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Platelet-derived microparticles and their cargos: The past, present and future

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Asian Journal of Pharmaceutical Sciences 2024年第2期19卷 72-88页

作者： Jingwen Guo Bufeng Cui Jie Zheng Chang Yu Xuran Zheng Lixin Yi Simeng zhang keke Wang Department of Pharmacy The First Hospital of China Medical UniversityShenyang 110001 China School of Pharmacy China Medical UniversityShenyang 110122China Key Laboratory of Medical Cell Biology of Ministry of Education Key Laboratory of Major Chronic Diseases of Nervous System of Liaoning ProvinceHealth Sciences Institute of China Medical UniversityShenyang 110122China Department of Pharmacy The Fourth Affiliated Hospital of China Medical UniversityShenyang 110032China Department of Medical Oncology the First Hospital of China Medical UniversityShenyang 110001China

All eukaryotic cells can secrete extracellular vesicles, which have a double-membrane structure and are important players in the intercellular communication involved in a variety of important biological processes. Platelets form platelet-derived microparticles (PMPs) in response to activation, injury, or apoptosis. This review introduces the origin, pathway, and biological functions of PMPs and their importance in physiological and pathological processes. In addition, we review the potential applications of PMPs in cancer, vascular homeostasis, thrombosis, inflammation, neural regeneration, biomarkers, and drug carriers to achieve targeted drug delivery. In addition, we comprehensively report on the origin, biological functions, and applications of PMPs. The clinical transformation, high heterogeneity, future development direction, and limitations of the current research on PMPs are also discussed in depth. Evidence has revealed that PMPs play an important role in cell-cell communication, providing clues for the development of PMPs as carriers for relevant cell-targeted drugs. The development history and prospects of PMPs and their cargos are explored in this guidebook.

关键词： Platelet-derived particles Application Heter ogeneity Potential and limitations

Ultra-high Temperature Ceramic Coatings:A Review on Preparation Technology and Development Prospect

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China's Refractories 2023年第3期32卷 42-49页

作者： LIU Shijie WANG Li DONG Binbin XU Biao GUO Yusen MIN Yongchao GUO Yanyan WEI Haoyu zhang keke YIN Chaofan Luoyang Institute of Science and Technology Luoyang 471023China

Ultra-high temperature ceramic coatings have ultra-high melting points,excellent mechanical properties and high temperature ablation *** unique performance combinations turn it into a promising material for use in extreme environment structures in rockets and hypersonic vehicles,particularly nozzles,leading edges and engine *** this paper,various preparation methods of ultra-high temperature ceramic coatings were reviewed,including plasma spraying,chemical vapor deposition,pack cementation,slurry sintering,hot pressing and their research ***,some new preparation methods of high temperature coatings,such as ion beam deposition,ultrasonic spraying,metal organic frame work coating,and magnetron sputtering,were *** development trend of ultra-high temperature coatings was prospected as well.

关键词： ultra-high temperature coating preparation process development prospect

The effect of the equatorially symmetric zonal winds of Saturn on its gravitational field

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Research in Astronomy and Astrophysics 2018年第4期18卷 15-22页

作者： Dali Kong keke zhang Gerald Schubert John D.Anderson Key Laboratory of Planetary Sciences Shanghai Astronomical Observatory Chinese Academy of SciencesShanghai 200030 China College of Engineering Mathematics and Physical Sciences University of Exeter Exeter EX4 4QF UK Lunar and Planetary Science Laboratory Macao University of Science and Technology Macao China Department of Earth Planetary and Space Sciences University of California Los Angeles CA 90095-1567 USA Jet Propulsion Laboratory 4800 Oak Grove Drive Pasadena CA 91109 USA

The penetration depth of Saturn’s cloud-level winds into its interior is unknown.A possible way of estimating the depth is through measurement of the effect of the winds on the planet’s gravitational *** use a self-consistent perturbation approach to study how the equatorially symmetric zonal winds of Saturn contribute to its gravitational *** important advantage of this approach is that the variation of its gravitational field solely caused by the winds can be isolated and identified because the leading-order problem accounts exactly for rotational distortion,thereby determining the irregular shape and internal structure of the hydrostatic *** assume that（i）the zonal winds are maintained by thermal convection in the form of non-axisymmetric columnar rolls and（ii）the internal structure of the winds,because of the Taylor-Proundman theorem,can be uniquely determined by the observed cloud-level *** calculate both the variation △J_n,n=2,4,6...of the axisymmetric gravitational coefficients J_n caused by the zonal winds and the non-axisymmetric gravitational coefficients △J_（nm） produced by the columnar rolls,where m is the azimuthal wavenumber of the *** consider three different cases characterized by the penetration depth 0.36 R_S,0.2 R_S and 0.1 R_S,where R_S is the equatorial radius of Saturn at the 1-bar pressure *** find that the high-degree gravitational coefficient （ J_（12）＋△J_（12）） is dominated,in all the three cases,by the effect of the zonal flow with ｜△J_（12）/J_（12）｜〉100%and that the size of the non-axisymmetric coefficientsdirectly reflects the depth and scale of the flow taking place in the Saturnian interior.

关键词： gravitation — planets and satellites individual(Saturn) — planets and satellites interiors

A model of Saturn inferred from its measured gravitational field

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Research in Astronomy and Astrophysics 2018年第4期18卷 7-14页

作者： Dali Kong keke zhang Gerald Schubert John D.Anderson Key Laboratory of Planetary Sciences Shanghai Astronomical Observatory Chinese Academy of Sciences Shanghai 200030 China College of Engineering Mathematics and Physical Sciences University of Exeter Exeter EX4 4QF UK Lunar and Planetary Science Laboratory Macao University of Science and Technology Macao China Department of Earth Planetary and Space Sciences University of California Los Angeles CA 90095-1567 USA Jet Propulsion Laboratory 4800 Oak Grove Drive Pasadena CA 91109 USA

We present an interior model of Saturn with an ice-rock core,a metallic region,an outer molecular envelope and a thin transition layer between the metallic and molecular *** shape of Saturn’s 1 bar surface is irregular and determined fully self-consistently by the required equilibrium *** the ice-rock core is assumed to have a uniform density,three different equations of state are adopted for the metallic,molecular and transition *** Saturnian model is constrained by its known mass,its known equatorial and polar radii,and its known zonal gravitational coefficients,J_（2n）,n=1,2,*** model produces an ice-rock core with equatorial radius 0.203 R_S,where R_S is the equatorial radius of Saturn at the 1-bar pressure surface;the core densityρ_c=10388.1 kgm^（3）corresponding to 13.06 Earth masses;and an analytical expression describing the Saturnian irregular shape of the 1-bar pressure *** model also predicts the values of the higher-order gravitational coefficients,J_8,J_10 and J_12,for the hydrostatic Saturn and suggests that Saturn’s convective dynamo operates in the metallic region approximately defined by 0.2 R_S

关键词： gravitation — planets and satellites individual(Saturn) — planets and satellites interiors

Saturn＇s gravitational field induced by its equatorially antisymmetric zonal winds

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Research in Astronomy and Astrophysics 2018年第5期18卷 29-36页

作者： Dali Kong keke zhang Gerald Schubert John D.Anderson Key Laboratory of Planetary Sciences Shanghai Astronomical Observatory Chinese Academy of Sciences Shanghai 200030 China College of Engineering Mathematics and Physical Sciences University of Exeter Exeter EX4 4QF UK Lunar and Planetary Science Laboratory Macao University of Science and Technology Macao China Department of Earth Planetary and Space Sciences University of California Los Angeles CA 90095-1567 USA Jet Propulsion Laboratory 4800 Oak Grove Drive Pasadena CA 91109 USA

The cloud-level zonal winds of Saturn are marked by a substantial equatorially antisymmetric component with a speed of about 50 m s^-1 which, if they are sufficiently deep, can produce measurable odd zonal gravitational coefficients △J2 k＋1, k = 1, 2, 3, 4. This study, based on solutions of the thermal-gravitational wind equation, provides a theoretical basis for interpreting the odd gravitational coefficients of Saturn in terms of its equatorially antisymmetric zonal flow. We adopt a Saturnian model comprising an ice-rock core, a metallic dynamo region and an outer molecular envelope. We use an equatorially antisymmetric zonal flow that is parameterized, confined in the molecular envelope and satisfies the solvability condition required for the thermal-gravitational wind equation. The structure and amplitude of the zonal flow at the cloud level are chosen to be consistent with observations of *** calculate the odd zonal gravitational coefficients △J2k＋1, k = 1, 2, 3, 4 by regarding the depth of the equatorially antisymmetric winds as a parameter. It is found that △J3 is-4.197 × 10^-8 if the zonal winds extend about 13 000 km downward from the cloud tops while it is-0.765 × 10^-8 if the depth is about 4000 km. The depth/profile of the equatorially antisymmetric zonal winds can eventually be estimated when the high-precision measurements of the Cassini Grand Finale become available.

关键词： gravitation - planets and satellites individual (Saturn) - planets and satellites interiors

Influence of stress on the creep behavior of Cu particle enhancement SnPb based composite solder joints

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Rare Metals 2007年第1期26卷 51-55页

作者： YAN Yanfu YAN Hongxing CHEN Fuxiao zhang keke ZHU Jinhong School of Materials Science and Engineering Henan University of Science and Technology Luoyang 471003 China

Lap joints with a 1 mm^2 cross-sectional area were fabricated using Cu particle enhancemem 63Sn37Pb based composite solder and 63Sn37Pb eutectic solder to examine the influence of stress on the creep behavior of the solder joints. The results indicate that the creep resistance of the composite solder joints is generally superior to that of the conventional 63Sn37Pb solder joints. At the same time, the creep rupture life of the composite solder joints is declined with increasing stress and drops faster than that of the 63Sn37Pb eutectic solder joints.

关键词： composite solder stress creep rupture life particle-enhancement 63Sn37Pb

Proteasome Inhibitor PS-341 Effectively Blocks Infection by the Severe Fever with Thrombocytopenia Syndrome Virus

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Virologica Sinica 2019年第5期34卷 572-582页

作者： Sihua Liu Hongyun Liu keke zhang Xueping Li Yuqin Duan Zhiyun Wang Tao Wang School of Life Sciences Tianjin UniversityTianjin 300073China School of Environmental Science and Engineering Tianjin UniversityTianjin 300073China

Severe fever with thrombocytopenia syndrome(SFTS)is an emerging hemorrhagic fever disease caused by SFTSV,a newly discovered phlebovirus that is named after the ***,no effective vaccines or drugs are available for use against SFTSV infection,as our understanding of the viral pathogenesis is ***(PS-341),a dipeptideboronic acid analog,is the first clinically approved proteasome inhibitor for use in *** this study,the antiviral efficacy of PS-341 against SFTSV infection was tested in human embryonic kidney HEK293T(293T)*** employed four different assays to analyze the antiviral ability of PS-341 and determined that PS-341 inhibited the proliferation of SFTSV in 293T cells under various treatment *** PS-341 did not affect the virus absorption,PS-341 treatment within a non-toxic concentration range resulted in a significant reduction of progeny viral titers in infected ***-luciferase reporter assays and Western blot analysis revealed that PS-341 could reverse the SFTSV-encoded nonstructural protein(NS)mediated degradation of retinoic acid-inducible gene-1(RIG-I),thereby antagonizing the inhibitory effect of NSs on interferons and blocking virus *** addition,we observed that inhibition of apoptosis promotes virus *** results indicate that targeting of cellular interferon pathways and apoptosis during acute infection might serve as the bases of future therapeutics for the treatment of SFTSV infections.

关键词： Bortezomib PS-341 Severe fever with thrombocytopenia syndrome virus(SFTSV) IFN-β Apoptosis

Effect of Magnetic Field Configuration on Stray-Crystal Formation with Different Platform Sizes during Directional Solidification of Single-Crystal Superalloy

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Acta Metallurgica Sinica(English Letters) 2024年第5期37卷 904-914页

作者： keke Lu Congjiang zhang Xiaotan Yuan Hongbin Yu Weili Ren Biao Ding Haibiao Lu Yunbo Zhong Zuosheng Lei Hui Wang Qiuliang Wang Peter KLiaw Xuezhi Qin Lanzhang Zhou State Key Laboratory of Advanced Special Steel Shanghai Key Laboratory of Advanced FerrometallurgyShanghai UniversityShanghai 200444China Institute of Electrical Engineering Chinese Academy of SciencesBeijing 100190China Department of Materials Science and Engineering The University of TennesseeKnoxvilleTN 37996USA Institute of Metal Research Chinese Academy of SciencesShenyang 110016China

The magnetic field is an effective means to control the solidification structure and the defects of metal and semiconductor *** work investigates the effects of Cusp magnetic field(CMF)and longitudinal magnetic field(LMF)on the stray-crystal formation in the platform regions during the directional solidification of single-crystal superalloy with the different cross section *** application of CMF reduces the formation of platform stray-crystal,while LMF increases its *** the platform size increases,the stray-crystal ratio increases regardless of whether the magnetic fields are applied or not,the effectiveness of CMF increases,while that of LMF *** reason that the effects of CMF and LMF on the platform stray-crystal formation could be attributed to the change of flow structure from the distribution characteristics of the thermoelectric magnetic force and the magnetic damping force near the liquid-solid interface.

关键词： Stray-crystal Magnetic field Single-crystal superalloy Cross section change Directional solidification

A qualitative study on nurses'reactions to inpatient suicide in a general hospital

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International Journal of Nursing Sciences 2016年第4期3卷 354-361页

作者： Shujie Wang Xiaoping Ding Deying Hu keke zhang Di Huang School of Nursing Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina Department of Nursing Union Hospital of Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China

Aims:To explore the impact of inpatient suicides on nurses working in front-line,the patterns of regulation and their needs for ***:Data were collected through purposive sampling by conducting semi-structured and individual in-depth interviews in a tertiary referral hospital in ***'s sevenstep phenomenological method was simultaneously used by two ***:Reactions to inpatient suicides revealed three central themes:(1)inpatients were highly likely to commit suicide,(2)inpatient suicide was difficult to prevent,and(3)nurses lacked the necessary suicide prevention *** responses mainly included shock and panic,self-accusation or guilt,sense of fear,and *** impacts on practice were stress,excessive vigilance,and *** and sharing of feelings played key roles in the regulation patterns of ***:Nurses who experienced inpatient suicide became *** interventions must be implemented to improve the coping mechanisms of nurses against the negative consequences of inpatient *** findings of this study will allow administrators to gain insight into the impacts of inpatient suicides on nurses in general *** information can be used to develop effective strategies and provide individual support and ongoing ***,nurses will acquire suicide prevention skills and help patients achieve swift recovery.

关键词： Inpatient suicide Nurses'reaction Impact General hospital Qualitative study