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CEPC Technical Design Report

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Radiation Detection Technology and Methods 2024年第1期8卷 I0003-I0016,1-1091页

作者： Waleed Abdallah Tiago Carlos Adorno de Freitas Konstantin Afanaciev Shakeel Ahmad Ijaz Ahmed Xiaocong Ai Abid Aleem Wolfgang Altmannshofer Fabio Alves Weiming An Rui An Daniele Paolo Anderle Stefan Antusch Yasuo Arai Andrej Arbuzov Abdesslam Arhrib Mustafa Ashry Sha Bai Yu Bai yang Bai Vipul Bairathi Csaba Balazs Philip Bambade Yong Ban Tripamo Bandyopadhyay Shou-Shan Bao Desmond P.Barber Ayse Bat Varvara Batozskaya Subash Chandra Behera Alexander Belyaev Michele Bertucci Xiao-Jun Bi Yuanjie Bi Tianjian Bian Fabrizio Bianchi Thomas Biekotter Michela Biglietti Shalva Bilanishvili Deng Binglin Denis Bodrov Anton Bogomyagkov Serge Bondarenko Stewart Boogert Maarten Boonekamp Marcello Borri Angelo Bosotti Vincent Boudry Mohammed Boukidi Igor Boyko Ivanka Bozovic Giuseppe Bozzi Jean-Claude Brient Anastasiia Budzinskaya Masroor Bukhari Vladimir Bytev Giacomo Cacciapaglia hua Cai Wenyong Cai Wujun Cai Yijian Cai Yizhou Cai Yu{2. Cai Haiying Cai hua{2.g Cai Lorenzo Calibbi Junsong Cang Guofu Cao Jianshe Cao Antoine Chance Xuejun Chang Yue Chang Zhe Chang Xinyuan Chang Wei Chao Auttakit Chatrabhuti Yimin Che Yuzhi Che Bin {2. Danping {2. Fuqing {2. Fusan {2. Gang {2. Guoming {2. hua-Xing {2. Huirun {2. Jinhui {2. Ji-Yuan {2. Kai {2. Mali {2. Mingjun {2. Mingshui {2. Ning {2. Shanhong {2. Shanzhen {2. Shao-Long {2. Shaomin {2. Shiqiang {2. Tianlu {2. Wei {2. Xiang {2. Xiaoyu {2. Xin {2. Xun {2. Xurong {2. Ye {2. Ying {2. Yukai {2. Zelin {2. Zilin {2. Gang {2. Boping {2. Chunhui {2. Hok Chuen {2.g huajie {2.g Shan {2.g Tongguang {2.g Yunlong Chi Pietro Chimenti Wen Han Chiu Guk Cho Ming-Chung Chu Xiaotong Chu Ziliang Chu Guglielmo Coloretti Andreas Crivellin Hanhua Cui Xiaohao Cui Zhaoyuan Cui Brunella D'Anzi Ling-Yun Dai Xin{2. Dai Xuwen Dai Antonio De Maria Nicola De Filippis Christophe De La Taille Francesca De Mori Chiara De Sio Elisa Del Core Shuangxue Deng Wei-Tian Deng Zhi Deng Ziyan Deng Bhupal Dev Tang Dewen Biagio Di Micco Ran Ding Siqin Dingl Yadong Ding Haiyi Dong Jianin AGH University of Science and Technology Faculty of Physics and Applied Computer ScienceKrakow Anhui University HefeiAnhui Applied Physics Department Federal Urdu University of ArtsScience and TechnologyIslamabad Banaras Hindu University Institute of ScienceVaranasi Bandirma Onyedi Eylul University Bandirma Beihang University Beijing Beijing Computational Science Research Center Beijing Beijing Conveyi LTD Beijing Beijing Glass Research Institute Co. LtdBeijing Beijing Institute of Technology Beijing Beijing Normal University Beijing Brown University ProvidenceRI Budker Institute of Nuclear Physics Novosibirsk Cadi Ayyad University Laboratory of Fundamental and Applied PhysicsPolydisciplinary FacultyMarrakech Cairo University Giza Center for Theory and Computation National Tsing Hua UniversityHsinchu Central china Normal University WuhanHubei Central South University ChangshaHunan Centro de Fisica Teorica de Particulas Universidade Tecnica de LisboaLisboa chengdu KaitengSifang Digital Radio&TV Equipment Co. LtdChengduSichuan china academy of engineering physics MianyangSichuan china building materials academy Beijing china Center of Advanced Science and Technology Beijing china Institute of Atomic Energy Beijing china Jiliang University HangzhouZhejiang china Nuclear Instrument CO. LTDBeijing china University of Geosciences Beijing china University of Geosciences WuhanHubei china University of Mining and Technology XuzhouJiangsu china West Normal University NanchongSichuan Chongqing University Department of PhysicsChongqing Chulalongkorn University Bangkok City University of Hong Kong Department of PhysicsHong Kong Cockcroft Institute Daresbury Cornell University IthacaNY CPPM(AMU/IPhU&CNRS/INP) Marseille Dalian Minzu University DalianLiaoning Dalian University of Technology Department of PhysicsDalian Deutsches Elektronen-Synchrotron DESY Hamburg Dzhelepov laboratory of Nuclear Problems of Joint Institute for Nuclear Research(DLNP JINR) Dubna East china University Of Science And Technol

The Circular Electron Positron Collider(CEPC)is a large scientific project initiated and hosted by china,fostered through extensive collaboration with international *** complex comprises four accelerators:a 30 GeV Linac,a 1.1 GeV Damping Ring,a Booster capable of achieving energies up to 180 GeV,and a Collider operating at varying energy modes(Z,W,H,and tt).The Linac and Damping Ring are situated on the surface,while the subterranean Booster and Collider are housed in a 100 km circumference underground tunnel,strategically accommodating future expansion with provisions for a potential Super Proton Proton Collider(SPPC).The CEPC primarily serves as a Higgs *** its baseline design with synchrotron radiation(SR)power of 30 MW per beam,it can achieve a luminosity of 5×10^(34)cm^(-2.s^(-1)per interaction point(IP),resulting in an integrated luminosity of 13 ab^(-1)for two IPs over a decade,producing 2.6 million Higgs *** the SR power to 50 MW per beam expands the CEPC's capability to generate 4.3 million Higgs bosons,facilitating precise measurements of Higgs coupling at sub-percent levels,exceeding the precision expected from the HL-LHC by an order of *** Technical Design Report(TDR)follows the Preliminary Conceptual Design Report(Pre-CDR,2.15)and the Conceptual Design Report(CDR,2.18),comprehensively detailing the machine's layout,performance metrics,physical design and analysis,technical systems design,R&D and prototyping efforts,and associated civil engineering ***,it includes a cost estimate and a preliminary construction timeline,establishing a framework for forthcoming engineering design phase and site selection *** is anticipated to begin around 2.2.-2.2.,pending government approval,with an estimated duration of 8 *** commencement of experiments and data collection could potentially be initiated in the mid-2.30s.

关键词： initiated exceeding precise

Antibody upstream sequence diversity and its biological implications revealed by repertoire sequencing

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Journal of genetics and Genomics 2021年第10期48卷 936-945页

作者： yan Zhu Xiujia yang Cuiyu Ma Haipei Tang Qilong Wang Junjie Guan Wenxi Xie {2. chen Yuan chen Minhui Wang Chunhong Lan Deqiang sun Lai Wei Caijun sun Xueqing Yu Zhenhai zhang state key {2. of Organ Failure Research National Clinical Research Center for Kidney DiseaseDivision of NephrologyNanfang HospitalSouthern Medical UniversityGuangzhou 510515China Department of Bioinformatics School of Basic Medical SciencesSouthern Medical UniversityGuangzhou 510515China Center for Precision Medicine Guangdong Provincial People's HospitalGuangdong Academy of Medical SciencesGuangzhou 510080China Guangdong-Hong Kong Joint laboratory on Immunological and genetic Kidney Diseases Guangdong Provincial People's HospitalGuangdong Academy of Medical SciencesGuangzhou 510080China key laboratory of Mental Health of the {2. of education Guangdong-Hong Kong-Macao Greater Bay Area Center for Brain Science and Brain-Inspired IntelligenceSouthern Medical UniversityGuangzhou 510515China Department of Nephrology Hainan Affiliated Hospital of Hainan Medical CollegeHaikou 570311China Department of Nephrology Hainan General HospitalHaikou 570311China Department of Center laboratory The Fifth Affiliated Hospital of Guangzhou Medical UniversityGuangzhou 510700China state key {2. of Ophthalmology Zhongshan Ophthalmic CenterSun Yat-sen UniversityGuangzhou 510060China School of Public Health Sun Yat-sen UniversityShenzhen 510006China Division of Nephrology Guangdong Provincial People's HospitalGuangdong Academy of Medical SciencesGuangzhou 510080China

The sequence upstream of the antibody variable region(antibody upstream sequence[AUS])consists of a 5′untranslated region(5′UTR)and a preceding leader *** sequence variations in AUS affect antibody engineering and PCR based antibody quantification and may also be implicated in mRNA transcription and ***,the diversity of AUSs remains *** 5′rapid amplification of cDNA ends and high-throughput antibody repertoire sequencing technique,we acquired full-length AUSs for human,rhesus macaque,cynomolgus macaque,mouse,and *** designed a bioinformatics pipeline and identified 3307 unique AUSs,corresponding to 302. and 1457 unique sequences for 5′UTR and leader region,*** analysis indicated that 92.(63.69%)leader sequences are novel relative to those recorded in the international ImMunogenetics information ***,leader sequences are more conserved than 5′UTR and seem to coevolve with their downstream V ***,single-nucleotide polymorphisms are position dependent for leader regions and may contribute to the functional reversal of the downstream V ***,the AUGs in AUSs were found to have little impact on gene *** together,our findings can facilitate primer design for capturing antibodies efficiently and provide a valuable resource for antibody engineering and molecule-level antibody studies.

关键词： Antibody upstream sequences 5′UTR Leader sequences Antibody repertoire sequencing Antibody repertoire

Modes of genetic adaptations underlying functional innovations in the rumen

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Science china(Life Sciences) 2021年第1期64卷 1-21页

作者： Xiangyu Pan Yudong Cai Zongjun Li Xianqing chen Rasmus Heller Nini Wang Yu Wang chen Zhao Yong Wang Han Xu Songhai Li Ming Li Cunyuan Li Shengwei Hu Hui Li Kun Wang Lei chen Bin Wei Zhuqing Zheng Weiwei Fu Yue yang Tingting zhang Zhuoting Hou Yueyang yan Xiaoyang Lv Wei sun Xinyu Li Shisheng huang Lixiang Liu Shengyong Mao Wenqing Liu Jinlian hua Zhipeng Li Guojie zhang Yulin chen Xihong Wang Qiang Qiu Brian PDalrymple Wen Wang Yu Jiang key laboratory of Animal {2.s Breeding and Reproduction of Shaanxi ProvinceCollege of Animal Science and TechnologyNorthwest A&F UniversityYangling712100China School of Ecology and Environment Northwestern Polytechnical UniversityXi’an710072China Section for Computational and RNA Biology Department of BiologyUniversity of CopenhagenCopenhagenDK-2100Denmark University of Chinese Academy of Sciences Beijing100049China Center for Excellence in Animal Evolution and genetics Chinese Academy of SciencesKunming650223China CEMS NCMISMDISAcademy of Mathematics and Systems ScienceChinese Academy of SciencesBeijing100080China Marine Mammal and Marine Bioacoustics laboratory Institute of Deep-sea Science and EngineeringChinese Academy of SciencesSanya572000China College of Life Sciences Shihezi UniversityShihezi832003China state key {2. for Conservation and Utilization of Subtropical Agro-Bioresources College of Animal Science and TechnologyGuangxi UniversityNanning530005China College of Animal Science and Technology Yangzhou UniversityYangzhou225009China Joint International Research laboratory of Agriculture and Agri-Product Safety of ministry of {2. of china Yangzhou UniversityYangzhou225009China key laboratory for Major Obstetric Diseases of Guangdong Province The Third Affiliated Hospital of Guangzhou Medical UniversityGuangzhou510150China School of Life Science and Technology Shanghai Tech UniversityShanghai201210China College of Animal Science and Technology Nanjing Agricultural UniversityNanjing210095China College of Veterinary Medicine Shaanxi Centre of Stem Cells Engineering&TechnologyNorthwest A&F UniversityYangling712100China Department of Special Economic Animal Nutrition and Feed Science Institute of Special Animal and Plant SciencesChinese Academy of Agricultural SciencesChangchun130112China Section for Ecology and Evolution Department of BiologyUniversity of CopenhagenCopenhagenDK-2100Denmark china National GeneBank BGI-ShenzhenShen

The rumen is the hallmark organ of ruminants and hosts a diverse ecosystem of microorganisms that facilitates efficient digestion of plant *** analyzed 897 transcriptomes from three Cetartiodactyla lineages:ruminants,camels and cetaceans,as well as data from ruminant comparative genomics and functional assays to explore the genetic basis of rumen functional *** identified genes with relatively high expression in the rumen,of which many appeared to be recruited from other *** genes show functional enrichment in ketone body metabolism,regulation of microbial community,and epithelium absorption,which are the most prominent biological processes involved in rumen *** modes of genetic change underlying rumen functional innovations were uncovered,including coding mutations,genes newly evolved,and changes of regulatory *** validated that the {2. ketogenesis rate-limiting gene(HMGCS2.with five ruminant-specific mutations was under positive selection and exhibits higher synthesis activity than those of other *** newly evolved genes(LYZ1 and DEFB1)are resistant to Gram-positive bacteria and thereby may regulate microbial community ***,we confirmed that the changes of regulatory elements accounted for the majority of rumen gene *** results greatly improve our understanding of rumen evolution and organ evo-devo in general.

关键词： rumen innovations comparative transcriptomics comparative genomics evo-devo evolution of organs

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Biomarkers of aging

Science china(Life Sciences) 2023年第5期66卷 893-1066页

作者： Aging Biomarker Consortium Hainan Bao Jiani Cao Mengting chen Min chen Wei chen Xiao chen yanhao chen Yu chen Yutian chen Zhiyang chen Jagadish K Chhetri Yingjie Ding Junlin Feng Jun Guo Mengmeng Guo Chuting He Yujuan Jia Haiping Jiang Ying Jing Dingfeng Li Jiaming Li Jingyi Li Qinhao Liang Rui Liang Feng Liu Xiaoqian Liu Zuojun Liu Oscar Junhong Luo Jianwei Lv Jingyi Ma Kehang Mao Jiawei Nie Xinhua Qiao Xinpei sun Xiaoqiang Tang Jianfang Wang Qiaoran Wang Siyuan Wang Xuan Wang yaning Wang Yuhan Wang Rimo Wu Kai Xia Fu-Hui Xiao Lingyan Xu Yingying Xu Haoteng yan Liang yang Ruici yang Yuanxin yang Yilin Ying Le zhang Weiwei zhang Wenwan zhang Xing zhang Zhuo zhang Min Zhou Rui Zhou Qingchen Zhu Zhengmao Zhu Feng Cao Zhongwei Cao Piu Chan Chang chen Guobing chen Hou-Zao chen Jun chen Weimin Ci Bi-sen Ding Qiurong Ding Feng Gao Jing-Dong JHan Kai huang Zhenyu Ju Qing-Peng Kong Ji Li Jian Li Xin Li Baohua Liu Feng Liu Lin Liu Qiang Liu Qiang Liu Xingguo Liu Yong Liu Xianghang Luo Shuai Ma Xinran Ma Zhiyong Mao Jing Nie Yaojin Peng Jing Qu Jie Ren Ruibao Ren Moshi Song Zhou Songyang Yi Eve sun Yu sun Mei Tian Shusen Wang Si Wang Xia Wang Xiaoning Wang yan-Jiang Wang Yunfang Wang Catherine CL Wong Andy Peng Xiang Yichuan Xiao Zhengwei Xie Daichao Xu Jing Ye Rui Yue Cuntai zhang Hongbo zhang Liang zhang Weiqi zhang Yong zhang Yun-Wu zhang Zhuohua zhang Tongbiao Zhao Yuzheng Zhao Dahai Zhu Weiguo Zou Gang Pei Guang-Hui Liu Aging Biomarker Consortium(ABC) Beijing 100101China CAS key laboratory of Genomic and Precision Medicine Beijing Institute of GenomicsChinese Academy of Sciences and China National Center for BioinformationBeijing 100101China state key {2. of Stem Cell and Reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China Department of Dermatology Xiangya HospitalCentral South UniversityChangsha 410008China Hunan key laboratory of Aging Biology Xiangya HospitalCentral South UniversityChangsha 410008China National Clinical Research Center for Geriatric Disorders Xiangya HospitalCentral South UniversityChangsha 410008China Clinic Center of Human Gene Research Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Hubei Clinical Research Center of Metabolic and Cardiovascular Disease Huazhong University of Science and TechnologyWuhan 430022China Hubei key laboratory of Metabolic Abnormalities and Vascular Aging Huazhong University of Science and TechnologyWuhan 430022China Stem Cell Translational Research Center Tongji HospitalTongji University School of MedicineShanghai 200065China Department of Nuclear Medicine Daping HospitalThird Military Medical UniversityChongqing 400042China CAS key laboratory of Nutrition Metabolism and Food SafetyShanghai Institute of Nutrition and HealthUniversity of Chinese Academy of SciencesChinese Academy of SciencesShanghai 200031China Shanghai key laboratory of Maternal Fetal Medicine Clinical and Translational Research Center of Shanghai First Maternity and Infant HospitalFrontier Science Center for Stem Cell ResearchShanghai Key Laboratory of Signaling and Disease ResearchSchool of Life Sciences and TechnologyTongji UniversityShanghai 200092China The Department of Endovascular Surgery The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China key laboratory of Regenerative Medicine of {2. of education Institute of Ageing and Regenerative MedicineJ

Aging biomarkers are a combination of biological parameters to(i)assess age-related changes,(ii)track the physiological aging process,and(iii)predict the transition into a pathological *** a broad spectrum of aging biomarkers has been developed,their potential uses and limitations remain poorly *** immediate goal of biomarkers is to help us answer the following three fundamental questions in aging research:How old are we?Why do we get old?And how can we age slower?This review aims to address this ***,we summarize our current knowledge of biomarkers developed for cellular,organ,and organismal levels of aging,comprising six pillars:physiological characteristics,medical imaging,histological features,cellular alterations,molecular changes,and secretory *** fulfill all these requisites,we propose that aging biomarkers should qualify for being specific,systemic,and clinically relevant.

关键词： aging senescence biomarker clock

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盘点气候风险机遇,展望健康繁荣未来

科学通报 2024年第27期69卷 4005-4011页

作者：张诗卉张弛蔡闻佳白玉琪 Max Callaghan 常楠陈彬陈慧琪程亮亮戴瀚程代鑫范维澄房小怡高仝耿阳关大博胡艺馨华峻翊黄存瑞黄弘黄建斌黄小猛纪思翰蒋俏蕾姜晓朋 Gregor Kiesewetter 李湉湉梁璐林波荣林华亮刘欢刘起勇刘小波刘钊刘竹刘昱甫陆波鲁晨曦罗震宇马伟米志付任超 Marina Romanello 沈鉴翔苏婧孙语泽孙昕璐汤绪 Maria Walawender 王灿王情汪蕊 Laura Warnecke 魏汪宇文三妹谢杨熊辉徐冰颜钰杨秀姚芳虹俞乐袁嘉灿曾仪娉张镜张璐张锐张尚辰张少辉赵梦真郑大山周浩周景博周子乔罗勇宫鹏清华大学地球系统科学系北京100084 北京理工大学管理学院北京100081 Mercator Research Institute on Global Commons and Climate Change Mercator Research Institute on Global Commons and Climate ChangeBerlin 10829Germany 南京医科大学公共卫生学院南京211166 北京师范大学环境学院北京100875 中山大学公共卫生学院广州510080 北京大学环境科学与工程学院北京100871 清华大学公共安全研究所北京100084 清华大学工程物理系北京100084 中国气象科学研究院气象影响与风险研究中心北京100086 山东师范大学商学院济南250013 清华大学建筑学院北京100084 南方科技大学统计与数据科学系深圳518055 中国海洋大学国际事务与公共管理学院青岛266003 清华大学万科公共卫生学院北京100084 清华大学新闻与传播学院北京100084 世界卫生组织驻华代表处北京100600 Pollution Management Research Group EnergyClimateand Environment ProgramInternational Institute for Applied Systems Analysis(IIASA)Laxenburg 1-A-2361Austria 中国疾病预防控制中心环境与健康相关产品安全所环境健康风险评估室北京102206 Department of Landscape Architecture&Environmental Planning University of CaliforniaBerkeley CA 94607USA 清华大学环境学院北京100084 中国疾病预防控制中心传染病预防控制所传染病预防控制国家重点实验室北京102206 北京经济管理职业学院临空经济管理学院北京100102 中国气象局国家气候中心北京100081 Geography College of Life and Environmental SciencesUniversity of ExeterExeter EX12LUUK 山东大学齐鲁医学院公共卫生学院流行病学系济南250002 The Bartlett School of Sustainable Construction University College LondonLondon WC1H 0ALUK 香港大学建筑学院中国香港999077 Institute for Global Health University College LondonLondon WC1H 0ALUK 清华大学人文学院北京100084 复旦大学大气与海洋系/大气科学研究院上海200438 复旦大学极端天气/气候事件与人体健康风险互联和治理国际卓越中心上海200438 北京航空航天大学经济与管理学院北京100083 香港科技大学计算机科学与工程系广州511453 清华大学气候变化与可持续发展研究院北京100084 北京大学体育教研部北京100871 清华大学苏世民学院北京100084 清华大学城市治理与可持续发展研究院北京100084 百度研究院北京100091 香港大学地球科学系和地理系中国香港999077

气候变化带来的健康风险与日俱增,煤炭消费及相关碳排放量的反弹,再度敲响了中国气候变化警钟.2.2.年,中国面临了严峻的气候挑战.极端天气事件发生的频率和强度不断上升,许多地区气温纪录屡创新高,全国平均气温攀升至历史第二高位,同时... 详细信息

气候变化带来的健康风险与日俱增,煤炭消费及相关碳排放量的反弹,再度敲响了中国气候变化警钟.2.2.年,中国面临了严峻的气候挑战.极端天气事件发生的频率和强度不断上升,许多地区气温纪录屡创新高,全国平均气温攀升至历史第二高位,同时降水量自2.12.以来创新低,南方地区遭遇夏秋连旱,而湖南和东北地区则出现了极端降雨和洪涝灾害.采取及时、充分的措施不仅能减轻气候变化对健康的影响,还将保护基础设施不被极端天气破坏.

关键词：煤炭消费极端天气事件基础设施气候变化极端降雨碳排放量气候风险盘点

Nucleic acids analysis

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Science china Chemistry 2021年第2期64卷 171-203页

作者： Yongxi Zhao Xiaolei Zuo Qian Li Feng chen yan-Ru chen Jinqi Deng Da Han Changlong Hao Fujian huang yanyi huang Guoliang Ke hua Kuang Fan Li Jiang Li Min Li Na Li Zhenyu Lin Dingbin Liu Juewen Liu Libing Liu Xiaoguo Liu Chunhua Lu Fang Luo Xiuhai Mao Jiashu sun Bo Tang Fei Wang Jianbin Wang Lihua Wang Shu Wang Lingling Wu Zai-Sheng Wu Fan Xia Chuanlai Xu yang yang Bi-Feng Yuan Quan Yuan Chao zhang Zhi Zhu Chaoyong yang Xiao-Bing zhang huanghao yang Weihong Tan Chunhai Fan Institute of Analytical Chemistry and Instrument for Life Science The Key Laboratory of Biomedical Information Engineering of Ministry of EducationSchool of Life Science and TechnologyXi’an Jiaotong UniversityXi’an 710049China Institute of Molecular Medicine Shanghai Key Laboratory for Nucleic Acid Chemistry and NanomedicineRenji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200127China School of Chemistry and Chemical engineering Frontiers Science Center for Transformative MoleculesInstitute of Translational MedicineShanghai Jiao Tong UniversityShanghai 200240China Cancer Metastasis Alert and Prevention Center Fujian Provincial Key Laboratory of Cancer Metastasis Chemoprevention and ChemotherapyState Key Laboratory of Photocatalysis on Energy and EnvironmentCollege of ChemistryFuzhou UniversityFuzhou 350108China CAS key laboratory of Standardization and Measurement for Nanotechnology CAS Center for Excellence in NanoscienceNational Center for Nanoscience and TechnologyBeijing 100190China state key Lab of Food Science and Technology International Joint Research Laboratory for Biointerface and BiodetectionSchool of Food Science and TechnologyJiangnan UniversityWuxi 214122China Faculty of Materials Science and Chemistry Engineering Research Center of Nano-Geomaterials of Ministry of EducationChina University of GeosciencesWuhan 430074China College of Chemistry and Molecular engineering Biomedical Pioneering Innovation Center(BIOPIC)Beijing Advanced Innovation Center for Genomics(ICG)Peking-Tsinghua Center for Life SciencesPeking UniversityBeijing 100871China state key {2. of Chemo/Biosensing and Chemometrics College of Chemistry and Chemical EngineeringHunan UniversityChangsha 410082China Division of Physical Biology CAS Key Laboratory of Interfacial Physics and TechnologyShanghai Institute of Applied PhysicsChinese Academy of SciencesShanghai 201800China Bioimaging Center Shanghai Synchrotron Radiation FacilityZhangjiang LaboratoryShanghai Advanced

Nucleic acids are natural biopolymers of nucleotides that store, encode, transmit and express genetic information, which play central roles in diverse cellular events and diseases in living things. The analysis of nucleic acids and nucleic acids-based analysis have been widely applied in biological studies, clinical diagnosis, environmental analysis, food safety and forensic *** the past decades, the field of nucleic acids analysis has been rapidly advancing with many technological *** this review, we focus on the methods developed for analyzing nucleic acids, nucleic acids-based analysis, device for nucleic acids analysis, and applications of nucleic acids analysis. The representative strategies for the development of new nucleic acids analysis in this field are summarized, and {2. advantages and possible limitations are discussed. Finally, a brief perspective on existing challenges and further research development is provided.

关键词： nucleic acids analysis signal amplification DNA nanotechnology aptamer biosensing

A YAP/TAZ-CD54 axis is required for CXCR2.CD44-tumor-specific neutrophils to suppress gastric cancer

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Protein & Cell 2023年第7期14卷 515-533页

作者： Pingping Nie Weihong zhang yan Meng Moubin Lin Feng{2. Guo Hui zhang Zhenzhu Tong Meng Wang Fan chen Liwei An yang Tang Yi Han Ruixian Yu Wenjia Wang Yuanzhi Xu Linxin Wei Zhaocai Zhou Shi Jiao CAS Center for Excellence in Molecular Cell Science Institute of Biochemistry and Cell BiologyShanghai Institutes for Biological SciencesChinese Academy of SciencesUniversity of Chinese Academy of SciencesShanghai 200031China state key {2. of genetic engineering School of Life SciencesZhongshan HospitalFudan UniversityShanghai 200438China Tongji University Cancer Center Department of Medical UltrasoundShanghai Tenth People's HospitalUltrasound Research and Education InstituteTongji University School of MedicineShanghai200072China Postdoctoral Station of Clinical Medicine Shanghai Tenth People's HospitalTongji University School of MedicineShanghai 200072China Tumor Immunology and Gene Therapy Center Shanghai Eastem Hepatobiliary Surgery HospitalShanghai 200438China Department of General Surgery Yangpu HospitalTongji University School of MedicineShanghai 200090China Department of General Surgery Hua'shan HospitalFudan University Shanghai Medical CollegeShanghai 200040China Department of Stomatology Shanghai Tenth People's HospitalTongji University School of MedicineShanghai 200072China Collaborative Innovation Center for Cancer Personalized Medicine School of Public HealthNanjing Medical UniversityNanjing 211166China

As an important part of tumor microenvironment,neutrophils are poorly understood due to their spatiotemporal heterogeneity in *** we defined,at single-cell resolution,CD44-CxCR2.neutrophils as tumor-specific neutrophils(tsNeus)in both mouse and human gastric cancer(GC).We uncovered a Hippo regulon in neutrophils with unique YAP signature genes(e.g.,ICAM1,CD14,EGR1)distinct from those identified in epithelial and/or cancer ***,knockout of YAP/TAz in neutrophils impaired their differentiation into CD54+tsNeus and reduced their antitumor activity,leading to accelerated GC ***,the relative amounts of CD54+tsNeus were found to be negatively associated with GC progression and positively associated with patient ***,GC patients receiving neoadjuvant chemotherapy had increased numbers of CD54+***,pharmacologically enhancing YAP activity selectively activated neutrophils to suppress refractory GC,with no significant inflammation-related side ***,our work characterized tumor-specific neutrophils in GC and revealed an essential role of YAP/TAZ-CD54 axis in tsNeus,opening a new possibility to develop neutrophil-based antitumor therapeutics.

关键词： neutrophils YAP TAZ gastriccancer

Genome-widemining, characterization, and development of microsatellite markers in gossypium species.

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Genome-widemining, characterization, and development of micr...

Metabolic tuning of a stable microbial community in the surface oligotrophic Indian Ocean revealed by integrated meta-omics

江苏省遗传学会第九次会员代表大会暨学术研讨会

作者： Qiong Wang Lei Fang Jiedan chen yan Hu Zhanfeng Si {2. Wang Lijing Chang Wangzhen Guo Tianzhen zhang state key {2. of Crop genetics and Germplasm Enhancement Cotton Hybrid R ＆D Engineering Center （the Ministry of Education） Nanjing Agricultural University

Although much research has been conducted to characterize microsatellites and develop markers, the distribution of microsatellites remains ambiguous and the use of microsatellite markers in genomic studies and marker-assisted selection is limited. To identify microsatellites for cotton research, we mined 100,2.0, 83,160, and 56,937 microsatellites with frequencies of 41.2. 49.1, and 74.8 microsatellites per Mb in the recently sequenced Gossypium species: G. hirsutum, G. arboreum, and G. raimondii, respectively. The distributions of microsatellites in their genomes were non-random and were positively and negatively correlated with genes and transposable elements, respectively. Of the 77,996 developed microsatellite markers, 65,498 were physically anchored to the 2. chromosomes of G. hirsutum with an average marker density of 34 markers per Mb. We confirmed 67,880（87%） universal and 7,705（9.9%） new genic microsatellite markers. The polymorphism was estimated in above three species by in silico PCR and validated with 505 markers in G. hirsutum. We further predicted 8,82. polymorphic microsatellite markers within G. hirsutum acc. TM-1 and G. barbadense cv. Hai712.. In our study, genome-wide mining and characterization of microsatellites, and marker development were very useful for the saturation of the allotetraploid genetic linkage map, genome evolution studies and comparative genomemapping.

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Marine Life Science & Technology 2022年第2期4卷 277-290页

作者： zhang-Xian Xie Ke-Qiang yan Ling-Fen Kong Ying-Bao Gai Tao Jin yan-Bin He Ya-Yu Wang Feng chen Lin Lin Zhi-Long Lin Hong-Kai Xu Zong-Ze Shao Si-Qi Liu Da-Zhi Wang state key {2. of Marine Environmental Science/College of the Environment and Ecology Xiamen UniversityXiamen361005China College of Ocean and Earth Sciences Xiamen UniversityXiamen361005China Southern Marine Science and engineering Guangdong laboratory(Zhuhai) Sun Yat-Sen UniversityZhuhai519082China BGI-Shenzhen Beishan Industrial Zone 11th BuildingShenzhen518083China BGI education Center University of Chinese Academy of SciencesShenzhen518083China key laboratory of Marine {2. Resources Third Institute of OceanographyMinistry of Natural Resources of ChinaXiamen361005China state key {2. Breeding Base of Marine genetic Resources/Fujian key {2. of Marine genetic Resources Xiamen361005China Institute of Marine and Environmental Technology University of Maryland Center for Environmental ScienceBaltimoreMD21202USA

Understanding the mechanisms,structuring microbial communities in oligotrophic ocean surface waters remains a major ecological *** redundancy and metabolic tuning are two mechanisms that have been proposed to shape microbial response to environmental ***,little is known about their roles in the oligotrophic surface ocean due to less integrative characterization of community taxonomy and ***,we applied an integrated meta-omics-based approach,from genes to proteins,to investigate the microbial community of the oligotrophic northern Indian *** spatial variabilities of both genomic and proteomic compositions indicated a stable microbial community that was dominated by Prochlorococcus,Synechococcus,and ***,fine tuning of some metabolic functions that are mainly driven by salinity and temperature was ***,a tuning divergence occurred between metabolic potential and activity in response to different environmental *** results indicate that metabolic tuning is an important mechanism for sustaining the stability of microbial communities in oligotrophic *** addition,integrated meta-omics provides a powerful tool to comprehensively understand microbial behavior and function in the ocean.

关键词： Microbial community Metabolic tuning Metaproteomics Metagenomics Oligotrophic ocean