检索结果-南通市图书馆

Signaling pathways and targeted therapies for psoriasis

Signal Transduction and Targeted Therapy 2023年第12期8卷 5835-5872页

作者： Jia Guo hanyi zhang Wenrui Lin Lixia Lu Juan Su Xiang Chen Department of Dermatology Xiangya HospitalCentral South UniversityNo.87 Xiangya RoadChangsha 410008 HunanChina National Engineering Research Center of Personalized Diagnostic and Therapeutic Technology Changsha 410008 HunanChina Hunan Key Laboratory of Skin Cancer and Psoriasis Changsha 410008 HunanChina Hunan Engineering Research Center of Skin Health and Disease Changsha 410008 HunanChina

Psoriasis is a common,chronic,and inflammatory skin disease with a high burden on individuals,health systems,and society *** the immunological pathologies and pathogenesis of psoriasis becoming gradually revealed,the therapeutic approaches for this disease have gained revolutionary ***,the mechanisms of less common forms of psoriasis remain ***,severe adverse effects and the recurrence of disease upon treatment cessation should be noted and addressed during the treatment,which,however,has been rarely explored with the integration of preliminary ***,it is crucial to have a comprehensive understanding of the mechanisms behind psoriasis pathogenesis,which might offer new insights for research and lead to more substantive progress in therapeutic approaches and expand clinical options for psoriasis *** this review,we looked to briefly introduce the epidemiology,clinical subtypes,pathophysiology,and comorbidities of psoriasis and systematically discuss the signaling pathways involving extracellular cytokines and intracellular transmission,as well as the cross-talk between *** the discussion,we also paid more attention to the potential metabolic and epigenetic mechanisms of psoriasis and the molecular mechanistic cascades related to its *** review also outlined current treatment for psoriasis,especially targeted therapies and novel therapeutic strategies,as well as the potential mechanism of disease recurrence.

关键词： psoriasis epidemiology treatment

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Design of PANDA ring-core fiber with 10 polarization-maintaining modes

引用

Photonics Research 2017年第1期5卷 1-5页

作者： Haozhe Yan Shangyuan Li Zhengyang Xie Xiaoping Zheng hanyi zhang Bingkun Zhou Tsinghua National Laboratory for Information Science and Technology Department of Electronic EngineeringTsinghua University

We present a polarization-maintaining PANDA ring-core fiber(PM-PRCF) characterized by the combination of a ring-core structure with two stress-applying rods. This special fiber design separates the adjacent modes and avoids the cutoff of the higher-order modes, which is a common problem in elliptical core polarization-maintaining few-mode fibers. Using a high-contrast index ring and stress-induced birefringence, the PM-PRCF features support for 10 vector modes, with effective refractive index separations from their adjacent modes >10^(-4).Broadband performance is investigated subsequently over a wide wavelength range from 1500 to 1630 *** proposed fiber is targeted at applications in space-division multiplexing while eliminating the complex multiple-input multiple-output signal processing.

关键词： core mode ring Design of PANDA ring-core fiber with 10 polarization-maintaining modes

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Low-power system model for quantum entangled photon-pair source

引用

Journal of Systems Engineering and Electronics 2024年第5期35卷 1287-1294页

作者： FENG Tianxuan zhang hanyi FAN Rong MA Honghao DONG Mengcheng LI Lijing School of Instrumentation and Optoelectronic Engineering Beihang UniversityBeijing 100191China Engineering Training Center Beihang UniversityBeijing 102206China Beijing Aerospace Automatic Control Institute Beijing 100854China

The quantum entangled photon-pair source,as an essential component of optical quantum systems,holds great potential for applications such as quantum teleportation,quan-tum computing,and quantum *** current workhorse technique for preparing photon pairs involves performing spon-taneous parametric down conversion(SPDC)in bulk nonlinear ***,the current power consumption and cost of preparing entangled photon-pair sources are relatively high,pos-ing challenges to their integration and *** this paper,we propose a low-power system model for the quantum entan-gled photon-pair source based on SPDC theory and phase matching *** model allows us to analyze the per-formance of each module and the influence of component cha-racteristics on the overall *** our experimental setup,we utilize a 5 mW laser diode and a typical type-II barium metabo-rate(BBO)crystal to prepare an entangled photon-pair *** experimental results are in excellent agreement with the model,indicating a significant step towards achieving the goal of low-power and low-cost entangled photon-pair *** achievement not only contributes to the practical application of quantum entanglement lighting,but also paves the way for the widespread adoption of optical quantum systems in the future.

关键词： low-power system model optical quantum system entangled photon-pair source spontaneous parametric down conversion

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Fast and deterministic optical phased array calibration via pointwise optimisation

引用

Light(Advanced Manufacturing) 2023年第2期4卷 39-47页

作者： Jingwen Shan hanyi zhang Lijing Li Weijie Deng Mingjie Sun Department of Opto-electronic Engineering Beihang UniversityBeijing 100191China Key Laboratory of Optical System Advanced Manufacturing Technology Chinese Academy of SciencesChangchun.*mingjie.sun@***

Owing to the structural errors in the optical phased array,an initial random phase reduces the quality of the deflection *** most commonly applied approach to phase calibration is based on adaptive ***,adaptive optimisation approaches have slow convergence and low diffraction *** proposed a pointwise optimisation approach to achieve fast and accurate beam *** approach conducts phase calibration,combining global traversal and local searches individually for each array *** built a phase-calibration optical system containing a one-dimensional optical waveguide phase array for further verification and designed the relevant *** simulation and experimental results demonstrate that the pointwise optimisation approach accelerates the calibration process and improves the diffraction efficiency.

关键词： Beam deflection Optical phase array Phase calibration

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The Number of Five Basic Elements' Motion of Traditional Chinese Medicine and Cancer Prediction

引用

Journal of Advances in Medicine Science 2020年第2期3卷 26-30页

作者： hanyi zhang OrientalSun Integrated Chinese and Western Medicine Hospital WuhanHubei430033China

"The number of five basic elements'motion"varies according to the date of birth,which is tightly tied to human *** predict cancer with"the number of five basic elements'motion"is simple,accurate,worth of research and *** theory of“five basic elements'motion and six climatic changes”is a key part of Traditional Chinese Medicine,“the number of five basic elements'motion”is strongly related to the physiology and pathology of human *** with folk pathology prediction,“the number of five basic elements'motion”has been proved to have some scientific validity and of high accuracy in cancer prediction,it is worth to study,research and be discussed in-depth.

关键词： The number of five basic elements'motion Cancer prediction Congenital pathology Acquired pathology

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Researches in microwave photonics based packages for millimeter wave system with wide bandwidth and large dynamic range

引用

Frontiers of Optoelectronics 2016年第2期9卷 186-193页

作者： Xiaoping ZHENG Shangyuan LI hanyi zhang Bingkun ZHOU Deptartrnent of Electronic Engineering Tsinghua University Beijing 100084 China

This paper presents an introduction to the researches in microwave photonics based packages and its application, a 973 project （No. 2012CB315600）, which focuses on addressing new requirements for millimeter wave （MMW） system to work with higher frequency, wider bandwidth, larger dynamic range and longer distance of signal distribution. Its key scientific problems, main research contents and objectives are briefed, and some latest achievements by the project team, including generation of linear frequency modulation wave （LFMW）, tunable optoelectronic oscillator （OEO） with lower phase noise, reconfigurable filter with higher Q value, time delay line with wider frequency range, down conversion with gain, and local oscillator （LO） transmission with stable phase, are introduced briefly.

关键词： linear frequency modulation wave (LFMW)generation tunable optoelectronic oscillator (OEO) recon-figurable filter time delay line down-conversion phasestable transmission

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

UWB-over-Fiber transmission system using a dual-output Mach-Zehnder modulator

引用

Chinese Optics Letters 2010年第5期8卷 454-456页

作者：赵颖郑小平张汉一周炳琨 State Key Laboratory on Integrated Optics Tsinghua National Laboratory for Information Science and TechnologyDepartment of Electronic EngineeringTsinghua University

A novel scheme for ultra-wideband（UWB） monocycle pulse generation is proposed based on a dual-output push-pull Mach-Zehnder modulator（MZM）.The MZM is driven by a non-return-to-zero（NRZ） data sequence and biased at the nonlinear point to generate edge-triggered *** combine the complementary pulses forming a monocycle UWB pulse,two schemes are used to implement incoherent summation structure. A proof-of-concept experiment of UWB-over-fiber down-link system is set ***,by using digital signal processing（DSP） to calculate the bit error rate（BER）,the transmission performance of two system configurations is studied.

关键词： Bit error rate Light modulators Optical communication Signal processing

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A Step Tunable External Cavity Semiconductor Laser for WDM Network Deployment

引用

光学学报 2003年第S1期23卷 317-318页

作者： Keying Wu, hanyi zhang, Xiaoping Zheng, Xiang Teng, Weiwei Shi, Yili Guo Dept. of Electronic Engineering, Tsinghua University, Beijing 100084, P. R. China Dept. of Electronic Engineering Tsinghua University Beijing 100084 P. R. China

We put forward a kind of tunable external cavity semiconductor laser with feedback on both chip facets. It outputs the single-frequency laser with high side-mode suppression ratio and the frequency could be step tuned.

关键词： for as et mode WDM

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

PPNet:基于预先预测的降雨短时预测模型

引用

电子与信息学报 2024年第2期46卷 492-502页

作者：宋毅张晗奕孙丰张敬林白琮航天宏图信息技术股份有限公司北京100195 浙江工业大学计算机与科学技术学院杭州310023 山东大学控制科学与工程学院济南250100

降雨短时预测一直以来都是气象预测问题中的热点问题。传统的预测方法基于数值天气预测模型展开预报,但近些年利用深度学习展开基于雷达回波图的降雨短时预测方法受到了广大研究者的关注。其中,时序预测网络存在不能并行计算导致耗时过... 详细信息

降雨短时预测一直以来都是气象预测问题中的热点问题。传统的预测方法基于数值天气预测模型展开预报,但近些年利用深度学习展开基于雷达回波图的降雨短时预测方法受到了广大研究者的关注。其中,时序预测网络存在不能并行计算导致耗时过长的问题且存在梯度爆炸问题。全卷积网络可以解决上述两个问题,但是却不具备时序信息提取的能力。因此,该文以泰勒冻结假设为理论依据,提出一个基于预先预测辅助推断结构的2维全卷积网络(PPNet)。网络先行提取粗粒度时序信息与空间信息,然后利用全卷积结构细化特征粒度,有效缓解2维卷积网络不能提取时序信息的缺陷。此外,该文还提供一种时序特征约束器对预先预测特征进行时间维度的特征约束,使预测特征更倾向于真实特征。消融实验证明所提预先预测辅助推断结构和时序特征约束器具有优秀的时序特征能力,可以提升网络对时序信息的敏感度。与目前最好的降雨预测算法或视频预测算法相比,该文网络均取得较好结果,特别在暴雨指标上达到最优。

关键词：降雨短时预测全卷积预先预测泰勒冻结特征约束

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

格状波分复用网络中的跨域段保护机制

引用

清华大学学报（自然科学版） 2007年第4期47卷 538-541页

作者：袁伟郑小平张汉一清华大学电子工程系北京100084

为了提高网络的生存性,提出一种适用于大规模多域光网络的跨域段保护机制。该机制改进现有“按域分段,域内保护”的段保护方案,将保护通道跨接在受保护域的前后邻域的边界节点上,使得工作通道中相邻的段之间互相重叠,从而实现对域边界... 详细信息

为了提高网络的生存性,提出一种适用于大规模多域光网络的跨域段保护机制。该机制改进现有“按域分段,域内保护”的段保护方案,将保护通道跨接在受保护域的前后邻域的边界节点上,使得工作通道中相邻的段之间互相重叠,从而实现对域边界节点和域间链路的完全保护,克服了现有方案中要求网络相邻域之间共享边界节点的限制。分析这种新机制的信令过程以及相关性能参数,通过仿真计算与一般的通道保护机制进行了比较。结果表明,跨域段保护机制具有更快的保护倒换速度和较好的资源利用率。

关键词：光网络跨域段保护工作通道保护通道

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：