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Surface property and in vitro toxicity effect of insoluble particles given by protein corona:Implication for PM cytotoxicity assessment

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Eco-Environment & health 2024年第2期3卷 137-144页

作者： Sisi Chen Yexuan zhang Hongjuan Chen Weijuan Zheng Xin Hu Li Mao Xuewen Guo Hongzhen lian State Key Laboratory of Analytical Chemistry for Life Science School of Chemistry&Chemical Engineering and Center of Materials AnalysisNanjing UniversityNanjing 210023China State Key Laboratory of Pharmaceutical Biotechnology School of Life ScienceNanjing UniversityNanjing 210023China Ministry of Education(MOE)Key Laboratory of Modern Toxicology School of Public HealthNanjing Medical UniversityNanjing 211166China

In vitro toxicological assessment helps explore key fractions of particulate matter(PM)in association with the toxic *** studies mainly discussed the toxicity effects of the water-soluble and organic-soluble fractions of ***,the toxicity of insoluble fractions is relatively poorly understood,and the adsorption of proteins is rarely *** this work,the formation of protein corona on the surface of insoluble particles during incubation in a culture medium was *** was found that highly abundant proteins in fetal bovine serum were the main components of the protein *** adsorbed proteins increased the dispersion stability of insoluble ***,the leaching concentrations of some metal elements(e.g.,Cu,Zn,and Pb)from PM increased in the presence of *** toxicity effects and potential mechanisms of the PM insoluble particle–protein corona complex on macrophage cells RAW264.7 were *** results revealed that the PM insoluble particle–protein corona complex could influence the phagosome pathway in RAW264.7 ***,it promoted the intracellular reactive oxygen species generation and induced a greater degree of cell differentiation,significantly altering cell ***,this work sheds new light on the combination of insoluble particles and protein corona in terms of PM cytotoxicity assessment.

关键词： Atmospheric particulate matter Insoluble particles Protein corona Cytotoxicity Proteomics

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Endoscopic polidocanol foam sclerobanding for the treatment of grade Ⅱ-Ⅲ internal hemorrhoids:A prospective,multi-center,randomized study

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World Journal of Gastroenterology 2024年第38期30卷 3326-3335页

作者： Chun-Ying Qu Fei-Yu zhang Yi zhang Ming-Ming Li Zheng-Hong Li Mei-Hong Cai Lei-Ming Xu Feng Shen Wen Wang Wu-lian Lin Feng-Yu Gao Hao zhang Guang-Yu Chen Department of Gastroenterology&Endoscopy Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200092China Department of Gastroenterology The 900th Hospital of the People’s Liberation Army Joint Service Support ForceFuzhou 350025Fujian ProvinceChina Department of Endoscopy Shandong Provincial Maternal and Child Health Care Hospital Affiliated to Qingdao UniversityJinan 250014Shandong ProvinceChina Department of Endoscopy Baoshan People’s Hospital of Yunnan ProvinceBaoshan 678000Yunnan ProvinceChina Department of Gastroenterology Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200092China

BACKGROUND Endoscopic rubber band ligation(ERBL)is a nonsurgical technique for the treatment of symptomatic internal hemorrhoids but is limited by recurrence and post-procedural *** To evaluate satisfaction,long-term recurrence,and post-procedural pain in managing internal hemorrhoids using a combination of polidocanol foam sclerotherapy and *** This was a prospective,multicenter,randomized study.A total of 195 consecutive patients diagnosed with grade II-III internal hemorrhoids were enrolled from four tertiary hospitals and randomly divided into a cap-assisted endoscopic polidocanol foam sclerobanding(EFSB)or an ERBL *** patients were followed-up for 12 ***-based severity and post-procedural pain were assessed using a hemorrhoid severity score(HSS)and a visual analog scale(VAS).Continuous variables were reported as medians and interquartile *** One hundred and ninety-five patients were enrolled,with 98 in the EFSB *** was lower in the EFSB group than in the ERBL group at 8 weeks[4.0(3.0-5.0)vs 5.0(4.0-6.0),P=0.003]and 12-month[2.0(1.0-3.0)vs 3.0(2.0-3.0),Phe EFSB group at 12 months(11.2%vs 21.6%,P=0.038).Multiple linear regression analysis demonstrated that EFSB treatment[B=-0.915,95%confidence interval(CI):−1.301 to−0.530,P=0.001]and rubber band number(B=0.843,95%CI:0.595-1.092,Phe VAS score 24 hours *** median VAS was lower in the EFSB group than in the ERBL[2.0(1.0-3.0)vs 3.0(2.0-4.0),Phe recurrence of prolapse and pain 24 hours post-procedure.

关键词： Internal hemorrhoids Endoscopic therapy Polidocanol foam Sclerotherapy Rubber band ligation Sclerobanding

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Inhibiting the phase transition of WO_(3)for highly stable aqueous electrochromic battery

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Journal of Energy Chemistry 2024年第8期95卷 86-95,I0003页

作者： Zhisheng Wu Zhendong lian Ting Ding Jielei Li Jincheng Xu Jinxiao Wang liangxing zhang Bo Wang Shi Chen Peng Xiao Hua Xu Shuang-Peng Wang Kar Wei Ng Joint Key Laboratory of the Ministry of Education Institute of Applied Physics and Materials EngineeringUniversity of MacaoAvenida da UniversidadeMacao 999078China School of Applied Physics and Materials Wuyi UniversityJiangmen 529020GuangdongChina Guangdong-Hong Kong-Macao Joint Laboratory for Intelligent Micro-Nano Optoelectronic Technology School of Physics and Optoelectronic EngineeringFoshan UniversityFoshan 528225GuangdongChina Guangzhou New Vision Optoelectronic Technology Co. Ltd.Guangzhou 510530GuangdongChina

Aqueous electrochromic battery(ECB)has shown intense potential for achieving energy storage and saving *** tungsten oxide(WO_(3))is the most promising EC material for commercialization,the cycling stability of WO_(3)-based aqueous ECBs is currently unsatisfactory due to the repeated phase transition during the redox process and the corrosion by acidic ***,we present a titanium-tungsten oxide alloy(Ti-WO_(3))with controllable morphology and crystal phase synthesized by a facile hot injection method to overcome the *** contrast to conventional monoclinic WO_(3),the Ti-WO_(3)nanorods can stably maintain their cubic crystal phase during the redox reaction in an acidic electrolyte,thus leading to dramatically enhanced response speed and cycling stability,Specifically,when working in a well-matched hybrid Al^(3+)/Zn^(2+)aqueous electrolyte,our phasetransition-free cubic Ti-WO_(3)exhibits an ultra-high cycling stability(>20000 cycles),fast response speed(3,95 s/4,65 s for bleaching/coloring),as well as excellent discharge areal capacity of 214.5 mA h m^(-2),We further fabricate a fully complementa ry aqueous electrochromic device,for the first time,using a Ti-WO_(3)/Prussian blue device ***,the complementary ECB shows>10000 stable operation cycles,attesting to the feasibility of our Ti-WO_(3)for practical *** work validates the significance of inhibiting the phase transitions of WO_(3)during the electrochromic process for realizing highly cyclable aqueous ECB,which can possibly provide a generalized design guidance for other high-quality metallic oxides for electrochemical applications.

关键词： Aqueous electrochromic battery Ti-WO_(3) Phase transition Long-term stability

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VX-509 attenuates the stemness characteristics of colorectal cancer stem-like cells by regulating the epithelial-mesenchymal transition through Nodal/Smad2/3 signaling

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World Journal of Stem Cells 2024年第2期16卷 207-227页

作者： Yun Yuan Xu-Fan zhang Yu-Chen Li Hong-Qing Chen Tian Wen Jia-lian Zheng Zi-Yi Zhao Qiong-Ying Hu Department of Laboratory Medicine Hospital of Chengdu University of Traditional Chinese MedicineChengdu 610072Sichuan ProvinceChina Department of Nuclear Medicine Hospital of Chengdu University of Traditional Chinese MedicineChengdu 610072Sichuan ProvinceChina College of Medical Technology Chengdu University of Traditional Chinese MedicineChengdu 611137Sichuan ProvinceChina Department of hepatology Affiliated Hospital of Liaoning University of Traditional Chinese MedicineShenyang 110032Liaoning ProvinceChina Hospital of Chengdu University of Traditional Chinese Medicine Chengdu 610072Sichuan ProvinceChina Traditional Chinese Medicine Regulating Metabolic Diseases Key Laboratory of Sichuan Province Chengdu 610072Sichuan ProvinceChina

BACKGROUND Colorectal cancer stem cells(CCSCs)are heterogeneous cells that can self-renew and undergo multidirectional differentiation in colorectal cancer(CRC)*** are generally accepted to be important sources of CRC and are responsible for the progression,metastasis,and therapeutic resistance of ***,targeting this specific subpopulation has been recognized as a promising strategy for overcoming *** To investigate the effect of VX-509 on CCSCs and elucidate the underlying *** CCSCs were enriched from CRC cell lines by in conditioned serum-free *** blot,Aldefluor,transwell and tumorigenesis assays were performed to verify the phenotypic characteristics of the *** anticancer efficacy of VX-509 was assessed in HCT116 CCSCs and HT29 CCSCs by performing cell viability analysis,colony formation,sphere formation,flow cytometry,and western blotting assessments in vitro and tumor growth,immunohistochemistry and immunofluorescence assessments in *** Compared with parental cells,sphere cells derived from HCT116 and HT29 cells presented increased expression of stem cell transcription factors and stem cell markers and were more potent at promoting migration and tumori-genesis,demonstrating that the CRC sphere cells displayed CSC ***-509 inhibited the tumor malignant biological behavior of CRC-stem-like cells,as indicated by their proliferation,migration and clonality in vitro,and suppressed the tumor of CCSC-derived xenograft tumors in ***,VX-509 suppressed the CSC character-istics of CRC-stem-like cells and inhibited the progression of epithelial-mesenchymal transition(EMT)signaling in *** was identified as the regulatory factor of VX-509 on CRC stem-like cells through analyses of differen-tially expressed genes and CSC-related database ***-509 markedly downregulated the expression of Nodal and its downstream phosphorylated Smad2/3 to inhibit EMT ***,VX-509 rev

关键词： Colorectal cancer stem cells Stemness VX-509 Epithelial-mesenchymal transition Nodal

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气候变化对青藏高原河流源区径流的影响

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Engineering 2024年第3期34卷 133-142页

作者： Zhenxin Bao Jianyun zhang Yanqing lian Guoqing Wang Junliang Jin Zhongrui Ning Jiapeng zhang Yanli Liu Xiaojun Wang State Key Laboratory of Hydrology-Water Resources and Hydraulic Engineering Hohai UniversityNanjing 210098China Nanjing Hydraulic Research Institute Nanjing 210024China Yangtze Institute for Conservation and Development Hohai UniversityNanjing 210098China College of Hydrology and Water Resources Hohai UniversityNanjing 210098China

The Tibetan Plateau(TP)is the headwater of the Yangtze,Yellow,and the transboundary Yarlung Zangbo,Lancang,and Nujiang Rivers,providing essential and pristine freshwater to around 1.6 billion people in Southeast and South ***,the temperature rise TP has experienced is almost three times that of the global warming *** rising temperature has resulted in glacier retreat,snow cover reduction,permafrost layer thawing,and so *** we show,based on the longest observed streamflow data available for the region so far,that changing climatic conditions in the TP already had significant impacts on the streamflow in the headwater basins in the *** analysis indicated that the annual average temperature in the headwater basins of these five major rivers has been rising on a trend averaging 0.38℃-decade^(-1) since 1998,almost triple the rate before 1998,and the change of streamflow has been predominantly impacted by precipitation in these headwater *** a result,streamflow in the Yangtze,Yarlung Zangbo,Lancang,and Nujiang River headwater areas is on a decreasing trend with a reduction of flow ranging from 3.0-10^(9)-5.9-10^(9) m^(3)·decade^(-1)(-9.12%to-16.89%per decade)since *** increased precipitation in the Tangnahai(TNH)and Lanzhou(LZ)Basins contributed to the increase of their streamflows at 8.04%and 14.29%per decade,*** the increased streamflow in the headwater basins of the Yellow River may ease some of the water resources concerns,the decreasing trend of streamflow in the headwater areas of the southeastern TP region since 1998 could lead to a water crisis in transboundary river basins for billions of people in Southeast and South Asia.

关键词： Tibetan Plateau Streamflow Change trend Climate change

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颅骨修补时机对脑室系统的影响

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中国医学影像技术 2011年第12期27卷 2448-2450页

作者：葛宇曦崔恒武张联合严肃张士良江苏大学临床医学院江苏镇江212013 武警浙江总队杭州医院放射科浙江杭州310000

目的探讨脑外伤颅骨修补前后脑室系统变化,为选择颅骨修补最佳时机提供影像学依据。方法收集脑外伤后接受颅骨修补术的53例患者的CT资料,根据修补前减压窗凹陷程度分为平坦组(20例)和凹陷组(33例),分别测量颅骨修补术前、后3脑室宽度及... 详细信息

目的探讨脑外伤颅骨修补前后脑室系统变化,为选择颅骨修补最佳时机提供影像学依据。方法收集脑外伤后接受颅骨修补术的53例患者的CT资料,根据修补前减压窗凹陷程度分为平坦组(20例)和凹陷组(33例),分别测量颅骨修补术前、后3脑室宽度及侧脑室大小(哈氏值),并对照分析两组患者颅骨修补前后脑室系统的变化。结果平坦组颅骨修补术后3脑室宽度平均增加(0.45±1.91)mm,哈氏值平均增加(1.70±11.41)mm,手术前后3脑室和侧脑室的变化差异无统计学意义(P>0.05);凹陷组颅骨修补术后3脑室宽度平均增加(3.73±2.97)mm,哈氏值平均增加(17.00±13.29)mm,手术前后3脑室及侧脑室变化差异有统计学意义(P<0.001)。结论脑外伤去大骨瓣减压术后减压窗平坦时行修补对脑室系统影响较小,凹陷时行颅骨修补对脑室系统影响较大,提示减压窗平坦时较适合进行颅骨修补术。

关键词：颅骨创伤和损伤手术 3脑室侧脑室体层摄影术,X线计算机

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政治合法性视野中的治理理论

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行政与法 2006年第9期 13-15页

作者：张荷莲曹任何湘潭大学管理学院湖南湘潭411105

治理理论的兴起有其复杂的社会背景和深刻的理论背景。就自身理论主张而言,治理理论及其实践在西方的兴起契合了政府合法性获取的两大基本要素的要求,有利于政府合法性基础的重建与巩固。治理的效能目标和民主诉求,对转型期我国政府合... 详细信息

治理理论的兴起有其复杂的社会背景和深刻的理论背景。就自身理论主张而言,治理理论及其实践在西方的兴起契合了政府合法性获取的两大基本要素的要求,有利于政府合法性基础的重建与巩固。治理的效能目标和民主诉求,对转型期我国政府合法性基础的重建与巩固具有重要启示意义。

关键词：治理善治政治合法性

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Mode-insensitive and mode-selective optical switch based on asymmetric Y-junctions and MMI couplers

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Photonics Research 2024年第3期12卷 423-430页

作者： SHIJIE SUN QIDONG YU YUANHUA Che TIANHANG lian YUHANG XIE DAMING zhang XIBIN WANG State Key Laboratory of Integrated Optoelectronics College of Electronic Science and EngineeringJilin UniversityChangchun 130012China

Driven by the large volume demands of data in transmission systems,the number of spatial modes supported by mode-division multiplexing(MDM)systems is being increased to take full advantage of the parallelism of the signals in different spatial *** a key element for photonic integrated circuits,the multimode waveguide optical switch(MWOS)is playing an important role for data exchange and signal ***,the function of the traditional MWOS is simple,which could only implement the mode-insensitive or mode-selective switching function;it is also difficult to scale to accommodate more spatial modes because of the limitation of the device ***,it is still challenging to realize a multifunctional and scalable MWOS that could support multiple modes with low power consumption and high ***,we propose and experimentally demonstrate a multifunctional MWOS based on asymmetric Y-junctions and multimode interference(MMI)couplers fabricated on a polymer waveguide *** mode-insensitive and mode-selective switching functions can be achieved via selectively heating different electrode *** fabricated device with the total length of∼0.8 cmshows an insertion loss of less than 12.1 dB,and an extinction ratio of larger than 8.4 dB with a power consumption of∼32 mW for both mode-insensitive and mode-selective switching functions,at 1550 nm *** proposed MWOS can also be scaled to accommodate more spatial modes flexibly and easily,which can serve as an important building block for MDM systems.

关键词： waveguide optical mode

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Hydraulic properties and drought response of a tropical bamboo (Cephalostachyum pergracile)

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Plant Diversity 2024年第3期46卷 406-415页

作者： Wanwalee Kongjarat Lu Han Amy Ny Aina Aritsara Shu-Bin zhang Gao-Juan Zhao Yong-Jiang zhang Phisamai Maenpuen Ying-Mei Li Yi-Ke Zou Ming-Yi Li Xue-Nan Li lian-Bin Tao Ya-Jun Chen CAS Key Laboratory of Tropical Forest Ecology Xishuangbanna Tropical Botanical GardenChinese Academy of SciencesYunnan 666303China University of the Chinese Academy of Sciences Beijing 100049China T-STAR Core Team Xishuangbanna Tropical Botanical GardenChinese Academy of SciencesYunnan 666303China School of Biology and Ecology University of MaineOronoMEUSA Climate Change Institute University of MaineOronoME 04469USA School of Biological and Chemical Science Pu’er UniversityXueyuan RoadYunnan 665000China Institute of Ecology and Geobotany School of Ecology and Environmental SciencesYunnan UniversityKunmingYunnan 650091China School of Ecology and Environment Southwest Forestry UniversityKunmingYunnan 650224China Yuanjiang Savanna Ecosystem Research Station Xishuangbanna Tropical Botanical GardenChinese Academy of SciencesYuanjiangYunnan 653300China

Bamboo plants are an essential component of tropical ecosystems,yet their vulnerability to climate extremes,such as drought,is poorly understood due to limited knowledge of their hydraulic *** pergracile,a commonly used tropical bamboo species,exhibited a substantially higher mortality rate than other co-occurring bamboos during a severe drought event in 2019,but the underlying mechanisms remain *** study investigated the leaf and stem hydraulic traits related to drought responses,including leaf-stem embolism resistance(P50leaf;P50stem) estimated using optical and X-ray microtomography methods,leaf pressure-volume and water-releasing ***,we investigated the seasonal water potentials,native embolism level(PLC) and xylem water source using stable *** found that *** exhibited strong resistance to embolism,showing low P50leaf,P50stem,and turgor loss point,despite its rapid leaf water ***,its leaves displayed greater resistance to embolism than its stem,suggesting a lack of effective hydraulic vulnerability segmentation(HVS) to protect the stem from excessive xylem *** the dry season,approximately 49% of the water was absorbed from the upper 20-cm-deep soil ***,significant diurnal variation in leaf water potentials and an increase in midday PLC from 5.87±2.33% in the wet season to 12.87±4.09%in the dry season were *** summary,this study demonstrated that the rapid leaf water loss,high reliance on surface water,and a lack of effective HVS in *** accelerated water depletion and increased xylem embolism even in the typical dry season,which may explain its high mortality rate during extreme drought events in 2019.

关键词： Climate change Drought Hydraulic safety Hydraulic vulnerability segmentation Stable isotope Tree mortality

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Role of gut microbiota in Crohn’s disease pathogenesis:Insights from fecal microbiota transplantation in mouse model

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World Journal of Gastroenterology 2024年第31期30卷 3689-3704页

作者： Qiang Wu lian-Wen Yuan Li-Chao Yang Ya-Wei zhang heng-Chang Yao liang-Xin Peng Bao-Jia Yao Zhi-Xian Jiang Geriatric Surgery of Department of General Surgery The Second Xiangya HospitalCentral South UniversityChangsha 410011Hunan ProvinceChina

BACKGROUND Inflammatory bowel disease,particularly Crohn’s disease(CD),has been associated with alterations in mesenteric adipose tissue(MAT)and the phenomenon termed“creeping fat”.Histopathological evaluations showed that MAT and intestinal tissues were significantly altered in patients with CD,with these tissues characterized by inflammation and *** To evaluate the complex interplay among MAT,creeping fat,inflammation,and gut microbiota in *** Intestinal tissue and MAT were collected from 12 patients with *** manifestations and protein expression levels were analyzed to determine lesion *** samples were collected from five recently treated CD patients and five control subjects and transplanted into *** intestinal and mesenteric lesions in these mice,as well as their systemic inflammatory status,were assessed and compared in mice transplanted with fecal samples from CD patients and control *** Pathological examination of MAT showed significant differences between CDaffected and unaffected colons,including significant differences in gut microbiota *** microbiota transplantation(FMT)from clinically healthy donors into mice with 2,4,6-trinitrobenzene sulfonic acid(TNBS)-induced CD ameliorated CD symptoms,whereas FMT from CD patients into these mice exacerbated CD ***,FMT influenced intestinal permeability,barrier function,and levels of proinflammatory factors and ***,FMT from CD patients intensified fibrotic changes in the colon tissues of mice with TNBS-induced *** Gut microbiota play a critical role in the histopathology of *** MAT and creeping fat may therefore have potential in the treatment of patients with CD.

关键词： Mesenteric adipose tissue Crohn’s disease Fecal microbiota transplantation Intestinal fibrosis Intestinal barrier

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