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Extended phase diagram of La_(1-x)Ca_(x)MnO_(3)by interfacial engineering

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Chinese Physics B 2021年第12期30卷 136-141页

作者： kexuan zhang Lili Qu Feng Jin Guanyin Gao Enda Hua Zixun zhang Lingfei Wang Wenbin Wu Hefei National Laboratory for Physical Sciences at Microscale University of Science and Technology of ChinaHefei 230026China Anhui Key Laboratory of Condensed Matter Physics at Extreme Conditions High Magnetic Field LaboratoryHFIPSAnhuiChinese Academy of SciencesHefei 230031China

The interfacial enhanced ferromagnetism in maganite/ruthenate system is regarded as a promising path to broaden the potential of oxide-based electronic device ***,we systematically studied the physical properties of La_(1-x)Ca_(x)MnO_(3)/SrRuO_(3)superlattices and compared them with the La1-x Cax MnO_(3)thin films and bulk *** La_(1-x)Ca_(x)MnO_(3)/SrRuO_(3)superlattices exhibit significant enhancement of Curie temperature(TC)beyond the corresponding thin films and *** on these results,we constructed an extended phase diagram of La_(1-x)Ca_(x)MnO_(3)under interfacial *** considered the interfacial charge transfer and structural proximity effects as the origin of the interfaceinduced high *** structural characterizations revealed a pronounced increase of B-O-B bond angle,which could be the main driving force for the high TCin the *** work inspires a deeper understanding of the collective effects of interfacial charge transfer and structural proximity on the physical properties of oxide heterostructures.

关键词： interfacial engineering oxygen octahedral coupling charge transfer oxide superlattices

Asymmetric interfaces and high-TC ferromagnetic phase in La_(0.67)Ca_(0.33)MnO_(3)/SrRuO_(3)superlattices

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Nano Research 2021年第10期14卷 3621-3628页

作者： Lili Qu Da Lan Liang Si Chao Ma Shasha Wang Liqiang Xu kexuan zhang Feng Jin Zixun zhang Enda Hua Binbin Chen Guanyin Gao Feng Chen Haifeng Du Karsten Held Lingfei Wang Wenbin Wu Hefei National Laboratory for Physical Science at the Microscale University of Science and Technology of ChinaHefei 230026China Institut fur Festkorperphysik TU Wien1040 ViennaAustria College of Materials Science and Engineering Hunan UniversityChangsha 410082China Anhui Key Laboratory of Condensed Matter Physics at the Extreme Conditions High Magnetic Field Laboratory and Hefei Science CenterChinese Academy of SciencesHefei 230031China Insititutes of Physical Science and Information Technology Anhui UniversityHefei 230601China

Interfacial magnetism in functional oxide heterostructures not only exhibits intriguing physical phenomena but also implies great potential for device *** these systems,interfacial structural and electronic reconstructions are essential for improving the stability and tunability of the magnetic *** this work,we constructed ultra-thinLa_(0.67)Ca_(0.33)MnO_(3)/SrRuO_(3)(SRO)layers into superlattices,which exhibited a robust ferromagnetic *** high Curie temperature(TC)reaches 291 K,more than 30 K higher than that of bulk *** found that the LCMO/SRO superlattices consisted of atomically-sharp and asymmetric *** a unique interface structure can trigger a sizable charge transfer as well as a ferroelectric-like polar *** two interfacial effects cooperatively stabilized the high-T_(C)ferromagnetic *** results could pave a promising approach towards effective control of interfacial magnetism and new designs of oxide-based spintronic devices.

关键词： oxide heterointerfaces asymmetric interfacial effects ferromagnetic order charge transfer

PCDH17 restricts dendritic spine morphogenesis by regulating ROCK2-dependent control of the actin cytoskeleton,modulating emotional behavior

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Zoological Research 2024年第3期45卷 535-550页

作者： Laidong Yu Fangfang Zeng Mengshu Fan kexuan zhang Jingjing Duan Yalu Tan Panlin Liao Jin Wen Chenyu Wang Meilin Wang Jialong Yuan Xinxin Pang Yan Huang Yangzhou zhang Jia-Da Li Zhuohua zhang Zhonghua Hu Hunan Key Laboratory of Molecular Precision Medicine Department of Critical Care MedicineXiangya HospitalCentral South UniversityChangshaHunan 410008China Center for Medical Genetics and Hunan Key Laboratory of Medical Genetics School of Life SciencesCentral South UniversityChangshaHunan 410008China National Clinical Research Center for Geriatric Disorders Xiangya HospitalCentral South UniversityChangshaHunan 410008China Hunan Provincial Clinical Research Center for Critical Care Medicine Xiangya HospitalCentral South UniversityChangshaHunan 410008China Hunan Key Laboratory of Animal Models for Human Diseases School of Life SciencesCentral South UniversityChangshaHunan 410008China MOE Key Lab of Rare Pediatric Diseases School of Life SciencesCentral South UniversityChangshaHunan 410008China Department of Neurosciences University of South China Medical SchoolHengyangHunan 421001China

Proper regulation of synapse formation and elimination is critical for establishing mature neuronal circuits and maintaining brain *** abnormalities,such as defects in the density and morphology of postsynaptic dendritic spines,underlie the pathology of various neuropsychiatric *** 17(PCDH17)is associated with major mood disorders,including bipolar disorder and ***,the molecular mechanisms by which PCDH17 regulates spine number,morphology,and behavior remain *** this study,we found that PCDH17 functions at postsynaptic sites,restricting the number and size of dendritic spines in excitatory *** overexpression of PCDH17 in the ventral hippocampal CA1 results in spine loss and anxiety-and depression-like behaviors in ***,PCDH17 interacts with actin-relevant proteins and regulates actin filament(F-actin)***,PCDH17 binds to ROCK2,increasing its expression and subsequently enhancing the activity of downstream targets such as LIMK1 and the phosphorylation of cofilin serine-3(Ser3).Inhibition of ROCK2 activity with belumosudil(KD025)ameliorates the defective F-actin organization and spine structure induced by PCDH17 overexpression,suggesting that ROCK2 mediates the effects of PCDH17 on F-actin content and spine ***,these findings reveal a novel mechanism by which PCDH17 regulates synapse development and behavior,providing pathological insights into the neurobiological basis of mood disorders.

关键词： Synapse development Dendritic spine Mood disorder Actin cytoskeleton Animal behavior

Association of variants in the KIF1A gene with amyotrophic lateral sclerosis

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Translational Neurodegeneration 2022年第1期11卷 235-247页

作者： Panlin Liao Yanchun Yuan Zhen Liu Xiaorong Hou Wanzhen Li Jin Wen kexuan zhang Bin Jiao Lu Shen Hong Jiang Jifeng Guo Beisha Tang Zhuohua zhang Zhonghua Hu Junling Wang Hunan Key Laboratory of Molecular Precision Medicine Department of Critical Care MedicineXiangya HospitalCentral South UniversityChangsha 410008China Department of Neurology Xiangya HospitalCentral South UniversityChangsha 410008China National Clinical Research Center for Geriatric Diseases Xiangya HospitalCentral South UniversityChangsha 410008China Key Laboratory of Hunan Province in Neurodegenerative Disorders Central South UniversityChangsha 410008China Center for Medical Genetics School of Life SciencesCentral South UniversityChangsha 410008China Engineering Research Center of Hunan Province in Cognitive Impairment Disorders Central South UniversityChangsha 410008China Hunan International Scientific and Technological Cooperation Base of Neurodegenerative and Neurogenetic Diseases Changsha 410008China Hunan Provincial Clinical Research Center for Critical Care Medicine Xiangya HospitalCentral South UniversityChangsha 410008China Hunan Key Laboratory of Animal Models for Human Diseases School of Life SciencesCentral South UniversityChangsha 410008China.

Background:Amyotrophic lateral sclerosis(ALS)is a devastating progressive neurodegenerative disease that affects neurons in the central nervous system and the spinal *** in many other neurodegenerative disorders,the genetic risk factors and pathogenesis of ALS involve dysregulation of cytoskeleton and neuronal ***,sen-sory and motor neuron diseases such as hereditary sensory and autonomic neuropathy type 2(HSAN2)and spastic paraplegia 30(SPG30)share several causative genes with ALS,as well as having common clinical ***1A encodes a kinesin 3 motor that transports presynaptic vesicle precursors(SVPs)and dense core vesicles and has been reported as a causative gene for HSAN2 and ***:Here,we analyzed whole-exome sequencing data from 941 patients with ALS to investigate the genetic association of KIF1A with ***:We identified rare damage variants(RDVs)in the KIF1A gene associated with ALS and delineated the clini-cal characteristics of ALS patients with KIF1A ***,these patients tended to exhibit sensory ***,the majority of these variants are located at the C-terminal cargo-binding region of the KIF1A *** examination revealed that the ALS-associated KIF1A variants located in the C-terminal region preferentially enhanced the binding of SVPs containing RAB3A,VAMP2,and *** of several disease-related KIF1A mutants in cultured mouse cortical neurons led to enhanced colocalization of RAB3A or VAMP2 with the KIF1A ***:Our study highlighted the importance of KIF1A motor-mediated transport in the pathogenesis of ALS,indicating KIF1A as an important player in the oligogenic scenario of ALS.

关键词： Amyotrophic lateral sclerosis KIF1A Axonal transport Presynaptic vesicle precursors

PINK1-mediated Drp1^(S616) phosphorylation modulates synaptic development and plasticity via promoting mitochondrial fission

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Signal Transduction and Targeted Therapy 2022年第5期7卷 1719-1734页

作者： Qingtao Gao Runyi Tian Hailong Han Jesse Slone Caifang Wang Xiao Ke Tongmei zhang Xiangyu Li Yuhong He Panlin Liao Fang Wang Ye Chen Shiqing Fu kexuan zhang Fangfang Zeng Yingxuan Yang Zhuo Li Jieqiong Tan Jiada Li Youming Lu Taosheng Huang Zhonghua Hu Zhuohua zhang Institute of Molecular Precision Medicine Xiangya HospitalKey Laboratory of Molecular Precision Medicine of Hunan Province and Center for Medical GeneticsHunan Key Laboratory of Medical GeneticsCentral South UniversityChangshaHunan 410008China Department of Pediatrics Jacobs School of Medicine and Biomedical SciencesUniversity at BuffaloBuffaloNew York 14203USA Department of Physiology School of Basic Medicine and Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430030China The Institute for Brain Research Collaborative Innovation Center for Brain ScienceHuazhong University of Science and TechnologyWuhanHubei 430030China Hunan Key Laboratory of Animal Models for Human Diseases School of Life SciencesCentral South UniversityChangshaHunan 410008China Department of Neurosciences University of South China Medical SchoolHengyangHunan 421001China National Clinical Research Center for Geriatric Disorders Xiangya HospitalCentral South UniversityChangshaHunan 410008China Department of Critical Care Medicine Hunan Provincial Clinical Research Center for Critical Care MedicineXiangya HospitalCentral South UniversityChangshaHunan 410008China

Dynamic change of mitochondrial morphology and distribution along neuronal branches are essential for neural circuitry formation and synaptic ***,the underlying mechanism remains *** show here that Pink1 knockout(KO)mice display defective dendritic spine maturation,reduced axonal synaptic vesicles,abnormal synaptic connection,and attenuated long-term synaptic potentiation(LTP).Drp1 activation via ^(S616) phosphorylation rescues deficits of spine maturation in Pink1 KO neurons.

关键词： plasticity activation synaptic

变乱交织促演进新陈代谢催变革——2023年世界政党政治发展述评

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当代世界 2024年第2期 62-65页

作者：张珂璇中央对外联络部世界政党研究所

2023年,世界形势错综复杂,国际秩序新旧交替,量变到质变趋势日益凸显,催动世界政党政治发生复杂深刻变化。在部分国家,传统政党面临的挑战增多,持非传统立场的政党及新兴政党趁势崛起、影响力有所扩大。一些政党内部斗争加剧,政党之间... 详细信息

2023年,世界形势错综复杂,国际秩序新旧交替,量变到质变趋势日益凸显,催动世界政党政治发生复杂深刻变化。在部分国家,传统政党面临的挑战增多,持非传统立场的政党及新兴政党趁势崛起、影响力有所扩大。一些政党内部斗争加剧,政党之间持续较量,影响社会稳定和民众福祉。以人工智能为标志的新科技革命正悄然改变政党政治的运行环境。整体来看,世界政党政治格局失序失稳、“变散乱”的一面愈发突出,同时在深度调整中面临转型发展的历史机遇。

关键词：世界政党政治新兴政党传统政党极右翼

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交流550kV SF_6高压套管的绝缘设计研究

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高压电器 2015年第2期51卷 106-111,115页

作者：张书琴张克选高延峰河南平芝高压开关有限公司河南平顶山467013

高压套管是高压开关设备中的一个至关重要的元件,其电场结构是一个典型的极不均匀电场结构,所以在设计中如何使其电场分布合理均匀就成为关键点。笔者从起晕场强及起晕电压入笔,给出了高压屏蔽环的设计思路;为了改善地电位附近场域分布... 详细信息

高压套管是高压开关设备中的一个至关重要的元件,其电场结构是一个典型的极不均匀电场结构,所以在设计中如何使其电场分布合理均匀就成为关键点。笔者从起晕场强及起晕电压入笔,给出了高压屏蔽环的设计思路;为了改善地电位附近场域分布,通过大量的电场解析,揭示了接地内置屏蔽筒的尺寸与瓷套的高度及内径间的关系;详细分析了套管在淋雨及干试状态下,由于瓷套外介质相对介电常数εr的变化所引起场域分布的变化情况及不同试验状态下的关注部位。最后给出了550 kV套管绝缘设计时,空气中各部位场强许可值的确定方法及其数值,为套管的研发提供了具有参考价值的经验数据。

关键词：高压套管高压屏蔽环内置屏蔽筒起晕场强起晕电压场域分布场强许可值

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关于加强城市社区建设的思考

学习论坛 2008年第9期24卷 70-72页

作者：张克轩中共洛阳市湟河回族区委河南洛阳471003

构建社会主义和谐社会是贯穿中国特色社会主义事业全过程的长期历史任务,实现建设和谐社会的目标也是广大群众的共同追求。社区作为社会组织形态的基本单元,在构建社会主义和谐社会中发挥着十分重要的基础作用,因此,要充分认识加强社区... 详细信息

构建社会主义和谐社会是贯穿中国特色社会主义事业全过程的长期历史任务,实现建设和谐社会的目标也是广大群众的共同追求。社区作为社会组织形态的基本单元,在构建社会主义和谐社会中发挥着十分重要的基础作用,因此,要充分认识加强社区建设的重大意义,明确社区建设的工作重点,掌握社区工作的方法。

关键词：社区建设重点方法

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GIS现场验收及运行中若干问题的研究

高压电器 2017年第5期53卷 193-199页

作者：张书琴张克选高延峰陈瑞旭河南平芝高压开关有限公司河南平顶山467013

由于GIS的一系列优点,使其在各个电压等级中得到了广泛的应用。文中首先针对超高压GIS站现场冲击绝缘试验中的试验波形进行了模拟计算、图解分析,说明了现场冲击试验的波形与GIS的管母线长度密切相关,冲击试验前应对试验区域进行模拟计... 详细信息

由于GIS的一系列优点,使其在各个电压等级中得到了广泛的应用。文中首先针对超高压GIS站现场冲击绝缘试验中的试验波形进行了模拟计算、图解分析,说明了现场冲击试验的波形与GIS的管母线长度密切相关,冲击试验前应对试验区域进行模拟计算、同时根据模拟计算结果选择合适的冲击试验波类型;其次,对现场充电试验中出现的电磁式电压互感器(PT)的铁磁谐振现象进行了分析,认为断路器断口间加装的均压电容、PT所连母线过短以及断路器切断PT所连母线时的相位角是引起PT铁心磁饱和、致使PT铁磁谐振的主要原因;再次,对GIS运行中相同位置三相避雷器(LA)的动作次数不同进行了分析,认为主要是由于系统中A、B、C三相电源相位角相差120°,从而使断路器动作瞬间在三相上所产生的操作过电压幅值不同、由此流过各相LA的冲击电流值不同所致;最后,对绝缘子沿面小溪状的爬电痕迹进行了解读,认为起因于断路器断口间加装的并联电容或/和邻近送电线路对空载线路的感应,使受电弧分解物侵蚀的绝缘子表面持续流过数值不高、但时间较长的感应电流所致。通过对GIS现场验收及运行中这些问题的研究,为GIS的安全运行提供了具有参考价值的理论基础及实践依据。

关键词：冲击绝缘试验充电试验铁磁谐振操作过电压断口电容感应电流爬电痕迹