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不同粗饲料间组合效应及肉牛育肥效果研究

家畜生态学报 2024年第5期45卷 13-23页

作者：王蕾丁军莉刘基伟栾博宇张国梁秦立红翟博李旭吉林省农业科学院吉林长春130033

为研究玉米秸秆、羊草和玉米秸秆青贮不同粗饲料间组合效应及肉牛育肥效果。试验利用体外发酵分别测定玉米秸秆与玉米秸秆青贮、羊草与玉米秸秆青贮以不同比例组合的产气量、干物质消失率、pH、微生物蛋白、氨态氮、挥发性脂肪酸,计算... 详细信息

为研究玉米秸秆、羊草和玉米秸秆青贮不同粗饲料间组合效应及肉牛育肥效果。试验利用体外发酵分别测定玉米秸秆与玉米秸秆青贮、羊草与玉米秸秆青贮以不同比例组合的产气量、干物质消失率、pH、微生物蛋白、氨态氮、挥发性脂肪酸,计算各组合的单项组合效应值和综合组合效应值,结合前期试验设计试验配方,并进行育肥试验。结果表明,(1)玉米秸秆∶玉米秸秆青贮为40∶60时产生最佳正组合效应。(2)羊草∶玉米秸秆青贮为60∶40时产生最佳正组合效应。(3)育肥试验三组平均日增重均随着饲养时间的增加呈现不同程度的增长,但饲养后期增长速度比饲养前期和中期有所降低,全期平均日增重试验Ⅰ组、Ⅲ组极显著高于Ⅱ组(P<0.01)。全期饲料转化率试验Ⅰ组、Ⅲ组显著高于Ⅱ组(P<0.05)。试验Ⅲ组经济效益极显著高于Ⅰ组、Ⅱ组(P<0.01)。综上,不同粗饲料间组合在肉牛育肥及经济效益上取得了较好的效果,其中以羊草+玉米秸秆+玉米秸秆青贮组合粗饲料的试验Ⅲ组效果最好,更好的发挥了肉牛的生产性能,提高了营养物质消化率,降低饲料成本,经济效益最好。

关键词：组合效应体外发酵育肥效果

内服中药复方治疗非酒精性脂肪性肝病的临床研究进展

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实用中医内科杂志 2024年第6期38卷 72-75页

作者：李艳刘丽丽施卫兵张国梁安徽中医药大学第一附属医院安徽合肥230031

近年来,非酒精性脂肪性肝病(NAFLD)的发生率逐年上升,是临床常见的慢性肝病之一,由于其发病机制复杂,现代医学的治疗不仅限于肝脏本身病变,还要控制代谢紊乱。非酒精性脂肪性肝病属于“肝癖”“积聚”“胁痛”等范畴,病位在肝、脾、肾,... 详细信息

近年来,非酒精性脂肪性肝病(NAFLD)的发生率逐年上升,是临床常见的慢性肝病之一,由于其发病机制复杂,现代医学的治疗不仅限于肝脏本身病变,还要控制代谢紊乱。非酒精性脂肪性肝病属于“肝癖”“积聚”“胁痛”等范畴,病位在肝、脾、肾,病理产物有痰、湿、瘀、热等,为虚实夹杂之病。中医药有着多靶点、多途径、整体调节的优势,现就内服中药复方治疗NAFLD的临床研究进行归纳,发现苓桂术甘汤、五苓散、苦黄颗粒、益肾化痰方、桂附理中汤、养肝消脂茶、大黄利胆胶囊、柴胡疏肝散、柴胡化浊饮等中药复方在改善非酒精性脂肪性肝病患者临床症状、肝功能、脂代谢、肝脏影像学指标、胰岛素抵抗、肠道功能、抗炎、血管性疾病危险因素等方面作用显著。

关键词：非酒精性脂肪性肝病中药肝脾临床研究进展

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Compositional and temperature variations of the Pacific upper mantle since the Cretaceous

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Acta Oceanologica Sinica 2016年第4期35卷 19-25页

作者： zhang guoliang Key Laboratory of Marine Geology and Environment Institute of Oceanology Chinese Academy of Sciences Laboratory for Marine Geology Qingdao National Laboratory for Marine Science and Technology

The geological evolution of the Earth during the mid-Cretaceous were shown to be anomalous, e.g., the pause of the geomagnetic field, the global sea level rise, and increased intra-plate volcanic activities, which could be attributed to deep mantle processes. As the anomalous volcanic activities occurred mainly in the Cretaceous Pacific, here we use basalt chemical compositions from the oceanic drilling（DSDP/ODP/IODP） sites to investigate their mantle sources and melting conditions. Based on locations relative to the Pacific plateaus, we classified these sites as oceanic plateau basalts, normal mid-ocean ridge basalts, and near-plateau seafloor basalts. This study shows that those normal mid-ocean ridge basalts formed during mid-Cretaceous are broadly similar in average Na8, La/Sm and Sm/Yb ratios and Sr-Nd isotopic compositions to modern Pacific spreading ridge（the East Pacific Rise）. The Ontong Java plateau（125–90 Ma） basalts have distinctly lower Na8 and143Nd/144 Nd, and higher La/Sm and 87Sr/86 Sr than normal seafloor basalts, whereas those for the near-plateau seafloor basalts are similar to the plateau basalts, indicating influences from the Ontong Java mantle source. The super mantle plume activity that might have formed the Ontong Java plateau influenced the mantle source of the simultaneously formed large areas of seafloor basalts. Based on the chemical data from normal seafloor basalts, I propose that the mantle compositions and melting conditions of the normal mid-ocean ridges during the Cretaceous are similar to the fast spreading East Pacific Rise. Slight variations of mid-Cretaceous normal seafloor basalts in melting conditions could be related to the local mantle source and spreading rate.

关键词： mantle temperature mantle source super mantle plume Cretaceous mid-ocean ridge basalt

Comparative Study of Magmatism in East Pacific Rise Versus Nearby Seamounts:Constraints on Magma Supply and Thermal Structure Beneath Mid-ocean Ridge

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Acta Geologica Sinica(English Edition) 2011年第6期85卷 1286-1298页

作者： zhang guoliang Key Laboratory of Marine Geology and Environment Institute of Oceanology Chinese Academy oJ Sciences Qingdao266071 China

Major elements of 2202 basalts from the East Pacific Rise （EPR） and 888 basalts from near- EPR seamounts are used to investigate their differences in magma crystallization pressures and mantle melting conditions. Crystallization pressure calculation from basalts with 5.0wt%〈MgO〈8.0wt % shows that magma crystallization pressures beneath near-EPR seamounts are positively and negatively correlated with Nas and Fes, respectively. However, these correlations are indistinct in axial lavas, which can be explained by chemical homogenization induced by extensive mixing processes. In each segment divided by major transforms and over-lapping spreading centers （OSCs）, near-EPR seamount lavas have higher magma crystallization pressures, higher Fes and lower Nas than the EPR lavas, which indicate cooler lithosphere, lower degrees and shallower melting depths beneath near-EPR seamounts than the EPR. The correlations between magma crystallization pressures and melting conditions beneath near-EPR seamounts imply that the source thermal state controls the melting degree and melt flux, and then melting process controls the shallow lithosphere temperature and magma crystallization depth （pressure）. The cooler mantle sources beneath near-EPR seamounts produce a lower degree of melting and a less robust magma supply, which results in a deep thermal equilibrium level and high magma crystallization pressure. The magma crystallization pressure decreases significantly as spreading rate of the EPR increases from ~80 mm/year in the north （16~N） to ~160 mm/year in the south （19~S）, while this trend is unobvious in near-EPR seamounts. This suggests that the magma supply controlled by spreading rate dominates the ridge crust temperature and magma crystallization depth, while the near-EPR seamount magma supply is not dominated by the axial spreading rate. Because most seamounts form and gain most of their volume within a narrow zone of 5-15 km from ridge axis, they provide good constraint on magma

关键词： crystallization pressure magma supply thermal structure seamount East Pacific Rise

血清1-磷酸鞘氨醇联合透明质酸检测对结直肠癌的诊断及预后价值

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海南医学院学报 2024年第6期30卷 407-412,420页

作者：陈丹丹胡嘉捷刘鷖雯何怡青杨翠霞张国良高锋杜艳上海交通大学医学院附属第六人民医院中心实验室上海200233 上海交通大学医学院附属第六人民医院检验科上海200233

目的:观察分析结直肠癌(CRC)患者血清1-磷酸鞘氨醇(S1P)和透明质酸(HA)的水平变化及相关性,探讨其对结直肠癌诊断和预后评估的临床价值。方法:收集47例结直肠癌患者(结直肠癌组)、30例肠道良性疾病患者(良性疾病组)和38名健康的体检者(... 详细信息

目的:观察分析结直肠癌(CRC)患者血清1-磷酸鞘氨醇(S1P)和透明质酸(HA)的水平变化及相关性,探讨其对结直肠癌诊断和预后评估的临床价值。方法:收集47例结直肠癌患者(结直肠癌组)、30例肠道良性疾病患者(良性疾病组)和38名健康的体检者(健康对照组)的临床资料,并检测所有受试者的血清S1P和HA水平。利用Spearman相关性分析评估两者相关性。采用受试者工作特征(ROC)曲线评估S1P、HA、癌胚抗原(CEA)和糖类抗原19-9(CA19-9)单独和联合诊断CRC的效能。结果:血清S1P水平在健康对照组、良性疾病组及结直肠癌组中逐次升高(P0.05)。根据Spearman相关性分析结果,结直肠癌组血清S1P水平和HA水平之间存在正相关关系(r=0.406,P0.05)。结论:血清S1P与HA结合检测在结直肠癌的辅助诊断及预后评估中具有一定的临床价值。

关键词： 1-磷酸鞘氨醇透明质酸结直肠癌

基于网络药理学研究消化复宁汤治疗浅表性胃炎胃脘痛的作用机制

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山西中医药大学学报 2024年第5期25卷 519-529页

作者：张怡李艳刘丽丽施卫兵赵进东张国梁徐经世安徽中医药大学第一临床医学院安徽合肥230031 安徽中医药大学第一附属医院安徽合肥230031 合肥综合性国家科学中心大健康研究院新安医学与中医药现代化研究所安徽合肥230038

目的:利用网络药理学方法及分子对接技术探究消化复宁汤治疗浅表性胃炎(CSG)胃脘痛的作用机制。方法:通过中药系统药理学数据库(TCMSP)、中医药百科全书数据库(ETCM)、本草图鉴数据库(HERB)搜索消化复宁汤组成药物的有效成分及靶点,在Ge... 详细信息

目的:利用网络药理学方法及分子对接技术探究消化复宁汤治疗浅表性胃炎(CSG)胃脘痛的作用机制。方法:通过中药系统药理学数据库(TCMSP)、中医药百科全书数据库(ETCM)、本草图鉴数据库(HERB)搜索消化复宁汤组成药物的有效成分及靶点,在GeneCards、DisGeNET、OMIM数据库搜索CSG的基因靶点,进而获得药物-疾病交集靶点;将交集靶点导入STRING蛋白质互作分析数据库和Cytoscape 3.9.1绘图软件,构建PPI网络图,并筛选核心靶点;再将核心靶点导入DAVID数据库,对其分别进行GO功能富集分析和KEGG通路富集分析;最后选择消化复宁汤的有效成分与核心靶点用AutoDockTool 1.5.6与PyMOL 2.5.0软件进行分子对接及可视化。结果:检索到消化复宁汤药物活性成分118个,靶点基因305个,浅表性胃炎疾病靶点973个,交集靶点118个;筛选出核心靶点21个,分别为IL-1β、ALB、IL-6、Akt1、TNF等。GO功能富集分析结果表明,消化复宁汤治疗CSG主要涉及炎症、药物反应,细胞生长凋亡等;KEGG通路富集程度相对较高的通路有癌症与糖尿病并发症通路、MAPK信号通路、IL-17信号通路、PI3K-Akt信号通路等。分子对接结果显示,核心作用靶点与有效成分具有较稳定的结合能力。结论:消化复宁汤中各种药物成分通过多靶点、多通路协同治疗CSG,为进一步研究CSG胃脘痛治疗提供了线索。

关键词：浅表性胃炎胃脘痛消化复宁汤网络药理学分子对接作用机制

Unveiling the spatial distribution and molecular mechanisms of terpenoid biosynthesis in Salvia miltiorrhiza and S. grandifolia using multi-omicsand DESI-MSI

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Horticulture Research 2023年第7期10卷 192-205页

作者： Jie Xia Ganggui Lou Lan zhang Yanbo Huang Jian Yang Juan Guo Zhechen Qi Zhenhao Li guoliang zhang Shengchun Xu Xijiao Song Xiaodan zhang Yukun Wei Zongsuo Liang Dongfeng Yang College of Life Sciences and Medicine Key Laboratory of Plant Secondary Metabolism and Regulation of Zhejiang ProvinceZhejiang Sci-Tech University310000HangzhouChina Eastern China Conservation Centre for Wild Endangered Plant Resources Shanghai Chenshan Botanical Garden200000ShanghaiChina State Key Lab Breeding Base Dao-Di Herbs National Resource Center Chinese Materia MedicaBeijingChina Academy of Chinese Medical Sciences100000BeijingChina Zhejiang Shouxiangu Botanical Drug Institute Co. Ltd310000HangzhouChina State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-products Zhejiang Academy of Agricultural Sciences310000HangzhouChina Shanghai Botanical Garden ShanghaiChina

Salvia miltiorrhiza and *** are rich in diterpenoids and have therapeutic effects on cardiovascular *** this study,the spatial distribution of diterpenoids in both species was analyzed by a combination of metabolomics and mass spectrometry imaging *** results indicated that diterpenoids in *** were mainly abietane-type norditerpenoid quinones with a furan or dihydrofuran D-ring and were mainly distributed in the periderm of the roots,*** and tanshinone *** compounds in *** were mainly phenolic abietane-type tricyclic diterpenoids with six-or seven-membered C-rings,and were widely distributed in the periderm,phloem,and xylem of the roots,e.g.11-hydroxy-sugiol,11,20-dihydroxy-sugiol,and 11,*** addition,the leaves of *** were rich in tanshinone biosynthesis precursors,such as 11-hydroxy-sugiol,while those of *** were rich in phenolic *** in the upstream pathway of tanshinone biosynthesis were highly expressed in the root of ***,and genes in the downstream pathway were highly expressed in the root of ***,we describe the specific tissue distributions and mechanisms of diterpenoids in two Salvia species,which will facilitate further investigations of the biosynthesis of diterpenoids in plant synthetic biology.

关键词： distribution phenolic roots

A 4H-SiC semi-super-junction shielded trench MOSFET: p-pillar is grounded to optimize the electric field characteristics

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Journal of Semiconductors 2022年第12期43卷 79-87页

作者： Xiaojie Wang Zhanwei Shen guoliang zhang Yuyang Miao Tiange Li Xiaogang Zhu Jiafa Cai Rongdun Hong Xiaping Chen Dingqu Lin Shaoxiong Wu Yuning zhang Deyi Fu Zhengyun Wu Feng zhang College of Physical Science and Technology Xiamen UniversityXiamen 361005China Key Laboratory of Semiconductor Material Sciences Institute of SemiconductorsChinese Academy of SciencesBeijing 100083China Shenzhen Research Institute of Xiamen University Shenzhen 518057China Jiujiang Research Institute of Xiamen University Jiujiang 332000China

A 4H-SiC trench gate metal-oxide-semiconductor field-effect transistor(UMOSFET)with semi-super-junction shiel-ded structure(SS-UMOS)is proposed and compared with conventional trench MOSFET(CT-UMOS)in this *** advantage of the proposed structure is given by comprehensive study of the mechanism of the local semi-super-junction structure at the bottom of the trench *** particular,the influence of the bias condition of the p-pillar at the bottom of the trench on the static and dynamic performances of the device is compared and *** on-resistance of SS-UMOS with grounded(G)and ungrounded(NG)p-pillar is reduced by 52%(G)and 71%(NG)compared to CT-UMOS,***,gate ox-ide in the GSS-UMOS is fully protected by the p-shield layer as well as semi-super-junction structure under the trench and p-base ***,a reduced electric-field of 2 MV/cm can be achieved at the corner of the p-shield ***,the quasi-intrinsic protective layer cannot be formed in NGSS-UMOS due to the charge storage effect in the floating p-pillar,resulting in a large electric field of 2.7 MV/cm at the gate oxide ***,the total switching loss of GSS-UMOS is 1.95 mJ/cm2 and is reduced by 18%compared with *** the contrary,the NGSS-UMOS has the slowest overall switching speed due to the weakened shielding effect of the p-pillar and the largest gate-to-drain capacitance among the *** proposed GSS-UMOS plays an important role in high-voltage and high-frequency applications,and will provide a valuable idea for device design and circuit applications.

关键词： breakdown voltage specific on-resistance silicon carbide switching energy loss super-junction-shield(SS) trench gate MOSFET grounded(G) ungrounded(NG)

Start-up of PN-anammox system under low inoculation quantity and its restoration after low-loading rate shock

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Frontiers of Environmental Science & Engineering 2021年第2期15卷 169-179页

作者： guoliang zhang Liang zhang Xiaoyu Han Shujun zhang Yongzhen Peng National Engineering Laboratory for Advanced Municipal Wastewater Treatment and Reuse Technology Engineering Research Center of BeijingBeijing University of TechnologyBeijing 100124China Research and Development Center of Beijing Drainage Group Technology Beijing 100124China

Partial nitritation(PN)-anaerobic ammonium oxidation(anammox)is a promising pathway for the biological treatment of ***,the destruction of the system caused by excessive accumulation of nitrate in long-term operation remains a *** this study,PNanammox was initialized with low inoculation quantity in an air-lift *** nitrogen removal rate of 0.71 kgN/(m^(3)·d)was obtained,which was far higher than the seed sludge(0.3 kgN/(m^(3)·d)).Thereafter,excess nitrate build-up was observed under low-loading conditions,and recovery strategies for the PN-anammox system were *** results suggest that increasing the nitrogen loading rate as well as the concentration of free ammonium failed to effectively suppress the nitrite oxidation bacteria(NOB)after the PN-anammox system was ***,effluent back-flow was added into the reactor to control the up-flow *** a result,an aggressive discharge of sludge that promoted the synergetic growth of functional bacteria was achieved,leading to the successful restoration of the PN-anammox *** partial nitritation and anammox activity were in balance,and an increase in nitrogen removal rate up to 1.07 kgN/(m^(3)·d)was obtained with a nitrogen removal efficiency of 82.4%after ***,the proportion of granular sludge(over 200 mm)increased from 33.67%to 82.82%.Ammonium oxidation bacteria(AOB)along with anammox bacteria were enriched in the granular sludge during the recovery period,which was crucial for the recovery and stable operation of the PN-anammox system.

关键词： PN-anammox Granular sludge Excess nitrate build-up Recovery strategy for partial nitrification Aggressive discharge of sludge