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Bioinspired Scraper-File Type Frequency-Doubling Ultrasonic Exciter

Journal of Bionic Engineering 2024年第4期21卷 1801-1816页

作者： Wenshuai Wu Mingshuo zhang Zeming Li guang Yao Xinggang jiang Deyuan zhang School of Mechanical Engineering and Automation Beihang UniversityBeijing100191China Institute of Bionic and Micro-Nano Systems Beihang UniversityBeijing100191China guangdong Provincial Key Laboratory of Minimally Invasive Surgical Instruments and Manufacturing Technology Guangdong University of TechnologyGuangzhou510006China

In the natural world,leaf-cutting ants cause vibrations through their mutual scraping of file-scraper *** this study,we designed a Biomimetic Ultrasonic Exciter(BUE)that imitates leaf-cutting *** operating characteristics of the BUE were studied through experimental testing and finite element *** results showed that the BUE could generate stable ultrasonic vibrations,and that the excitation frequency only needed to be half the Output Frequency(OF).This frequency-doubling phenomenon was conducive to achieving BUE *** further explore the phenomenon of frequency-doubling vibration output,this study designed scrapers of five different sizes,conducted excitation and first-order natural frequency measurement tests,and the corresponding finite element *** was found that each scraper could operate in frequency-doubling mode,but the operating frequency and natural mode frequencies did not correspond with one *** further explicate experimental and simulation results,a two-degrees-of-freedom vibration model was *** was evident that the contact relationship between the dentate disc and scraper introduced strong nonlinear factors into the system,accounting for the frequency-doubling phenomenon and the difference between the BUE’s operating and mode *** BUE could be expected to facilitate the production of high-power micro-ultrasonic generators and has potential application value in the fields of mechanical processing,industrial production,and medical health.

关键词： Leaf-cutting ants Power ultrasound Nonlinear vibration Ultrasonic scalpel Micro vibrator

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Successful splenic artery embolization in a patient with Behçet’s syndrome-associated splenic rupture:A case report

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World Journal of Gastrointestinal Surgery 2024年第4期16卷 1184-1188页

作者： guang-Zhao Zhu Dong-Hua ji Department of Interventional Therapy The First Affiliated Hospital of Dalian Medical UniversityDalian 116011Liaoning ProvinceChina

BACKGROUND Splenic rupture associated with Behçet’s syndrome(BS)is extremely rare,and there is no consensus on its *** this case report,a patient with BSassociated splenic rupture was successfully treated with splenic artery embolization(SAE)and had a good prognosis after the *** SUMMARY The patient was admitted for pain in the left upper abdominal *** was diagnosed with splenic *** oral and genital aphthous ulcers were observed,and acne scars were found on his *** had a 2-year history of BS diagnosis,with symptoms of oral and genital *** that time,he was treated with oral corticosteroids for 1 month,but the symptoms did not *** underwent SAE to treat the *** the first day after SAE,the patient reported a complete resolution of abdominal pain and was discharged 5 d *** months after the intervention,a computed tomography examination showed that the splenic hematoma had formed a stable cystic effusion,suggesting a good *** SAE might be a good choice for BS-associated splenic rupture based on good surgical practice and material selection.

关键词： Splenic artery embolization Behçet’s syndrome Splenic rupture Case report

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Optical grade (Gd_(0.95-x)Lu_(x)Eu_(0.05))_(3)Al_(5)O_(12) ceramics with near-zero optical loss: Effects of Lu^(3+) doping on structural feature, microstructure evolution, and far-red luminescence

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Journal of Advanced Ceramics 2024年第1期13卷 113-123页

作者： Zhigang Sun ji-guang Li Huiyu Qian Yoshio Sakka Tohru SSuzuki Bin Lu School of Materials Science and Chemical Engineering Ningbo UniversityNingbo 315211China Research Center for Electronic and Optical Materials National Institute for Materials ScienceIbaraki 305-0044Japan Key Laboratory of Photoelectric Detection Materials and Devices of Zhejiang Province Ningbo 315211China

A chemical co-precipitation strategy was employed to synthesize a series of(Gd_(0.95−x)Lu_(x)Eu_(0.05))_(3)Al_(5)O_(12)(x=0.1−0.95)powder phosphors,followed by vacuum sintering to achieve transparent garnet ceramic *** density functional theory indicated Lu_(3)Al_(5)O_(12) was formed in priority compared with Gd_(3)Al_(5)O_(12) during solid-phase *** high-temperature sintering,the Lu^(3+)substitution for Gd^(3+)suppressed point mass diffusion leading to a smaller grain *** in-line transmittances of bulk specimens with x=0.1,0.3,0.5,0.7,and 0.95 nm were~83.5%,80.1%,68.8%,73.7%,and 82.2%at 710 nm(Eu^(3+)emission center),respectively,among which the sample of x=0.1 exhibited the optical grade with near-zero optical loss in agreement with the defect-free single crystal(~100%of the theoretical transmittance).The resulting particle and ceramic materials both presented characteristic Eu^(3+)emission arising from 5D0→7FJ(J=1−4)transition,where the dominant far-red emission at~710 nm arising from ^(5)D_(0)→^(7)F_(4) transition overlapped with the absorption of phytochrome(PFR).The photoluminescence excitation and photoluminescence intensities of(Gd_(0.95−x)Lu_(x)Eu_(0.05))_(3)Al_(5)O_(12) powders and ceramics generally increased at a higher Gd^(3+)/Lu^(3+)***^(3+)dopants delayed the fluorescence lifetime while the bulk samples had shorter lifetime compared to the particle *** transparent(Gd_(0.85)Lu_(0.1)Eu_(0.05))3Al_(5)O_(12) ceramic phosphor exhibited good thermal stability with a high thermal quenching temperature above 533 *** designed ceramic phosphor-converted light-emitting diode had a saturation injection current of 435 mA and a current-dependent color rendering *** importantly,our report marked the developmental stage of transparent ceramic materials towards zero optical loss.

关键词： transparent ceramics garnet phosphors light-emitting diode(LED) optical properties Gibbs free energy

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B cell development and antibody responses in human immune system mice:current status and future perspective

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Science China(Life Sciences) 2024年第4期67卷 645-652页

作者： Tao zhang Wentao Liu Yong-guang Yang Key Laboratory of Organ Regeneration&Transplantation of the Ministry of Education The First Hospital of Jilin UniversityChangchun 130061China National-Local Joint Engineering Laboratory of Animal Models for Human Diseases Jilin UniversityChangchun 130061China International Center of Future Science Jilin UniversityChangchun 130061China

Humanized immune system(HIS)mice have been developed and used as a small surrogate model to study human immune function under normal or disease *** variations are found between models,most HIS mice show robust human T cell ***,there has been unsuccessful in constructing HIS mice that produce high-affinity human antibodies,primarily due to defects in terminal B cell differentiation,antibody affinity maturation,and development of primary follicles and germinal *** this review,we elaborate on the current knowledge about and previous attempts to improve human B cell development in HIS mice,and propose a potential strategy for constructing HIS mice with improved humoral immunity by transplantation of human follicular dendritic cells(FDCs)to facilitate the development of secondary follicles.

关键词： humanized immune system mouse humoral immunity germinal center B cell follicular dendritic cell

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Evaluation of the injection and plugging ability of a novel epoxy resin in cement cracks

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Petroleum Science 2024年第2期21卷 1211-1220页

作者： guang-Yao Leng Wei Yan Hai-Mu Ye Er-Dong Yao ji-Bin Duan Zheng-Xian Xu Ke-Pei Li jing-Ru zhang Zhong Li State Key Laboratory of Petroleum Resource&Prospecting China University of Petroleum(Beijing)Beijing102249China CNPC Liaohe Oilfield Gas Storage Co.LTD Panjin124000LiaoningChina CNOOC Research Institute Co. Ltd.Beijing100028China

Sustained casing pressure(SCP)is a crucial issue in the oil and gas production *** resins,exhibiting exceptional compressive strength,ductility,and shear bonding strength,have the potential to form reliable *** injectivity and sealing capacity of the epoxy resin is crucial parameters for the success of shallow remediation *** study aimed to develop and assess a novel solid-free resin sealant as an alternative to Portland cement for mitigating fluid *** investigation evaluated the viscosity,compressive strength,and brittleness index of the epoxy resin sealant,as well as its tangential and normal shear strengths in conjunction with casing *** flow characteristics and sealing abilities of conventional cement and epoxy resin were comparatively analyzed in *** results showed that the application of a viscosity reducer facilitated control over the curing time of the epoxy resin,ranging from 1.5 to 6 h,and reduced the initial viscosity from 865.53 to 118.71 m Pa,*** mechanical properties of the epoxy resin initially increased with a rise in curing agent content before experiencing a minor *** epoxy resin containing 30%curing agent exhibited optimal mechanical *** a 14-day curing period,the epoxy resin's compressive strength reached81.37 MPa,2.12 times higher than that of cement,whereas the elastic modulus of cement was 2.99 times greater than that of the epoxy *** brittleness index of epoxy resin is only 3.42,demonstrating high flexibility and *** tangential and normal shear strengths of the epoxy resin exceeded those of cement by 3.17 and 2.82 times,*** a 0.5 mm-wide crack,the injection pressure of the epoxy resin remained below 0.075 MPa,indicating superior injection and flow ***,the injection pressure of cement surged dramatically to 2.61 MPa within 5 *** breakthrough pressure of0.5 PV epoxy resin reached 7.53 MPa,decreasing the crack's perme

关键词： Sustained casing pressure Epoxy resin sealant Curing agent Viscosity reducer Mechanical properties Crack sealing

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Discovery of the choristodere Hyphalosaurus baitaigouensis from the Lower Cretaceous jiufotang Formation of western Liaoning,China and its paleobiogeographic significance

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Journal of Palaeogeography 2024年第3期13卷 547-562页

作者： Li-Jun zhang Shu-An ji Hai-Chun zhang South China Sea Culture Museum Hainan Tropical Ocean UniversitySanya 572022Hainan ProvinceChina Key Laboratory of Stratigraphy and Paleontology Ministry of Natural ResourcesInstitute of GeologyChinese Academy of Geological SciencesBeijing 100037China State Key Laboratory of Palaeobiology and Stratigraphy Nanjing Institute of Geology and Palaeontology and Center for Excellence in Life and PaleoenvironmentChinese Academy of SciencesNanjing 210008Jiangsu ProvinceChina

The water-living reptile genus Hyphalosaurus was previously discovered in the Lower Cretaceous Yixian Formation bearing the middle Jehol Biota in western Liaoning,*** complete skeletons of Hyphalosaurus are reported for the first time from the jiufotang Formation bearing the late Jehol Biota at two sites in western *** show the typical characteristics of Hyphalosaurus baitaigouensis in terms of the contact between some cranial bones and the number of cervical and dorsal vertebrae,and therefore are assigned to *** discovery extends the stratigraphic range of this species from the Yixian Formation to the overlying jiufotang *** paper further briefly compares the main characteristics of the two skeletons,summarizes the temporal and spatial distribution of Hyphalosaurus,and discusses the palaeogeographic evolution of western Liaoning at the middle and late Jehol Biota stages based on the aquatic habits of Hyphalosaurus and the geological background of western *** analytical results show that the volcanic downwarped lakes,with distinct geographical divisions in western Liaoning during the deposition of the Yixian Formation,had not completely disappeared till the deposition of the jiufotang *** palaeo-lake in the Fuxin-Yixian Basin underwent the process of generation,expansion and shrinkage during the depositional period of the Yixian Formation and finally merged into a large *** palaeo-Dalinghe River,which connected the main basins in western Liaoning during the depositional period of the jiufotang Formation,was formed simultaneously.

关键词： Western liaoning Jehol biota jiufotang formation Hyphalosaurus baitaigouensis Palaeobiogeography

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Diabetic retinopathy identification based on multi-sourcefree domain adaptation

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International Journal of Ophthalmology(English edition) 2024年第7期17卷 1193-1204页

作者： guang-Hua zhang guang-Ping Zhuo Zhao-Xia zhang Bin Sun Wei-Hua Yang Shao-Chong zhang School of Big Data Intelligent Diagnosis&Treatment Industry Taiyuan UniversityTaiyuan 030032Shanxi ProvinceChina Shanxi Key Laboratory of Intelligent Optimization Computing and Blockchain Technology Taiyuan Normal UniversityTaiyuan 030619Shanxi ProvinceChina Shanxi Eye Hospital Taiyuan 030002Shanxi ProvinceChina College of Computer Science and Technology Taiyuan Normal UniversityTaiyuan 030619Shanxi ProvinceChina Shenzhen Eye Institute Shenzhen Eye HospitalJinan UniversityShenzhen 518040Guangdong ProvinceChina

AIM:To address the challenges of data labeling difficulties,data privacy,and necessary large amount of labeled data for deep learning methods in diabetic retinopathy(DR)identification,the aim of this study is to develop a source-free domain adaptation(SFDA)method for efficient and effective DR identification from unlabeled ***:A multi-SFDA method was proposed for DR *** method integrates multiple source models,which are trained from the same source domain,to generate synthetic pseudo labels for the unlabeled target ***,a softmax-consistence minimization term is utilized to minimize the intra-class distances between the source and target domains and maximize the inter-class *** is performed using three color fundus photograph datasets(APTOS2019,DDR,and EyePACS).RESULTS:The proposed model was evaluated and provided promising results with respectively 0.8917 and 0.9795 F1-scores on referable and normal/abnormal DR identification *** demonstrated effective DR identification through minimizing intra-class distances and maximizing inter-class distances between source and target ***:The multi-SFDA method provides an effective approach to overcome the challenges in DR *** method not only addresses difficulties in data labeling and privacy issues,but also reduces the need for large amounts of labeled data required by deep learning methods,making it a practical tool for early detection and preservation of vision in diabetic patients.

关键词： diabetic retinopathy multisource-free domain adaptation pseudo-label generation softmaxconsistence minimization

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Therapeutic potential of targeting protein tyrosine phosphatases in liver diseases

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Acta Pharmaceutica Sinica B 2024年第8期14卷 3295-3311页

作者： Ao Wang Yi zhang Xinting Lv guang Liang Department of Pharmacy and Institute of Inflammation Zhejiang Provincial Affiliated People’s HospitalHangzhou Medical CollegeHangzhou 310014China Key Laboratory of Natural Medicines of the Changbai Mountain Ministry of EducationYanbian UniversityYanji 133002China Chemical Biology Research Center School of Pharmaceutical SciencesWenzhou Medical UniversityWenzhou 325035China

Protein tyrosine phosphorylation is a post-translational modification that regulates protein structure to modulate demic organisms’homeostasis and *** physiological process is regulated by two enzyme families,protein tyrosine kinases(PTKs)and protein tyrosine phosphatases(PTPs).As an important regulator of protein function,PTPs are indispensable for maintaining cell intrinsic physiology in different systems,as well as liver physiological and pathological *** of PTPs has been implicated in multiple liver-related diseases,including chronic liver diseases(CLDs),hepatocellular carcinoma(HCC),and liver injury,and several PTPs are being studied as drug therapeutic ***,given the regulatory role of PTPs in diverse liver diseases,a collated review of their function and mechanism is ***,based on the current research status of targeted therapy,we emphasize the inclusion of several PTP members that are clinically significant in the development and progression of liver *** an emerging breakthrough direction in the treatment of liver diseases,this review summarizes the research status of PTP-targeting compounds in liver diseases to illustrate their potential in clinical ***,this review aims to support the development of novel PTP-based treatment pathways for liver diseases.

关键词： Tyrosine phosphorylation PTPs Signal transduction CLDs HCC Allosteric inhibitor PROTACs Drug development

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Novel data-driven sparse polynomial chaos and analysis of covariance for aerodynamics of compressor cascades with dependent geometric uncertainties

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Chinese Journal of Aeronautics 2024年第6期37卷 89-108页

作者： Zhengtao GUO Wuli CHU Haoguang zhang Tianyuan ji School of Power and Energy Northwestern Polytechnical UniversityXi’an 710072China

Polynomial Chaos Expansion(PCE)has gained significant popularity among engineers across various engineering disciplines for uncertainty ***,traditional PCE suffers from two major ***,the orthogonality of polynomial basis functions holds only for independent input variables,limiting the model’s ability to propagate uncertainty in dependent ***,PCE encounters the"curse of dimensionality"due to the high computational cost of training the model with numerous polynomial *** practical manufacturing,compressor blades are subject to machining precision limitations,leading to deviations from their ideal geometric *** deviations require a large number of geometric parameters to describe,and exhibit significant *** efficiently quantify the impact of high-dimensional dependent geometric deviations on the aerodynamic performance of compressor blades,this paper firstly introduces a novel approach called Data-driven Sparse PCE(DSPCE).The proposed method addresses the aforementioned challenges by employing a decorrelation algorithm to directly create multivariate basis functions,accommodating both independent and dependent random ***,the method utilizes an iterative Diffeomorphic Modulation under Observable Response Preserving Homotopy regression algorithm to solve the unknown coefficients,achieving model sparsity while maintaining fitting ***,the study investigates the simultaneous effects of seven dependent geometric deviations on the aerodynamics of a high subsonic compressor cascade by using the DSPCE method proposed and sensitivity analysis of *** joint distribution of the dependent geometric deviations is determined using Quantile-Quantile plots and normal copula functions based on finite measurement *** results demonstrate that the correlations between geometric deviations significantly impact the variance of aerodynamic performance and the flow ***,

关键词： Data-driven sparse polyno-mial chaos Analysis of covariance Dependent uncertainty Aerodynamic performance Compressor cascade

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Performance evaluation for multi-target tracking with temporal dimension specifics

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Chinese Journal of Aeronautics 2024年第2期37卷 446-458页

作者： Zhenzhen SU Hongbing ji Cong TIAN Yongquan zhang School of Computer Science and Technology Xidian UniversityXi’an 710071China School of Electronic Engineering Xidian UniversityXi’an 710071China

With the great development of Multi-Target Tracking(MTT)technologies,many MTT algorithms have been proposed with their own advantages and *** to the fact that requirements to MTT algorithms vary from the application scenarios,performance evaluation is significant to select an appropriate MTT algorithm for the specific application *** this paper,we propose a performance evaluation method on the sets of trajectories with temporal dimension specifics to compare the estimated trajectories with the true *** proposed method evaluates the estimate results of an MTT algorithm in terms of tracking accuracy,continuity and ***,its computation is based on a multi-dimensional assignment problem,which is formulated as a computable form using linear *** enhance the influence of recent estimated states of the trajectories in the evaluation,an attention function is used to reweight the trajectory errors at different time ***,simulation results show that the proposed performance evaluation method is able to evaluate many aspects of the MTT *** evaluations are worthy for selecting suitable MTT algorithms in different application scenarios.

关键词： Multi-target tracking Temporal dimension specifics Performance evaluation Random finite sets Linear programming

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