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Knockdown of ATRX enhances radiosensitivity in glioblastoma

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中华神经外科杂志(英文) 2024年第3期10卷 1-10页

作者： Zhao Yue Chen Yifei Liu Ruoyu Liu Minghang You Na Zhao Kai zhang jiashu Xu Bainan Medical School of Chinese PLA Beijing China Department of Emergency Medicine Hainan Hospital of Chinese PLA General Hospital Sanya Hainan China Department of Neurosurgery The First Medical Center Chinese PLA General Hospital Beijing China Center of Cognition and Brain Science Beijing Institute of Basic Medical Sciences Beijing China

Background Glioblastoma are highly malignant type of primary brain tumors. Treatment for glioblastoma multiforme (GBM) generally involves surgery combined with chemotherapy and radiotherapy. However, the development of tumoral chemo- and radioresistance induces complexities in clinical practice. Multiple signaling pathways are known to be involved in radiation-induced cell survival. However, the role of alpha-thalassemia X-linked mutant retardation syndrome (ATRX), a chromatin remodeling protein, in GBM radioresistance remains *** In the present study, the ATRX mutation rate in patients with glioma was obtained from The Cancer Genome Atlas, while its expression analyzed using bioinformatics. Datasets were also obtained from the Gene Expression Omnibus, and ATRX expression levels following irradiation of GBM were determined. The effects of ATRX on radiosensitivity were investigated using a knockdown *** The present study demonstrated that the ATRX mutation rate in patients with GBM was significantly lower than that in patients with low-grade glioma, and that patients harboring an ATRX mutation exhibited a prolonged survival, compared with to those harboring the wild-type gene. Single-cell RNA sequencing demonstrated that ATRX counts increased 2 days after irradiation, with ATRX expression levels also increasing in U-251MG radioresistant cells. Moreover, the results of in vitro irradiation assays revealed that ATRX expression was increased in U-251MG cells, while ATRX knockdown was associated with increased levels of *** High ATRX expression levels in primary GBM may contribute to high levels of radioresistance. Thus ATRX is a potential target for overcoming the radioresistance in GBM.

关键词： Glioblastoma ATRX Radiosensitivity Knockdown

基于时频Grad-CAM的调制识别网络可解释分析

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西南交通大学学报 2024年第5期59卷 1215-1224页

作者：梁先明倪帆陈文洁张家树中国电子科技集团公司第十研究所四川成都610036 西南交通大学信息科学与技术学院四川成都610031 西南交通大学计算机与人工智能学院四川成都610031

针对时频深度学习调制识别方法存在可解释性差的问题,提出一种基于时频梯度加权类激活映射(GradCAM)的调制识别网络可解释框架.该框架通过时频Grad-CAM可视化深度模型中隐含层的关键特征,从视觉上解释网络隐含层提取的时频深度特征对于... 详细信息

针对时频深度学习调制识别方法存在可解释性差的问题,提出一种基于时频梯度加权类激活映射(GradCAM)的调制识别网络可解释框架.该框架通过时频Grad-CAM可视化深度模型中隐含层的关键特征,从视觉上解释网络隐含层提取的时频深度特征对于正确与错误识别中的作用,揭示低信噪比环境下网络性能下降的内在机理,并通过量化和排序网络中每层不同卷积核的贡献值来判断网络的冗余程度.仿真实验结果验证了基于时频Grad-CAM的调制识别网络可解释性框架的有效性;可解释分析结果表明,在低信噪比环境下,网络特征提取区域有大量噪声存在,且本文所测试的调制识别网络冗余程度较为严重.

关键词：可解释深度学习梯度类加权激活映射调制识别时频分析

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芳烃装置运行优化与节能分析

江西化工 2024年第3期40卷 98-104页

作者：汪晓雯张加书中国石油化工股份有限公司九江分公司江西九江332000

芳烃是重要的基础化工原料,而发展芳烃是炼化产业逐步从“燃料型”向“燃料-化工型”和“化工型”转型的重要途径。芳烃装置具有流程长、工艺复杂、运行能耗高的特点,节能降耗有助于提升芳烃装置的竞争力。通过对芳烃联合装置运行能耗... 详细信息

芳烃是重要的基础化工原料,而发展芳烃是炼化产业逐步从“燃料型”向“燃料-化工型”和“化工型”转型的重要途径。芳烃装置具有流程长、工艺复杂、运行能耗高的特点,节能降耗有助于提升芳烃装置的竞争力。通过对芳烃联合装置运行能耗进行分析,本研究梳理了装置的主要损耗,如燃料气、电和蒸汽等,并针对性地提出平衡蒸汽、优化分馏塔操作、提升加热炉效率和优化装置负荷,以及采用先进芳烃型催化剂等技术方案和措施,以期进一步降低装置运行能耗,达到行业领先水平。

关键词：芳烃联合装置加热炉对二甲苯节能

A novel strong tracking finite-difference extended Kalman filter for nonlinear eye tracking

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Science in China(Series F) 2009年第4期52卷 688-694页

作者： zhang ZuTao zhang jiashu School of Mechanical Engineering Southwest Jiaotong University Chengdu 610031 China Sichuan Key Lab of Signal and Information Processing Southwest Jiaotong University Chengdu 610031 China

Non-intrusive methods for eye tracking are important for many applications of vision-based human computer interaction. However, due to the high nonlinearity of eye motion, how to ensure the robust- ness of external interference and accuracy of eye tracking poses the primary obstacle to the integration of eye movements into today＇s interfaces. In this paper, we present a strong tracking finite-difference extended Kalman filter algorithm, aiming to overcome the difficulty in modeling nonlinear eye tracking. In filtering calculation, strong tracking factor is introduced to modify a priori covariance matrix and improve the accuracy of the filter. The filter uses finite-difference method to calculate partial derivatives of nonlinear functions for eye tracking. The latest experimental results show the validity of our method for eye tracking under realistic conditions.

关键词： strong tracking finite-difference extended Kalman filter (STFDEKF) eye tracking extended Kalman filter (EKF) suboptimal fadingfactor

A strong tracking nonlinear robust filter for eye tracking

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控制理论与应用（英文版） 2010年第4期8卷 503-508页

作者： Zutao zhang jiashu zhang School of Mechanical Engineering Southwest Jiaotong University Chengdu Sichuan 610031 China Sichuan Key Lab of Signal and Information Processing Southwest Jiaotong University Chengdu Sichuan 610031 China

Non-intrusive methods for eye tracking are important for many applications of vision-based human computer ***,due to the high nonlinearity of eye motion,how to ensure the robustness of external interference and accuracy of eye tracking pose the primary obstacle to the integration of eye movements into today＇s *** this paper,we present a strong tracking unscented Kalman filter （ST-UKF） algorithm,aiming to overcome the difficulty in nonlinear eye *** the proposed ST-UKF,the Suboptimal fading factor of strong tracking filtering is introduced to improve robustness and accuracy of eye *** with the related Kalman filter for eye tracking,the proposed ST-UKF has potential advantages in robustness and tracking *** last experimental results show the validity of our method for eye tracking under realistic conditions.

关键词： Eye tracking Strong tracking unscented Kalman filter (ST-UKF) Unscented Kalman filter (UKF) Strong tracking filtering (STF)

竖向增层基坑开挖对既有车站结构变形影响规律

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城市轨道交通研究 2024年第7期27卷 169-174,180页

作者：张志伟尤强张嘉树许明杨王海涛中铁十四局集团隧道工程有限公司济南250002 大连交通大学土木工程学院大连116028

[目的]近距离基坑开挖的施工扰动会导致既有运营车站产生较大的变形,进而影响列车正常运行,因此需要研究竖向增层情况下,基坑开挖对下方既有车站的结构变形影响规律。[方法]以北京地铁6号线苹果园站三层段基坑工程为例,采用Midas GTS N... 详细信息

[目的]近距离基坑开挖的施工扰动会导致既有运营车站产生较大的变形,进而影响列车正常运行,因此需要研究竖向增层情况下,基坑开挖对下方既有车站的结构变形影响规律。[方法]以北京地铁6号线苹果园站三层段基坑工程为例,采用Midas GTS NX有限元软件建立基坑模型,分析竖向增层深基坑开挖引起的既有车站结构变形规律,并将模拟结果与现场监测结果进行对比。[结果及结论]随着基坑开挖的进程,既有车站结构的竖向变形不断增加,顶板变形曲线呈正态分布形式。车站顶板中跨变形值>边跨变形值,车站顶端竖向变形值>底端竖向变形值。当所取车站截面距基坑大于9.7 m(即0.81倍基坑开挖深度)时,边跨、中跨顶板的差异变形消失。对比数值模拟数据与实际监测结果可知,数值模拟分析所得的既有车站变形规律与实际监测结果一致,且最大变形量均小于控制值10.0 mm。

关键词：地铁基坑开挖既有车站

Remote Three-Factor Authentication Protocol with Strong Robustness for Multi-Server Environment

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China Communications 2017年第6期14卷 126-136页

作者： Min zhang jiashu zhang Wenrong Tan Sichuan Province Key Lab of Signal and Information Processing Southwest JiaoTong University Sichuan 610031 China School of Foreign Languages Southwest Minzu University Sichuan 610041 China School of Computer Science and Technology Southwest Minzu University Sichuan 610041 China

If a user wants to acquire different network services from various application servers in a traditional single server environment,the user must register these servers separately and remember different usernames and passwords for different *** solve these problems,a lot of authentication schemes for multi-server environment have been ***,Odelu and Das et *** a secure multi-server authentication protocol based on smart card,biometric and elliptic curve cryptography(ECC) .We firstly analyze Odelu et al.'s scheme and find some flaws as follows:1) the scheme may suffer Denial of Service(Dos) attack and insider attack;2) The scheme doesn't have strong robustness because improper work of the register center(RC) may lead to the collapse of the whole system;3) There are some design flaws in this *** example,the user cannot choose his/her identity randomly and the register center needs to maintain a data *** order to solve these problems,this paper proposes a new secure three-factor authentication protocol for multi-server environment based on Chebyshev chaotic map and secure sketch *** verify the security of the proposed scheme,we simulate our scheme using BAN logic and Pro Verif *** a thorough analysis,we can see that the proposed schemenot only has stronger security but also has less computation cost than Odelu et al.'s protocol.

关键词：多服务器认证协议环境认证鲁棒性椭圆曲线密码体制 Chebyshev 远程协议安全

Neural FIR adaptive Laguerre equalizer with a gradient adaptive amplitude for nonlinear channel in communication systems

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Science in China(Series F) 2009年第10期52卷 1881-1890页

作者： ZHAO HaiQuan zhang jiashu Key Laboratory of Signal and Information Processing of Sichuan Province Southwest Jiaotong University Chengdu 610031 China

To mitigate the linear and nonlinear distortions in communication systems, two novel nonlinear adaptive equalizers are proposed on the basis of the neural finite impulse response （FIR） filter, decision feedback architecture and the characteristic of the Laguerre filter. They are neural FIR adaptive decision feedback equalizer （SNNDFE） and neural FIR adaptive Laguerre equalizer （LSNN）. Of these two equalizers, the latter is simple and with characteristics of both infinite impulse response （IIR） and FIR filters; it can use shorter memory length to obtain better performance. As confirmed by theoretical analysis, the novel LSNN equalizer is stable （0 〈α〈1）. Furthermore, simulation results show that the SNNDFE can get better equalized performance than SNN equalizer, while the latter exhibits better performance than others in terms of convergence speed, mean square error （MSE） and bit error rate （BER）. Therefore, it can reduce the input dimension and eliminate linear and nonlinear interference effectively. In addition, it is very suitable for hardware implementation due to its simple structure.

关键词： decision feedback nonlinear channel adaptive equalizer neural network Laguerre filter

A self-recovery fragile watermarking scheme for image authentication with superior localization

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Science in China(Series F) 2008年第10期51卷 1487-1507页

作者： HE HongJie zhang jiashu CHEN Fan Sichuan Key Lab of Signal and Information Processing Southwest Jiaotong University Chengdu 610031 China Information Security and National Computing Grid Lab Southwest Jiaotong University Chengdu 610031 China

To address the problems of the inferior localization and high probability of false rejection in existing self-recovery fragile watermarking algorithms, this paper proposes a new self-recovery fragile watermarking scheme with superior localization, and further discusses the probability of false rejection （PFR） and the probability of false acceptance （PFA） of the proposed scheme. Moreover, four measurements are defined to evaluate the quality of a recovered image. In the proposed algorithm, the original image is divided into 2×2 blocks to improve localization precision and decrease PFR under occurrence of random tampering. The PFR under occurrence of region tampering can be effectively decreased by randomly embedding the watermark of each block in conjunction with a novel method of tamper detection. Compared with the current self-recovery fragile watermarking algorithms, the proposed scheme not only resolves the tamper detection problem of self-embedding watermarking, but also improves the robustness against the random tampering of self-embedding watermarking. In addition, the subjective measurements are provided to evaluate the performance of the self-recovery watermarking schemes for image authentication.

关键词： digital watermarking tamper recovery probability of false rejection probability of false acceptance