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TENSILE AND CREEP PROPERTIES OF Fe_3Al-BASED ALLOY WITH DIFFERENT GRAIN SIZES

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中国有色金属学会会刊：英文版 1997年第4期7卷 58-62页

作者： zhang Zhonghua, sun Yangshan department of Materials science and engineering, southeast university. nanjing 210096.State Key Laboratory of Solid State Microstructures of nanjing university. nanjing 210008

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关键词： Fe 3Al mechanical properties microstructure

Single and Multiple Dynamic Impacts Behaviour of Ultra-high Performance Cementitious Composite

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Journal of Wuhan university.of Technology(Materials science) 2011年第6期26卷 1227-1234页

作者：张文华张云升 department of Materials science and engineering Jiangsu Key Laboratory of Construction MaterialsSoutheast University

Single and multiple dynamic impacts tests were conducted on ultra-high performance cementitious composite （UHPCC） with various volume fractions of steel fibers （0, 1%, 2%, 3%, 4%） by using the split hopkinson pressure bar （SHPB）. Besides, the ultrasonic velocity method was used to test the damage on specimens caused by dynamic impacts. For single dynamic impact, the data suggest that UHPCC obviously presents dynamic strength enhancement. With increasing of strain rate, the peak stress and peak strain increase rapidly. For multiple dynamic impacts, the results show that addition of steel fibers can obviously enhance the properties of UHPCC to resist the repeated dynamic impacts. Firstly, the number of impacts sharply increases with the increasing of volume fraction of steel fibers. Secondly, the energy absorption ability linearly increases with addition of steel fibers. Thirdly, the steel fibers can prevent the disruption phenomenon and maintain the integrity of specimen.

关键词： UHPCC SHPB dynamic behavior multiple impacts

Meiotic transcriptional reprogramming mediated by cell-cell communications in humans and mice revealed by scATACseq and scRNA-seq

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Zoological Research 2024年第3期45卷 601-616页

作者： Hai-Quan Wang Xiao-Long Wu jing zhang Si-Ting Wang Yong-Juan Sang Kang Li Chao-Fan Yang Fei sun Chao-Jun Li State Key Laboratory of Reproductive Medicine and Offspring Health Center for Global HealthSchool of Public HealthNanjing Medical UniversityNanjingJiangsu 211166China Medical School Nanjing UniversityNanjingJiangsu 210093China Zhejiang university.School of Medicine HangzhouZhejiang 310016China department of Urology and Andrology Sir Run Run Shaw HospitalZhejiang University School of MedicineHangzhouZhejiang 310000China Model Animal Research Center of Medical School Nanjing UniversityNanjingNanjingJiangsu 210093China Liangzhu Laboratory Zhejiang UniversityHangzhouZhejiang 311121China

Meiosis is a highly complex process significantly influenced by transcriptional ***,studies on the mechanisms that govern transcriptomic changes during meiosis,especially in prophase I,are ***,we performed single-cell ATAC-seq of human testis tissues and observed reprogramming during the transition from zygotene to pachytene *** event,conserved in mice,involved the deactivation of genes associated with meiosis after reprogramming and the activation of those related to spermatogenesis before their functional ***,we identified 282 transcriptional regulators(TRs)that underwent activation or deactivation subsequent to this *** suggested that physical contact signals from Sertoli cells may regulate these TRs in spermatocytes,while secreted ENHO signals may alter metabolic patterns in these *** results further indicated that defective transcriptional reprogramming may be associated with non-obstructive azoospermia(NOA).This study revealed the importance of both physical contact and secreted signals between Sertoli cells and germ cells in meiotic progression.

关键词： Single-cell RNA-seq Single-cell ATAC-seq Spermatogenesis Meiosis Transcriptional reprogramming Cell-cell communication

STING signaling in islet macrophages impairs insulin secretion in obesity

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science china(Life sciences) 2024年第2期67卷 345-359页

作者： Ze Hong Saihua Chen jing sun Dan Cheng Hanli Guo Jiahao Mei Xiang zhang Munire Maimaiti Haiping Hao Peng Cao Haiyang Hu Chen Wang School of Pharmacy Nanjing University of Chinese MedicineNanjing 210023China State Key Laboratory of Natural Medicines Department of Life Science and TechnologyChina Pharmaceutical UniversityNanjing 211198China School of Life sciences Westlake UniversityHangzhou 310012China

The innate immune regulator stimulator of interferon genes(STING)mediates self-DNA sensing and leads to the induction of type I interferons and inflammatory cytokines,which promotes the progression of various inflammatory and autoimmune *** immune system plays a critical role in regulating obesity-induced islet dysfunction,whereas the potential effect of STING signaling is not fully ***,we demonstrate that STING is mainly expressed and activated in islet macrophages upon high-fat diet(HFD)***^(-/-)alleviates HFD-induced islet inflammation by inhibiting the expression of pro-inflammatory cytokines and the infiltration of ***,palmitic acid incubation promotes mitochondrial DNA leakage into the cytosol and subsequently activates STING pathway in ***,STING activation in macrophages impairs glucose-stimulated insulin secretion by mediating the engulfment ofβcell insulin secretory *** inhibiting STING activation enhances insulin secretion to control ***,our results reveal a regulatory mechanism in controlling the islet inflammation and insulin secretion in dietinduced obesity and suggest that selective blocking of the STING activation may be a promising strategy for treating type 2 diabetes.

关键词： STING obesity type 2 diabetes insulin macrophages islet

Comprehensive optimization of piezoelectric coefficient and depolarization temperature in Mn-doped Bi_(0.5)Na_(0.5)TiO_(3)-Bi_(0.5)K_(0.5)TiO_(3)-BaTiO_(3)lead-free piezoceramics

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Journal of Materials science & Technology 2024年第5期172卷 255-263页

作者： Huashan Zheng Enwei sun Huajie Luo Xiaoyu zhang Yixiao Yang Bin Yang Rui zhang Shantao zhang Wenwu Cao Condensed Matter science and Technology Institute School of Instrumentation Science and EngineeringHarbin Institute of TechnologyHarbin150080China Advanced Innovation Center for Materials Genome engineering University of Science and Technology BeijingBeijing100083China National Laboratory of Solid State Microstructures Department of Materials Science and EngineeringCollege of Engineering and Applied Science&Collaborative Innovation Center of Advanced MicrostructuresNanjing UniversityNanjing210093China department of Mathematics and Materials Research Institute The Pennsylvania State UniversityUniversity ParkPennsylvania16802United States of America

Lead-free Bi_(_(0.5))Na_(_(0.5))TiO_(3)(BNT)piezoelectric ceramics have the advantages of large coercive fields and high Curie *** the improvement of piezoelectric coefficient(d 33)is usually accompanied by a huge sacrifice of depolarization temperature(T d).In this work,a well-balanced performance of d 33 and T d is achieved in MnO_(2)-doped 0.79(Bi_(_(0.5))Na_(_(0.5))TiO_(3))-0.14(Bi_(0.5)K_(0.5)TiO_(3))-0.07BaTiO_(3)ternary *** in-corporation of 0.25 mol%MnO_(2)enhances the d 33 by more than 40%,while T d remains almost unchanged(i.e.,d 33=181 pC/N,T d=184℃).X-ray diffraction(XRD)shows that an appropriate fraction of the small axis-ratio ferroelectric phase(pseudo-cubic,P c)coexists with the long-range ferroelectric phase(tetrag-onal,T)under this MnO_(2)*** force microscopy(PFM)has revealed a special domain configuration,namely large striped and layered macro domains embedded with small *** study provides a distinctive avenue to design BNT-based piezoelectric ceramics with high piezoelectric performance and temperature stability.

关键词： BNT-BKT-BT ceramics Mn doping Piezoelectric Depolarization temperature Phase structure

MICROPLASTIC DEFORMATION BEHAVIOUR OF STEEL 1Cr18Ni9Ti

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Acta Metallurgica Sinica(English Letters) 1990年第9期3卷 191-195页

作者： ZHU Ping zhang Lining southeast university.nanjing,china zhang Lining Professor,department of Materials science and engineering.southeast university.nanjing 210018,china

The regularity and mechanism of the microplastic deformation of steel 1Cr18Ni9Ti both solu- tion-treated and prestrained were *** the different stages of microplastic deformation,stage 1 corresponds to the dislocation moving and exhausting in the regions near grain *** 2,being the early stage of macroplastic deformation,corresponds to the extensive operation and generation of dislocations in the interior of grains and also dislo- cation emission from the grain *** regularities of the effect of prestrain on macro-and micro-yield strength are different.

关键词： microplasticity 1Cr18Ni9Ti dislcoation

Skyway:Accelerate Graph Applications with a Dual-Path Architecture and Fine-Grained Data Management

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Journal of computer science & Technology 2024年第4期39卷 871-894页

作者： Mo Zou Ming-Zhe zhang Ru-Jia Wang Xian-He sun Xiao-Chun Ye Dong-Rui Fan zhi-Min Tang Institute of Computing Technology Chinese Academy of SciencesBeijing 100190China university.of Chinese Academy of sciences Beijing 100049China Institute of Information engineering Chinese Academy of SciencesBeijing 100045China department of computer science Illinois Institute of TechnologyChicagoIL 60616U.S.A.

Graph processing is a vital component of many AI and big data ***,due to its poor locality and complex data access patterns,graph processing is also a known performance killer of AI and big data *** this work,we propose to enhance graph processing applications by leveraging fine-grained memory access patterns with a dual-path architecture on top of existing software-based graph *** first identify that memory accesses to the offset,edge,and state array have distinct locality and impact on *** then introduce the Skyway architecture,which consists of two primary components:1)a dedicated direct data path between the core and memory to transfer state array elements efficiently,and 2)a data-type aware fine-grained memory-side row buffer hardware for both the newly designed direct data path and the regular memory hierarchy data *** proposed Skyway architecture is able to improve the overall performance by reducing the memory access interference and improving data access efficiency with a minimal *** evaluate Skyway on a set of diverse algorithms using large real-world *** a simulated fourcore system,Skyway improves the performance by 23%on average over the best-performing graph-specialized hardware optimizations.

关键词： graph application computer architecture memory hierarchy

Privacy-Preserving Multi-Keyword Fuzzy Adjacency Search Strategy for Encrypted Graph in Cloud Environment

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computers, Materials & Continua 2024年第3期78卷 3177-3194页

作者： Bin Wu Xianyi Chen Jinzhou Huang Caicai zhang jing Wang jing Yu zhiqiang Zhao Zhuolin Mei School of computer and Big Data science Jiujiang UniversityJiujiang332005China Jiujiang Key Laboratory of Network and Information Security Jiujiang332005China School of computer and Software Nanjing University of Information Science&TechnologyNanjing210044China School of computer engineering Hubei University of Arts and ScienceXiangyang441053China School of Modern Information Technology Zhejiang Institute of Mechanical and Electrical EngineeringHangzhou310053China Information Center Jiangxi Changjiang Chemical Co.Ltd.Jiujiang332005China School of Mathematics and computer science Ningxia Normal UniversityGuyuan756099China

In a cloud environment,outsourced graph data is widely used in companies,enterprises,medical institutions,and so *** owners and users can save costs and improve efficiency by storing large amounts of graph data on cloud *** on cloud platforms usually have some subjective or objective attacks,which make the outsourced graph data in an insecure *** issue of privacy data protection has become an important obstacle to data sharing and *** to query outsourcing graph data safely and effectively has become the focus of *** query is a basic and frequently used operation in graph,and it will effectively promote the query range and query ability if multi-keyword fuzzy search can be supported at the same *** work proposes to protect the privacy information of outsourcing graph data by encryption,mainly studies the problem of multi-keyword fuzzy adjacency query,and puts forward a *** our scheme,we use the Bloom filter and encryption mechanism to build a secure index and query token,and adjacency queries are implemented through indexes and query tokens on the cloud *** proposed scheme is proved by formal analysis,and the performance and effectiveness of the scheme are illustrated by experimental *** research results of this work will provide solid theoretical and technical support for the further popularization and application of encrypted graph data processing technology.

关键词： Privacy-preserving adjacency query multi-keyword fuzzy search encrypted graph

An unconstrained optimization method using nonmonotone second order Goldstein's line search

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science china Mathematics 2007年第10期50卷 1389-1400页

作者： Wen-yu sun~(1+) Qun-yan ZHOU~(1,2) ~1 School of Mathematics and computer science,nanjing Normal university.nanjing 210097,china ~2 department of Basic Courses,jiangsu.Teachers university.of Technology,Changzhou 213001,china 1. School of Mathematics and computer science Nanjing Normal University Nanjing 210097 China 2. department of Basic Courses Jiangsu Teachers University of Technology Changzhou 213001 China

In this paper, an unconstrained optimization method using the nonmonotone second order Goldstein's line search is proposed. By using the negative curvature information from the Hessian,the sequence generated is shown to converge to a stationary point with the second order optimality conditions. Numerical tests on a set of standard test problems confirm the efficiency of our new method.

关键词： nonmonotone method, direction of negative curvature, line search, descent pair,unconstrained optimization