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Journal of Genetics and Genomics 2024年第9期51卷 970-973页

作者： Jialong Deng Ziyuan Zhou Wangjun liao Qing lin Yiyue zhang Innovation Centre of Ministry of Education for Development and Diseases School of MedicineSouth China University of TechnologyGuangzhouGuangdong 510006China Department of Hematology The Sixth Affiliated HospitalSchool of MedicineSouth China University of TechnologyFoshanGuangdong 528200China Department of Oncology Nanfang HospitalSouthern Medical UniversityGuangzhouGuangdong 510515China

Cancer is a major global health issue;in 2020,there were 19.29 million new cancer cases and 9.96 million cancer deaths worldwide(Siegel et al.,2023).Despite ongoing research,chemotherapy remains the primary treatment due to its broad anti-cancer effects(Marra and Curigliano,2021).However,intravenous chemotherapeutic drugs commonly induce hematotoxicity,necessitating dose adjustments or treatment ***-induced thrombocytopenia(CIT)and neutropenia(CIN)are the primary manifestations of chemotherapy-induced hematotoxicity,which requires intervention due to the heightened risk of bleeding and infection(Blayney and Schwartzberg,2022).Currently,there are no FDA-approved treatments for CIT(Song and Al-Samkari,2023).While a CIT mouse model using 5-FU has been developed for drug evaluation(Shin et al.,2023),it lacks a comprehensive hematotoxicity assessment and the benefits of high throughput,cost-effectiveness,and ***,it is urgent to develop a high-throughput CIT model for risk assessment and safer chemotherapy strategies with clinical potential.

关键词： chemotherapy treatment visibility

Effect of aflibercept combined with triamcinolone acetonide on aqueous humor growth factor and inflammatory mediators in diabetic macular edema

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International Journal of Ophthalmology(English edition) 2024年第2期17卷 297-303页

作者： De-Shuang Li Hong-Xia liao Jing-lin zhang Bo Qin Shenzhen Aier Eye Hospital Aier Eye HospitalJinan UniversityShenzhen 518031Guangdong ProvinceChina Guangzhou Aier Eye Hospital Jinan UniversityGuangzhou 510040Guangdong ProvinceChina

AIM:To investigate the efficacy of aflibercept combined with sub-tenon injection of triamcinolone acetonide(TA)in treating diabetic macular edema(DME)and to examine changes in growth factors and inflammatory mediator levels in aqueous humor after ***:Totally 67 DME patients(67 eyes)and 30 cataract patients(32 eyes)were enrolled as the DME group and the control group,*** DME group was divided into the aflibercept group(34 cases)and the aflibercept combined with TA group(combined group,33 cases).The aqueous humor of both groups was collected during the study *** aqueous levels of vascular endothelial growth factor(VEGF),monocyte chemoattractant protein-1(MCP-1),interleukin-6(IL-6),interleukin-8(IL-8),and interleukin-1β(IL-1β)were detected using a microsphere suspension array technology(Luminex 200TM).Aqueous cytokines,best-corrected visual acuity(BCVA),central macular thickness(CMT),and complications before and after treatment were compared between the aflibercept group and combined ***:The concentrations of VEGF,MCP-1,IL-6,and IL-8 in the aqueous humor were significantly higher in the DME group than those of the control group(all P0.05).CONCLUSION:The cytokines VEGF,MCP-1,IL-6,and IL-8 in the aqueous humor of DME patients are significantly *** and aflibercept combined with TA have good efficacy in DME patients,can effectively reduce CMT,improve the patient’s vision,and have high *** combined with TA can quickly downregulate the aqueous humor cytokines and help to relieve macular edema ***,the long-term eff

关键词： diabetic macular edema aqueous humor cytokines aflibercept triamcinolone acetonide

Deformation Characteristics of Hydrate-Bearing Sediments

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Journal of Ocean University of China 2024年第1期23卷 149-156页

作者： DONG lin LI Yanlong zhang Yajuan HU Gaowei liao Hualin CHEN Qiang WU Nengyou Key Laboratory of Gas Hydrate Ministry of Natural ResourcesQingdao Institute of Marine GeologyQingdao 266237China Laboratory for Marine Mineral Resources Laoshan LaboratoryQingdao 266237China College of Oceanography Hohai UniversityNanjing 210098China College of Petroleum Engineering China University of Petroleum(East China)Qingdao 266555China

The safe and efficient development of natural gas hydrate requires a deep understanding of the deformation behaviors of *** this study,a series of triaxial shearing tests are carried out to investigate the deformation properties of hydrate-bearing *** of volumetric and lateral strains versus hydrate saturation are analyzed *** indicate that the sediments with high hydrate saturation show dilative behaviors,which lead to strain-softening characteristics during *** volumetric strain curves have a tendency to transform gradually from dilatation to compression with the increase in effective confining *** easy prediction model is proposed to describe the relationship between volumetric and axial *** model coefficientβis the key dominating factor for the shape of volumetric strain curves and can be determined by the hydrate saturation and stress ***,a modified model is established for the calculation of lateral *** corresponding determination method is provided for the easy estimation of model coefficients for medium sand sediments containing *** study provides a theoretical and experimental reference for deformation estimation in natural gas hydrate development.

关键词： gas hydrate deformation characteristics volumetric strain lateral strain prediction model

Organic Brønsted Acid-Catalyzed Stereoselective Cationic RAFT Polymerization:The Effect of RAFT Agents

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Chinese Journal of Polymer Science 2024年第6期42卷 711-717页

作者： Zheng-Yi zhang Zan Yang Yun liao Sai-Hu liao Key Laboratory of Molecule Synthesis and Function Discovery(Fujian Province University) College of ChemistryFuzhou UniversityFuzhou350108China State Key Laboratory of Physical Chemistry of Solid Surfaces College of Chemistry and Chemical EngineeringXiamen UniversityXiamen361005China Beijing National Laboratory for Molecular Sciences Beijing100190China

The tacticity of vinyl polymers is a key factor affecting the properties of ***,organic Brønsted acids have been demonstrated as effective catalysts for the development of highly stereoselective cationic reversible addition-fragmentation chain transfer(RAFT)polymerizations of vinyl ethers,in which the use of RAFT agents could allow the control the molecular weight and tacticity of polymer products ***,the effect of RAFT agents on the tacticity-regulation remains elusive and lacks of *** this study,we synthesized four types of RAFT agents and evaluated their influence in the stereoselective cationic polymerization of isobutyl vinyl ether in the presence of PADI as a Brønsted acid catalyst,which unveils that the Z group of RAFT agents could not only affect the polydispersity of the products,but also exert a profound effect on the *** extensive screening of the RAFT agents,high stereoregularity(isotacticity,90%m)was obtained when using dithiocarbonate ester-type RAFT agents with a benzyloxy Z group.

关键词： Bronsted acid catalysis Stereoselective cationic polymerization RAFT polymerization Chain transfer agents Tacticity

Microwave-assisted fast synthesis and red-emitting properties of a borotellurate-based phosphor with excellent thermostability

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Journal of Rare Earths 2024年第6期42卷 1036-1045,I0002页

作者： Yuefei Xiang Hong Li Hongzhi zhang lin Yang Canyuan liao Tongsheng Yang Junpeng Li Zewen Guo Jing Zhu Key Laboratory of LCR Materials and Devices of Yunnan Province Yunnan Key Laboratory of Carbon Neutrality and Green Low-carbon TechnologiesSchool of Materials and Energy Yunnan UniversityKunming650091China

At present,with the increasing application needs of phosphor-converted white light-emitting diode(wLED),the synthetic efficiency and thermal stability of phosphor become urgent ***,this research reports a microwave-assisted fast synthesis approach to obtain a Sm^(3+)-activated borotellurate Na_(2)Y_(2)TeO_(4)(BO_(3))_(2)(NYTB)red phosphor with high crystallinity,excellent thermostability,and low chromaticity *** the NYTB-based phosphor,in contrast to the conventional solid-state synthesis,the microwave-assisted synthesis method involves lower synthesis temperature and shorter processing ***,the concentration quenching mechanism was *** w-LED device packaged with the studied phosphor exhibits a near-standard white light with proper CCT and high Ra parameters.

关键词： Borotellurate Samarium Microwave-assisted synthesis Red-emitting Thermal stability Rareearths

A fast forward computational method for nuclear measurement using volumetric detection constraints

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Nuclear Science and Techniques 2024年第2期35卷 47-63页

作者： Qiong zhang lin-Lv lin University of Electronic Science and Technology of China Chengdu 610000China

Owing to the complex lithology of unconventional reservoirs,field interpreters usually need to provide a basis for interpretation using logging simulation *** the various detection tools that use nuclear sources,the detector response can reflect various types of information of the *** Monte Carlo method is one of the primary methods used to obtain nuclear detection responses in complex ***,this requires a computational process with extensive random sampling,consumes considerable resources,and does not provide real-time response ***,a novel fast forward computational method(FFCM)for nuclear measurement that uses volumetric detection constraints to rapidly calculate the detector response in various complex environments is ***,the data library required for the FFCM is built by collecting the detection volume,detector counts,and flux sensitivity functions through a Monte Carlo ***,based on perturbation theory and the Rytov approximation,a model for the detector response is derived using the flux sensitivity function method and a one-group diffusion *** environmental perturbation is constrained to optimize the model according to the tool structure and the impact of the formation and borehole within the effective detection ***,the method is applied to a neutron porosity tool for *** various complex simulation environments,the maximum relative error between the calculated porosity results of Monte Carlo and FFCM was 6.80%,with a rootmean-square error of 0.62 *** field well applications,the formation porosity model obtained using FFCM was in good agreement with the model obtained by interpreters,which demonstrates the validity and accuracy of the proposed method.

关键词： Nuclear measurement Fast forward computation Volumetric constraints

Design and tailoring of patterned ZnO nanostructures for perovskite light absorption modulation

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International Journal of Minerals,Metallurgy and Materials 2024年第5期31卷 855-861页

作者： Haonan Si Xuan Zhao Qingliang liao Yue zhang Academy for Advanced Interdisciplinary Science and Technology Beijing Advanced Innovation Center for Materials Genome EngineeringUniversity of Science and Technology BeijingBeijing 100083China Key Laboratory of Advanced Materials and Devices for Post-Moore Chips Ministry of EducationBeijing Key Laboratory for Advanced Energy Materials and TechnologiesSchool of Materials Science and EngineeringUniversity of Science and Technology BeijingBeijing 100083China

Lithography is a pivotal micro/nanomanufacturing technique,facilitating performance enhancements in an extensive array of devices,encompassing sensors,transistors,and photovoltaic *** key to creating highly precise,multiscale-distributed patterned structures is the precise control of the lithography ***,high-quality patterned ZnO nanostructures are constructed by systematically tuning the exposure and development times during *** optimizing these parameters,ZnO nanorod arrays with line/hole arrangements are successfully *** ZnO nanostructures with highly controllable morphology and structure possess discrete three-dimensional space structure,enlarged surface area,and improved light capture ability,which achieve highly efficient energy conversion in perovskite solar *** lithography process management for these patterned ZnO nanostructures provides important guidance for the design and construction of complex nanostructures and devices with excellent performance.

关键词： lithography patterned ZnO nanorod arrays light absorption perovskite solar cell

Bioinspired designs in active metal-based batteries

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Nano Research 2024年第2期17卷 587-601页

作者： Fan zhang Ting liao Cheng Yan Ziqi Sun School of Chemistry and Physics Queensland University of TechnologyGeorge StreetBrisbaneQLD 4000Australia School of Mechanical Medical and Process Engineering Queensland University of TechnologyGeorge StreetBrisbaneQLD 4000Australia QUT Centre for Materials Science Queensland University of TechnologyGeorge StreetBrisbaneQLD 4000Australia

Active metal-based batteries are drawing increased attention because of their inherent high energy density and specific *** grand challenges,such as dendrite growth,electrode degradation,rapid performance fading,etc.,have limited their practical ***,which involves taking cues from the structures and functions of the natural world,can lead to a wealth of conceptually fresh approaches to regulator the metal ion transportation to achieve a dendrite-free metal plating,thwart the side-reaction reactions,and retard the structural distortions,for a more reliable and secure operation of active metal-based *** this review,we concentrate on the fabrication and application of bioinspired designs in active metal-based batteries with enhanced performance,along with discussion on the challenges and opportunities associated with this promising *** anticipate that this review can offer some insights into the development of functional materials by learning from nature and provide some approaches for the innovations of either the battery structures or the energy materials for metal-based batteries.

关键词： bioinspired materials energy storage devices metal-based batteries

Hybrid vibration isolation optimization of a flexible manipulator based on neural network agent model

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Chinese Journal of Aeronautics 2024年第5期37卷 482-505页

作者： Yongxin zhang Liang LI Dingguo zhang Wei-Hsin liao Xian GUO School of Science Nanjing University of Science and TechnologyNanjing 210094China Department of Mechanical and Automation Engineering The Chinese University of Hong KongHong KongChina

Segmented Active Constrained Layer Damping(SACLD)is an intelligent vibration-damping structure,which could be applied to the sectors of aviation,aerospace,and transportation engineering to reduce the vibration of flexible ***,machine learning technology is widely used in the engineering field because of its efficient multi-objective *** dynamic simulation of a rotational segmental flexible manipulator system is presented,in which enhanced active constrained layer damping is carried out,and the neural network model of Genetic Algorithm-Back Propagation(GA-BP)algorithm is *** suppression and structural optimization of the SACLD manipulator model are studied based on vibration mode and damping *** modal responses of the SACLD manipulator model at rest and rotation are *** addition,the four model indices are optimized using the GA-BP neural network:axial incision size,axial incision position,circumferential incision size,and circumferential incision ***,the best model for vibration suppression is obtained.

关键词： Machine learning Vibration suppression Flexible manipulator Segmented active constrained layer damping Structural optimization

Optical properties of an Er^(3+)-doped phosphate glass waveguide formed by single-energy H^+ ion implantation

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Optoelectronics Letters 2019年第2期15卷 104-107页

作者： CHEN Jing-yi YAN Sen ZHENG Rui-lin zhang liao-lin GUO Hai-tao LIU Chun-xiao College of Electronic and Optical Engineering Nanjing University of Posts and Telecommunications School of Material Science and Engineering Jiangxi University of Science and Technology State Key Laboratory of Transient Optics and Photonics Xi'an Institute of Optics and Precision Mechanics Chinese Academy of Sciences

In this work, we report the fabrication of an optical waveguide by single-energy H^+ ion implantation in the Er^(3+)-doped phosphate *** ion implantation conditions are with energy of 0.4 MeV and a fluence of 8.0×10^(16) ions/cm^*** dark mode spectrum of the waveguide structure was measured by the prism coupling *** refractive index change along with the penetration depth was fitted by using the reflectivity calculation method(RCM).Finally, the calculated near-field light intensity distribution shows superior waveguide properties, which demonstrates its promising potentials for compact optical integrated devices.

关键词： implantation properties waveguide