我要写书评

暂无评论

Journal of Iron and Steel Research International 2024年第6期31卷 1449-1458页

作者： Yi-bo zhang hua-zhi Gu Lv-ping Fu Ao huang mei-je zhang The State Key Laboratory of Refractories and Metallurgy Wuhan University of Science and TechnologyWuhan 430081HubeiChina

Lightweight refractory materials with thermal insulation properties and erosion resistance are advantageous for hightemperature *** zirconia refractories were prepared using starch as a pore-forming agent,basic magnesium carbonate as a stabilizer,and nano-zirconia as an *** effects of the nano-zirconia content on the pore and thermal insulation properties of the lightweight zirconia refractories were investigated based on the porosity,phase composition,microstructure,and thermal ***-zirconia was shown to have a high surface energy,and its addition effectively increased the driving force for sintering,reduced the sintering temperature,and promoted the sintering reaction,thereby reducing the apparent porosity and improving the density of the prepared *** to the superplasticity of nano-zirconia,the surface stress caused plastic deformation between particles,which increased the migration rate of grain boundaries and trapped more gas inside the material before it diffused to the surface,thereby enhancing the closed porosity of the *** presence of closed pores could extend the thermal conduction path,decrease the conduction rate,and hinder the conduction effect to effectively reduce the thermal conductivity of the *** a nano-zirconia content of 0.75 wt.%,the prepared lightweight zirconia had the highest closed porosity and the lowest thermal *** apparent porosity,closed porosity,and total porosity of the material were 2.8%,7.0%,and 9.8%,respectively,and the thermal conductivity at 800℃was 1.37 W m^(-1)k^(-1).

关键词： Sintering Nano-zirconia Closed pore:Thermal conductivity Refractory material

Influence of gallic acid on porcine neutrophils phosphodiesterase 4,IL-6,TNF-α and rat arthritis model

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Integrative Agriculture 2015年第4期14卷 758-764页

作者： JIANG Dai-xun zhang mei-hua zhang Qian CHEN Yi-shan MA Wen-jing WU Wei-peng MU Xiang CHEN Wu Beijing Key Laboratory of Traditional Chinese Veterinary Medicine Beijing University of Agriculture

Our previous studies showed that the anti-inflammatory effects of Paeonia lactiflora roots extract may be mediated, at least in part, through its gallic acid content, and this effect may be regulated in part by an inhibition on c AMP-phosphodiesterase（PDE）. To explore the anti-inflammatory effect and mechanism, the influence of gallic acid on neutrophils PDE4 activity and expression, TNF-α and IL-6 content and rat arthritis model were further studied. PDE4 activity and gene express were calculated respectively by substrate c AMP change examined with HPLC and real-time RT-PCR. The concentration of IL-6 and TNF-α in supernatant were assayed by ELISA method. Model of rat arthritis was caused by complete Freund＇s adjuvant. Results showed that gallic acid had a dose-dependent restraint on PDE4 activity of neutrophils in vitro, promoted significantly PDE4 A expression（P〈0.01）, and had no influence on the expressions of PDE4 B and 4D. However, PDE4 C expression was not detected. Gallic acid could promote IL-6 release（P〈0.05）, and inhibit TNF-α release of neutrophils（P〈0.05）. The experiment in vivo showed that gallic acid had obvious restraint on local inflammation of animal model（P〈0.05）. Therefore, the anti-inflammatory effect of gallic acid may be mediated in part through an inhibition on PDE4 activity and further an increase of IL-6 and a decrease of TNF-α of neutrophils, and this effect seemed to have no relationship with PDE4 expression.

关键词： gallic acid phosphodiesterase 4 inflammation IL-6 TNF-α neutrophils

On the Pathwise Uniqueness of Solutions of One-dimensional Reflected Stochastic Differential Equations with Jumps

在线全文

学校读者我要写书评

暂无评论

Acta Mathematicae Applicatae Sinica 2024年第1期40卷 149-163页

作者： hua zhang School of Statistics and Data Science&Key Laboratory of Data Science in Finance and Economics Jiangxi University of Finance and EconomicsNanchang330013China

In this paper, we are concerned with the problem of the pathwise uniqueness of one-dimensional reflected stochastic differential equations with jumps under the assumption of non-Lipschitz continuous coefficients whose... 详细信息

关键词： reflected diffusion processes with jumps pathwise uniqueness local time Meyer It?'s formula

Effect of depot medroxyprogesterone acetate on bone mineral density in adolescent women

在线全文

学校读者我要写书评

暂无评论

Chinese Medical Journal 2013年第21期126卷 4043-4047页

作者： zhang mei-hua zhang Wei zhang Ai-dong Yang Yan Gai Ling Shandong Prov Inst Sci & Technol Family Planning Key Lab Improving Birth Outcome Tech Jinan 250002 Shandong Peoples R China

Background Depot medroxyprogesterone acetate （DMPA） as a hormonal contraceptive is highly effective and widely used, but it may reduce bone mineral density （BMD） and increase the risk of osteoporosis. We compared BMD between users of intramuscular DMPA and nonhormonal subjects. Methods The study included 102 women aged between 16 and 18 years using DMPA for 24 months and 97 women aged between 16 and 18 years using nonhormonal contraception as nonusers control group. BMD of the lumbar spine and femoral neck was measured every 12 months for 24 months using dual-energy X-ray absorptiometry, comparing mean BMD changes in DMPA users and nonusers.

关键词： depot medroxyprogesterone acetate bone mineral density contraception adolescents

Interpretation of the Standards of Basic Dataset of Chronic Diseases Behavior Risk Factor Surveillance in Adults

在线全文

学校读者我要写书评

暂无评论

Biomedical and Environmental Sciences 2024年第5期37卷 551-556页

作者： ZHAO Yan Fang zhang mei WEI Wen Qiang SUN Ke Xin LI Xin hua WANG Li Min National Center for Chronic and Noncommunicable Disease Control and Prevention(NCNCD) Chinese Center for Disease Control and PreventionBeijing 100050China Cancer Hospital Chinese Academy of Medical SciencesBeijing 100021China Chinese Center for Disease Control and Prevention Beijing 102206China People's Medical Publishing House Beijing 100021China

BACKGROUND China’s Behavioral Risk Factor Surveillance System(BRFSS)originated from the World Bankfunded HealthⅦLoan Project in the 1990s,which conducted behavioral risk factor surveillance in seven cities and one province^([1]).Drawing on the World Health Organization’s(WHO)STEPwise approach to surveillance(STEPs)and the *** Risk Factor Surveillance System(BRFSS)^([2,3]).

关键词： funded Basic originated