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Transfer RNA-derived small RNA serves as potential non-invasive diagnostic marker and a novel therapeutic target for acute pancreatitis

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World Journal of Gastroenterology 2025年第1期31卷 152-156页

作者： Jing zhang Chun-Lin Ou Department of Immunology School of Basic MedicineCentral South UniversityChangsha 410000Hunan ProvinceChina Department of Pathology Xiangya HospitalCentral South UniversityChangsha 410008Hunan ProvinceChina

Transfer RNA(tRNA)-derived fragments,a new type of tRNA-derived small RNA(tsRNA),can be cleaved from tRNA by enzymes to regulate target gene expression at the transcriptional and translational *** are not only degradation fragments but also have biological functions,including those in immune inflammation,metabolic disorders,and cell *** dysregulation is closely associated with multiple diseases,including various cancers and acute pancreatitis(AP).AP is a common gastrointestinal disease,and its incidence increases *** development is associated with tsRNAs,which regulate cell injury and induce inflammation,especially pyroptosis and ***,serum tRF36 has the potential to serve as a non-invasive diagnostic biomarker and leads to pancreatic acinar cell ferroptosis causing inflammation to promote *** show the characteristics of tsRNAs and their diagnostic value and function in AP,and discuss the potential opportunities and challenges of using tsRNAs in clinical applications and research.

关键词： Transfer RNA derived small RNAs Acute pancreatitis Liquid biopsy Biomarker Cell pyroptosis Ferroptosis

Management of diamondback moth, Plutella xylostella （Lepidoptera： Plutellidae） by mating disruption

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Insect Science 2012年第6期19卷 643-648页

作者： Qing-Jun Wu shu-fa zhang Jin-Liang Yao Bao-Yun Xu Shao-Li Wang You-Jun zhang Department of Plant Protection Institute of Vegetables and FlowersChinese Academy of Agricultural SciencesBeijing Hebei North University ZhangjiakouHebei Province Plant Protection Station of Yanqing County BeijingChina

Field trials were conducted in China in 2008 and 2009 to evaluate the efficacy of mating disruption （MD） on diamondback moth, Plutella xylostella, in cabbage, Brassica oleracea var. capitata. Effectiveness was positively correlated with the MD dispenser density in the field. A density of 167 MD dispensers per ha produced an average population decrease of about 50% compared to the conventional-practice field. Significant fewer males were captured in pheromone-treated and conventional-practice fields than in the blank control field, but the difference was not significant between the pheromone-treated and conventional-practice fields. In addition, fewer eggs and larvae were observed in pheromone-treated fields. Our results suggest mating disruption coupled with minimal insecticidal supplements is a promising solution for resistance management and control of diamondback moth infestation.

关键词： mating disruption Plutella xylostella resistance management sexpheromone

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张家口地区玉米虫害种类综述

河北北方学院学报（自然科学版） 2013年第1期29卷 37-40页

作者：闫海燕周桂梅韩文素沈福英张树发河北北方学院农林科技学院植物保护教研室河北张家口075000 唐山市农业科学研究院河北唐山063000

根据查阅文献资料,对张家口地区玉米上已有的主、次要害虫及潜在害虫种类及其防治进行了总结阐述,并对未来的防治工作提出相应的意见及建议。

关键词：张家口地区玉米虫害综述

Possible quantum paraelectric state in Kitaev spin liquid candidate H3LiIr2O6

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Science China(Physics,Mechanics & Astronomy) 2020年第11期63卷 109-114页

作者： shuai Wang Long zhang fa Wang International Center for Quantum Materials School of PhysicsPeking UniversityBeijing 100871China Kavli Institute for Theoretical Sciences and CAS Center for Excellence in Topological Quantum Computation University of Chinese Academy of SciencesBeijing 100190China Physical Science Laboratory Huairou National Comprehensive Science CenterBeijing 101400China Collaborative Innovation Center of Quantum Matter Beijing 100871China

A new quantum spin liquid(QSL)candidate material H3LiIr2O6 was synthesized recently and was found not to show any magnetic order or phase transition down to low *** this work,we study the quantum dynamics of the hydrogen ions,i.e.,protons,in this material by combining first-principles calculations and theoretical *** show that each proton and its adjacent oxygen ions form an electric *** dipole interactions and the proton tunneling are captured by a transverse-field Ising model with a quantum disordered paraelectric ground *** dipole excitations have an energy gap△d=60 meV,and can be probed by the infrared optical spectroscopy and the dielectric *** argue that the electric dipole fluctuations renormalize the magnetic interactions in H3LiIr2O6 and lead to a Kitaev QSL state.

关键词： spin liquid Kitaev material quantum paraelectricity first-principles calculations

Simulation of fixed-bed adsorption process considering particle size distribution

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Chinese Journal of Chemical Engineering 2024年第10期74卷 175-189页

作者： Zhaoyuan zhang Yidan shu School of Materials Science and Engineering Sun Yat-sen UniversityGuangzhou 510275China The Key Laboratory of Low-carbon Chemistry&Energy Conservation of Guangdong Province Guangzhou 510275China

The distribution of adsorbent particle sizes typically has a significant impact on adsorption *** fixed-bed adsorption studies adopt the assumption of average particle size to simplify the adsorption model,but this does not eliminate the deviation between experiments and simulations caused by particle size distribution in *** this study,the population balance equation(PBE)and fixed-bed adsorption kinetics model were combined to simulate the adsorption process in a fixed-bed reactor,modeling the distribution of adsorbate uptake over time on adsorbent particles of different *** integrated and optimized the PBE and fixed-bed mass transfer model in the algorithm,and the resulting combined model adopts a variable time step size,which can achieve a balance between computational efficiency and error while ensuring computational *** slicing the model in the spatial dimension,multiple sets of PBE can be calculated in parallel,improving computational *** adsorption process of single-component and multi-component CO_(2)/CH_(4)/N_(2)on 4A zeolite without binder was simulated,and the influence of adsorbent particle size distribution was *** results show that the assumption of average adsorbent particle size,which was commonly made in published work,will underestimate the time required for adsorbates to break through the fixed bed compared with the assumption of uniform adsorbent particle *** model helps to consider the impact of adsorbent particle size distribution on the adsorption process,thereby improving the prediction accuracy of adsorbent performance.

关键词： Population balance equation Particle size distribution Fixed-bed adsorption

Ubiquitination in diabetes and its complications:A perspective from bibliometrics

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World Journal of Diabetes 2025年第1期16卷 187-203页

作者： Li-Yuan Xiong Wei Zhao fa-Quan Hu Xue-Mei Zhou Yu-Jiao Zheng College of Traditional Chinese Medicine Anhui University of Chinese MedicineHefei 230012Anhui ProvinceChina

BACKGROUND Diabetes has a substantial impact on public health,highlighting the need for novel ***,an intracellular protein modification process,is emerging as a promising strategy for regulating pathological *** hypothesize that ubiquitination plays a critical role in the development and progression of diabetes and its complications,and that understanding these mechanisms can lead to new therapeutic *** To uncover the research trends and advances in diabetes ubiquitination and its complications,we conducted a bibliometric *** Studies on ubiquitination in diabetes mellitus and its complications were retrieved from the Web of Science Core *** mapping analysis was conducted using the CiteSpace *** We gathered 791 articles published over the past 23 years,focusing on ubiquitination in diabetes and its associated *** articles originated from 54 countries and 386 institutions,with China as the leading *** Jiao Tong University has the highest number of publications in this *** most prominent authors contributing to this research area include Wei-Hua zhang,with zhang Y being the most frequently cited ***,The Journal of Biological Chemistry is noted as the most cited in this *** predominant keywords included expression,activation,oxidative stress,phosphorylation,ubiquitination,degradation,and insulin *** The role of ubiquitination in diabetes and its complications,such as diabetic nephropathy and cardiomyopathy,is a key research ***,these areas require further investigations.

关键词： Diabetes mellitus Ubiquitination Bibliometric analysis CiteSpace Research trends

Clinical considerations of anticoagulation therapy for patients with atrial fibrillation

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2012年第8期13卷 609-615页

作者： shu zhang Arrhythmias Center and Clinical EP Lab. Cardiovascular Institute and Fuwai HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100037China

Atrial fibrillation (AF) increases the risk of stroke. New anticoagulation agents have recently provided alternative and promising approaches. This paper reviews the current state of anticoagulation therapy in AF patients, focusing on various clinical scenarios and on comparisons, where possible, between western and eastern populations.

关键词： Anticoagulation therapy Atrial fibrillation,Warfarin Dabigatran Riveroxaban Apixaban

Subretinal fibrosis secondary to neovascular age-related macular degeneration:mechanisms and potential therapeutic targets

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Neural Regeneration Research 2025年第2期20卷 378-393页

作者： Jingxiang zhang Xia Sheng Quanju Ding Yujun Wang Jiwei Zhao Jingfa zhang Department of Ophthalmology People’s Hospital of Huangdao DistrictQingdaoShandong ProvinceChina Department of Urology People’s Hospital of Huangdao DistrictQingdaoShandong ProvinceChina Department of Ophthalmology Shanghai General Hospital(Shanghai First People’s Hospital)Shanghai Jiao Tong University School of MedicineShanghaiChina National Clinical Research Center for Eye Diseases Shanghai Key Laboratory of Ocular Fundus DiseasesShanghai Engineering Center for Visual Science and PhotomedicineShanghai Engineering Center for Precise Diagnosis and Treatment of Eye DiseasesShanghaiChina

Subretinal fibrosis is the end-stage sequelae of neovascular age-related macular *** causes local damage to photoreceptors,retinal pigment epithelium,and choroidal vessels,which leads to permanent central vision loss of patients with neovascular age-related macular *** pathogenesis of subretinal fibrosis is complex,and the underlying mechanisms are largely ***,there are no effective treatment options.A thorough understanding of the pathogenesis of subretinal fibrosis and its related mechanisms is important to elucidate its complications and explore potential *** current article reviews several aspects of subretinal fibrosis,including the current understanding on the relationship between neovascular age-related macular degeneration and subretinal fibrosis;multimodal imaging techniques for subretinal fibrosis;animal models for studying subretinal fibrosis;cellular and non-cellular constituents of subretinal fibrosis;pathophysiological mechanisms involved in subretinal fibrosis,such as aging,infiltration of macrophages,different sources of mesenchymal transition to myofibroblast,and activation of complement system and immune cells;and several key molecules and signaling pathways participating in the pathogenesis of subretinal fibrosis,such as vascular endothelial growth factor,connective tissue growth factor,fibroblast growth factor 2,platelet-derived growth factor and platelet-derived growth factor receptor-β,transforming growth factor-βsignaling pathway,Wnt signaling pathway,and the axis of heat shock protein 70-Toll-like receptors 2/*** review will improve the understanding of the pathogenesis of subretinal fibrosis,allow the discovery of molecular targets,and explore potential treatments for the management of subretinal fibrosis.

关键词： choroidal neovascularization epithelial-mesenchymal transition mesenchymal transition myofibroblast neovascular age-related macular degeneration submacular fibrosis subretinal fibrosis therapeutic targets transforming growth factor-β vascular endothelial growth factor

Structural and microwave absorption properties of CoFe_(2)O_(4)/residual carbon composites

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 221-232页

作者： Yuanchun zhang Shengtao Gao Xingzhao zhang Dacheng Ma Chuanlei Zhu Jun He Joint National-Local Engineering Research Centre for Safe and Precise Coal Mining Anhui University of Science and TechnologyHuainan 232001China School of Chemical and Blasting Engineering Anhui University of Science and TechnologyHuainan 232001China

Electromagnetic interference,which necessitates the rapid advancement of substances with exceptional capabilities for bsorbing electromagnetic waves,is of urgent concern in contemporary *** this work,CoFe_(2)O_(4)/residual carbon from coal gasification fine slag(CFO/RC)composites were created using a novel hydrothermal *** mechanisms for microwave absorption,including conductive loss,natural resonance,interfacial dipole polarization,and magnetic flux loss,are involved in these ***,compared with pure residual carbon materials,this composite offers superior capabilities in microwave *** 7.76GHz,the CFO/RC-2 composite achieves an impressive minimum reflection loss(RL_(min))of-43.99 dB with a thickness of 2.44 ***,CFO/RC-3 demonstrates an effective absorption bandwidth(EAB)of up to 4.16 GHz,accompanied by a thickness of *** study revealed the remarkable capability of the composite to diminish electromagnetic waves,providing a new generation method for microwave absorbing materials of superior quality.

关键词： coal gasification slag residual carbon hydrothermal method microwave absorption CoFe_(2)O_(4)