检索结果-南通市图书馆

Geomorphology-oriented theoretical framework and construction method for value-added DEM

Journal of Geographical Sciences 2024年第1期34卷 165-184页

作者： zhang haiping TANG Guoan XIONG Liyang YANG Xin LI Fayuan Key Laboratory of Virtual Geographic Environment Ministry of EducationNanjing Normal UniversityNanjing 210023China School of Geography Nanjing Normal UniversityNanjing 210023China Jiangsu Center for Collaborative Innovation in Geographical Information Resource Development and Application Nanjing 210023China

Digital elevation model(DEM)plays a fundamental role in the study of the earth system by expressing surface configuration,understanding surface process,and revealing surface *** is widely used in analysis and modeling in the field of ***,traditional DEM has the defect of single attribute,which is difficult to support the research in earth system science oriented to geoscience process and mechanism ***,realizing the value-added data model on the basis of traditional DEM is necessary to serve digital elevation modeling and terrain analysis under the background of a new geomorphology research paradigm and earth observation technology.A theoretical framework for value-added DEM that mainly includes concept,connotation,content,and categories,is constructed in this *** relationship between different types of value-added DEMs as well as the research significance and application category of this theoretical framework are also *** following are different methods of value-added DEMs:(1)value-added methods of DEM space and time dimensions that emphasize the integration of the ground and underground as well as coupling of time and space,(2)attribute-based value-added methods composed of material(including underground,surface,and ground)and morphological properties,and(3)value-added methods of features and physical elements that consider geographical objects and landform features formed by natural processes and artificial *** digital terrace,slope,and watershed models are used as examples to illustrate application scenarios of the three kinds of value-added *** study aims to improve expression methods of DEMs under the background of new surveying and mapping technologies by adding value to the DEM at three levels of dimensions,attributes,and elements as well as support knowledge-driven digital geomorphological analysis in the era of big data.

关键词： spatial data model value-added DEM digital terrain analysis geomorphological ontology geomorphology

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Identification of P-type plasma membrane H^(+)-ATPases in common wheat and characterization of TaHA7 associated with seed dormancy and germination

引用

Journal of Integrative Agriculture 2024年第7期23卷 2164-2177页

作者： Bingli Jiang Wei Gao Yating Jiang Shengnan Yan Jiajia Cao Litian zhang Yue zhang Jie Lu Chuanxi Ma Cheng Chang haiping zhang Key Laboratory of Wheat Biology and Genetic Improvement on Southern Yellow&Huai River Valley Ministry of Agriculture and Rural Affairs/College of AgronomyAnhui Agricultural UniversityHefei 230036China

The P-type plasma membrane(PM)H^(+)-ATPases(HAs)are crucial for plant development,growth,and *** HAs have been thoroughly characterized in many different ***,despite their importance,the functions of HAs in germination and seed dormancy(SD)have not been validated in ***,we identified 28 TaHA genes(TaHA1-28)in common wheat,which were divided into five *** examination of gene expression in strong-and weak-SD wheat varieties led to the discovery of six candidate genes(TaHA7/-12/-14/-16/-18/-20).Based on a single nucleotide polymorphism(SNP)mutation(C/T)in the TaHA7 coding region,a CAPS marker(HA7)was developed and validated in 168 wheat varieties and 171 Chinese mini-core collections that exhibit diverse germination and SD *** further verified the roles of the two allelic variations of TaHA7 in germination and SD using wheat mutants mutagenized with ethyl methane sulphonate(EMS)in‘Jimai 22’and‘Jing 411’backgrounds,and in transgenic Arabidopsis ***7 appears to regulate germination and SD by mediating gibberellic acid(GA)and abscisic acid(ABA)signaling,metabolism,and *** results presented here will enable future research regarding the TaHAs in wheat.

关键词： wheat P-type plasma membrane H^(+)-ATPase seed dormancy abscisic acid gibberellin

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Neoadjuvant camrelizumab(an anti-PD-1 antibody)plus chemotherapy or apatinib(a VEGFR-2 inhibitor)for initially unresectable stage II–III non-small-cell lung cancer:a multicentre,two-arm,phase 2 exploratory study

引用

Signal Transduction and Targeted Therapy 2024年第7期9卷 3015-3023页

作者： Haoran Xia Han zhang Zheng Ruan Huibiao zhang Liangdong Sun Hezhong Chen Yongxin Zhou Lele zhang Dongliang Bian Xinsheng Zhu Jing zhang Fenghuan Sun Huansha Yu Nan Song Xiaogang Liu Yuming Zhu haiping zhang Wenxin He Jian Chen Jie Yang Guohan Chen Shiliang Xie Dongfang Tang Xiaomiao zhang Liang Duan Deping Zhao Qinchuan Li Peng zhang Gening Jiang Department of Thoracic Surgery Shanghai Pulmonary HospitalTongji University School of MedicineShanghaiChina Department of Thoracic Surgery Shanghai General HospitalShanghai Jiao Tong University School of MedicineShanghaiChina Department of Thoracic Surgery Huadong Hospital Affiliated to Fudan UniversityShanghaiChina Department of Thoracic Surgery Changhai HospitalNaval Medical UniversityShanghaiChina Department of Thoracic-Cardiovascular Surgery Tongji HospitalTongji University School of MedicineShanghaiChina Central Laboratory Shanghai Pulmonary HospitalTongji University School of MedicineShanghaiChina Experimental Animal Center Shanghai Pulmonary HospitalTongji University School of MedicineShanghaiChina Department of Oncology Shanghai Pulmonary HospitalTongji University School of MedicineShanghaiChina Department of Thoracic Surgery Shanghai East HospitalTongji University School of MedicineShanghaiChina

This multicentre,two-arm,phase 2 study aimed to explore the efficacy and safety of neoadjuvant camrelizumab plus chemotherapy or apatinib in patients with initially unresectable stage II–III non-small-cell lung cancer(NSCLC).Eligible patients regardless of PD-L1 expression received neoadjuvant camrelizumab 200 mg and platinum-doublet chemotherapy every 3 weeks(arm A)or those with PD-L1-positive tumors received neoadjuvant camrelizumab and apatinib 250 mg once daily(arm B),for 2–4 cycles,followed by *** primary endpoint was major pathological response(MPR)*** patients in arm A and 21 in arm B were *** rates were 50.0%(15/30)in arm A and 42.9%(9/21)in arm B,with all patients achieving R0 *** these patients,the MPR and pathological complete response rates were both 20.0%(95%CI 4.3–48.1)in arm A and were 55.6%(95%CI 21.2–86.3)and 11.1%(95%CI 0.3–48.2)in arm B,*** corresponding objective response rates were 33.3%(95%CI 11.8–61.6)and 55.6%(95%CI 21.2–86.3).With a median follow-up of 22.4 months(95%CI 19.0–26.0),the median event-free survival was not reached(NR;95%CI 13.6-NR)in arm A and 16.8 months(95%CI 8.6-NR)in arm *** 3 or above treatment-related adverse events occurred in eight(26.7%)patients in arm A and three(14.3%)in arm *** analysis showed baseline TYROBP expression was predictive of treatment response in arm *** camrelizumab plus chemotherapy or apatinib exhibits preliminary efficacy and manageable toxicity in patients with initially unresectable stage II–III NSCLC.

关键词： Surgery chemotherapy treatment

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

石墨烯负载单原子Mo上合成气催化转化机理:碳组分和Mo-C作用的影响

引用

高等学校化学学报 2024年第7期45卷 101-110页

作者：孔雪张海平夏文生张庆红万惠霖厦门大学化学化工学院固体表面物理化学国家重点实验室醇醚酯化工清洁生产国家工程实验室福建省理论与计算化学重点实验室厦门361005

金属在合成气转化反应中的催化性能与其在反应中的碳化密切相关,然而所形成的金属碳化物的组成和结构十分复杂,使得催化剂活性相的鉴定变得极为困难,因而催化剂中碳组分的作用具有研究意义.本文采用密度泛函理论(DFT)计算研究了单原子M... 详细信息

金属在合成气转化反应中的催化性能与其在反应中的碳化密切相关,然而所形成的金属碳化物的组成和结构十分复杂,使得催化剂活性相的鉴定变得极为困难,因而催化剂中碳组分的作用具有研究意义.本文采用密度泛函理论(DFT)计算研究了单原子Mo负载在无缺陷石墨烯(Mo/pri-graphene)和单碳空位石墨烯(Mo/sv-graphene)上合成气转化制醇的反应机理,以探究碳组分对钼基催化剂上C—O活化的调控作用.结果表明,具有较弱Mo-C作用的Mo/pri-graphene和具有较强Mo-C作用的Mo/sv-graphene上的合成气转化机理存在明显差别.Mo/pri-graphene上最优途径为CO→HCO→CH_(2)O→CH_(3)O→CH_(3)/CH_(4),物种CH_(3)O因转化为CH_(3)/CH_(4)的活化自由能垒偏高而具有一定的稳定性;Mo/sv-graphene上最优途径则为CO→HCO→CH_(2)O→CH_(2)OH→CH_(3)OH/CH_(3)(CH_(4)),共存的产物CH_(3)OH和CH_(3)(CH_(4))为后续的碳链增长提供了可能.Mo/sv-graphene上CO加氢反应的各基元步骤的活化自由能垒总体低于Mo/pri-graphene,其原因是Mo/sv-graphene与反应底物分子间的作用强度低于Mo/pri-graphene与底物分子的作用,Mo/sv-graphene中碳组分可以参与底物分子的活化与转化.因此,催化剂中的碳组分可以调控(和/或参与)底物分子与催化剂间的作用,继而改变反应的活性和选择性.

关键词：单原子钼/石墨烯合成气转化碳反应机理

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

我国夏季奥运会优势项目的项群特征演变分析

引用

体育科技文献通报 2024年第5期32卷 1-3页

作者：张海萍贵州师范大学体育学院贵州贵阳550025

为揭示我国夏季奥运会优势项目的项群特征,本文运用文献资料法等研究方法,分析了第23届至第32届奥运会我国金牌项目的项群分布及演变情况。结果显示:我国技能主导类项群竞技优势总体优于体能主导类项群,优势项目项群发展不稳定,技能主... 详细信息

为揭示我国夏季奥运会优势项目的项群特征,本文运用文献资料法等研究方法,分析了第23届至第32届奥运会我国金牌项目的项群分布及演变情况。结果显示:我国技能主导类项群竞技优势总体优于体能主导类项群,优势项目项群发展不稳定,技能主导类项群呈现明显的波动状态,技战能主导类项群整体呈现“倒U型”,体能主导类项群稳步增长,成为新的主要夺金点。据此,建议:完善技能主导类项群后备力量培养体系,提高项目的可持续发展能力;继续强化体能,稳固体能主导类项群优势;关注技能主导类格斗对抗型项群的分项发展,重建竞技优势。

关键词：夏季奥运会竞技优势项群特征

来源：

维普期刊数据库

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

LINC00319调控PENK调节PI3K/AKT信号通路在骨肉瘤中的机制研究

引用

医学分子生物学杂志 2024年第3期21卷 247-253页

作者：夏非张海平南通大学第二附属医院(南通市第一人民医院)手外科江苏省南通市226000

目的探讨LINC00319调控前脑啡肽(proenkephalin,PENK)调节PI3K/AKT信号通路在骨肉瘤(osteosarcoma,OS)中的机制。方法提取OS患者及非OS患者外周血RNA,qPCR法检测LINC00319及PENK表达水平,分析LINC00319与PENK相关性。在MG63细胞中敲低或过表达LINC00319,qPCR及蛋白质印迹法分别检测PENK的mRNA及蛋白表达。OS小鼠移植瘤模型分为shNC组及shLINC00319组,称量肿瘤重量,免疫组化实验检测肿瘤组织中PENK、AKT、p-AKT、PI3K的表达。MG63细胞分为shNC组、shLINC00319组、shLINC00319+shPENK组,EdU法检测细胞增殖,Transwell法检测细胞侵袭,蛋白质印迹法检测AKT、p-AKT、PI3K蛋白表达水平。结果相较非OS患者,LINC00319在OS患者外周血高表达,PENK在OS患者外周血低表达,PENK与LINC00319表达呈负相关。敲低LINC00319后,PENK mRNA及蛋白水平上调,过表达LINC00319后,PENK mRNA及蛋白水平下调。相较于shNC组,shLINC00319组小鼠肿瘤重量降低,肿瘤组织中AKT蛋白表达水平不变,p-AKT蛋白表达水平降低,PI3K蛋白表达水平降低。相较于shNC组MG63细胞,shLINC00319组细胞增殖与侵袭能力降低,p-AKT、PI3K蛋白表达水平下降;相较于shLINC00319组细胞,shLINC00319+shPENK组细胞的增殖与侵袭能力以及p-AKT、PI3K蛋白的表达水平均有所升高。结论LINC00319在OS患者外周血高表达,PENK在OS患者外周血低表达,两者表达呈负相关性。LINC00319的高表达通过抑制PENK水平,进而激活PI3K/AKT信号通路促进OS细胞增殖及细胞侵袭。

关键词：骨肉瘤 LINC00319 PENK PI3K/Akt

来源：

维普期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

市政工程中软土地基施工技术

引用

科技资讯 2024年第10期22卷 116-118页

作者：张海平张文韬无棣县公用事业服务中心无棣县建丰市政工程有限公司山东滨州251900

城市基础设施建设中,软土地基是一种常见的地质,其具有压缩性高、承载能力差、不均匀沉降等特点。为了有效提升市政工程施工质量,在施工过程中应当对软土地基进行有效处理,确保市政工程可以顺利完成。在市政工程中,软土地基的处理,直接... 详细信息

城市基础设施建设中,软土地基是一种常见的地质,其具有压缩性高、承载能力差、不均匀沉降等特点。为了有效提升市政工程施工质量,在施工过程中应当对软土地基进行有效处理,确保市政工程可以顺利完成。在市政工程中,软土地基的处理,直接影响市政工程的施工质量。为保证工程质量,需要对软土地基进行科学处理。基于此,就市政工程中软土地基施工技术展开分析。

关键词：市政工程软土地基施工技术强夯技术

来源：

维普期刊数据库

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

Hemin associated to cetyltrimethylammonium broide micelles: a biomimetic catalyst for 2,4,6-trichlorophenol degradation

引用

Science China Chemistry 2015年第7期58卷 1220-1226页

作者： Lihui zhang Cheng Gu Ran Hong haiping zhang State Key Laboratory of Pollution Control & Resource Reuse School of Environment Nanjing University School of Chemistry and Chemical Engineering Pingdingshan University

For the first time, an efficient, green, economical biomimetic catalyst （hemin-cetyltrimethylammonium bromide micelles） was discovered to degrade 2,4,6-trichlorophenol （TCP）. The degradation experiments indicate that pH, temperature, the addition of 2-methyIimidazole, and the amount of hydrogen peroxide influence the degradation process. Test of reusability revealed that CTAB micelles can protect hemin from destruction by H202 and that the materials can be recycled. This material can be of great use for waste-water treatment.

关键词： hemin-CTAB micelles biomimetic catalyst degrade TCP recycle

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

《评估指南》背景下幼儿园保育教育质量评估的实施现状、问题与建议——基于浙江省11个地市3088个样本的调查研究

引用

幼儿教育 2024年第27期 3-8页

作者：虞莉莉张海萍浙江省教育厅教研室浙江杭州310012 浙江师范大学儿童发展与教育学院浙江杭州311231 上海师范大学天华学院上海201800

在《幼儿园保育教育质量评估指南》颁布实施的背景下,本研究从评估观念、评估实施、评估结果反馈与运用、困难与需求四个层面,对浙江省11个地市3088位园长、教师进行问卷调查。结果发现:在贯彻落实保教质量评估过程中,浙江省形成了整体... 详细信息

在《幼儿园保育教育质量评估指南》颁布实施的背景下,本研究从评估观念、评估实施、评估结果反馈与运用、困难与需求四个层面,对浙江省11个地市3088位园长、教师进行问卷调查。结果发现:在贯彻落实保教质量评估过程中,浙江省形成了整体推进与个性探索并存的相关经验,地区、园际和教师个体在评估理念和评估实践方面存在差异,幼儿园教师有接受培训指导和减轻负担的现实需求。本研究提出了相关建议。

关键词：幼儿园保教质量评估指南实施现状

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Genomic correlates of the response to first-line PD-1 blockade plus chemotherapy in patients with advanced non-small-cell lung cancer

引用

中华医学杂志(英文版) 2024年第18期

作者： Jiang Tao Chen Jian Wang Haowei Wu Fengying Chen Xiaoxia Su Chunxia zhang haiping Zhou Fei Yang Ying zhang Jiao Sun Huaibo zhang Henghui Zhou Caicun Ren Shengxiang Department of Medical Oncology Shanghai Pulmonary Hospital &amp Thoracic Cancer Institute Tongji University School of Medicine Shanghai China Department of Thoracic Surgery Shanghai Pulmonary Hospital &amp Genecast Biotechnology Co. Ltd Wuxi Jiangsu China Biomedical Innovation Center Beijing Shijitan Hospital Capital Medical University Beijing China School of Oncology Capital Medical University Beijing China

Background: Programmed death 1 (PD-1) blockade plus chemotherapy has become the new first-line standard of care for patients with advanced non-small-cell lung cancer (NSCLC). Yet not all NSCLC patients benefit from this regimen. This study aimed to investigate the predictors of PD-1 blockade plus chemotherapy in untreated advanced ***: We integrated clinical, genomic, and survival data from 287 patients with untreated advanced NSCLC who were enrolled in one of five registered phase 3 trials and received PD-1 blockade plus chemotherapy or chemotherapy alone. We randomly assigned these patients into a discovery cohort (n = 125), a validation cohort (n = 82), and a control cohort (n = 80). The candidate genes that could predict the response to PD-1 blockade plus chemotherapy were identified using data from the discovery cohort and their predictive values were then evaluated in the three cohorts. Immune deconvolution was conducted using transcriptome data of 1014 NSCLC patients from The Cancer Genome Atlas ***: A genomic variation signature, in which one or more of the 15 candidate genes were altered, was correlated with significantly inferior response rates and survival outcomes in patients treated with first-line PD-1 blockade plus chemotherapy in both discovery and validation cohorts. Its predictive value held in multivariate analyses when adjusted for baseline parameters, programmed cell death ligand 1 (PD-L1) expression level, and tumor mutation burden. Moreover, applying both the 15-gene panel and PD-L1 expression level produced better performance than either alone in predicting benefit from this treatment combination. Immune landscape analyses revealed that tumors with one or more variation in the 15-gene panel were associated with few immune infiltrates, indicating an immune-desert tumor ***: These findings indicate that a 15-gene panel can serve as a negative prediction biomarker for first-line PD-1 blockade plus ch

关键词： Non-small-cell lung cancer (NSCLC) Programmed death 1 (PD-1) blockade Gene panel Prediction Biomarker

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：