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Wuhan university.Journal of Natural sciences 2004年第5期9卷 585-589页

作者： zhang jing 1,2 , sun zhi-hui 1 1.department of computer science and engineering, southeast university. nanjing 210096. jiangsu. china 2.department of Electricity and Information engineering, jiangsu.university. Zhenjiang 212001, jiangsu. china department of computer science and engineering Southeast University. Nanjing 210096 Jiangsu China

Outlier detection has very important applied value in data mining literature. Different outlier detection algorithms based on distinct theories have different definitions and mining processes. The three-dimensional space graph for constructing applied algorithms and an improved GridOf algorithm were proposed in terms of analyzing the existing outlier detection algorithms from criterion and theory. Key words outlier - detection - three-dimensional space graph - data mining CLC number TP 311. 13 - TP 391 Foundation item: Supported by the National Natural science Foundation of china (70371015)Biography: zhang jing (1975-), female, Ph. D, lecturer, research direction: data mining and knowledge discovery.

关键词： outlier detection three-dimensional space graph data mining

TENSILE　PROPERTIES　AND　CREEP　RESISTANCE　OF　Fe_3Al－BASED　ALLOYS　CONTAINING　NIOBIUM

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Acta Metallurgica Sinica(English Letters) 1996年第2期9卷 135-139页

作者： zhang Zhonghua sun Yangshan GUO Jun(department of Materials science and engineering, southeast university. nanjing 210096.china) southeast Univ Nanjing China

Small amount(0.5-0.8at.%) of niobium addition to the multicomponent alloys based on Fe3Al(Fe-28Al-5Cr-0.5Mo-0.05Zr-0.05B-0.1Ce) results in the microstructural refinement and the increase in the yield strength at temperatures up to 600℃,but is not beneficial to room temperature *** of microanalysis indicate that the addition of niobium causes the formation of precipitates with complex compositions which strengthen both matrix and grain boundaries and enhance the creep resistance of the alloys.

关键词： Fe_3Al,Nb,tensile property creep

Feasible Synthesis of N,O-Bidentate Difluoroboron Chromophores through Direct Functionalization of Quinoxalin-2(1H)-ones with Ketones in One Shot

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Chinese Journal of Chemistry 2024年第13期42卷 1481-1486页

作者： Shuaichen zhang jing zhang Xiang Ling Yifan Zhao Yue Ma Peng sun State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs Artemisinin Research Center and Institute of Chinese Materia MedicaChina Academy of Chinese Medical SciencesBeijing 100700China department of Pharmaceutics School of PharmacyChina Pharmaceutical UniversityState Key Laboratory of Natural MedicinesNanjingJiangsu 210009China

Organic difluoroboron complexes are a kind of potential platforms for a wide range of applications owing to their excellent photophysical ***,we have explored a simple and direct synthesis methodology for a library of N,O-bidentate difluoroboron complexes from quinoxalin-2(1H)-ones and ketones in one *** photophysical properties of the generated complexes were evaluated and the application potential of these compounds on subcellular imaging was also explored.

关键词： N,O-Bidentate difluoroboron Chromophores Quinoxalin-2(1H)-ones Ketones/Green chemistry Synthetic method C-CcouplingI Boron

The clinical antiprotozoal drug nitazoxanide and its metabolite tizoxanide extend Caenorhabditis elegans lifespan and healthspan

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Acta Pharmaceutica Sinica B 2024年第7期14卷 3266-3280页

作者： Wenfeng Li Shuming Chen jing Lang jing Luo Jiahui Chen Liping zhang zhijie sun Deli Dong department of Pharmacology China Pharmaceutical UniversityNanjing 210009China

The drugs extending healthspan in clinic have always been *** is an FDA-approved clinical antiprotozoal *** is rapidly metabolized to tizoxanide after absorption in *** previous studies find that nitazoxanide and its metabolite tizoxanide induce mild mitochondrial uncoupling and activate cellular AMPK,oral nitazoxanide protects against experimental hyperlipidemia,hepatic steatosis,and ***,we demonstrate that both nitazoxanide and tizoxanide extend the lifespan and healthspan of Caenorhabditis elegans through Akt/AMPK/sir 2.1/daf16 ***,both nitazoxanide and tizoxanide improve high glucose-induced shortening of *** *** has been a clinical drug with a good safety profile,we suggest that it is a novel anti-aging drug.

关键词： Nitazoxanide Tizoxanide C.elegans Healthspan Lifespan AMPK Akt Mitochondrial uncoupling

Viral-mediated gene therapy in pediatric neurological disorders

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World Journal of Pediatrics 2024年第6期20卷 533-555页

作者： jing Peng Wei-Wei Zou Xiao-Lei Wang zhi-Guo zhang Ran Huo Li Yang department of Pediatrics Clinical Research Center for Chidren Neurodevelopmental disablities of Hunan ProvinceXiangya HospitalCentral South UniversityChangsha 410008China Reproductive Medicine Center Department of Obstetrics and Gynecologythe First Affiliated Hospital of Anhui Medical UniversityHefeiChina State Key Laboratory of Reproductive Medicine Nanjing Medical UniversityNanjingChina

Background Due to the broad application of next-generation sequencing,the molecular diagnosis of genetic disorders in pediatric neurology is no longer an unachievable ***,treatments for neurological genetic disorders in children remain primarily *** the other hand,with the continuous evolution of therapeutic viral vectors,gene therapy is becoming a clinical *** this perspective,we wrote this review to illustrate the current state regarding viral-mediated gene therapy in childhood neurological *** sources We searched databases,including PubMed and Google Scholar,using the keywords"adenovirus vector,""lentivirus vector,"and"AAv"for gene therapy,and"immunoreaction induced by gene therapy vectors,""administration routes of gene therapy vectors,"and"gene therapy"with"NCL,""SMA,""DMD,""congenital myopathy,""MPS""leukodystrophy,"or"pediatric metabolic disorders".We also screened the database of *** using the keywords"gene therapy for children"and then filtered the results with the ones aimed at neurological *** time range of the search procedure was from the inception of the databases to the *** We presented the characteristics of commonly used viral vectors for gene therapy for pediatric neurological disorders and summarized their merits and drawbacks,the administration routes of each vector,the research progress,and the clinical application status of viral-mediated gene therapy on pediatric neurological *** Viral-mediated gene therapy is on the brink of broad clinical ***-mediated gene therapy will dramatically change the treatment pattern of childhood neurological disorders,and many children with incurable diseases will meet the dawn of a ***,the vectors must be optimized for better safety and efficacy.

关键词： Gene therapy Neurological disorders Pediatrics Viral vectors

Web Application Comprehension Based on Dependence Analysis

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Wuhan university.Journal of Natural sciences 2004年第5期9卷 731-734页

作者： WU Jun-hua 1,2 , XU Bao-wen 1 , JIANG Ji-xiang 1 1.department of computer science and engineering, southeast university. nanjing 210096. jiangsu. china 2.College of computer science and engineering, nanjing university.of Technology, nanjing 210009, jiangsu., china southeast university Department of Computer Science and Engineering Nanjing Jiangsu China (GRID:grid.263826.b) (ISNI:***) Najing university.of Technology College of Computer Science and Engineering Nanjing Jiangsu China (GRID:grid.41156.37) (ISNI:***) southeast university Department of Computer Science and Engineering Nanjing Jiangsu China (GRID:grid.263826.b) (ISNI:***)

Many research indicate a lot of money and time are spent on maintaining and modifying program delivered. So the policies to support program comprehension are very important. Program comprehension is a crucial and difficult task. Insufficient design, illogical code structure, short documents will enhance the comprehensive difficulty. Developing Web application is usually a process with quick implementation and delivery. In addition, generally a Web application is coded by combining mark language statements with some embedded applets. Such programming mode affects comprehension of Web applications disadvantageously. This paper proposes a method to improving understanding Web by dependence analysis and slice technology. Key words Web application comprehension - program dependence - hyper graph - pogram slicing CLC number TP 311 Foundation item: Supported in part by the Young Scientist’s Fund of NSFC (60373066, 60303024). National Grand Fundamental Research 973 Program of china (2002CB312000) and National Research Foundation for the Doctoral Program of Higher Education of chinaBiography: WU Jun-hua (1965-), female, Ph. D. research direction: software engineering.

关键词： Web application comprehension program dependence hyper graph pogram slicing

TENSILE STRENGTH AND CREEP RESISTANCE OF Mg-9Al-1Zn BASED ALLOYS WITH CALCIUM ADDITION

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Acta Metallurgica Sinica(English Letters) 2001年第5期14卷 330-334页

作者： Y.S. sun, W.M. zhang and X.G. Mm department of Materials science and engineering, southeast university. nanjing 210096. china Dept. of Mat. Sci. and Eng. Southeast Univ. Nanjing 210096 China

Small amount of calcium addition to the Mg-9Al-0.8Zn-0.2Mn (AZ91) alloy resulted in obvious influence on mechanical properties. The yield strength of the alloys increased with the increase of Ca addition and the maximum strength was obtained from the alloy containing 0.15% of Ca. The creep resistance at the temperatures between 150-220°C was also significantly increased with Ca addition. The creep rate (at 200°C, 50 MPa) of the alloy with 0.15% Ca addition was one order of magnitude lower than that of the base alloy (AZ91). Microstructural observations revealed that the addition of calcium refined the microstructure and enhanced the thermal stability of the β precipitates, which accounted for the improvement of creep resistance at high temperatures.

关键词： Additives Aluminum alloys Calcium Creep Tensile strength

A Feedback-Based Web Search Engine

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Wuhan university.Journal of Natural sciences 2004年第5期9卷 561-568页

作者： zhang Wei-feng 1,2,3 , XU Bao-wen 2,3,4 , ZHOU Xiao-yu 2,3,4 1. department of computer science and engineering, nanjing university.of Posts and Telecommunications, nanjing 210003, jiangsu. china 2. department of computer science and engineering, southeast university. nanjing 210096. jiangsu. china 3. jiangsu.Institute of Software Quality, nanjing 210096.jiangsu. china 4. The State Key Laboratory of Software engineering, Wuhan university. Wuhan 430072, Hubei, china department of computer science and engineering Nanjing University of Posts and Telecommunications . Nanjing 210003 Jiangsu China

Web search engines are very useful information service tools in the Internet. The current web search engines produce search results relating to the search terms and the actual information collected by them. Since the selections of the search results cannot affect the future ones, they may not cover most people’s interests. In this paper, feedback information produced by the user’s accessing lists will be represented by the rough set and can reconstruct the query string and influence the search results. And thus the search engines can provide self-adaptability. Key words WWW - search engine - query reconstruction - feedback CLC number TP 311. 135.4 Foundation item: Supported by the National Natural science Fundation of china (60373066). National Grand Fundamental Research 973 Program of china (2002CB31200). Opening Foundation of State Key Laboratory of Software engineering in Wuhan university. Opening Foundation of jiangsu.Key Laboratory of computer Information Processing Technology in Soochow university.Biography: zhang Wei-feng (1975-), male, Ph.D. research direction: artificial intelligence, search engine, data mining, network language.

关键词： WWW search engine query reconstruction feedback

Heuristic for no-wait flow shops with makespan minimization based on total idle-time increments

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science in china(Series F) 2008年第7期51卷 896-909页

作者： LI XiaoPing1,2 & WU Cheng3 1 School of computer science & engineering, southeast university. nanjing 210096. china 2 Key Laboratory of computer Network and Information Integration (southeast university., Ministry of Education, nanjing 210096. china 3 department of Automation, Tsinghua university. Beijing 100084, china 1. School of computer science & engineering Southeast University Nanjing 210096 China 2. Key Laboratory of computer Network and Information Integration (southeast university. Ministry of Education Nanjing 210096 China 3. department of Automation Tsinghua University Beijing 100084 China

No-wait flow shops with makespan minimization are classified as NP-hard. In this paper, the optimization objective is equivalently transformed to total idle-time minimization. The independence relationship between tasks is analyzed, and objective increment properties are established for the fundamental operators of the heuristics. The quality of the new schedules generated during a heuristic is judged only by objective increments and not by the traditional method, which computes and compares the objective of a whole schedule. Based on objective increments, the time complexity of the heuristic can be decreased by one order. A seed phase is presented to generate an initial solution according to the transformed objective. Construction and improvement phases are introduced by experimental analysis. The FCH （fast composite heuristic） is proposed and compared with the most effective algorithms currently available for the considered problem. Experimental results show that the effectiveness of the FCH is similar to that of the best methods but requires far less computation time. The FCH can also be efficient in real time scheduling and rescheduling for no-wait flow shops.

关键词： no-wait flow shops heuristic makespan Tabu search