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Recursive Projected Filter Algorithm with Binary-Valued Observations

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Journal of Systems Science & Complexity 2024年第5期37卷 1832-1860页

作者： zhang Xiaoyan WANG ying XUE Wenchao ZHAO Yanlong Key Laboratory of Systems and Control Institute of Systems ScienceAcademy of Mathematics and Systems ScienceChinese Academy of SciencesBeijing 100190China School of Mathematical Sciences University of Chinese Academy of SciencesBeijing 100049China

This paper focuses on the state estimate for a class of systems with both process noise and measurement noise under binary-valued observations,in which the Gaussian assumption on the predicted density of the state is not required.A recursive projected filter algorithm with time-varying thresholds is constructed to estimate the state under binary-valued *** time-varying thresholds are designed as the prediction value of the measurement,which can provide more information about the system *** convergence property is established with some suitable stability,boundedness and observability *** particular,the estimation error between state and estimate is proved to be asymptotically bounded in the mean-square sense,whose upper bound is related to the variance of process ***,the theoretical results are demonstrated via numerical examples of first-order and high-order systems.

关键词： Binary-valued observations convergence recursive filter time-varying thresholds

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Bacterial persisters: molecular mechanisms and therapeutic development

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Signal Transduction and Targeted Therapy 2024年第8期9卷 3305-3336页

作者： Hongxia Niu Jiaying Gu ying zhang School of Basic Medical Science and Key Laboratory of Blood-stasis-toxin Syndrome of Zhejiang Province Zhejiang Chinese Medical UniversityHangzhou 310053 ZhejiangChina State Key Laboratory for the Diagnosis and Treatment of Infectious Diseases The First Affiliated Hospital of Zhejiang University School of MedicineHangzhou 310003 ZhejiangChina Jinan Microecological Biomedicine Shandong Laboratory Jinan 250022 ShandongChina

Persisters refer to genetically drug susceptible quiescent(non-growing or slow growing)bacteria that survive in stress environments such as antibiotic exposure,acidic and starvation *** cells can regrow after stress removal and remain susceptible to the same *** are underlying the problems of treating chronic and persistent infections and relapse infections after treatment,drug resistance development,and biofilm infections,and pose significant challenges for effective *** the characteristics and the exact mechanisms of persister formation,especially the key molecules that affect the formation and survival of the persisters is critical to more effective treatment of chronic and persistent ***,genes related to persister formation and survival are being discovered and confirmed,but the mechanisms by which bacteria form persisters are very complex,and there are still many unanswered *** article comprehensively summarizes the historical background of bacterial persisters,details their complex characteristics and their relationship with antibiotic tolerant and resistant bacteria,systematically elucidates the interplay between various bacterial biological processes and the formation of persister cells,as well as consolidates the diverse anti-persister compounds and *** hope to provide theoretical background for in-depth research on mechanisms of persisters and suggest new ideas for choosing strategies for more effective treatmentofpersistent infections.

关键词： mechanisms treatment persist

Flow behavior of a coupled model between horizontal well and fractal reservoir

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Energy Geoscience

Energy Geoscience 2024年第4期5卷 267-277页

作者： Peiqing lian Jianfang Sun Jincai zhang Zhihui Fan Sinopec Petroleum Exploration and Production Research Institute Beijing100083China Sinopec Tech Houston HoustonTX77056USA

Many research findings have proven that the system of porous medium reservoirs exhibits different heterogeneous structures at various scales,demonstrating some form of self-similarity with fractal *** this paper,fractal theory is incorporated into the reservoir to investigate coupled flow between reservoir and horizontal *** examining the pore structure of highly heterogeneous reservoirs,the fractal dimension can be *** methods are utilized to solve the Green function of a point source in a reservoir with fractal *** Green's function and the principle of spatial superposition,a finite flow model for a horizontal well coupled with a fractal reservoir is developed to calculate the flow rate and flow profile of the horizontal *** model also accounts for the impact of wellbore friction and is solved numerically.A specific example is used for calculation to analyze the influence of fractal parameters on the production and flow rate of the horizontal *** considering the fractal characteristics of oil reservoirs,the flow rate of the horizontal well is lower than that in Euclidean *** the fractal dimension increases,the connectivity of pores in the reservoir improves,making it easier to drive the fluid into the wellbore,and the flow distribution along the wellbore becomes more ***,as the anomalous diffusion index increases,the connectivity between pores deteriorates,thus the distribution of flow rate along the wellbore becomes more uneven.

关键词： Fractal dimension Reservoir Horizontal well Anomalous diffusion index

Interleukins in Epilepsy:Friend or Foe

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Neuroscience Bulletin 2024年第5期40卷 635-657页

作者： Yuan Dong Xia zhang ying Wang Neuropsychiatry Research Institute The Affiliated Hospital of Qingdao UniversityQingdao UniversityQingdao266000China Program in Cellular and Molecular Medicine Boston Children’s HospitalBostonMA02115USA

Epilepsy is a chronic neurological disorder with recurrent unprovoked seizures,affecting~65 million *** in patients with epilepsy and animal models suggests a contribution of neuroinflammation to epileptogenesis and the development of ***(ILs),as one of the major contributors to neuroinflammation,are intensively studied for their association and modulatory effects on ictogenesis and *** are commonly divided into pro-and anti-inflammatory cytokines and therefore are expected to be pathogenic or neuroprotective in ***,both protective and destructive effects have been reported for many *** may be due to the complex nature of ILs,and also possibly due to the different disease courses that those ILs are involved *** this review,we summarize the contributions of different ILs in those processes and provide a current overview of recent research advances,as well as preclinical and clinical studies targeting ILs in the treatment of epilepsy.

关键词： Epilepsy Interleukins Neuroinflammation

A Double-Timescale Reinforcement Learning Based Cloud-Edge Collaborative Framework for Decomposable Intelligent Services in Industrial Internet of Things

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China Communications 2024年第10期21卷 181-199页

作者： zhang Qiuyang Wang ying Wang Xue School of Information and Communication Engineering Beijing University of Posts and TelecommunicationsBeijing 100876China State Key Laboratory of Networking and Switching Technology(Beijing University of Posts and Telecommunications) Beijing 100876China

With the proportion of intelligent services in the industrial internet of things(IIoT)rising rapidly,its data dependency and decomposability increase the difficulty of scheduling computing *** this paper,we propose an intelligent service computing *** the framework,we take the long-term rewards of its important participants,edge service providers,as the optimization goal,which is related to service delay and computing *** the different update frequencies of data deployment and service offloading,double-timescale reinforcement learning is utilized in the *** the small-scale strategy,the frequent concurrency of services and the difference in service time lead to the fuzzy relationship between reward and *** solve the fuzzy reward problem,a reward mapping-based reinforcement learning(RMRL)algorithm is proposed,which enables the agent to learn the relationship between reward and action more *** large time scale strategy adopts the improved Monte Carlo tree search(MCTS)algorithm to improve the learning *** simulation results show that the strategy is superior to popular reinforcement learning algorithms such as double Q-learning(DDQN)and dueling Q-learning(dueling-DQN)in learning speed,and the reward is also increased by 14%.

关键词： computing service edge intelligence industrial internet of things(IIoT) reinforcement learning(RL)

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Parameter calibration of discrete element model for alfalfa seeds based on EDEM simulation experiments

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International Journal of Agricultural and Biological Engineering 2024年第3期17卷 33-38页

作者： Xinjiu zhang Hongti Wang Fangyan Wang Zhengguo lian College of Mechanical and Electrical Engineering Qingdao Agricultural UniversityQingdao 266109ShandongChina

In order to establish an accurate discrete element model of alfalfa seeds,real physical experiments were combined with simulation experiments,and the contact parameters of alfalfa seeds were calibrated using the repose angle of alfalfa seeds as the response *** intrinsic parameters(thousand grain weight,triaxial size,density)and contact parameters(static friction coefficient,rolling friction coefficient)of alfalfa seeds were obtained through physical experiments,and a spherical particle model was *** the Plackett Burman experiment,the static friction coefficient between alfalfa seeds,the rolling friction coefficient between alfalfa seeds,and the static friction coefficient between alfalfa seeds and ABS plastic were determined to have a significant impact on the *** steepest climb test is used to narrow down the selection range of the optimal parameters,and the box Behnken test is used to obtain the quadratic regression equation of the repose *** optimal parameter combination was obtained with the objective of minimizing the repose angle error:the static friction coefficient between alfalfa seeds and alfalfa seeds was 0.418,the rolling friction coefficient between alfalfa seeds and alfalfa seeds was 0.086,and the static friction coefficient between alfalfa seeds and ABS plastic was *** repose angle and mass flow rate experiments show that the model is effective and reliable.

关键词： alfalfa seeds discrete element parameter calibration EDEM

Structural engineering of BaWO_(4)/CsPbX_(3)/CsPb_(2)X_(5)(X=Cl,Br,I)heterostructures towards ultrastable and tunable photoluminescence

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Nano Research 2024年第3期17卷 1636-1645页

作者： Peng Liu Yan Xu Bohan Li Yuchi zhang Hongzhou lian Jun Lin Department of Chemistry College of SciencesNortheastern UniversityShenyang 110819China State Key Laboratory of Rare Earth Resource Utilization Chang Chun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022China

Construction of lead halide perovskite nanocrystals(LHP NCs)heterostructures is essential to obtain highly stable photoluminescence and expand their ***,a novel self-assembly strategy combining with a solvent-free thermal-assisted synthesis and a water-triggered reaction is developed to subsequently grow BaWO_(4)/CsPbX_(3)/CsPb_(2)X_(5)(X=Cl,Br,I)heterostructures at low nucleation temperature with high *** as-obtained ternary BaWO_(4)/CsPbX_(3)/CsPb_(2)X_(5)(X=Cl,Br,I)heterostructures exhibit remarkably enhanced panchromatic emission and ultrastable luminescence ascribing to the low-defect growth based on lattice *** white light-emitting diodes(WLEDs)have been constructed with a high correlated color temperature(CCT)of 7225 K and luminous efficiency of 74.4 lm·***^(3+)-doped BaWO_(4)/CsPbX_(3)/CsPb_(2)X_(5)(Ln^(3+)=Eu^(3+),Tb^(3+),Dy^(3+),Sm^(3+),Yb^(3+)/Er^(3+))nanocomposites are further designed with excitation-dependent photoluminescence and thermochromic properties,making them excellent candidates for high-level anti-counterfeiting and *** work offers a green and universal approach in assembling CsPbX_(3)(X=Cl,Br,I)on lattice-matched tungstate with adjustable panchromatic emission for versatile optical applications.

关键词： inorganic lead halide perovskites solvent-free synthesis panchromatic emission anti-counterfeiting and encryption application

Role of Diabetes Mellitus on Treatment Effects in Drug-susceptible Initial Pulmonary Tuberculosis Patients in China

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Biomedical and Environmental Sciences 2017年第9期30卷 671-675页

作者： MA Yan HUANG Mai Ling LI Tao DU Jian SHU Wei XIE Shi Heng WANG Hong Hong ZHU Guo Feng TAN Shou Yong FU Yan Yong MA Li Ping zhang lian ying LIU Fei ying HU Dai Yu zhang Yan Ling LI Xiang Qun LIU Yu Hong LI liang Beijing Chest Hospital Capital Medical UniversityBeijing 101149China Beijing Tuberculosis and Thoracic Tumor Research Institute Beijing 101149China Administration Office Clinical Center on Tuberculosis ControlChinese Center for Disease Control and PreventionBeijing 101149China National Center for Tuberculosis Control and Prevention Chinese Center for Disease Control and PreventionBeijing 102206China Shanghai Municipal Center for Disease Control and Prevention Shanghai 200336China Guangzhou Chest Hospital Guangzhou 510095GuangdongChina Tianjin Centers for Disease Control and Prevention Tianjin 300041China Department of TB Control Henan Center for Disease Control and PreventionZhengzhou 450016HenanChina Hebei Center for Disease Control and Prevention Shijiazhuang 050021HebeiChina Department of TB Control Guangxi Center for Disease Control and PreventionNanning 530021GuangxiChina Chongqing Anti-tuberculosis Institute Chongqing 400050China Yunnan Center for Disease Control and Prevention Kunming 650022YunnanChina

We assessed the role of diabetes mellitus（DM） on treatment effects in drug‐susceptible initial pulmonary tuberculosis（PTB） patients. A prospective study was conducted in eight provinces of China from October 2008 to December 2010. We enrolled 1,313 confirmed drug‐susceptible initial PTB patients, and all subjects received the treatment regimen（2 H3 R3 E3 Z3/4 H3 R3） as recommended by the national guidelines. Of the 1,313 PTB patients, 157（11.9%） had DM; these patients had more sputum smear‐positive rates at the end of the second month [adjusted odds ratios（aO R） 2.829, 95% confidence intervals（CI） 1.783‐4.490], and higher treatment failure（aO R 2.120, 95% CI 1.565‐3.477） and death rates（aO R 1.536, 95% CI 1.011‐2.628）. DM was a contributing factor for culture‐positive rates at the end of the second month and treatment failure and death of PTB patients, thus playing an unfavorable role in treatment effects of PTB.

关键词： Tuberculosis Diabetes mellitus Treatment outcome

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Enhanced photocatalytic performance by regulating the Ce^(3+)/Ce^(4+)ratio in cerium dioxide

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Frontiers of Chemical Science and Engineering 2024年第3期18卷 75-87页

作者： Zhi Li Dongsheng Jia Wei zhang ying Li Mitang Wang Dongliang zhang School of Materials and Chemistry University of Shanghai for Science and TechnologyShanghai200093China

Cerium dioxide(CeO_(2))photocatalysts are used in treating environmental pollution and addressing the energy crisis due to their excellent oxygen storage capacities and abundant oxygen *** this paper,CeO_(2)precursors were synthesized with different water-alcohol ratios via a solvothermal method,and CeO_(2)photocatalysts with different Ce^(3+)/Ce^(4+)ratios were obtained by changing the precursor calcination atmospheres(air,Ar)as well as the calcination *** effects of CeO_(2)with different Ce^(3+)/Ce^(4+)ratios in photocatalytic degradations of methylene blue under visible light were investigated.X-ray photoelectron spectroscopy results showed that the surfaces of the samples calcined under Ar had higher Ce^(3+)/Ce^(4+)ratios and oxygen vacancy concentrations,which reduced the band gaps of the catalysts and improved their utilization of visible *** addition,the many Ce^(3+)/Ce^(4+)redox centers and oxygen vacancies on the sample surfaces improved the separation and transfer efficiencies of the photogenerated *** sample C2-Ar calcined under Ar showed a high adsorption capacity and excellent photocatalytic activity by removing 96%of the methylene blue within 120 min,which was more than twice the degradation rate of the sample(C2-air)prepared via calcination under *** experiments showed that photogenerated holes played a key role in the photocatalytic *** addition,a synergistic photocatalytic mechanism for the Ce^(3+)/Ce^(4+)redox centers and oxygen vacancies was elucidated in detail,and the sensitization of cerium dioxide by dyes aided the degradation of methylene blue.

关键词： CeO_(2) oxygen vacancies Ce^(3+)/Ce^(4+)ratios photocatalytic dye-sensitization