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Acoustofluidics-enhanced biosensing with simultaneously high sensitivity and speed

Microsystems & Nanoengineering 2024年第3期10卷 335-346页

作者： Yuang Li Yang Zhao Yang Yang Wenchang zhang Yun zhang Sheng Sun lingqian zhang Mingxiao Li Hang Gao Chengjun Huang Institute of Microelectronics of the Chinese Academy of Sciences Beijing 100029P.R.China University of Chinese Academy of Sciences Beijing 101408P.R.China Department of Medicine Brigham and Women’s HospitalHarvard Medical SchoolBostonMA 02115USA

Simultaneously achieving high sensitivity and detection speed with traditional solid-state biosensors is usually limited since the target molecules must passively diffuse to the sensor surface before they can be *** techniques have been applied to shorten the diffusion time by continuously moving molecules through the biosensing ***,the binding efficiencies of the biomolecules are still limited by the inherent laminar flow inside microscale *** this study,focused traveling surface acoustic waves were directed into an acoustic microfluidic chip,which could continuously enrich the target molecules into a constriction zone for immediate detection of the immune reactions,thus significantly improving the detection sensitivity and *** demonstrate the enhancement of biosensing,we first developed an acoustic microfluidic chip integrated with a focused interdigital transducer;this transducer had the ability to capture more than 91%of passed ***,polystyrene microbeads were pre-captured with human IgG molecules at different concentrations and loaded for detection on the *** representative results,~0.63,2.62,11.78,and 19.75 seconds were needed to accumulate significant numbers of microbeads pre-captured with human IgG molecules at concentrations of 100,10,1,and 0.1 ng/mL(~0.7 pM),respectively;this process was faster than the other methods at the hour level and more sensitive than the other methods at the nanomolar *** results indicated that the proposed method could significantly improve both the sensitivity and speed,revealing the importance of selective enrichment strategies for rapid biosensing of rare molecules.

关键词： fluid continuously simultaneous

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中国流通创新研究与展望——基于文献内容Citespace分析

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商业经济研究 2024年第4期 5-9页

作者：朱齐举张令骞广州商学院经济学院广东广州510555

党的二十大对建立现代流通体系提出新要求,流通创新是现代流通体系适应新发展格局的必然要求。流通领域在我国经济发展各时期均扮演重要角色,本研究利用文献计量和可视化分析,对CNKI数据库检索出的1985-2022年间的流通创新研究进行统计... 详细信息

党的二十大对建立现代流通体系提出新要求,流通创新是现代流通体系适应新发展格局的必然要求。流通领域在我国经济发展各时期均扮演重要角色,本研究利用文献计量和可视化分析,对CNKI数据库检索出的1985-2022年间的流通创新研究进行统计分析。研究发现,我国流通创新研究可划分为探索期、快速发展期和繁荣稳定期三个阶段,相关研究在2017年达到高峰;累计发文量呈线性上升趋势,预示今后几年发文量仍将保持平稳增长。根据普莱斯定律发现,流通创新核心研究作者群与核心研究机构群均未形成;文章通过选取前九大聚类词进行分析,对热点形成的原因加以讨论;根据近五年的关键词时间区图对我国流通创新未来研究的趋势进行了预测。

关键词：流通创新 CiteSpace 文献计量知识图谱

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Responses of properties in the plasma sheet and at the geosynchronous orbit to interplanetary shock

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Chinese Science Bulletin 2009年第18期54卷 3308-3317页

作者： YAO Li LIU ZhenXing ZUO PingBing zhang lingqian DUAN SuPing State Key Laboratory of Space Weather (Center for Space Science and Applied Research Chinese Academy of Sciences) Beijing100190 China Graduate University of Chinese Academy of Sciences Beijing 100049 China

On July 22, 2004, the WIND spacecraft detected a typical interplanetary shock. There was sustaining weak southward magnetic field in the preshock region and the southward field was suddenly enhanced across the shock front (i.e., southward turning). When the shock impinged on the magnetosphere, the magnetospheric plasma convection was abruptly enhanced in the central plasma sheet, which was directly observed by both the TC-1 and Cluster spacecraft located in different regions. Simultaneously, the Cluster spacecraft observed that the dawn-to-dusk electric field was abruptly enhanced. The variations of the magnetic field observed by TC-1, Cluster, GOES-10 and GOES-12 that were distributed in different regions in the plasma sheet and at the geosynchronous orbit are obviously distinct. TC-1 observations showed that the magnetic intensity kept almost unchanged and the elevation angle decreased, but the Cluster spacecraft, which was also in the plasma sheet and was further from the equator, observed that the magnetic field was obviously enhanced. Simultaneously, GOES-12 located near the midnight observed that the magnetic intensity sharply increased and the elevation angle decreased, but GOES-10 located in the dawn side observed that the magnetic field was merely compressed with its three components all sharply increasing. Furthermore, the energetic proton and electron fluxes at nearly all channels observed by five LANL satellites located at different magnetic local times (MLTs) all showed impulsive enhancements due to the compression of the shock. The responses of the energetic particles were much evident on the dayside than those on the nightside. Especially the responses near the midnight were rather weak. In this paper, the possible reasonable physical explanation to above observations is also discussed. All the shock-induced responses are the joint effects of the solar wind dynamic pressure pulse and the magnetic field southward turning.

关键词：地球同步轨道行星际激波反应属性血浆

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New progress of Double Star-Cluster joint exploration and study

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Science China(Technological Sciences) 2008年第10期51卷 1565-1579页

作者： LIU ZhenXing PU ZuYin CAO JinBin SHEN Chao LU Li zhang lingqian Center for Space Science and Applied Research Chinese Academy of SciencesBeijing 100080China School of Earth and Space Science Peking UniversityBeijing 100080China

The magnetic reconnection of magnetosphere and the magnetospheric space storms (including magnetospheric substorm, magnetic storm, magnetospheric particle storm) has long been one of the most challenging subjects in the so-lar-terrestrial physics. The reconnection mechanism and global triggering process of the magnetospheric space storms are still unclear up to now. Based on the Double Star Program (DSP) and Cluster joint measurements, we have observed the solar wind density hole, the component magnetic field reconnection in the magnetopause, the structures of magnetic storm ring current, global and multi-scale driven and triggering processes of magnetospheric substorm. In this paper we will briefly introduce these results.

关键词： solar wind magnetic reconnection magnetospheric substorm magnetic storm

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SERS devices with "hedgehog-like" nanosphere arrays for detection of trace pesticides

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Journal of Innovative Optical Health Sciences 2021年第4期4卷 72-81页

作者： Yang Liu Xin Li Jie Cheng Na Zhou lingqian zhang Haiyang Mao Chengjun Huang Institute of Microelectronics of Chinese Academy of Sciences Beijing 100029P.R.China University of Chinese Academy of Sciences Beijing 100049P.R.China Wuxi Internet of Things Innovation Center Co.Ltd.Advanced Sensing Department Wuxi 214001P.R.China

The development of surface-enhanced Raman scattering(SERS)devices for detection of trace pesticides has attracted more and more *** this work,a large-area self-assembly ap-proach assisted with reactive ion etching(RIE)is proposed for preparing SERS devices consisting of Ag-covered"hedgehog-like"nanosphere arrays(Ag/HLNAs).Such a SERS device has an enhancement factor of 2.79×107,a limit of detection(LOD)up to 10-12 M for Rhodamine 6G(R6G)analytes,and a relative standard deviation(RSD)smaller than 10%,demonstrating high ***,for pesticide detections,the device achieves an LOD of 10-s M for thiram *** indicates that the proposed SERS device has a promising opportunity in detecting toxic organic pesticides.

关键词： surface-enhanced Raman scattering(SERS) self-assembly Ag-covered"hedgehog-like"nanosphere arrays(Ag/HLNAs) pesticide detections

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3D spiral channels combined with flexible micro-sieve for high-throughput rare tumor cell enrichment and assay from clinical pleural effusion samples

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Bio-Design and Manufacturing 2022年第2期5卷 358-370页

作者： Jie Cheng Lina zhang Yiran zhang Yifei Ye Wenjie Zhao lingqian zhang Yuang Li Yang Liu Wenchang zhang Hongyan Guo Mingxiao Li Yang Zhao Chengjun Huang Institute of Microelectronics Chinese Academy of SciencesBeijing 100029China School of Future Technology University of Chinese Academy of SciencesBeijing 100049China Department of Cellular and Molecular Biology Beijing Chest HospitalCapital Medical UniversityBeijing Tuberculosis and Thoracic Tumor Research InstituteBeijing 101149China National Engineering Research Center for Beijing Biochip Technology Beijing 102206China

The sieving and enrichment of rare tumor cells from large-volume pleural effusion(PE)samples is a promising technique for cell-based lung tumor diagnosis and drug tests,which features high throughput and recovery,purification,as well as viability rates of rare target cells as the prerequisites for high sensitivity,specificity,and accuracy of tumor cell *** this paper,we propose a three-dimensional(3 D)sieving method for rare tumor cell enrichment,which effectively eliminates the"dead zones"in traditional two-dimensional(2 D)cell filters with a dimension-raising strategy to satisfy the requirements mentioned *** prototype device was combined with a funnel-shaped holder,a flexible micropore membrane in the middle,and a3 D spiral fluid channel covered on the membrane as a three-layer ice-creaming cone composite *** by gravity alone,the device performed as follows:(1)20-fold throughput compared with the 2 D commercial planee hich was up to 20 mL/min for a threefold dilution of whole blood sample;(2)high recovery rates of 84.5%±21%,86%±25%,83%±14%for 100,1000,and 10000 cells/mL,respectively,in 30 mL phosphate buffer saline(PBS)sample,and a 100%positive detection rate in the case of≤5 A549 cells in 1 mL PBS;(3)a typical purification rate of 85.5%±9.1%;and(4)a viability rate of>93%.In the demonstration application,this device effectively enriched rare target cells from large volumes(>25 mL)of clinical pleural *** following results indicated that tumor cells were easy-to-discover in the enriched PE samples,and the proliferation capability of purified cells was(>4.6 times)significantly stronger than that of unprocessed cells in the subsequent 6-day *** above evaluation indicates that the proposed easily reproducible method for the effective execution of rare cell enrichments and assays is expected to become a practical technique for clinical cell-based tumor diagnosis.

关键词： Cell enrichment High throughput Pleural effusion Liquid biopsy 3D printing

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A direct Z-scheme Bi_(2)WO_(6)/La_(2)Ti_(2)O_(7) photocatalyst for selective reduction of CO_(2) to CO

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Chinese Journal of Structural Chemistry 2023年第4期42卷 38-45页

作者： Jianxiong Chen Lichao Lin Peiling Lin Lujiang Xiao lingqian zhang Ying Lu Wenyue Su State Key Laboratory of Photocatalysis on Energy and Environment College of ChemistryFuzhou UniversityFuzhou350116PR China

Simulating photosynthesis to convert CO_(2)into valuable chemicals is an effective strategy to achieve sustainable carbon recycles,and the high conversion efficiency and selectivity of photocatalytic conversion CO_(2)to specific chemicals are the key ***,a direct Z-scheme Bi_(2)WO_(6)/La_(2)Ti_(2)O_(7)photocatalyst is successfully syn-thesized by electrostatic self-assembly *** selectivity of CO_(2)reduction to CO is improved from 74%of La_(2)Ti_(2)O_(7)to nearly 100%,and the CO yield is 7.5 times that of individual La_(2)Ti_(2)O_(7).The improvement of the photocatalytic performance is attributed to the formation of Z-scheme heterojunction between Bi_(2)WO_(6)and La_(2)Ti_(2)O_(7),which facilitates the separation and transfer of photogenerated *** work provides a new insight for the construction of efficient photocatalyst for selective reduction of CO_(2)to CO.

关键词： La_(2)Ti_(2)O_(7) Bi_(2)WO_(6) Z-scheme heterojunction Photocatalytic CO_(2)reduction CO selectivity

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The distribution characteristics of the flows in the near-Earth region: TC-1 observational results

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Chinese Science Bulletin 2007年第23期52卷 3267-3271页

作者： zhang lingqian LIU ZhenXing WANG JiYe MA ZhiWei PU ZhuYin SHEN Chao GUO JiuLing Center for Space and Applied Research Chinese Academy of Sciences Beijing 100080 China College of Physics and Electronic Engineering Central University for Nationalities Beijing 100081 China Institute of Plasma Physics Chinese Academy of Sciences Hefei 230031 China School of Earth and Space Science Peking University Beijing 100871 China Modern Education Technology Center Peking University Beijiing 100871 China

TC-1 observational results clearly indicate that the velocity of the flows in the near-Earth region is de- pendent on the satellite location. The flow speed decreases while satellite moves close to the Earth. The plasma flow in the region close to the Earth tends to drift into the midnight region from the dawn and dusk region while the flow in the region away from the Earth shows an opposite drift. The obser- vational results also show that the tailward flows are mainly located in the plasma sheet boundary while the earthward flow becomes dominant in the plasma sheet. It is found that both the strong tailward and earthward flows are distributed in the region around X= -11Re, which coincides with the trigger region of the substorm onset. Hence, it may suggest that the flows are related with the trigger of the substorm onset. In addition, the BBFs coming from the mid-tail maily distributed in the region where X<-9RE and |Z|<3RE that differs from the convection.

关键词：地球磁尾地形分布数据收集

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Ion flux dropout observed near dipolarization front

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Chinese Science Bulletin 2014年第8期59卷 4790-4796页

作者： Xueling Shi Tao Chen lingqian zhang Suping Duan Jiang Liu Zhaohai He State Key Laboratory of Space Weather Center for Space Science and Applied Research Chinese Academy of Sciences College of Earth Sciences University of Chinese Academy of Sciences Department of Earth Planetary and Space Sciences Institute of Geophysics and Planetary Physics University of California Los Angeles CA 90095 USA

An ion flux dropout near the dipolarization front(DF) at around XGSM=-11 REin the Earth's plasma sheet was observed by Time History of Events and Macroscale Interaction during substorms(THEMIS) on March31, 2009. The ion differential energy fluxes at energies from 450 e V to 150 ke V measured by the ESA and SST instruments from THC began to decrease about 2 s before the detection of the DF and reached a local minimum 6 s later. Then, the ion fluxes gradually increased to form a dropout around the DF. The spatial extent of the dropout was about 4,000 km. For energies above 20 ke V, the ion fluxes after the dropout are greater than those before it,contrary to the fluxes at energies below 20 ke V. The associated ion density variation indicates that the ion flux dropout coincides with the ion density dropout. Taking advantage of multipoint observations, THD, THC, and THE detected the same DF consecutively. Only THC detected an obvious ion flux dropout; THD observed an indistinct one about 2 s before THC; no high-energy(E [ 30 ke V) ion flux dropout was observed by THE. Our study suggests that the ion flux dropout may evolve withthe earthward-propagating DF, and its properties can depend on locations relative to the DF.

关键词：能量通量离子流双极化观测等离子体片总谐波失真 THC 空间范围

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Convective high-speed flow and field-aligned high-speed flows explored by TC-1

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Chinese Science Bulletin 2008年第15期53卷 2371-2375页

作者： zhang lingqian LIU ZhenXing MA ZhiWei W. BAUMJOHANN M.W. DUNLOP WANG GuangJun WANG Xiao H. REME C. CARR Centre for Space Science and Applied Research Chinese Academy of Sciences Beijing 100080 China Institute for Fusion Theory and Simulation Zhejiang University Hangzhou 310027 China Space Research Institute Austrian Academy of Sciences 68042 Graz Austria Space Sciences Division Rutherford Appleton Laboratory Chilton Didcot Oxfordshire OX11 0QX United Kingdom Centre d'Etude Spatiale des Rayonnements F-78140 Toulouse Codex France Imperial College London SW7 2BZ United Kingdom

From June 1, 2004 to October 31, 2006, a total 465 high-speed flow events are observed by the TC-1 satellite in the near-Earth region (?13 RE < x < ?9 RE, |Y |<10 RE, |Z|<5 RE). Based on the angle between the flow and the magnetic field, the high-speed flow events are further divided into two types, that is, field-aligned high-speed flow (FAHF) in the plasma sheet boundary and convective bursty bulk flow (BBF) in the center plasma sheet. Among the total 465 high-speed flow events, there are 371 FAHFs, and 94 BBFs. The CHF are mainly concentrated in the plasma sheet, the intersection angle between the flow and the magnetic field is larger, the magnetic field intensity is relatively weak. The FHF are mainly distributed near the boundary layer of the plasma sheet, the intersection angle between the flow and magnetic field is smaller, and the magnetic field intensity is relatively strong. The convective BBFs have an important effect on the substorm.

关键词：高速流对流磁场地球科学

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