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Human papillomavirus sperm infection： a possible risk factor for male infertility

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Asian Journal of Andrology 2014年第6期16卷 929-930页

作者： li zhang zong-Yao Hao Xian-Sheng zhang Chao-Zhao liang Department of Urology The First Affiliated Hospital of Anhui Medical Universityand Institute of Urology Anhui Medical University Anhui China.

Dear Editor, It is well-established that human papillomavirus （HPV）-infection represents one of the most common sexually transmitted infections in both males and females worldwide, Although HPV has been extensively investigated in oncology due to its causal role in cervical and penile carcinogenesis, and also the attachment of HPV to the equatorial region of the sperm head in semen has been clearly observed via optimized in situ hybridization technology described by Schillaci et al. relatively little attention has been paid to the issue whether the presence of HPV in semen has significance and consequence for sperm dysfunction and male infertility.

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Effect of Total Flavone of Haw Leaves on Nuclear Factor Erythroid-2 Related Factor and Other Related Factors in Nonalcoholic Steatohepatitis Rats

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Chinese Journal of Integrative Medicine 2018年第4期24卷 265-271页

作者： WANG De-jun CAI Yue-qin PAN Shui-zhen zhang li-zong CHEN Yun-xiang CHEN Fang-ming JIN Ming YAN Mao-xiang li Xiao-dong CHEN Zhi-yun Laboratory Animal Research Center Zhejiang Chinese Medical University Hangzhou 310053 China Drug Safety Evaluation Center Zhejing Academy of Medical Sciences Hangzhou 310053 China The First Affiliated Hospital of Zhejiang Chinese Medical University Hangzhou 310053 China

Objective： To investigate the effect of total flavone of haw leaves（TFHL） on the expression of nuclear factor erythroid-2 related factor（Nrf2） and other related factors in nonalcoholic steatohepatitis（NASH） rats induced by high-fat diet and then to further discuss the mechanism of TFHL＇s prevention against NASH. Methods： High-fat diet was fed to 40 rats to establish the NASH model. Then model rats were intragastrically administrated with 40, 80, 160 mg/（kg·day） TFHL, respectively. The pathological changes of liver tissues in NASH rats were detected by oil red O and hematoxylin-eosin（HE） stainings. The expression of Nrf2 in rat liver was examined through immunohistochemistry. The level of 8-iso-prostaglandin F2α in serum was detected through enzyme linked immunosorbent assay（EliSA）. The mR NA and protein levels of Nrf2 and other related factors in liver tissue were measured by real-time reverse transcriptionpolymerase chain reaction and western blot. Results： lipid deposition, hepatic steatosis, focal necrosis in lobular inflammation and ballooning degeneration were emerged in livers of NASH rats. The 8-iso-prostaglandin F2α in the serum of NASH rats increased significantly compared with the control group（P〈0.05）. The mR NA of Nrf2, hemeoxyenase1（HO-1） and the mR NA and protein levels of quinine oxidoreductase（NQO1） in NASH rats liver tissue showed a striking increase, while the mR NA levels of Keap1, r-glutamylcysteine synthethase（rG CS） and glutathione S-transferase（GST） were significantly decreased compared with the control group（P〈0.05）. After TFHL treatment, 8-iso-prostaglandin F2α level in serum significantly decreased, and Nrf2 mR NA and protein levels in hepatocytes nucleus enhanced compared with the model group（P〈0.05 or 0.01）. Meanwhile the Keap1 mR NA, the mR NA and protein levels of HO-1, NQO1 antibody, rG CS antibody, GST increased after TFHL treatment（P〈0.05 or 0.01）. Conclusions： Nrf2 and other related factors were involved in development of NASH, and

关键词： nonalcoholic steatohepatitis total flavone of Haw leaves nuclear factor erythroid-2 related factor

Neutron dose equivalent rate for heavy ion bombardment

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Nuclear Science and Techniques 1998年第3期 17-19页

作者： li Gui Sheng, zhang Tian Mei, li zong Wei, Su You Wu and zhang Shu Min ( Institute of Modern Physics, the Chinese Academy of Sciences,Lanzhou 730000)

１ＩｎｔｒｏｄｕｃｔｉｏｎＴｈｅｅｘａｃｔｄｏｓｅｅｑｕｉｖａｌｅｎｔｍｅａｓｕｒｅｍｅｎｔｏｆｎｅｕｔｒｏｎｓｗｉｔｈｅｎｅｒｇｙｇｒｅａｔｅｒｔｈａｎ１４ＭｅＶｉｓａｒａｔｈｅｒｄｉｆｉｃｕｌｔｐｒｏｂｌｅｍｉｎ... 详细信息

１ＩｎｔｒｏｄｕｃｔｉｏｎＴｈｅｅｘａｃｔｄｏｓｅｅｑｕｉｖａｌｅｎｔｍｅａｓｕｒｅｍｅｎｔｏｆｎｅｕｔｒｏｎｓｗｉｔｈｅｎｅｒｇｙｇｒｅａｔｅｒｔｈａｎ１４ＭｅＶｉｓａｒａｔｈｅｒｄｉｆｉｃｕｌｔｐｒｏｂｌｅｍｉｎｒａｄｉａｔｉｏｎｐｒｏｔｅｃｔｉ...

关键词： Heavy ion reactions 18 O ion Neutrondose equivalent rate

Neutron yields and emission rates in the forward direction for 50 MeV/u 18O-ion on thick Be,Cu,Au targets

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Nuclear Science and Techniques 1997年第4期 47-50页

作者： li Gui Sheng, zhang Tian Mei, li zong Wei, Su You Wu and zhang Shu Min ( Institute of Modern Physics, the Chinese Academy of Sciences, Lanzhou 730000)

Ｎｅｕｔｒｏｎｙｉｅｌｄｓａｎｄｅｍｉｓｉｏｎｒａｔｅｓｉｎｔｈｅｆｏｒｗａｒｄｄｉｒｅｃｔｉｏｎｆｏｒ５０ＭｅＶ／ｕ１８ＯｉｏｎｏｎｔｈｉｃｋＢｅ，Ｃｕ，ＡｕｔａｒｇｅｔｓＬｉＧｕｉＳｈｅｎｇ，ＺｈａｎｇＴｉ... 详细信息

Ｎｅｕｔｒｏｎｙｉｅｌｄｓａｎｄｅｍｉｓｉｏｎｒａｔｅｓｉｎｔｈｅｆｏｒｗａｒｄｄｉｒｅｃｔｉｏｎｆｏｒ５０ＭｅＶ／ｕ１８ＯｉｏｎｏｎｔｈｉｃｋＢｅ，Ｃｕ，ＡｕｔａｒｇｅｔｓＬｉＧｕｉＳｈｅｎｇ，ＺｈａｎｇＴｉａｎＭｅｉ，ＬｉＺｏｎｇＷｅｉ...

关键词： Threshold detector Neutron activation Heavy ion reactions Neutron yield Neutron emission rate

A Way to Build Software Culture: Distributed Object-Oriented Software Engineering over Internet

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Wuhan University Journal of Natural Sciences 2001年第Z1期6卷 359-361页

作者： Tian Ai jing, zhang ling, li zong rong Department of Computer Science, Hubei University, Wuhan 430062, China State Key Laboratory of Software Engineering, Wuhan University, Wuhan 430072, China Department of Computer Science Hubei University Wuhan 430062 China

This paper focuses on Distributed Object Oriented Software Engineering over Internet, which is a way to build software culture. We believe that our work will contribute to better understanding of how to meet the needs of the big potential software market and to promote the software industry in developing country. The United States and Western Europe have well established software industry and related civilization. Software science, technology, and engineering are needed in China; however, maybe what is needed, first of all, is software civilization, including software ideas, customs, skills, arts, etc. We will draw a framework for the software culture as following: Software is the most important commodity in this age; Brilliance of hardware component era has become past fact; A software component era is ahead; Traditional linear process model is obsolete; Modern software engineering has a new face, object evolution model; Distributed object oriented software engineering over Internet is an approach to software component era; and Complete software civilization will be formed all over the world in next century.

关键词： software software engineering object oriented methodology software component software culture

Shexiang Tongxin Dropping Pill(麝香通心滴丸)Reduces Coronary Microembolization in Rats via Regulation of Mitochondrial Permeability Transition Pore Opening and AKT-GSK3βPhosphorylation

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Chinese Journal of Integrative Medicine 2021年第7期27卷 527-533页

作者： DING Yu ZHU Hou-yong zhang li-zong GAO Bei-bei ZHOU liang HUANG Jin-yu Central Laboratory Hangzhou First People's HospitalZhejiang University School of MedicineHangzhou310006China Department of Cardiology Hangzhou Chinese Medical HospitalHangzhou310007China Experimental Animal Research Center Zhejiang Chinese Medical UniversityHangzhou310053China Department of Cardiology Hangzhou First People's HospitalZhejiang University School of MedicineHangzhou310006China

Objective To investigate the protective effects of Shexiang Tongxin Dropping Pill(麝香通心滴丸,STDP)following sodium laurate-induced coronary microembolization(CME)in *** Forty rats were divided into 4 groups:the control(sham)group,CME group,low-dose STDP pretreatment group(20 mg·kg^(−1)·d^(−1)),and high-dose STDP pretreatment group(40 mg·kg^(−1)·d^(−1)).The rats were intragastric administrated with STDP 2 weeks before ***,the histopathological alterations were observed using optical microscopy and transmission electron *** biomarkers were analyzed by enzyme-linked immunosorbent *** functions including the mitochondrial permeability transition pore(mPTP)mtDNA copy number were determined and proteins of AKT/GSK3βwere analyzed by Western *** The rats in the CME group showed a significant increase in the fibrinogen-like protein 2 expression level and mitochondrial dysfunction and a decrease in the expression level of antioxidant biomarkers(superoxide dismutase and catalase,P<0.01 for all).In contrast,the rats in the low-and high-dose STDP pretreatment groups showed a significant decrease in coronary microthrombi(P<0.05);moreover,STDP restored the antioxidant-related protein activities and mitochondrial function,inhibited mPTP opening,decreased AKT-Ser473 phosphorylation,and increased GSK3β-Ser9 phosphorylation(P<0.05 or P<0.01).Conclusion STDP may be useful for treatment of CME,possibly via regulation of mPTP opening and AKT/GSK3βphosphorylation.

关键词： Shexiang Tongxin Dropping Pill Chinese medicine coronary microembolization mitochondrial permeability transition pore AKT GSK3β

云计算环境中基于用户访问需求的角色查找算法

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通信学报 2011年第7期32卷 169-175页

作者：杨柳唐卓李仁发张宗礼湖南大学嵌入式系统与网络实验室湖南长沙410082

提出了一种云计算环境中基于角色的访问控制模型CARBAC,将角色分为用户角色和资源拥有者管理角色。针对管理角色对用户访问的角色指派,提出了在混杂角色层次关系中基于用户权限的角色查找算法。对于一组给定的授权,该算法能在云计算系... 详细信息

提出了一种云计算环境中基于角色的访问控制模型CARBAC,将角色分为用户角色和资源拥有者管理角色。针对管理角色对用户访问的角色指派,提出了在混杂角色层次关系中基于用户权限的角色查找算法。对于一组给定的授权,该算法能在云计算系统的角色中选择一组数量最少的角色指派给用户。仿真实验表明,针对云计算环境中的海量用户访问,本算法能显著减少系统中角色的数量,缩短用户授权时间,提高系统运行效率。

关键词：云计算角色查询访问控制

发芽小麦对克氏原螯虾生长及非特异性免疫指标的影响

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淡水渔业 2014年第2期44卷 57-61页

作者：张宗利周鑫南京农业大学无锡渔业学院江苏无锡214182 中国水产科学院淡水渔业研究中心江苏无锡214081

以投喂商品饲料的克氏原螯虾(Procambarus Clarkii)为对照组,分别用发芽1 d、2 d、3 d的小麦投喂的克氏原螯虾作为试验组,投喂35 d后测定各组螯虾的生长指标、营养指数,以及螯虾肝胰腺和肌肉中非特异性免疫相关酶活性和蛋白浓度,探究发... 详细信息

以投喂商品饲料的克氏原螯虾(Procambarus Clarkii)为对照组,分别用发芽1 d、2 d、3 d的小麦投喂的克氏原螯虾作为试验组,投喂35 d后测定各组螯虾的生长指标、营养指数,以及螯虾肝胰腺和肌肉中非特异性免疫相关酶活性和蛋白浓度,探究发芽小麦在克氏原螯虾代谢强度较低的秋冬季节替代商品饲料的效果。结果显示:肝胰腺中,投喂发芽1 d小麦组超氧化物歧化酶活性最高,投喂发芽1 d和3 d小麦组溶菌酶活性显著低于对照组和投喂发芽2 d小麦组,投喂发芽2 d小麦组酸性磷酸酶显著低于对照组和其他两组;肌肉中,投喂发芽1 d小麦组超氧化物歧化酶和碱性磷酸酶活性与对照组无差异,溶菌酶和酸性磷酸酶活性显著高于对照组;投喂发芽小麦后克氏原螯虾的成活率、增重率、营养指数和肝胰腺中蛋白浓度与对照组相比无显著差异。结果表明:发芽1 d的小麦与商品饲料均有提高克氏原螯虾生长速度和非特异性免疫功能的作用,且效果相近,可以作为克氏原螯虾秋冬季节的替代饵料。

关键词：克氏原螯虾(Procambarus Clarkii) 发芽小麦生长性能非特异性免疫相关酶

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聚碳级双酚A结晶精制过程的研究

化学工程 2005年第6期33卷 14-17页

作者：张宗礼吕惠生肖观秀李永辉天津大学石油化工技术开发中心天津300072

研究了以甲苯为溶剂,从双酚A-苯酚的加合物晶体中,用结晶方法制备双酚A的精制工艺,讨论了加合物晶体中苯酚的质量分数、结晶终温、结晶时间、溶剂比对双酚A的结晶收率、产品熔点和产品色号的影响,得出了用甲苯溶剂结晶法从加合物晶体中... 详细信息

研究了以甲苯为溶剂,从双酚A-苯酚的加合物晶体中,用结晶方法制备双酚A的精制工艺,讨论了加合物晶体中苯酚的质量分数、结晶终温、结晶时间、溶剂比对双酚A的结晶收率、产品熔点和产品色号的影响,得出了用甲苯溶剂结晶法从加合物晶体中提纯具有特殊用途的聚碳级双酚A晶体的适宜工艺条件为溶剂摩尔比0∶1,结晶终温38℃,结晶时间190 m in。

关键词：双酚A 苯酚加合物晶体甲苯溶剂结晶法