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飞秒激光切割CFRP质量实验及模拟研究

河北工程大学学报（自然科学版） 2024年第3期41卷 108-112页

作者：张王艺张寰臻李超张都河北工程大学数理科学与工程学院河北邯郸056038

为了探究飞秒激光切割碳纤维增强树脂基复合材料(CFRP)的主要影响因素,采用控制变量法探究了不同能量密度和光斑重叠率对热影响区宽度、表面粗糙度及切缝锥度的影响规律,基于双温方程,采用时间差分法模拟了飞秒激光与碳纤维相互作用时电... 详细信息

为了探究飞秒激光切割碳纤维增强树脂基复合材料(CFRP)的主要影响因素,采用控制变量法探究了不同能量密度和光斑重叠率对热影响区宽度、表面粗糙度及切缝锥度的影响规律,基于双温方程,采用时间差分法模拟了飞秒激光与碳纤维相互作用时电子-晶格的温度场演变过程。实验结果显示:在脉冲频率不变条件下,提高激光功率可使切缝热影响区宽度增加,粗糙度及切缝锥度加大,切割质量下降;在固定激光功率并单一提升脉冲频率条件下,切割质量随脉冲频率增加而降低并趋于饱和。模拟结果显示:能量密度越大,电子和晶格的平衡温度越高,达到热平衡所用的时间越长,热效应越明显。分析指出光斑重叠率和脉冲能量密度是影响加工质量的两个重要因素,激光功率及脉冲频率的改变可改变脉冲能量密度和光斑重叠率,间接影响加工质量。

关键词：飞秒激光 CFRP 双温模拟切割

推拿“委中”穴对坐骨神经慢性压迫性损伤模型大鼠海马CA3区突触可塑性的影响

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中医杂志 2024年第15期65卷 1602-1610页

作者：黄红叶陈水金陈乐春张幻真蒋晶晶江煜陈进城林志刚福建中医药大学附属康复医院福建省福州市350003

目的从海马突触可塑性角度探讨推拿委中穴缓解坐骨神经痛的可能作用机制。方法 60只SD大鼠随机分为假手术组、模型组、推拿组、MK-801组、MK-801+推拿组,每组12只。所有大鼠侧脑室置管术后,除假手术组外其余各组大鼠制备右侧坐骨神经... 详细信息

目的从海马突触可塑性角度探讨推拿委中穴缓解坐骨神经痛的可能作用机制。方法 60只SD大鼠随机分为假手术组、模型组、推拿组、MK-801组、MK-801+推拿组,每组12只。所有大鼠侧脑室置管术后,除假手术组外其余各组大鼠制备右侧坐骨神经慢性压迫性损伤模型。造模后第4天,推拿组大鼠开始推拿“委中”穴干预,每日1次持续10 min,共干预14天;MK-801组大鼠开始侧脑室注射0.25μg/μl的N-甲基-D天冬氨酸受体2B (NR2B)阻断剂地佐环平(MK-801) 0.5μl,每日1次,共14天。MK-801+推拿组大鼠在侧脑室注射MK-801 30 min后进行推拿干预,时间方法同上;模型组和假手术组大鼠不进行任何干预。大鼠造模前1天(基础值)及造模第4、10、14、18天进行自发痛行为评分和机械足反射阈值(PWTs)检测,第19天各组大鼠脑组织取材后,使用尼氏染色观察海马CA3区尼氏阳性细胞数量与形态,透射电镜观察海马CA3区突触数目、突触间隙、突触后致密物厚度、活性带长度与突触界面曲率,免疫荧光染色和免疫印迹法检测海马CA3区突触相关蛋白NR2B、突触后致密物95(PSD95)的表达。结果与假手术组同时间比较,模型组造模后第4、10、14、18天时自发性疼痛评分显著增加,PWTs降低(P<0.05);与模型组比较,推拿组大鼠在造模第10、14、18天自发性疼痛评分显著下降,在造模第14、18天PWTs显著升高(P<0.05);与推拿组比较,MK-801+推拿组自发性疼痛评分在造模第10、14、18天升高,在造模第14、18天PWTs降低(P<0.05)。与假手术组比较,模型组大鼠海马CA3区神经元排列紊乱,尼氏阳性细胞数量、突触数目、突触后致密度厚度、活性带长度、突触界面曲率减小,突触间隙变宽,海马CA3区NR2B、PSD95免疫荧光阳性表达及免疫印迹蛋白表达减少(P<0.05)。与模型组比较,推拿组大鼠海马CA3区神经细胞排列密集,尼氏阳性细胞数量、突触数目、突触后致密物厚度、活性带长度均增加,突触间隙明显变窄,海马CA3区NR2B、PSD95免疫荧光阳性表达及免疫印迹蛋白表达较模型组增加(P<0.05)。与推拿组比较,MK-801+推拿组海马CA3区神经元形态破坏严重,尼氏阳性细胞数量、突触数目、突触后致密物厚度、活性带长度、突触界面曲率减小,突触间隙变宽,NR2B、PSD95免疫荧光阳性表达和免疫印迹蛋白表达降低(P<0.05)。结论推拿“委中”穴具有显著的镇痛作用,显著增加海马CA3区NR2B和PSD95蛋白表达水平从而调控海马突触可塑性是其发挥镇痛作用的可能作用机制之一。

关键词：坐骨神经痛推拿委中穴海马突触可塑性 N-甲基-D天冬氨酸受体2B

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Chinese Tuina remodels the synaptic structure in neuropathic pain rats by downregulating the expression of N-methyl D-aspartate receptor subtype 2B and postsynaptic density protein-95 in the spinal cord dorsal horn

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中医杂志:英文版 2023年第4期43卷 715-724页

作者： HUANG Hongye WANG Bingqian CHEN Shuijin FANG Jiayu WANG Xiaohua CHEN Lechun JIANG Yu zhang huanzhen CHEN Jincheng LIN Zhigang College of Rehabilitation Medicine Fujian University of Traditional Chinese MedicineFuzhou 350122China Fujian University of Traditional Chinese Medicine Subsidiary Rehabilitation Hospital Fuzhou 350003China Fujian Provincial Key Laboratory of Rehabilitation Technology Fuzhou 350003China Peking University International Hospital Beijing 102206China

OBJECTIVE:To investigate whether the Chinese massage system,Tuina,exerts analgesic effects in a rat model of chronic constriction injury(CCI)by remodeling the synaptic structure in the spinal cord dorsal horn(SCDH).METHODS:Sixty-nine male Sprague–Dawley rats were randomly and evenly divided into the normal group,sham group,CCI group,CCI+Tuina group,CCI+MK-801[an N-methyl D-aspartate receptor subtype 2B(NR2B)antagonist]group,and CCI+MK-801+Tuina *** neuropathic pain model was established using CCI with right sciatic nerve *** was administered 4 d after CCI surgery,using pressing manipulation for 10 min,once *** function was observed with the inclined plate test,and pain behaviors were observed by the Von Frey test and acetone spray *** 19 d after surgery,the L3-L5 spinal cord segments were ***,interleukin 1β(IL-1β),and tumor necrosis factor-α(TNF-α)levels were detected by enzyme-linked immunosorbent *** protein expression levels of NR2B and postsynaptic density protein-95(PSD-95)were detected by Western blot,and the synaptic structure was observed by transmission electron microscopy(TEM).RESULTS:CCI reduced motor function and caused mechanical and cold allodynia in rats,increased glutamate concentration and TNF-αand IL-1βlevels,and increased expression of synapse-related proteins NR2B and PSD-95 in the *** revealed that the synaptic structure of SCDH neurons was *** of these disease-induced changes were reversed by Tuina and intrathecal injection of MK-801(P<0.05 or<0.01).For the majority of experiments,no significant differences were found between the CCI+MK-801 and CCI+MK-801+Tuina ***:Chinese Tuina can alleviate pain by remodeling the synaptic structure,and NR2B and PSD-95 receptors in the SCDH may be among its targets.

关键词： neuralgia spinal cord dorsal horn receptors N-Methyl-D-aspartate disks large homolog 4 protein neuronal plasticity Chinese Tuina

Ammonia removal from low-strength municipal wastewater by powdered resin combined with simultaneous recovery as struvite

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Frontiers of Environmental Science & Engineering 2021年第1期15卷 125-134页

作者： Kuo Fang Fei Peng Hui Gong huanzhen zhang Kaijun Wang State Key Joint Laboratory of Environment Simulation and Pollution Control School of EnvironmentTsinghua UniversityBeijing 100084China School of Water Resources&Environment China University of GeosciencesBeijing 100083China

Low-strength municipal wastewater is considered to be a recoverable nutrient resource with economic and environmental ***,various technologies for nutrient removal and recovery have been *** this paper,powdered ion exchange resin was employed for ammonia removal and recovery from imitated low-strength municipal *** effects of various working conditions(powdered resin dosage,initial concentration,and pH value)were studied in batch experiments to investigate the feasibility of the approach and to achieve performance *** maximum adsorption capacity determined by the Langmuir model was 44.39 mg/g,which is comparable to traditional ion exchange ***,the effects of co-existing cations(Ca^(2+),Mg^(2+),K^(+))were *** on the above experiments,recovery of ammonia as struvite was successfully achieved by a proposed two-stage crystallization process coupled with a powdered resin ion exchange *** electron microscopy(SEM)and X-ray diffractometry(XRD)results revealed that struvite crystals were successfully gained in alkaline conditions(pH=10).This research demonstrates that a powdered resin and two-stage crystallization process provide an innovative and promising means for highly efficient and easy recovery from low-strength municipal wastewater.

关键词： Ammonia removal and recovery Powdered resin Crystallization process Struvite Co-existing cations

推拿对坐骨神经慢性压迫损伤大鼠脊髓背角小胶质细胞P2Y12/RhoA/ROCK2通路及c-Fos蛋白表达的影响

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中国中医药信息杂志 2024年第7期31卷 100-105页

作者：蒋晶晶林志刚黄红叶张幻真陈乐春林惠伍诗烨陈水金福建中医药大学附属康复医院福建福州350003 福建省康复技术重点实验室福建福州350003 福建中医药大学福建福州350100

目的观察推拿对坐骨神经慢性压迫损伤大鼠脊髓背角小胶质细胞P2Y12/RhoA/ROCK2通路及c-Fos蛋白表达的影响,探讨推拿治疗腰椎间盘突出症的作用机制。方法采用右侧坐骨神经慢性压迫损伤模拟腰椎间盘突出症神经性疼痛。将24只雄性SD大鼠随... 详细信息

目的观察推拿对坐骨神经慢性压迫损伤大鼠脊髓背角小胶质细胞P2Y12/RhoA/ROCK2通路及c-Fos蛋白表达的影响,探讨推拿治疗腰椎间盘突出症的作用机制。方法采用右侧坐骨神经慢性压迫损伤模拟腰椎间盘突出症神经性疼痛。将24只雄性SD大鼠随机分为空白组、模型组和推拿组,每组8只。造模后第4日,推拿组以按揉法干预,连续14 d。测量造模前及造模后第4、10、17 d大鼠机械缩足阈值(PWT)、热痛阈值(PWL),免疫荧光染色检测大鼠右侧脊髓背角Iba1、P2Y12蛋白表达,Western blot检测右侧脊髓背角RhoA、ROCK2蛋白表达,免疫组化检染色测右侧脊髓背角c-Fos阳性细胞数量。结果与空白组比较,模型组大鼠造模后第4、10、17日PWT、PWL明显降低(P<0.001),右侧脊髓背角Iba1、P2Y12、RhoA、ROCK2蛋白表达明显升高(P<0.001,P<0.05),c-Fos阳性细胞数明显增加(P<0.001);与模型组比较,推拿组大鼠造模后第10、17日PWT、PWL明显升高(P<0.05,P<0.01,P<0.001),右侧脊髓背角Iba1、P2Y12、RhoA、ROCK2蛋白表达明显降低(P<0.001,P<0.01,P<0.05),c-Fos阳性细胞数明显减少(P<0.001)。结论推拿可能通过调控脊髓背角P2Y12/RhoA/ROCK2通路及c-Fos表达抑制小胶质细胞激活,降低神经元兴奋性,对腰椎间盘突出症发挥镇痛作用。

关键词：腰椎间盘突出症推拿脊髓背角小胶质细胞 P2Y12/RhoA/ROCK2通路 c-Fos 大鼠

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SiC_p/Al复合材料纳秒脉冲光纤激光刻蚀

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中国激光 2017年第1期44卷 146-151页

作者：张寰臻黄婷肖荣诗北京工业大学激光工程研究院高功率及超快激光先进制造实验室北京100124 河北工程大学数理科学与工程学院河北邯郸056038

研究了在高压辅助气体作用下运用纳秒脉冲激光刻蚀SiC陶瓷颗粒增强Al基复合材料的可行性。结果表明,刻蚀深度随激光能量的增加而增大。由于刻蚀过程中发生了复杂的冶金反应,在刻蚀表面很难观察到独立的SiC颗粒。重凝层内Al、Si、C、O元... 详细信息

研究了在高压辅助气体作用下运用纳秒脉冲激光刻蚀SiC陶瓷颗粒增强Al基复合材料的可行性。结果表明,刻蚀深度随激光能量的增加而增大。由于刻蚀过程中发生了复杂的冶金反应,在刻蚀表面很难观察到独立的SiC颗粒。重凝层内Al、Si、C、O元素空间分布相对均匀,其厚度和表面粗糙度随激光能量的增加而增加,并呈饱和趋势。高压同轴气体的机械作用是材料蚀除的主要机制。

关键词：激光刻蚀复合材料铝合金碳化硅

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飞秒激光加工最新研究进展

机械工程学报 2016年第17期52卷 176-186页

作者：肖荣诗张寰臻黄婷北京工业大学激光工程研究院北京100124 河北工程大学理学院邯郸056038

飞秒激光作为一种先进的加工技术,以其"冷加工"、多光子非线性效应、突破衍射极限等特质可实现对任意材料由微纳到宏观尺度复杂三维零件的精密加工,在微纳和精密机械、微纳电子、微纳光学、表面工程、生物医学等领域展露了巨大的市场应... 详细信息

飞秒激光作为一种先进的加工技术,以其"冷加工"、多光子非线性效应、突破衍射极限等特质可实现对任意材料由微纳到宏观尺度复杂三维零件的精密加工,在微纳和精密机械、微纳电子、微纳光学、表面工程、生物医学等领域展露了巨大的市场应用前景。文章重点针对近三年来飞秒激光刻蚀、切割、制孔、功能表面制备、体内加工和聚合加工的研究进展进行综述,并探讨了飞秒激光在与材料相互作用机制、加工精度、加工方式、加工对象等方面面临的机遇和挑战。

关键词：飞秒激光精密加工刻蚀功能表面双光子吸收

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煤炭企业安全煤量多元价值评估模型及应用

矿业研究与开发 2023年第6期43卷 206-212页

作者：原白云管玉玉高保彬张焕珍刘森河南理工大学工商管理学院能源经济研究中心河南焦作市454000 河南理工大学安全科学与工程学院河南焦作市454000

煤炭企业瓦斯治理管理理念由被动向主动转变,对于推动煤炭资源由储量变成安全煤量,实现瓦斯治理工作的价值具有重要意义。为了促进煤炭企业主动增加瓦斯治理投入,提高瓦斯治理效率,从经济、生态、安全产出三个维度界定安全煤量的多元价... 详细信息

煤炭企业瓦斯治理管理理念由被动向主动转变,对于推动煤炭资源由储量变成安全煤量,实现瓦斯治理工作的价值具有重要意义。为了促进煤炭企业主动增加瓦斯治理投入,提高瓦斯治理效率,从经济、生态、安全产出三个维度界定安全煤量的多元价值,采用不同的价值评估方法,构建安全煤量多元价值评估模型,并将该模型应用于山西潞安化工集团公司进行验证。结果表明,该模型可量化安全煤量的总价值,进而以价值驱动煤炭企业瓦斯治理工作由被动需要变为主动创造。

关键词：煤炭企业安全煤量瓦斯治理多元价值评估模型

N-doped graphene quantum dot-decorated N-TiO2/P-doped porous hollow g-C_(3)N_(4) nanotube composite photocatalysts for antibiotic photodegradation and H2 production

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International Journal of Minerals,Metallurgy and Materials 2024年第1期31卷 165-178页

作者： Jingshu Yuan Yao zhang Xiaoyan zhang Junjie zhang Shen’gen zhang Institute for Advanced Materials and Technology University of Science and Technology BeijingBeijing 100083China Xi’an Fanyi University Xi’an 710105China Shunde Graduate School of University of Science and Technology Beijing Foshan 528399China State Key Laboratory of Lunar and Planetary Sciences Macao University of Science and TechnologyMacao SAR 820000China

Exclusive responsiveness to ultraviolet light (~3.2 eV) and high photogenerated charge recombination rate are the two primary drawbacks of pure TiO_(2). We combined N-doped graphene quantum dots (N-GQDs), morphology regulation, and heterojunction construction strategies to synthesize N-GQD/N-doped TiO_(2)/P-doped porous hollow g-C_(3)N_(4) nanotube (PCN) composite photocatalysts (denoted as G-TPCN). The optimal sample (G-TPCN doped with 0.1wt% N-GQD, denoted as 0.1% G-TPCN) exhibits significantly enhanced photoabsorption, which is attributed to the change in bandgap caused by elemental doping (P and N), the improved light-harvesting resulting from the tube structure, and the upconversion effect of N-GQDs. In addition, the internal charge separation and transfer capability of0.1% G-TPCN are dramatically boosted, and its carrier concentration is 3.7, 2.3, and 1.9 times that of N-TiO_(2), PCN, and N-TiO_(2)/PCN(TPCN-1), respectively. This phenomenon is attributed to the formation of Z-scheme heterojunction between N-TiO_(2) and PCNs, the excellent electron conduction ability of N-GQDs, and the short transfer distance caused by the porous nanotube structure. Compared with those of N-TiO_(2), PCNs, and TPCN-1, the H2 production activity of 0.1%G-TPCN under visible light is enhanced by 12.4, 2.3, and 1.4times, respectively, and its ciprofloxacin (CIP) degradation rate is increased by 7.9, 5.7, and 2.9 times, respectively. The optimized performance benefits from excellent photoresponsiveness and improved carrier separation and migration efficiencies. Finally, the photocatalytic mechanism of 0.1% G-TPCN and five possible degradation pathways of CIP are proposed. This study clarifies the mechanism of multiple modification strategies to synergistically improve the photocatalytic performance of 0.1% G-TPCN and provides a potential strategy for rationally designing novel photocatalysts for environmental remediation and solar energy conversion.

关键词： N-doped TiO_(2) N-doped graphene quantum dots P-doped g-C_(3)N_(4) porous hollow nanotube heterojunction photocatalysis