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Magma mixing in upper mantle: Evidence from high Mg~# olivine hosted melt inclusions in MORBs near East Pacific Rise 13°N

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Chinese Science Bulletin 2010年第16期55卷 1643-1656页

作者： zhang guoliang JIANG ShaoQing OUYANG HeGen CHEN DaiGeng YIN XueBo WANG XiaoYuan WANG XiaoMei ZENG ZhiGang Key Laboratory of Marine Geology and Environment Institute of Oceanology Chinese Academy of Sciences Qingdao 266071 China Graduate University of Chinese Academy of Sciences Beijing 100049 China Chinese Academy of Geological Sciences Beijing 100037 China East China Mineral Exploration and Development Bureau Nanjing 210007 China

在 MORB 的进化期间，岩浆通常招待的早形成的 high-Mg# 橄榄石斑晶融化包括，它关于岩浆的早阶段的进化记录重要信息。从近的东方太平洋的五件 MORB 样品升起(EPR )

关键词：橄榄石融化包括 MORB 混合的岩浆上面的披风东方和平的上升

Berbamine inhibits SARS-CoV-2 infection by compromising TRPMLs-mediated endolysosomal trafficking of ACE2

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Signal Transduction and Targeted Therapy 2021年第5期6卷 1433-1435页

作者： Lihong Huang Terrence Tsz-Tai Yuen Zuodong Ye Shuyan Liu guoliang zhang Hin Chu Jianbo Yue City University of Hong Kong Shenzhen Research Institute ShenzhenChina Department of Biomedical Sciences City University of Hong KongHong KongChina Department of Microbiology Li Ka Shing Faculty of MedicineThe University of Hong KongHong KongChina National Clinical Research Center for Infectious Diseases Shenzhen Third People’s HospitalShenzhenChina

Dear Editor,Middle East respiratory syndrome-related coronavirus(MERS-CoV)is the pathogen responsible for the outbreak of MERS,and we are currently being affected by coronavirus disease 2019(COVID-19)due to infection by the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).The S protein of SARS-CoV-2 or MERS-CoV binds angiotensin-converting enzyme 2(ACE2)or dipeptidyl peptidase-4(DPP4),respectively,to facilitate viral particles entry into *** COVID-19 pandemic has caused major socioeconomic disruptions globally.

关键词： ACE2 infection respiratory

基于网络药理学研究消化复宁汤治疗浅表性胃炎胃脘痛的作用机制

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山西中医药大学学报 2024年第5期25卷 519-529页

作者：张怡李艳刘丽丽施卫兵赵进东张国梁徐经世安徽中医药大学第一临床医学院安徽合肥230031 安徽中医药大学第一附属医院安徽合肥230031 合肥综合性国家科学中心大健康研究院新安医学与中医药现代化研究所安徽合肥230038

目的:利用网络药理学方法及分子对接技术探究消化复宁汤治疗浅表性胃炎(CSG)胃脘痛的作用机制。方法:通过中药系统药理学数据库(TCMSP)、中医药百科全书数据库(ETCM)、本草图鉴数据库(HERB)搜索消化复宁汤组成药物的有效成分及靶点,在Ge... 详细信息

目的:利用网络药理学方法及分子对接技术探究消化复宁汤治疗浅表性胃炎(CSG)胃脘痛的作用机制。方法:通过中药系统药理学数据库(TCMSP)、中医药百科全书数据库(ETCM)、本草图鉴数据库(HERB)搜索消化复宁汤组成药物的有效成分及靶点,在GeneCards、DisGeNET、OMIM数据库搜索CSG的基因靶点,进而获得药物-疾病交集靶点;将交集靶点导入STRING蛋白质互作分析数据库和Cytoscape 3.9.1绘图软件,构建PPI网络图,并筛选核心靶点;再将核心靶点导入DAVID数据库,对其分别进行GO功能富集分析和KEGG通路富集分析;最后选择消化复宁汤的有效成分与核心靶点用AutoDockTool 1.5.6与PyMOL 2.5.0软件进行分子对接及可视化。结果:检索到消化复宁汤药物活性成分118个,靶点基因305个,浅表性胃炎疾病靶点973个,交集靶点118个;筛选出核心靶点21个,分别为IL-1β、ALB、IL-6、Akt1、TNF等。GO功能富集分析结果表明,消化复宁汤治疗CSG主要涉及炎症、药物反应,细胞生长凋亡等;KEGG通路富集程度相对较高的通路有癌症与糖尿病并发症通路、MAPK信号通路、IL-17信号通路、PI3K-Akt信号通路等。分子对接结果显示,核心作用靶点与有效成分具有较稳定的结合能力。结论:消化复宁汤中各种药物成分通过多靶点、多通路协同治疗CSG,为进一步研究CSG胃脘痛治疗提供了线索。

关键词：浅表性胃炎胃脘痛消化复宁汤网络药理学分子对接作用机制

Unveiling the spatial distribution and molecular mechanisms of terpenoid biosynthesis in Salvia miltiorrhiza and S. grandifolia using multi-omicsand DESI-MSI

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Horticulture Research 2023年第7期10卷 192-205页

作者： Jie Xia Ganggui Lou Lan zhang Yanbo Huang Jian Yang Juan Guo Zhechen Qi Zhenhao Li guoliang zhang Shengchun Xu Xijiao Song Xiaodan zhang Yukun Wei Zongsuo Liang Dongfeng Yang College of Life Sciences and Medicine Key Laboratory of Plant Secondary Metabolism and Regulation of Zhejiang ProvinceZhejiang Sci-Tech University310000HangzhouChina Eastern China Conservation Centre for Wild Endangered Plant Resources Shanghai Chenshan Botanical Garden200000ShanghaiChina State Key Lab Breeding Base Dao-Di Herbs National Resource Center Chinese Materia MedicaBeijingChina Academy of Chinese Medical Sciences100000BeijingChina Zhejiang Shouxiangu Botanical Drug Institute Co. Ltd310000HangzhouChina State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-products Zhejiang Academy of Agricultural Sciences310000HangzhouChina Shanghai Botanical Garden ShanghaiChina

Salvia miltiorrhiza and *** are rich in diterpenoids and have therapeutic effects on cardiovascular *** this study,the spatial distribution of diterpenoids in both species was analyzed by a combination of metabolomics and mass spectrometry imaging *** results indicated that diterpenoids in *** were mainly abietane-type norditerpenoid quinones with a furan or dihydrofuran D-ring and were mainly distributed in the periderm of the roots,*** and tanshinone *** compounds in *** were mainly phenolic abietane-type tricyclic diterpenoids with six-or seven-membered C-rings,and were widely distributed in the periderm,phloem,and xylem of the roots,e.g.11-hydroxy-sugiol,11,20-dihydroxy-sugiol,and 11,*** addition,the leaves of *** were rich in tanshinone biosynthesis precursors,such as 11-hydroxy-sugiol,while those of *** were rich in phenolic *** in the upstream pathway of tanshinone biosynthesis were highly expressed in the root of ***,and genes in the downstream pathway were highly expressed in the root of ***,we describe the specific tissue distributions and mechanisms of diterpenoids in two Salvia species,which will facilitate further investigations of the biosynthesis of diterpenoids in plant synthetic biology.

关键词： distribution phenolic roots

A 4H-SiC semi-super-junction shielded trench MOSFET: p-pillar is grounded to optimize the electric field characteristics

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Journal of Semiconductors 2022年第12期43卷 79-87页

作者： Xiaojie Wang Zhanwei Shen guoliang zhang Yuyang Miao Tiange Li Xiaogang Zhu Jiafa Cai Rongdun Hong Xiaping Chen Dingqu Lin Shaoxiong Wu Yuning zhang Deyi Fu Zhengyun Wu Feng zhang College of Physical Science and Technology Xiamen UniversityXiamen 361005China Key Laboratory of Semiconductor Material Sciences Institute of SemiconductorsChinese Academy of SciencesBeijing 100083China Shenzhen Research Institute of Xiamen University Shenzhen 518057China Jiujiang Research Institute of Xiamen University Jiujiang 332000China

A 4H-SiC trench gate metal-oxide-semiconductor field-effect transistor(UMOSFET)with semi-super-junction shiel-ded structure(SS-UMOS)is proposed and compared with conventional trench MOSFET(CT-UMOS)in this *** advantage of the proposed structure is given by comprehensive study of the mechanism of the local semi-super-junction structure at the bottom of the trench *** particular,the influence of the bias condition of the p-pillar at the bottom of the trench on the static and dynamic performances of the device is compared and *** on-resistance of SS-UMOS with grounded(G)and ungrounded(NG)p-pillar is reduced by 52%(G)and 71%(NG)compared to CT-UMOS,***,gate ox-ide in the GSS-UMOS is fully protected by the p-shield layer as well as semi-super-junction structure under the trench and p-base ***,a reduced electric-field of 2 MV/cm can be achieved at the corner of the p-shield ***,the quasi-intrinsic protective layer cannot be formed in NGSS-UMOS due to the charge storage effect in the floating p-pillar,resulting in a large electric field of 2.7 MV/cm at the gate oxide ***,the total switching loss of GSS-UMOS is 1.95 mJ/cm2 and is reduced by 18%compared with *** the contrary,the NGSS-UMOS has the slowest overall switching speed due to the weakened shielding effect of the p-pillar and the largest gate-to-drain capacitance among the *** proposed GSS-UMOS plays an important role in high-voltage and high-frequency applications,and will provide a valuable idea for device design and circuit applications.

关键词： breakdown voltage specific on-resistance silicon carbide switching energy loss super-junction-shield(SS) trench gate MOSFET grounded(G) ungrounded(NG)

Relationship between Ballistic Coefficient and Static Mechanical Properties for Armor Materials

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Journal of University of Science and Technology Beijing 2001年第1期8卷 53-54页

作者： Junpin Lin, Yong zhang, Zhi Lin, guoliang Chen The State Key Laboratory for Advanced Metal Materials, University of Science and Technology Beijing, Beijing 100083, China State Key Lab. Advanced Metal Mat. Univ. of Sci. and Technology Beijing Beijing 100083 China

The relationship between the ballistic coefficient and the static mechanical properties of armor materials was studied. The results show that the ballistic coefficient is determined by the strength, hardness and the toughness of materials. According to the Martel rule, the equation of the relationship between ballistic coefficient and static mechanical properties satisfies the following formula: W-s=M(1+NK1C/rho )Hr. From the mixture law of composite, the prerequisite, for which ballistic coefficient has maximum to reinforcement volume fraction, is obtained by the following equation: dWs/Df=b(K(1)rho (0)-K(0)rho (1))H/rho (2)+(a+bK/rho)(H-1-H-0).

关键词： armor materials ballistic coefficient toughness

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建筑工程管理中创新模式的应用以及发展分析

智能城市应用 2024年第5期7卷 87-89页

作者：张国良世源科技工程有限公司北京100089

随着建筑行业规模的扩大,建筑企业之间的竞争越来越激烈,建筑企业为了能够提高自身的实力,应该更加注重建筑工程的管理工作,并且对建筑管理当中存在的弊端进行优化,在现代化的建筑工程管理当中,应该对于传统的管理模式进行创新,才能适... 详细信息

随着建筑行业规模的扩大,建筑企业之间的竞争越来越激烈,建筑企业为了能够提高自身的实力,应该更加注重建筑工程的管理工作,并且对建筑管理当中存在的弊端进行优化,在现代化的建筑工程管理当中,应该对于传统的管理模式进行创新,才能适应建筑行业的发展要求,对于管理当中的各个环节和内容都要做到全面严格的管理。基于此,本篇文章针对建筑工程管理模式创新的重要意义进行了说明,并阐述了建筑工程管理当中创新模式的应用策略,分析了建筑工程管理中创新模式的发展趋势。

关键词：建筑工程工程管理创新模式应用及发展

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社区闲置交易系统开发实施的前景分析

经济研究导刊 2024年第10期 54-57页

作者：刘珉彤朱敏娜潘柯文王岚张国梁熊高强南京理工大学紫金学院商学院南京210023

随着人们生活水平的不断提高,生活物质更新速度也在不断提升。特别是大学生群体的闲置物品繁多,闲置物品怎样处理或者转手就成了一个难题。因此,以处置大学生群体闲置物品为前提,同时受到新兴互联网思维的影响,服务于大学生的二手交易... 详细信息

随着人们生活水平的不断提高,生活物质更新速度也在不断提升。特别是大学生群体的闲置物品繁多,闲置物品怎样处理或者转手就成了一个难题。因此,以处置大学生群体闲置物品为前提,同时受到新兴互联网思维的影响,服务于大学生的二手交易平台应运而生。通过二手交易平台,大学生可以把自己不用的东西卖给需要它的人,这样不仅可以减轻家庭经济压力,还可以为自己积累一些物质财富。基于此,通过从细分市场、制订营销模式及开发风险等方面入手,研究闲置交易系统的构建。

关键词：大学生闲置交易微信小程序

Performance of Nanofiltration and Reverse Osmosis Membranes in Metal Effluent Treatment

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Chinese Journal of Chemical Engineering 2008年第3期16卷 441-445页

作者：刘飞妮张国亮孟琴章宏梓 College of Biological and Environmental Engineering Zhejiang University of Technology Hangzhou 310014 China College of Materials Science and Chemical Engineenng Zhejiang University Hangzhou 310027 China

The performance of different nanofiltration （NF） and reverse osmosis （RO） membranes was studied in treating the toxic metal effluent from metallurgical industry. The characteristics and filtration behavior of the processes including the wastewater flux, salt rejection and ion rejection versus operating pressure were evaluated. Then the wastewater flux of RO membrane was compared with theoretical calculation using mass transfer models, and good consistency was observed. It was found that a high rejection rate more than 95% of metal ions and a low Chemical Oxygen Demand （COD） value of 10 mg·L^-1 in permeate could be achieved using the RO composite membrane, while the NF rejection of the salt could be up to 78.9% and the COD value in the permeate was 35 mg·L^-1. The results showed that the product water by both NF and RO desalination satisfied the State Reutilization Qualification, but NF would be more suitable for large-scale industrial practice, which offered significantly higher permeate flux at low operating pressure.

关键词： nanofiltration reverse osmosis metal effluent reuse