检索结果-南通市图书馆

Pharmacological Mechanism of Chinese Medicine in Systemic Lupus Erythematosus:A Narrative Review

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Integrative Medicine 2025年第2期31卷 157-169页

作者： ZHU Bo-yu LIU Zhi-chao ZHAO Zhen-xi HUANG Hui-ping zhang Na XIA Jia CHEN wei-wei Department of Rheumatology Shanghai Municipal Hospital of Traditional Chinese MedicineShanghai University of Traditional Chinese MedicineShanghai(200071)China

Systemic lupus erythematosus(SLE)is a chronic autoimmune disorder affecting multiple systems,characterized by the development of harmful autoantibodies and immune complexes that lead to damage in organs and *** medicine(CM)plays a role in mitigating complications,enhancing treatment effectiveness,and reducing toxicity of concurrent medications,and ensuring a safe ***,CM mainly solves the disease comprehensively through multi-target and multi-channel regulation process,therefore,its treatment mechanism is often complicated,involving many molecular *** review introduces the research progress of pathogenesis of SLE from the aspects of genetics,epigenetics,innate immunity and acquired immunity,and then discusses the molecular mechanism and target of single Chinese herbal medicine and prescription that are commonly used and effective in clinic to treat SLE.

关键词： systemic lupus erythematosus Chinese medicine natural extracts treatment review

Advances in TENGs for Marine Energy Harvesting and In Situ Electrochemistry

在线全文

学校读者我要写书评

暂无评论

Nano-Micro Letters 2025年第5期17卷 540-603页

作者： Chuguo zhang Yijun Hao Xiangqian Lu wei Su Hongke zhang Zhong Lin Wang Xiuhan Li School of Electronic and Information Engineering Beijing Jiaotong UniversityBeijing 100044People’s Republic of China CAS Center for Excellence in Nanoscience Beijing Key Laboratory of Micro-Nano Energy and SensorBeijing 100190People’s Republic of China Beijing Institute of Nanoenergy and Nanosystems Chinese Academy of SciencesBeijing 101400People’s Republic of China

The large-scale use of ample marine energy will be one of the most important ways for human to achieve sustainable development through carbon neutral development *** a burgeoning technological method for electromechanical conversion,triboelectric nanogenerator(TENG)has significant advantages in marine energy for its low weight,cost-effectiveness,and high efficiency in low-frequency *** can realize the efficient and economical harvesting of low-frequency blue energy by constructing the floating marine energy harvesting *** paper firstly introduces the power transfer process and structural composition of TENG for marine energy harvesting in *** addition,the latest research works of TENG on marine energy harvesting in basic research and structural design are systematically reviewed by ***,the advanced research progress in the power take-off types and engineering study of TENG with the marine energy are comprehensively ***,the challenges and problems faced by TENG in marine energy and in situ electrochemical application are summarized and the corresponding prospects and suggestions are proposed for the subsequent development direction and prospects to look forward to promoting the commercialization process of this field.

关键词： Triboelectric nanogenerator Marine energy Power take-off Self-powered Electrochemistry

Intricate interplay between shear stress and extrusion temperature in Mg−Al composite rods

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Transactions of Nonferrous Metals Society of China 2025年第1期35卷 105-125页

作者： Jian-xing ZHAO Chao-wei ZENG Ting YUAN wei PENG Zhen-wei SUN Ou zhang Hong-jun HU College of Materials Science and Engineering Chongqing University of TechnologyChongqing 400054China

The Mg−Al composite rods of aluminum core-reinforced magnesium alloy were prepared by the extrusion−shear(ES)process,and the microstructure,deformation mechanism,and mechanical properties of the Mg−Al composite rods were investigated at different extrusion temperatures and shear *** experimental results show that the proportion of dynamic recrystallization(DRX)and texture for Al and Mg alloys are controlled by the combination of temperature and shear *** texture type of the Al alloys exhibits slight variations at different *** the increase of temperature,the DRX behavior of Mg alloy shifts from discontinuous DRX(DDRX),continuous DRX(CDRX),and twin-induced DRX(TDRX)dominant to CDRX,the dislocation density in Mg alloy grains decreases significantly,and the average value of Schmid factor(SF)of the basalslip system *** particular,partial grains exhibit a distinct dominant slip system at 390℃.The hardness and thickness of the bonding layer,as well as the yield strength and elongation of the Mg alloy,reach their maximum at 360℃as a result of the intricate influence of the combined temperature and shear stress.

关键词： Mg−Al composite rod texture evolution deformation mechanism intermetallic compound extrusion−shear process

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

台阶式溢洪道滑行水流消能特性研究

长江科学院院报 2014年第6期31卷 37-40页

作者：张峰刘韩生张为法西北农林科技大学水利与建筑工程学院陕西杨凌712100 中国水电工程顾问集团西北勘察设计研究院西安710000

台阶式溢洪道消能率无法详细反映其消能特性,为了突出反映台阶消能作用,从总消能水头中扣除光滑溢洪道原有消能水头得到纯台阶消能部分,计算了单位高度纯台阶消能率,以及台阶消能所占总消能的比重。结果表明:滑行水流的单位高度纯台阶... 详细信息

台阶式溢洪道消能率无法详细反映其消能特性,为了突出反映台阶消能作用,从总消能水头中扣除光滑溢洪道原有消能水头得到纯台阶消能部分,计算了单位高度纯台阶消能率,以及台阶消能所占总消能的比重。结果表明:滑行水流的单位高度纯台阶消能率约为0.80%/m^0.83%/m,与单宽流量和台阶数目均无关,随台阶高度增大增幅为4.5%;纯台阶消能所占总消能比重随单宽流量增大而增加,随台阶数目增多而减小;此外,还对单宽流量增加时消能率下降的原因进行了探讨。结果分析表明:大单宽流量消能率下降是由于光滑溢洪道能作用降低而纯台阶消能不变导致的。

关键词：台阶式溢洪道滑行水流单宽流量台阶高度消能率

斯木塔斯台阶式陡槽溢洪道水力特性模型试验研究

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

中国农村水利水电 2011年第1期 93-96页

作者：张为法刘韩生西北农林科技大学水利与建筑工程学院陕西杨凌712100

斯木塔斯水电站原设计方案泄水建筑物中溢洪道采用了台阶式消能方式,为了论证在高水头,小单宽流量下台阶式溢洪道应用的合理性,有必要对设计方案进行模型试验的研究。借助大比尺的模型试验,对该溢洪道段的流态,压强,掺气,消能率等进行... 详细信息

斯木塔斯水电站原设计方案泄水建筑物中溢洪道采用了台阶式消能方式,为了论证在高水头,小单宽流量下台阶式溢洪道应用的合理性,有必要对设计方案进行模型试验的研究。借助大比尺的模型试验,对该溢洪道段的流态,压强,掺气,消能率等进行了观测。试验结果表明各项水力特性良好,消能效果显著,满足工程实际的需要,为工程决策提供了科学依据。模型试验验证了台阶消能工在高水头,小单宽流量下应用的可行性,对类似工程具有一定的参考价值。

关键词：台阶溢洪道掺气浓度时均压强消能率

Synthesis of intermetallic PtCo fuel cell catalysts from bimetallic core@shell structured nanoparticles

在线全文

学校读者我要写书评

暂无评论

Journal of Energy Chemistry 2025年第2期101卷 1-6页

作者： Le zhang Lei Tong Shuai Li Chang-Song Ma Kun-Ze Xue Hai-wei Liang Hefei National Research Center for Physical Sciences at the Microscale Department of Chemistry University of Science and Technology of China

The high activity and stability of intermetallic PtCo nanocatalysts toward oxygen reduction reaction make them a top candidate as low-Pt cathode catalysts in proton exchange membrane fuel cells（PEMFCs）.However,forming intermetallic structures typically requires high-temperature annealing,posing a challenge for achieving well-size control and highly ordered *** we report the design and synthesis of bimetallic co re@shell structured precursors for affording high-performance intermetallic PtCo *** fabrication of the core@shell precursor involves using a molecular ligand containing both sulfur and oxygen donors to selectively bind with Pt colloidal nanoparticles as the core and chelate Co ions as the *** high-temperature annealing,the ligand transforms into carbon coatings around alloy nanoparticles,preventing particle sintering;meanwhile,Co ions in the shell can easily diffuse into the Pt core,which helps to increase the thermodynamic driving force for forming intermetallic *** benefits enable us to obtain the catalyst with finely dispersed nanoparticles（～3.5 nm）and a high ordering degree of 72%.With 0.1 mgPt/cm2cathode loading,the catalyst delivers superior performance and durability in PEMFCs,showing an initial mass activity of 0.56 A/mgPt,an initial power density of 1.05 W/cm2at 0.67 V（H2-air）,and a voltage loss of 26 mV at 0.8 A/cm2after the accelerated durability test.

关键词： Bimetallic structure Fuel cells Intermetallic PtCo Oxygen reduction reaction

Investigation on coal damage and fracture extension law of liquid nitrogen injection pre-cooling and fracturing under true triaxial stress

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

International Journal of Mining Science and Technology 2025年第2期35卷 213-229页

作者： Botao Li Haifei Lin Jianping wei Hongtu zhang Shugang Li Zongyong wei Lei Qin Pei Wang Rongwei Luo Zeran Liu School of Safety Science and Engineering Henan Polytechnic UniversityJiaozuo 454003China State Key Laboratory Cultivation Base for Gas Geology and Gas Control Henan Polytechnic UniversityJiaozuo 454003China State Collaborative Innovation Center of Coal Work Safety and Clean-efficiency Utilization Henan Polytechnic UniversityJiaozuo 454003China College of Safety Science and Engineering Xi’an University of Science and TechnologyXi’an 710054China Key Laboratory of Shaanxi Province Universities of Gas Disaster Prevention and Control in Western Coal Mines Xi’an 710054China

To more accurately describe the coal damage and fracture evolution law during liquid nitrogen(LN_(2))fracturing under true triaxial stress,a thermal-hydraulic-mechanical-damage(THMD)coupling model for LN_(2) fracturing coal was developed,considering the coal heterogeneity and thermophysical parameters of *** accuracy and applicability of model were verified by comparing with LN_(2) injection pre-cooling and fracturing experimental *** effects of different pre-cooling times and horizontal stress ratios on coal damage evolution,permeability,temperature distribution,and fracture characteristics were *** results show that the permeability and damage of the coal increase exponentially,while the temperature decreases exponentially during the fracturing *** the pre-cooling time increases,the damage range of the coal expands,and the fracture propagation becomes more *** initiation pressure and rupture pressure decrease and tend to stabilize with longer precooling *** the horizontal stress ratio increases,fractures preferentially extend along the direction of maximum horizontal principal stress,leading to a significant decrease in both initiation and rupture *** a horizontal stress ratio of 3,the initiation pressure drops by 48.07%,and the rupture pressure decreases by 41.36%.The results provide a theoretical basis for optimizing LN_(2) fracturing techniques and improving coal seam modification.

关键词： Liquid nitrogen fracturing Thermal–hydraulic-mechanical-damage coupling Heterogeneous coal True triaxial stress Fracture morphology

Design,Synthesis and Pharmacological Evaluation of Novel 4-Phenoxyquinoline Derivatives as VEGFR2 Kinase Inhibitors for Tumor Treatment

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chemical Research in Chinese Universities 2025年第1期41卷 66-78页

作者： JIANG wei CHEN Jiayan WANG Haifeng XUE Aiqi zhang Xinyang GUAN Jichi wei Lulu CAI Jianfeng HU Yong LIU Dan College of Chemical Engineering Shenyang University of Chemical TechnologyShenyang110142P.R.China Institute of Materials Engineering College of Engineering and Applied SciencesNanjing UniversityNanjing210093P.R.China Department of Chemistry University of South Florida4202 E.Fowler AveTampaFL33620USA

Vascular endothelial growth factor 2(VEGFR2)plays a vital role in regulating of tumor metastasis and angiogenesis,which has emerged as one of the effective targets for clinical tumor ***,a series of novel facilely accessible 4-phenoxyquinoline derivatives was prepared and assessed for their antitumor activity against three human tumor cell lines(SGC-7901,HepG2 and A549).Among these compounds,6a,6b and 6c show strong antitumor activity on HepG2 cells[the drug concentration of eliminating half of tumor cells(IC_(50))=9.33,1.84,8.54μmol/L].Notably,compound 6b shows potent selective inhibitory activity against VEGFR2 kinase with an IC_(50) value of 4.66 nmol/*** excellent anti-angiogenesis capability of compound 6b was confirmed by tube formation and chick chorioallantoic membrane(CAM)*** vivo studies confirmed that compound 6b was able to inhibit tumor growth in HepG2 xenografts of BALB/c nude mice without obvious side or toxic *** results demonstrated that compound 6b exhibited remarkable anti-angiogenesis and tumor growth inhibitory effects with less toxicity in vitro and in vivo *** findings highlighted the potential of compound 6b as a promising VEGFR2 kinase inhibitor for the development of antitumor drugs.

关键词： ar endothelial growth factor 2(VEGFR2) 4-Phenoxyquinoline Inhibitor Anti-tumor Angiogenesis

The role of sulfur cycle in new particle formation:Cycloaddition reaction of SO_(3)to H_(2)S

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Environmental Sciences 2025年第2期148卷 489-501页

作者： Haijie zhang wei Wang Liang fan Junling Li Yanqin Ren Hong Li Rui Gao Yisheng Xu State Key Laboratory of Environmental Criteria and Risk Assessment Chinese Research Academy of Environmental SciencesBeijing 100012China Key Laboratory of Cluster Science Ministry of Education of ChinaSchool of Chemistry and Chemical EngineeringBeijing Institute of TechnologyBeijing 100081China

The chemistry of sulfur cycle contributes significantly to the atmospheric nucleation process,which is the first step of new particle formation(NPF).In the present study,cycloaddition reaction mechanism of sulfur trioxide(SO_(3))to hydrogen sulfide(H_(2)S)which is a typical air pollutant and toxic gas detrimental to the environment were comprehensively investigate through theoretical calculations and Atmospheric Cluster Dynamic Code ***-phase stability and nucleation potential of the product thiosulfuric acid(H_(2)S_(2)O_(3),TSA)were further analyzed to evaluate its atmospheric *** any catalysts,the H_(2)S+SO_(3)reaction is infeasible with a barrier of 24.2 kcal/*** nucleation precursors formic acid(fa),sulfuric acid(SA),and water(H_(2)O)could effectively lower the reaction barriers as catalysts,even to a barrierless reaction with the efficiency of cis-SA>trans-fa>trans-SA>H_(2)***,the gas-phase stability of TSA was investigated.A hydrolysis reaction barrier of up to 61.4 kcal/mol alone with an endothermic isomerization reaction barrier of 5.1 kcal/mol under the catalytic effect of SA demonstrates the sufficient stability of ***,topological and kinetic analysis were conducted to determine the nucleation potential of *** clusters formed by TSA and atmospheric nucleation precursors(SA,ammonia NH_(3),and dimethylamine DMA)were thermodynamically ***,the gradually decreasing evaporation coefficients for TSA-base clusters,particularly for TSA-DMA,suggests that TSA may participate in NPF where the concentration of base molecules are relatively *** present new reaction mechanismmay contributes to a better understanding of atmospheric sulfur cycle and NPF.

关键词： New particle formation(NPF) Atmospheric sulfur cycle Nucleation process Reaction mechanism Hydrogen sulfide(H_(2)S) Atmospheric Cluster Dynamic Code (ACDC)