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秸秆还田配施磷肥对豫西旱地小麦碳同化物积累的影响及其生理机制

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草业学报 2024年第6期33卷 89-104页

作者：张俊豪柴雪茹马嵩科张冬霞张静乔唱唱李爽黄明王贺正河南科技大学农学院河南洛阳471000

为明确秸秆还田配施磷肥对豫西旱地小麦碳同化物积累特性和产量的影响,2021-2022年度,以洛旱22为材料,采用裂区试验设计,主区为玉米秸秆还田处理,分别为秸秆不还田(S0)、秸秆全量还田(S1),副区为施磷量处理,分别为0 kg·hm^(-2) (P_(0))... 详细信息

为明确秸秆还田配施磷肥对豫西旱地小麦碳同化物积累特性和产量的影响,2021-2022年度,以洛旱22为材料,采用裂区试验设计,主区为玉米秸秆还田处理,分别为秸秆不还田(S0)、秸秆全量还田(S1),副区为施磷量处理,分别为0 kg·hm^(-2) (P_(0))、75 kg·hm^(-2) (P_(1))、112.5 kg·hm^(-2) (P_(2))、150 kg·hm^(-2) (P_(3))、187.5 kg·hm^(-2) (P_(4)),测定了不同处理下小麦干物质积累特性和产量及其构成因素,以及花后旗叶净光合速率、相对叶绿素含量(SPAD值),旗叶和籽粒的可溶性糖、蔗糖含量及蔗糖酶活性。结果表明,同一施磷水平下,与秸秆不还田相比,秸秆还田提高了小麦旗叶SPAD值和净光合速率,增加了旗叶和籽粒中的可溶性糖、蔗糖含量、蔗糖合成酶和磷酸蔗糖合成酶活性,最终使成熟期干物质积累量和籽粒产量分别显著增加9.25%~14.60%和2.17%~6.31%。同一秸秆处理下,随施磷量的增加,旗叶SPAD值、净光合速率,旗叶和籽粒中的可溶性糖、蔗糖含量、蔗糖合成酶和磷酸蔗糖合成酶及干物质积累量呈先上升后下降趋势。从互作效应看,S1P_(3)处理下旗叶SPAD值和净光合速率,旗叶和籽粒中的可溶性糖和蔗糖含量,蔗糖合成酶和磷酸蔗糖合成酶活性等各指标均最高,从而获得最高产量,较S0P_(0)处理增产35.70%。因此,秸秆还田配施磷150 kg·hm^(-2) 是本试验条件下的最适宜种植方式,可在豫西旱地小麦栽培上推广。

关键词：旱地小麦秸秆还田磷肥蔗糖酶活性

Interference Pattern of Density-Density Correlation for Incoherent Atoms with Vortices Released from an Optical Lattice

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Chinese Physics Letters 2011年第1期28卷 26-29页

作者： XU Zhi-Jun zhang dong-Mei LIU xia-Yin College of Science Zhejiang University of Technology Hangzhou 310023

For a series of incoherent condensate atomic clouds with vortices （an orbital angular momentum） released from an optical lattice, the density-density correlation function of this freely expanding ultracold gases is theoretically investigated. It is shown that the nonzero angular momentum of the atoms has an important effect on the fringe pattern of density-density correlation. Particularly, for a short expansion time, even the rotation direction of the atoms could have an observable effect on the fringe pattern. Observation of this specific fringe pattern would constitute experimental evidence for the presence of a vortex in an atomic condensate.

关键词： Quantum gases, liquids and solids Optics, quantum optics and lasers Statistical physics and nonlinear systems

浅谈rasH2-Tg小鼠短期致癌性试验的设计要点

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中南药学 2024年第8期22卷 2100-2107页

作者：张佳珊张冬霞宫田田张素才北京昭衍新药研究中心股份有限公司生物制品安全性评价北京市重点实验室北京100176 中国药科大学药学院南京211198

rasH2-Tg小鼠是当前转基因替代模型中应用最广泛的短期致癌性试验模型小鼠,对遗传阳性致癌物和非遗传阳性致癌物均敏感,且自发肿瘤率较低。目前国内外相关指导原则还没有针对该转基因小鼠致癌性试验的详细设计要求,本文通过汇总并分析了... 详细信息

rasH2-Tg小鼠是当前转基因替代模型中应用最广泛的短期致癌性试验模型小鼠,对遗传阳性致癌物和非遗传阳性致癌物均敏感,且自发肿瘤率较低。目前国内外相关指导原则还没有针对该转基因小鼠致癌性试验的详细设计要求,本文通过汇总并分析了2013—2022年在美国获批上市且采用该转基因小鼠进行的51个新药的致癌性试验申报资料,并结合实际工作经验对试验设计要点进行整理论述,为国内新药致癌性试验的开展提供参考。

关键词：致癌性试验 rasH2-Tg小鼠替代小鼠模型

Interleukins in Epilepsy:Friend or Foe

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Neuroscience Bulletin 2024年第5期40卷 635-657页

作者： Yuan dong xia zhang Ying Wang Neuropsychiatry Research Institute The Affiliated Hospital of Qingdao UniversityQingdao UniversityQingdao266000China Program in Cellular and Molecular Medicine Boston Children’s HospitalBostonMA02115USA

Epilepsy is a chronic neurological disorder with recurrent unprovoked seizures,affecting~65 million *** in patients with epilepsy and animal models suggests a contribution of neuroinflammation to epileptogenesis and the development of ***(ILs),as one of the major contributors to neuroinflammation,are intensively studied for their association and modulatory effects on ictogenesis and *** are commonly divided into pro-and anti-inflammatory cytokines and therefore are expected to be pathogenic or neuroprotective in ***,both protective and destructive effects have been reported for many *** may be due to the complex nature of ILs,and also possibly due to the different disease courses that those ILs are involved *** this review,we summarize the contributions of different ILs in those processes and provide a current overview of recent research advances,as well as preclinical and clinical studies targeting ILs in the treatment of epilepsy.

关键词： Epilepsy Interleukins Neuroinflammation

Infection-stimulated Anemia Results Primarily from Interferon Gamma-dependent, Signal Transducer and Activator of Transcription 1-independent Red Cell Loss

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Chinese Medical Journal 2015年第7期128卷 948-955页

作者： Zheng Wang dong-xia zhang Qi Zhao Department of Pediatric Surgery General Hospital of Chinese People's Liberation Army Beijing 100037 China Department of Immunology Yuhuangding Hospital Yantai Shandong 264000 China

Background： Although the onset of anemia during infectious disease is commonly correlated with production of inflammatory cytokines, the mechanisms by which cytokines induce anemia are poorly defined. This study focused on the mechanism research. Methods： Different types of mice were infected perorally with Toxoplasma gondii strain ME49. At the indicated times, samples fi＇om each mouse were harvested, processed, and analyzed individually. Blood samples were analyzed using a Coulter Counter and red blood cell （RBC） survival was measured by biotinylation. Levels of tumor necrosis factor-α （TNF-α）, inducible nitric oxide synthase （iNOS）, and inducible protein 10 （IP-10） mRNA in liver tissue were measured by real-time polymerase chain reaction. Results： T. gondii-infected mice exhibited anemia due to a decrease in both erythropoiesis and survival time of RBC in the circulation （P 〈 0.02）. In addition, infection-stimulated anemia was associated with fecal occult, supporting previous literature that hemorrhage is a consequence of T. gondii infection in mice. Infection-induced anemia was abolished in interferon gamma （IFNy） and I FNy receptor deficient mice （P 〈 0.05） but was still evident in mice lacking TNF-α, iNOS, phagocyte NADPH oxidase or IP-10 （P 〈 0.02）. Neither signal transducer and activator of transcription 1 （STAT1） deficient mice nor 129S6 controls exhibited decreased erythropoiesis, but rather suffered from an anemia resulting solely from increased loss of circulating RBC. Conclusions： Infection-stimulated decrease in erythropoiesis and losses of RBC have distinct mechanistic bases. These results show that during T. gondii infection, IFNγ is responsible foran anemia that results from both a decrease in erythropoiesis and a STAT1 independent loss of circulating RBC.

关键词： Anemia Helnorrhage Signal Transducer and Activator of Transcription 1 Tmot)lasma gondii

A-site assisted perovskite crystallization via ion-exchange MOFs for high efficient and stable perovskite solar cells

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Journal of Energy Chemistry 2024年第6期93卷 436-442,I0011页

作者： Xingrui zhang Jian zhang Wei Wang Boyuan Hu Yayu dong Debin xia Kaifeng Lin Yulin Yang MIIT Key Laboratory of Critical Materials Technology for New Energy Conversion and Storage School of Chemistry and Chemical EngineeringHarbin Institute of TechnologyHarbin 150001HeilongjiangChina

Here,a novel strategy is proposed targeting the volatility of A-site cations and the disordered arrangement of perovskite grains through employing Cs~+contained metal-organic frameworks In-aip(Cs)obtained by ion-exchange and crystalline *** forces between Cs-O atoms split the pore channels of the pristine In-aip,endowing In-aip(Cs)with multidimensional charge transport channels,In addition,the partially freed Cs~+in the interlayer compensates for the vacancy of A-site cations during the perovskite preparation *** In-aip(Cs)modified perovskite films have a flat morphology,large grains and excellent optoelectronic *** from the high-quality perovskite films and faster charge extraction,the In-aip(Cs)-modified PSCs achieved a champion PCE of 23.03%,superior to the In-aip-modified(22.29%)and control device(21.13%),More importantly,the unencapsulated PSCs modified with In-aip(Cs)exhibited outstanding humidity and thermal *** a period of almost 1000 h,the unencapsulated In-aip(Cs)-modified device retained 85%of its initial PCE after storing in a glove box at 85℃,and retained 87%of the primary PCE upon storage in ambient condition at 25℃under a humidity of 40%.

关键词： Metal-organic frameworks PSCs Stability Defect passivation

Seasonal thermal energy storage using natural structures:GIS-based potential assessment for northern China

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Building Simulation 2024年第4期17卷 561-574页

作者： Yichi zhang Jianjun xia Midea HVAC Heating&Ventilation Equipment Co. LtdFoshan528311China Building Energy Research Center Tsinghua UniversityBeijing100084China

Seasonal thermal energy storage(STES)allows storing heat for long-term and thus promotes the shifting of waste heat resources from summer to winter to decarbonize the district heating(DH)*** being a promising solution for sustainable energy system,large-scale STES for urban regions is lacking due to the relatively high initial investment and extensive land *** close the gap,this study assesses the potentials of using two naturally available structures for STES,namely valley and ground pit *** on geographical information system(GIS)methods,the available locations are searched from digital elevation model and selected considering several criteria from land uses and construction *** costs of dams to impound the reservoir and the yielded storage capacities are then quantified to guide the choice of suitable *** assessment is conducted for the northern China where DH systems and significant seasonal differences of energy demand *** total,2,273 valley sites and 75 ground pit sites are finally identified with the energy storage capacity of 15.2 billion GJ,which is much larger than the existing DH demand in northern *** results also prove that 682 valley sites can be achieved with a dam cost lower than 20 CNY/m^(3).By conducting sensitivity analysis on the design dam wall height and elevations,the choices of available natural structures are expanded but practical issues about water pressures and constructions are also ***,the identified sites are geographically mapped with nearest urban regions to reveal their roles in the DH *** general,560 urban regions are found with potential STES units and most of them have STES storage capacities larger than their own DH *** novel planning methodology of this study and publicly available datasets create possibilities for the implementations of large-scale STES in urban DH systems.

关键词： seasonal thermal energy storage geographical information system district heating water reservoir

A hybrid RNA-protein biosensor for high-throughput screening of adenosylcobalamin biosynthesis

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Synthetic and Systems Biotechnology 2024年第3期9卷 513-521页

作者： xia Yang Huiying Wang dongqin Ding Huan Fang Huina dong Dawei zhang College of Biological and Pharmaceutical Sciences China Three Gorges UniversityYichangHubei443002China Tianjin Institute of Industrial Biotechnology Chinese Academy of SciencesTianjin300308China Key Laboratory of Engineering Biology for Low-Carbon Manufacturing Tianjin Institute of Industrial BiotechnologyChinese Academy of SciencesTianjin300308China University of Chinese Academy of Sciences Beijing100049China

Genetically encoded circuits have been successfully utilized to assess and characterize target variants with desirable traits from large mutant *** is an essential coenzyme that is required in many intracellular physiological reactions and is widely used in the pharmaceutical and food ***-throughput screening techniques capable of detecting adenosylcobalamin productivity and selecting superior adenosylcobalamin biosynthesis strains are critical for the creation of an effective microbial cell factory for the production of adenosylcobalamin at an industrial *** this study,we developed an RNA-protein hybrid biosensor whose input part was an endogenous RNA riboswitch to specifically respond to adenosylcobalamin,the inverter part was an orthogonal transcriptional repressor to obtain signal inversion,and the output part was a fluorescent protein to be easily *** hybrid biosensor could specifically and positively correlate adenosylcobalamin concentrations to green fluorescent protein expression levels in *** study also improved the operating concentration and dynamic range of the hybrid biosensor by systematic *** individual cell harboring the hybrid biosensor presented over 20-fold higher fluorescence intensity than the negative ***,using such a biosensor combined with fluorescence-activated cell sorting,we established a high-throughput screening platform for screening adenosylcobalamin *** study demonstrates that this platform has significant potential to quickly isolate high-productive strains to meet industrial demand and that the framework is acceptable for various metabolites.

关键词： Adenosylcobalamin Genetically encoded biosensor Riboswitch Transcriptional repressor High-throughput screening

Multifunctional MOF@COF Nanoparticles Mediated Perovskite Films Management Toward Sustainable Perovskite Solar Cells

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Nano-Micro Letters 2024年第9期16卷 195-208页

作者： Yayu dong Jian zhang Hongyu zhang Wei Wang Boyuan Hu Debin xia Kaifeng Lin Lin Geng Yulin Yang MIIT Key Laboratory of Critical Materials Technology for New Energy Conversion and Storage School of Chemistry and Chemical EngineeringHarbin Institute of TechnologyHarbin 150001HeilongjiangPeople’s Republic of China School of Materials Science and Engineering East China Jiaotong UniversityNanchang 330013JiangxiPeople’s Republic of China School of Materials Science and Engineering Harbin Institute of TechnologyHarbin 150001HeilongjiangPeople’s Republic of China

Although covalent organic frameworks(COFs)with highπ-conjugation have recently exhibited great prospects in perovskite solar cells(PSCs),their further application in PSCs is still hindered by face-to-face stacking and aggregation ***,metal-organic framework(MOF-808)is selected as an ideal platform for the in situ homogeneous growth of a COF to construct a core-shell MOF@COF nanoparticle,which could effectively inhibit COF stacking and *** synergistic intrinsic mechanisms induced by the MOF@COF nanoparticles for reinforcing intrinsic stability and mitigating lead leakage in PSCs have been *** complementary utilization ofπ-conjugated skeletons and nanopores could optimize the crystallization of large-grained perovskite films and eliminate *** resulting PSCs achieve an impressive power conversion efficiency of 23.61%with superior open circuit voltage(1.20 V)and maintained approximately 90%of the original power conversion efficiency after 2000 h(30-50%RH and 25-30℃).Benefiting from the synergistic effects of the in situ chemical fixation and adsorption abilities of the MOF@COF nanoparticles,the amount of lead leakage from unpackaged PSCs soaked in water(<5 ppm)satisfies the laboratory assessment required for the Resource Conservation and Recovery Act Regulation.

关键词： Perovskite solar cells Covalent organic frameworks Metal-organic frameworks Lead leakage Stability