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An indoor calibration light source of the transmissometers based on spatial light modulation

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Optoelectronics Letters 2022年第2期18卷 65-71页

作者： LIANG Jing zhang guoyu zhang Jian XU Da CHONG Wei SUN Jiliang School of Opto-Electronic Engineering Changchun University of Science and TechnologyChangchun 130022China1 Opto-Electronic Measurement and Control Instrumentation Jilin Province Engineering Research CenterChangchun 130022China Key Laboratory of Opto-Electronic Measurement and Optical Information Transmission Technology Ministry of EducationChangchun 130022China Meteorological Observation Center China Meteorological AdministrationBeijing 100081China

Aiming at the problem that the calibration results of the transmissometers cannot be traced to the meteorological optical range(MOR) defined by the World Meteorological Organization(WMO). We designed an indoor calibration light source of the transmissometers based on spatial light modulation, focusing on the design of a non-intersecting CzernyTurner spectroscopic system which achieved a spectral resolution of less than 1 nm in the range from 380 nm to 780 nm. Then, the calibration light source’s spectrum matching model is established and the digital micromirror device(DMD)’s surface illuminance distribution law is simulated and analyzed. Finally, the MOR error of the calibrated light source is inverted. The results show that the simulation spectrum error of the 2 700 K absolute color temperature is below ±7.4% in the wavelength range from 380 nm to 780 nm, and the MOR error meets the requirements of the International Civil Aviation Organization in 40-2 000 m of MOR.

关键词： source light error

A Light Source System of Multi-star Simulator with Adjustable Background and Controllable Magnitude

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空间科学学报 2017年第6期37卷 760-765页

作者： SUN Gaofei LIU Shi zhang guoyu zhang Yu LEI Jie MA Yiyuan College of Optoelectronic Engineering Changchun University of Science and Technology Changchun 130022 Optical Measurement and Control Instrumentation Jilin Province Engineering Research Center Changchun 130022 Key Laboratory of Space System Simulation Beijing 100853

A light source of multi-star simulator capable of background adjustment and magnitude control has been *** integrating spheres are employed as the star-point light source and the background light source respectively.A beam splitter prism has been designed to serve as the beam combiner for the star-point and the background light sources,and a mathematical model has been constructed respectively to compute the light flux of the two integrating spheres.A magnitude testing system and a background testing system have been created using low-light illuminometer,luminance meter,and testing instruments to measure the star-point magnitude and the background luminance of the multi-star *** test results suggest that the star-point magnitude is adjustable from0 to+5 m_v,with a simulation precision superior to ±0.026 m_*** maximum background luminance is 3.8×10~5 cd·m^(-2),and the minimum background luminance is6.4×10^(-2)cd·m^(-2).The designed light source system can meet the requirements for simulating the stellar map with a sky background.

关键词： Adjustable background Controllable magnitude Multi-Star simulator Light source

Design of Optical and Mechanical Structure for Lunar Simulator Based on Variable Shape and Adjustable Radiance

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空间科学学报 2015年第5期35卷 647-652页

作者： LIU Shi zhang guoyu SUN Gaofei WANG Lingyun GAO Yujuni College of Optoelectronic Engineering Changchun University of Science and Technology Optical Measurement and Control Instrumentation Jilin Province Engineering Research Center Changchun Institute of Optics Fine Machines and PhysicsChinese Academy of Sciences

To simulate the different lunar phases and ensure continuous adjustability of the radiant brightness,a new broad spectrum light and frosted glass were applied and designed in the optical system for lunar simulator with the shapes and radiance being able to be *** to the engineering demand and index requirements of the optical system,three major design aspects are addressed,including the high reliability and maintainability for broad-spectrum light,heat dissipation in lunar simulator for long working hours,and bearing of the main frame under different working *** designing a reasonable machine structure,and through the structure itself with the matrix arrangement of 48 axial flow fans,an effectively cooling air duct is *** and temperature were calculated by the finite element software *** results showed that the displacement deformation reached 0.33 mm and stress deformation reached 0.02 MPa at the temperature of 20℃;when the main frame was in the temperature field between 20℃ and65℃,the maximum displacement deformation reached 13.30 mm and maximum stress deformation is 97.90 MPa,and the amount of this deformation is very small in considering of the mechanical structure dimensions and weight of the lunar simulator.

关键词： Lunar simulator Adjustable shapes and radiance Opt

Star Point Energy Center Correction of Star Simulator Based on Polar Coordinates

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空间科学学报 2016年第3期36卷 407-412页

作者： WANG Lingyun WANG Xinghua WANG Bo zhang guoyu SUN Gaofei LIU Shi LI Wenjun Changchun University of Science and Technology Changchun 130022 Jilin Engineering Research Center of Photoelectric Measurement and Control Instrument Changchun 130022 Tianjin Jinhang Institute of Technical Physics Tianjin 300308

In this paper,various aberrations have been *** only the effects of aberration on geometrical center position are taken into account,but also the deviation of displayed star position energy center caused by aberration is *** two aspects have been taken into comprehensive evaluation and star position *** correction method based on polar coordinates is proposed,and cumbersome partition correction and calculated quantity based on two-dimensional coordinates can be *** experimental results show that the correction processing based on polar coordinates is simpler and easier compared with any other correction *** addition,the correction results are significantly more accurate.

关键词： Aberration Energy center Correction Polar coordinates

Bispecific antibodies in cancer therapy:Target selection and regulatory requirements

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Acta Pharmaceutica Sinica B 2023年第9期13卷 3583-3597页

作者： Yanze Sun Xinmiao Yu Xiao Wang Kai Yuan Gefei Wang Lingrong Hu guoyu zhang Wenli Pei Liping Wang Chengliang Sun Peng Yang State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Drug Design and Optimization ChinaPharmaceutical UniversityNanjing 210009China Department of Medicinal Chemistry School of PharmacyChina Pharmaceutical UniversityNanjing 211198China Institute of Innovative Drug Discovery and Development China Pharmaceutical UniversityNanjing 211198China

In recent years,the development of bispecific antibodies(bsAbs)has been rapid,with many new structures and target combinations being *** boom in bsAbs has led to the successive issuance of industry guidance for their development in the US and ***,there is a high degree of similarity in target selection,which could affect the development of diversity in *** review presents a classification of various bsAbs for cancer therapy based on structure and target selection and examines the advantages of bsAbs over monoclonal antibodies(mAbs).Through database research,we have identified the preferences of available bsAbs combinations,suggesting rational target selection options and warning of potential wastage of medical *** have also compared the US and Chinese guidelines for bsAbs in order to provide a reference for their development.

关键词： Bispecific antibody Target selection Structure Regulatory guidance Cancer immunotherapy Clinical trials Oncology Mechanism

Karyotype Stability and Unbiased Fractionation in the Paleo-Allotetraploid Cucurbita Genomes

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Molecular Plant 2017年第10期10卷 1293-1306页

作者： Honghe Sun Shan WU guoyu zhang Chen Jiao Shaogui Guo Yi Ren Jie zhang Haiying zhang Guoyi Gong zhangcai Jia Fan zhang Jiaxing Tian William J. Lucas Jeff J. Doyle Haizhen Li zhangjun Fei Yong Xu National Engineering Research Center for Vegetables Beijing Academy of Agriculture and Forestry Sciences Key Laboratory of Biology and Genetic Improvement of Horticultural Crops (North China) Beijing Key Laboratory of Vegetable Germplasm Improvement Beijing 100097 China Boyce Thompson Institute Cornell University Ithaca NY 14853 USA Department of Plant Biology College of Biological Sciences University of California Davis CA 95616 USA Section of Plant Breeding & Genetics School of Integrated Plant Sciences Cornell University Ithaca NY 14853 USA USDA-ARS Robert W. Holley Center for Agriculture and Health Ithaca NY 14853 USA

The Cucurbita genus contains several economically important species in the Cucurbitaceae family. Here, we report high-quality genome sequences of C. maxima and C. moschata and provide evidence supporting an allotetraploidization event in Cucurbita. We are able to partition the genome into two homoeologous subgenomes based on different genetic distances to melon, cucumber, and watermelon in the Benincaseae tribe. We estimate that the two diploid progenitors successively diverged from Benincaseae around 31 and 26 million years ago （Mya）, respectively, and the allotetraploidization happened at some point between 26 Mya and 3 Mya, the estimated date when C. maxima and C. moschata diverged. The subgenomes have largely maintained the chromosome structures of their diploid progenitors. Such long-term karyotype stability after polyploidization has not been commonly observed in plant polyploids. The two subgenomes have retained similar numbers of genes, and neither subgenome is globally dominant in gene expression. Allele-specific expression analysis in the C. maxima ×C. moschata interspecific F1 hybrid and their two parents indicates the predominance of trans-regulatory effects underlying expression divergence of the parents, and detects transgressive gene expression changes in the hybrid correlated with heterosis in important agronomic traits. Our study provides insights into polyploid genome evolution and valuable resources for genetic improvement of cucurbit crops.

关键词： Cucurbita maxima Cucurbita moschata paleo-allotetraploid karyotype stability unbiased fractionation allele-specific expression

Research on Solar Simulation System for Test of Solar Radiation Measuring Instrument

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Instrumentation 2017年第1期4卷 3-11页

作者： ZhengRu zhang guoyu Lyu Wenhua Yan Jiajun Su Shi zhang Jian Changchun University of Science and Technology Changchun 130022 Key Laboratory of Photoelectric Measurement&Optical Information Transmission Technology of Ministry of Education Changchun 130022 Meteorological Observation Center China Meteorological AdministrationBeijing 10008 Jiangsu Radio Science Research Institute Co.Ltd. Wuxi 214073

Since traditional solar simulators are mainly applied to spacecraft and photovoltaic industry,they are not suitable for solar radiation measuring instrument test. Therefore,a deep research is carried out on solar simulators to test of solar radiation measuring instrument,so that obtain the requirements of performance test of solar radiation measuring instrument. With a combination of the requirements for national regulations of metrological verification and performance test of pyranometer and pyrheliometer,it lays emphasis on the research of design methods for improving radiation uniformity and stability of solar simulators; it also focuses on design methods of multidimensional detection workbench,which achieves different detection of solar radiation. After practical test,solar irradiation is within Φ60 mm; irradiation non-uniformity is better than ±0.8%; instability is better than ±0.72%;rotating angle precision is better than 0.09°. Then,solar simulator is used to carry out pyranometer sensitivity test,pyranometer directional response test,pyranometer tilt response test and non-linearity test for radiation instruments. Test results showthat the solar simulator meets the testing requirements of solar radiation measuring instruments.

关键词： Solar Simulation System Irradiation Non-uniformity Irradiation Stability Solar Radiation Measuring Instrument Test

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习近平抓落实思想研究

社会主义研究 2017年第5期 1-9页

作者：张国玉国家行政学院中国领导科学研究中心国家行政学院政治学教研部

抓落实思想既是习近平总书记新理念新思想新战略的重要组成部分,又是贯彻落实新理念新思想新战略的重要指导。习近平总书记抓落实思想主要可以归纳为两个维度:一是通过干部抓落实,通过抓住"关键少数"抓落实;二是运用制度抓落实,健全抓... 详细信息

抓落实思想既是习近平总书记新理念新思想新战略的重要组成部分,又是贯彻落实新理念新思想新战略的重要指导。习近平总书记抓落实思想主要可以归纳为两个维度:一是通过干部抓落实,通过抓住"关键少数"抓落实;二是运用制度抓落实,健全抓落实的督查问责制度。靠干部抓落实又有三大要点:第一,要树立求真务实的态度,第二,要明确科学管用的方法,第三,要夯实钉钉子的作风。通过干部抓落实和运用制度抓落实,二者相辅相成,相得益彰。通过干部抓落实为健全制度探索简便管用的经验,运用制度抓落实又切实保证干部抓落实的态度、方法和作风,进而提升抓落实的效果。

关键词：习近平抓落实执行力

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中国共产党思想领导力的构成要素与逻辑体系

甘肃社会科学 2021年第4期 9-16页

作者：张国玉中共中央党校〔国家行政学院〕党的建设教研部北京100089

中国共产党思想领导力是中国共产党的指导思想对人们思想和行动产生的一种定向的积极影响力,这种影响力旨在把党的正确主张转化为群众的自觉行动。领导理念、领导内容、领导方式和领导目的构成了阐释中国共产党思想领导力的要素和层次,... 详细信息

中国共产党思想领导力是中国共产党的指导思想对人们思想和行动产生的一种定向的积极影响力,这种影响力旨在把党的正确主张转化为群众的自觉行动。领导理念、领导内容、领导方式和领导目的构成了阐释中国共产党思想领导力的要素和层次,并形成一个有机的逻辑体系。作为领导理念的思想领导力,重在探讨思想领导力“是什么”,强调思想领导力的方向性。作为领导内容的思想领导力,主要分析思想领导力“领什么”,旨在发挥领导者思想的影响力。作为领导方式的思想领导力,重点阐述思想领导力“怎么领”,强调思想领导力重在赢得人们的思想认同和自觉行动。作为领导目的的思想领导力,侧重探讨思想领导力的“为什么”,中国共产党思想领导力的根本目的在于实现人民群众的自我革新,从而为迈向和接近共产主义远大理想和中国特色社会主义共同理想提供力量保证,确保中国共产党思想领导力的恒久传承。

关键词：中国共产党领导力思想领导变革领导