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Unraveling the mechanism of action of Shangxia liangji formula for treating insomnia:a metabolomics and network pharmacology approach

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Traditional Medicine Research 2025年第2期10卷 16-29页

作者： Xia-Jie Quan Hao liang Yong-Hong Tang li Jiang Xiong-ying Ji Feng-ying zhang Ping zhang Bo Ouyang Department of Information The Affiliated Nanhua HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421002China Department of Neurology The Affiliated Nanhua HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421002China Department of Gastroscopy The Affiliated Nanhua HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421002China Department of Traditional Chinese Medicine The Affiliated Nanhua HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421002China

Background:Insomnia is a prevalent clinical condition and Shangxia liangji formula(SXLJF)is a well-established method of ***,the specific mechanism of action of SXLJF remains ***:The mouse model of insomnia was established by intraperitoneal injection of ***-two mice were randomly divided into a negative control group,model group,SXLJF group(18.72 g/kg/day),and positive control group(diazepam,2 mg/kg)and treated with the corresponding drugs for 7 consecutive *** open field test and pentobarbital-induced sleeping test were ***-MS-based untargeted metabolomics and network pharmacology were applied to explore the potential targets of SXLJF for treating ***,key targets were validated using ***:Behavioral tests demonstrated that SXLJF reduced the total distance,average velocity,central distance,and sleep latency,and prolonged sleep *** and network pharmacology revealed potential targets,signaling pathways,metabolic pathways,and metabolites associated with the anti-insomnia effects of ***,tyrosine hydroxylase(TH)and tyrosine metabolism emerged as crucial metabolic pathways and targets,***-qPCR results supported the role of TH in the mechanism of SXLJF in treating ***:In conclusion,TH and tyrosine metabolism may represent significant targets and pathways for SXLJF in treating insomnia.

关键词： Shangxia liangji formula insomnia metabolomics network pharmacology tyrosine hydroxylase tyrosine metabolism

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Investigation of bubbles escape behavior from low basicity mold flux for high-Mn high-Al steels using 3D X-ray microscope

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 102-110页

作者： Qiang liu Xiang li Shen Du Ming Gao Yanbin Yin Jiongming zhang State Key Laboratory of Advanced Metallurgy University of Science and Technology BeijingBeijing 100083China

During the continuous casting process of high-Mn high-Al steels,various types of gases such as Ar need to escape through the top of the *** which,the behavior of bubbles traversing the liquid slag serves as a restrictive link,closely associated with viscosity and the thickness of liquid *** contrast to two-dimensional surface observation,three-dimensional(3D)analysis method can offer a more intuitive,accurate,and comprehensive ***,this study employs a 3D X-ray microscope(3D-XRM)to obtained spatial distribution and 3D morphological characteristics of residual bubbles in mold flux under different basicity of liquid slag,different temperatures,and different holding *** results indicate that as basicity of slag increases from 0.52 to 1.03,temperature increases from 1423 to 1573 K,the viscosity of slag decreases,the floating rate of bubbles *** addition,when holding time increases from 10 to 30 s,the bubbles floating distance increases,and the volume fraction and average equivalent sphere diameter of the bubbles solidified in the mold flux gradually *** one word,increasing the basicity,temperature,and holding time leading to an increase in the removal rate of bubbles especially for the *** findings of bubbles escape behavior provide valuable insights into optimizing low basicity mold flux for high-Mn high-Al steels.

关键词： mold flux low basicity bubbles three-dimensional X-ray microscope viscosity

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Defect Engineering:Can it Mitigate Strong Coulomb Effect of Mg^(2+)in Cathode Materials for Rechargeable Magnesium Batteries?

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Nano-Micro Letters 2025年第1期17卷 135-159页

作者： Zhengqing Fan Ruimin li Xin zhang Wanyu Zhao Zhenghui Pan Xiaowei Yang School of Chemistry and Chemical Engineering Shanghai Jiao Tong UniversityShanghai 200240People’s Republic of China School of Chemistry and Chemical Engineering Taiyuan University of TechnologyTaiyuan 030024People’s Republic of China School of Materials Science and Engineering Tongji UniversityShanghai 201804People’s Republic of China

Rechargeable magnesium batteries(RMBs)have been considered a promising“post lithium-ion battery”system to meet the rapidly increasing demand of the emerging electric vehicle and grid energy storage ***,the sluggish diffusion kinetics of bivalent Mg^(2+)in the host material,related to the strong Coulomb effect between Mg^(2+)and host anion lattices,hinders their further development toward practical *** engineering,regarded as an effective strategy to break through the slow migration puzzle,has been validated in various cathode materials for *** this review,we first thoroughly understand the intrinsic mechanism of Mg^(2+)diffusion in cathode materials,from which the key factors affecting ion diffusion are further ***,the positive effects of purposely introduced defects,including vacancy and doping,and the corresponding strategies for introducing various defects are *** applications of defect engineering in cathode materials for RMBs with advanced electrochemical properties are also ***,the existing challenges and future perspectives of defect engineering in cathode materials for the overall high-performance RMBs are described.

关键词： Rechargeable magnesium battery Sluggish diffusion kinetic Defect engineering Cathode materials Ion migration

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本体论研究的几个基本问题

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山西师大学报（社会科学版） 2009年第5期36卷 1-4页

作者：谢维营张丽英上饶师范学院政法系江西上饶334001 江西师范大学政法学院南昌330022

什么是本体论?为什么要研究本体论?如何研究本体论?这是本体论研究的几个基本问题。在中文语境里,本体论就是本体论,不等于英文的"ontology",也不能简单地归结为"存在论"或"是论"。之所以要研究本体论,是因为本体论虽然是一个历史概念,... 详细信息

什么是本体论?为什么要研究本体论?如何研究本体论?这是本体论研究的几个基本问题。在中文语境里,本体论就是本体论,不等于英文的"ontology",也不能简单地归结为"存在论"或"是论"。之所以要研究本体论,是因为本体论虽然是一个历史概念,但并没有过时;马克思主义哲学超越了传统本体论,但不等于不可以有自己的本体论;哲学本体论不能代替自然科学对世界的解释,不过在涉及科学的深层次问题时,哲学本体论的"假设"或"承诺"并非完全多余;哲学是人学,本体论归根结底是为人的生存作论证的。用批判的眼光审视传统本体论,建构适应时代需要的新型本体论,是现代本体论的基本研究方法。

关键词：本体论存在论研究价值研究方法

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Establishment and Utilization of a Tetracycline-controlled Inducible RNA Interfering System to Repress Gene Expression in Chronic Myelogenous Leukemia Cells

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Acta Biochimica et Biophysica Sinica 2005年第12期37卷 851-856页

作者： Fan YANG Yun zhang ying-li CAO Shu-Hui WANG li liU Department of Microbiology and Etiology,Institute of Basic Medical .sic Medical Sciences. Chinese Academy q/’Medical Sciences and Peking Union Medical College.Beijing 100005.China DepartmentofMicrobiologyandEtiology InstituteofBasicMedicalSciencesChineseAcademyofMedicalSciencesandPekin

RNA interference (RNAi),a posttranscriptional gene silencing process mediated by small double-stranded RNA specifically complementary to the targeted transcript,has been used extensively in the developmentof novel therapeutic approaches against various human diseases including chronic myelogenous leukemia (CML).*** report the successful construction of a tetracycline-controlled siRNA in CML cell line K562.A K562cell line stably expressing the reverse tetracycline-controlled transactivator (rtTA) was constructed.A tetracy-cline responsive element(TRE) was integrated into the RNA polymerase Ⅲ promoter region of pBS/U6 thatwas used to drive specific siRNA to target the novel cytokine receptor-like factor 3 (CRLF3) gene,The resultsshow that rtTA was able to recognize the TRE to prevent siRNA-mediated exogenous and endogenous CRLF3gene ***,CRLF3-siRNA mediated gene repression could be induced in a dose-dependentmanner in the presence of ***,the inducible siRNAi system in K562 cells might be useful for thestudy of RNAi-mediated therapeutic approaches against CML.

关键词： inducible siRNA tetracycline reverse tetracycline-controlled transactivator U6 promoter CRLF3

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Molecule‑Level Multiscale Design of Nonflammable Gel Polymer Electrolyte to Build Stable SEI/CEI for lithium Metal Battery

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Nano-Micro Letters 2025年第1期17卷 404-423页

作者： Qiqi Sun Zelong Gong Tao zhang Jiafeng li Xianli Zhu Ruixiao Zhu lingxu Wang Leyuan Ma Xuehui li Miaofa Yuan Zhiwei zhang Luyuan zhang Zhao Qian Longwei Yin Rajeev Ahuja Chengxiang Wang Key Laboratory for liquid‑Solid Structural Evolution and Processing of Materials(Ministry of Education) School of Materials Science and EngineeringShandong UniversityJinan 250061People’s Republic of China Condensed Matter Theory Department of Physics and AstronomyUppsala UniversityUppsala 75120Sweden

The risk of flammability is an unavoidable issue for gel polymer electrolytes(GPEs).Usually,flameretardant solvents are necessary to be used,but most of them would react with anode/cathode easily and cause serious interfacial instability,which is a big challenge for design and application of nonflammable ***,a nonflammable GPE(SGPE)is developed by in situ polymerizing trifluoroethyl methacrylate(TFMA)monomers with flame-retardant triethyl phosphate(TEP)solvents and liTFSI–liDFOB dual lithium *** is strongly anchored to PTFMA matrix via polarity interaction between-P=O and-CH_(2)CF_(3).It reduces free TEP molecules,which obviously mitigates interfacial reactions,and enhances flame-retardant performance of TEP *** TEP molecules are also inhibited in solvation of li^(+),leading to anion-dominated solvation sheath,which creates inorganic-rich solid electrolyte interface/cathode electrolyte interface *** coordination structure changes li^(+)transport from sluggish vehicular to fast structural transport,raising ionic conductivity to 1.03 mS cm^(-1) and transfer number to 0.41 at 30℃.The li|SGPE|li cell presents highly reversible li stripping/plating performance for over 1000 h at 0.1 mA cm^(−2),and 4.2 V liCoO_(2)|SGPE|li battery delivers high average specific capacity>120 mAh g^(−1) over 200 *** study paves a new way to make nonflammable GPE that is compatible with li metal anode.

关键词： Anchoring effect Nonflammable gel electrolyte In situ cross-linked Electrode-electrolyte interface li metal battery

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晶间变形行为对AZ31镁合金延展性的影响

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塑性工程学报 2021年第4期28卷 136-145页

作者：张丽英张晨郭翰韬张梦奇张盼盼张子英郜敏山西能源学院机电工程系山西晋中030600 北京建筑大学机电车辆工程学院北京100044 太原供水集团有限公司山西太原030000

利用拉伸试验结合电子背散射衍射技术研究了AZ31镁合金在不同加载方式下的晶间变形行为,并通过Matlab软件计算了不同晶间变形行为之间Schmid因子、几何相容性因子m’值以及晶间变形相容性mk值,诠释了晶间变形行为对镁合金整体塑性的影响... 详细信息

利用拉伸试验结合电子背散射衍射技术研究了AZ31镁合金在不同加载方式下的晶间变形行为,并通过Matlab软件计算了不同晶间变形行为之间Schmid因子、几何相容性因子m’值以及晶间变形相容性mk值,诠释了晶间变形行为对镁合金整体塑性的影响,并与试验结果进行了对比。结果表明,晶界附近的应变调节受相邻晶粒的Schmid因子、几何相容性因子m’值以及晶间变形相容性mk值的影响。晶间变形行为的优先级主要影响晶粒的Schmid因子,对m’值和mk值影响不大。在晶界周围区域,mk值与伸长率是单调递增的关系,相邻晶粒中B-B行为较高的mk值在拉伸试验中表现出更高的伸长率。

关键词： Schmid因子几何相容性因子晶间变形相容性 AZ31镁合金延展性

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Oxidation Resistance of Form-stable Hightemperature Phase Change Thermal Energy Storage Materials Doped by Impregnated Graphite

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Journal of Wuhan University of Technology(Materials Science) 2025年第1期40卷 1-12页

作者： li Baorang DAI Jianhuan zhang Wei liU Xiangchen YANG liu School of Energy Power and Mechanical Engineering North China Electric Power UniversityBeijing 102206China School of Ener-gy and Environment Southeast UniversityNanjing 210096China

We adopted the solution impregnation route with aluminum dihydrogen phosphate solution as liquid medium for effective surface modification on graphite *** mass ratio of graphite to Al(H_(2)PO_(4))_(3) changed from 0.5:1 to 4:1,and the impregnation time changed from 1 to 7 *** typical composite phase change thermal storage materials doped with the as-treated graphite were fabricated using form-stable *** investigate the oxidation and anti-oxidation behavior of the impregnated graphite at high temperatures,the samples were put into a muffle furnace for a cyclic heat *** on SEM,EDS,DSC techniques,analyses on the impregnated technique suggested an optimized processing conditions of a 3 h impregnation time with the ratio of graphite:Al(H_(2)PO_(4))_(3) as 1:3 for graphite impregnation *** investigations on high-temperature phase change heat storage materials doped by the treated graphite suggested excellent oxidation resistance and thermal cycling performance.

关键词： phase change materials graphite impregnation method oxidation,sintering thermal analysis

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我国网络游戏法律规制论析——以《网络游戏管理暂行办法》为例

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东北师大学报（哲学社会科学版） 2015年第6期 16-20页

作者：高英彤张丽滢高尚东北师范大学政法学院吉林长春130117 北华大学法学院吉林吉林市132013 北京大学法学院北京100871

2010年文化部出台的《网络游戏管理暂行办法》是迄今为止我国最重要的网络游戏法律规制文件。该部法律文件运行五年来,在唱响网上主旋律,推进依法规范网络游戏有序发展中发挥了重要作用,但其在法律效力的权威性、法律适用的规范性、法... 详细信息

2010年文化部出台的《网络游戏管理暂行办法》是迄今为止我国最重要的网络游戏法律规制文件。该部法律文件运行五年来,在唱响网上主旋律,推进依法规范网络游戏有序发展中发挥了重要作用,但其在法律效力的权威性、法律适用的规范性、法律执行的保障性以及保护青少年免于网络游戏中的暴力、色情等内容侵蚀、防止未成年人游戏沉迷和实现网游开发商、运营商经济效益和社会责任平衡等方面还亟待加强与完善。完善我国网络游戏法律规制体系,提高对网络游戏的治理能力迫在眉睫。

关键词：网络游戏法律规制《网络游戏管理暂行办法》

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数字化时代高职院校“三教”改革的现实路径

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成人教育 2024年第3期44卷 74-79,86页

作者：张丽颖张学军苏州健雄职业技术学院创新创业学院江苏太仓215411

数字化时代呼唤数字化技术技能人才,数字技术与职业教育的深度融合深刻影响着教师的教和学生的学。产业数字化、数字产业化推动了技术知识的更新迭代,促进了高职院校课程内容优化重组和教学资源扩容提质。深化数字化时代高职院校教师、... 详细信息

数字化时代呼唤数字化技术技能人才,数字技术与职业教育的深度融合深刻影响着教师的教和学生的学。产业数字化、数字产业化推动了技术知识的更新迭代,促进了高职院校课程内容优化重组和教学资源扩容提质。深化数字化时代高职院校教师、教材、教法“三教”改革,只有以技术知识开发为主线、顺应改革的现实要求、把握改革的现实状况、优化改革的现实路径,才能提高学生综合职业能力,培养数字化技术技能人才,推动高职院校高质量发展。

关键词：数字化时代高职院校三教改革技术知识

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