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Chinese Journal of Structural Chemistry 2005年第8期24卷 930-934页

作者： zhang dong-heng DU Jian-Long HAN Ling-Qin SUN Wen-Hua Key Laboratory of Engineering Plastics Institute of Chemistry The Chinese Academy of Sciences Beijing 100080 State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of Matter The Chinese Academy of Sciences Fuzhou 350002 China College of Chemistry & Environmental Science Hebei UniversityChina Baoding 071002

The title nickel complex （C34H3oCl2N2NiO4, Mr = 660.21） has been synthesized and its crystal structure was determined by single-crystal X-ray structure analysis. It crystallizes in the monoclinic system, space group P21/n with a = 11.026（8）, b = 11.491（8）, c = 12.119（9） A°, β=91.328（13）°, Z= 2, V= 1535.0（19） ,A°^3, Dc = 1.428 g/cm^3, F（000） = 684 andμ（MoKa） = 0.848 mm^-1 The structure was refined to R = 0.0544 for 1813 observed reflections with I 〉 2σ（I） and wR =0.0867 for 3132 unique reflections. The molecule of the complex is high symmetrical. Ni（Ⅱ） atom is located in the symmetric center and coordinated to two phenolic oxygen and two imino nitrogen atoms, forming two six-membered rings. Upon activation with methylaluminoxane （MAO）, it is active for ethylene oligomerization.

关键词： nickel complex salicylaldimine ethylene oligomerization

Downregulation of Serum PTEN Expression in Mercury-Exposed Population and PI3K/AKT Pathway-Induced Inflammation

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Biomedical and Environmental Sciences 2024年第4期37卷 354-366页

作者： MEI Peng DING En Min YIN Hao Yang DING Xue Xue WANG Huan WANG Jian Feng HAN Lei zhang heng dong ZHU Bao Li School of Public Health Nanjing Medical UniversityNanjing 210000JiangsuChina Institute of Occupational Disease Prevention Jiangsu Province Center for Disease Prevention and ControlNanjing 21000JiangsuChina Suzhou Center for Disease Prevention and Control Suzhou 215004JiangsuChina Center for Global Health School of Public HealthNanjing Medical UniversityNanjing 210000JiangsuChina

Objective This study investigated the impact of occupational mercury(Hg) exposure on human gene transcription and expression, and its potential biological *** Differentially expressed genes related to Hg exposure were identified and validated using gene expression microarray analysis and extended validation. Hg-exposed cell models and PTEN lowexpression models were established in vitro using 293T cells. PTEN gene expression was assessed using qRT-PCR, and Western blotting was used to measure PTEN, AKT, and PI3K protein levels. IL-6 expression was determined by *** Combined findings from gene expression microarray analysis, bioinformatics, and population expansion validation indicated significant downregulation of the PTEN gene in the high-concentration Hg exposure group. In the Hg-exposed cell model(25 and 10 μmol/L), a significant decrease in PTEN expression was observed, accompanied by a significant increase in PI3K, AKT, and IL-6 ***, a low-expression cell model demonstrated that PTEN gene knockdown led to a significant decrease in PTEN protein expression and a substantial increase in PI3K, AKT, and IL-6 *** This is the first study to report that Hg exposure downregulates the PTEN gene, activates the PI3K/AKT regulatory pathway, and increases the expression of inflammatory factors, ultimately resulting in kidney inflammation.

关键词： PTEN Occupational mercury exposure Occupational health PI3K/AKT pathway 293T cell IL-6

Association between the HOTAIR Polymorphism and Susceptibility to Lead Poisoning in a Chinese Population

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Biomedical and Environmental Sciences 2018年第6期31卷 473-478页

作者： CHEN Lin ZHAO Qiu Ni QIAN Xiu Rong ZHU Bao Li DING En Min WANG Bo Shen zhang heng dong YANG Hong Key Laboratory of Environmental Medicine and Engineering Ministry of EducationSchool of Public HealthSoutheast UniversityNanjing 210009JiangsuChina Institute of Occupational Disease Prevention Jiangsu Provincial Center for Disease Prevention and ControlNanjing 210028JiangsuChina Nanjing Center for Disease Prevention and Control Nanjing 210003JiangsuChina School of Public Health Nantong UniversityNantong 226019JiangsuChina

This study explored the association between the lncRNA HOTAIR polymorphism and susceptibility to lead poisoning in a Chinese population. We speculated that lead poisoning caused elevated levels of oxidative stress, which, in turn, activate the HOTAIR gene to cause apoptosis. Three lncRNA HOTAIR tagSNPs（rs7958904, rs4759314, and rs874945） were genotyped by TaqM an genotyping technology in 113 lead-sensitive and 113 lead-resistant Chinese workers exposed to lead. Rs7958904 was significantly associated with susceptibility to lead poisoning（P = 0.047）. The rs7958904 G allele had a protective effect compared with the C allele and reduced the risk of lead poisoning（P = 0.016）. Rs7958904 may act as a potential biomarker for predicting the risk of lead poisoning and distinguishing lead-sensitive individuals from lead-resistant individuals.

关键词： HOTAIR Association between the HOTAIR Polymorphism and Susceptibility to Lead Poisoning in a Chinese Population

Association between Polymorphisms of MALAT1 and Blood Lead Levels in Lead-exposed Workers

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Biomedical and Environmental Sciences 2018年第7期31卷 527-530页

作者： QIAN Xiu Rong CHEN Lin LIU Ji Ting ZHU Bao Li ZHAO Qiu Ni DING En Min WANG Bo Shen zhang heng dong XU Ming School of Public Health Nantong University Nantong 226019 Jiangsu China Institute of Occupational Disease Prevention Jiangsu Provincial Center for Disease Prevention and Control Nanjing 210028 Jiangsu China Key Laboratory of Environmental Medicine and Engineering Ministry of Education School of Public Health Southeast University Nanjing 210009 Jiangsu China School of Public Health Suzhou University Suzhou 215021 Jiangsu China Nanjing center for disease prevention and control Nanjing 210003 Jiangsu China

Lead,a heavy metal,which is nonessential but may be harmful to the human body,has been widely used to manufacture many products for use in the modern ***-acid batteries have the advantages of low price,high safety,and... 详细信息

关键词： Association between Polymorphisms of MALAT1 and Blood Lead Levels in Lead-exposed Workers BLL

Effects of α-adrenoreceptor antagonists on apoptosis and proliferation of pancreatic cancer cells in vitro

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World Journal of Gastroenterology 2008年第15期14卷 2358-2363页

作者： Su-Gang Shen dong zhang heng-Tong Hu Jun-Hui Li Zheng Wang Qing-Yong Ma Department of Hepatobiliary and Pancreas Surgery The First Affiliated Hospital Medical College Xi'an Jiaotong University Xi'an 710061 Shaanxi Province China

AIM: To discuss the expression of α-adrenoreceptors in pancreatic cancer cell lines PC-2 and PC-3 and the effects of α1- and α2-adrenoreceptor antagonists, yohimbine and urapidil hydrochloride, on the cell lines in vitro. METHODS: We cultured the human ductal pancreatic adenocarcinoma cell lines PC-2 and PC-3 and analyzed the mRNA expression of α1- and α2-adrenergic receptors by reverse transcription polymerase chain reaction (RT-PCR). The effects of yohimbine and urapidil hydrochloride on cell proliferation were assessed by 3-(4,5-dimethylthiasol-2-yl)- 2,4,-diphenyltetrazolium bromide (MTT) assay. Apoptosis was detected using the terminal deoxyribonucleotidyl transferase (TdT)-mediated biotin-16-dUTP nick-end labeling (TUNEL) assay and flow cytometry (FCM). RESULTS: PC-2 expressed mRNA in α1- and α2- adrenoreceptors. MTT assays showed that urapidil hydrochloride had no effect on PC-3 cell lines. However, exposure to urapidil hydrochloride increased DNA synthesis in PC-2 cell lines as compared to the control group. PC-2 cell lines were sensitive to both drugs. The proliferation of the 2 cell lines was inhibited by yohimbine. Cell proliferation was inhibited by yohimbine via apoptosis induction. CONCLUSION: The expression of α1- and α2- adrenoreceptors is different in PC-2 and PC-3 cell lines, which might be indicative of their different functions. The α2-adrenoceptor antagonist, yohimbine, can inhibit theproliferation of both cell lines and induce their apoptosis, suggesting that yohimbine can be used as an anticancer drug for apoptosis of PC-2 and PC-3 cells.

关键词： Alpha-adrenoreceptor Pancreatic cancer Yohimbine Urapidil hydrochloride

Studies　on　Thiosemicarbazides　and　Related　Heterocycles(ⅩⅩⅥ)──Synthesis　of　3-[5'-amino-1'-(4"-chlorophenyl)-1',2',3'-triazol-4'-yl]-4-aryl-1,2,4-triazoline-5-thiones

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Chemical Research in Chinese Universities 1997年第1期13卷 29-35页

作者： zhang Zi yi, dong heng shan and GUAN Zuo wu (National Laboratory of Applied Organic Chemistry, Department of Chemistry, Lanzhou University, Lanzhou, 730000) YANG Shi yan (State Key Laboratory for Oxo Synthesis and Selective Oxidization,

The treatment of 5 amino 1 (4 chlorophenyl) 1,2,3 triazol 4 carbohydrazide with equimolecular aryl isothiocyanate gave new derivatives 1 a—l . Twelve title compounds were obtained in 42% to 87% yields when compounds 1 a—l were respectively treated with sodium hydroxide aqueous solution(2 mol/L). The products of Dimroth rearrangement were not observed in the experiment. The structures of all the compounds were confirmed by means of IR, 1H NMR, MS and elementary analysis.

关键词： Triazole 1,2,4 Triazoline 5 thione Heterocycle Synthesis

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基于小波尺度积的图像边缘检测算法

计算机工程与设计 2009年第19期30卷 4465-4467页

作者：张东衡彭安民上海医疗器械高等专科学校精密医疗器械系

图像边缘检测技术是图像处理中最重要的内容之一,针对噪声大、灰度对比度低的图像,利用小波尺度乘积模极大值对其进行边缘检测。在进行二进小波变换后,先把相邻尺度的小波系数直接相乘,抑制噪声和增强图像边缘信息,再运用模极大值检测... 详细信息

图像边缘检测技术是图像处理中最重要的内容之一,针对噪声大、灰度对比度低的图像,利用小波尺度乘积模极大值对其进行边缘检测。在进行二进小波变换后,先把相邻尺度的小波系数直接相乘,抑制噪声和增强图像边缘信息,再运用模极大值检测图像边缘,利用隶属函数确定阈值。该算法可以免除传统小波模极大值边缘检测后繁杂的边缘链接,简单易实现,实验证明其对抑制噪声和增强弱边缘有良好的效果。

关键词：小波变换尺度积边缘检测模极大值模糊增强

Boosting hydrocarbon conversion via Cu-doping induced oxygen vacancies on CeO2 in CO2 electroreduction

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Journal of Energy Chemistry 2025年第1期100卷 66-76页

作者： Lei Xue Tong Shi Chenhui Han heng zhang Fenrong Liu Haorun Li Yan Wang Xiaojun Gu Shanghong Zeng Inner Mongolia Key Laboratory of Chemistry and Physics of Rare Earth Materials School of Chemistry and Chemical Engineering Inner Mongolia University State Key Laboratory of Coal Conversion Institute of Coal Chemistry Chinese Academy of Sciences Institute of Catalysis Department of Chemistry Zhejiang University National Key Laboratory of Baiyunobo Rare Earth Resource Research and Comprehensive Utilization Baotou Research Institute of Rare Earths

Conversion of CO2back to hydrocarbons is the most direct way of closing the“carbon cycle”,and its significance is further enlarged if this process is driven by renewable energies such as ***,precisely controlling the product selectivity towards hydrocarbons against the competitive hydrogen evolution remains challenging,especially for Cu-based ***,we report a novel defect engineering strategy,by which Cu-doping-induced oxygen vacancies on CeO2nanorods were effectively created,with adjustable vacancy/Cu *** resulting optimum catalyst shows up to 79% catalytic current density to hydrocarbons （excluding CO）,with 49% faradaic efficiency to *** and density functional theory unveil that the ratio between oxygen vacancy and Cu affects significantly the formation of*CHO and activation of H2O,which leads to the following deep hydrogenation to *** findings may spur new insights for designing and developing more controllable chemical process relevant to CO2utilization.

关键词： Oxygen vacancy Hydrocarbon production Reaction mechanism

Bioinspired Ultrasensitive Flexible Strain Sensors for Real-Time Wireless Detection of Liquid Leakage

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NANO-MICRO LETTERS 2025年第1期17卷 1-18页

作者： Zhou, Weilong Du, Yu Chen, Yingying zhang, Congyuan Ning, Xiaowei Xie, heng Wu, Ting Hu, Jinlian Qu, Jinping Huazhong Univ Sci & Technol Sch Chem & Chem Engn Key Lab Mat Chem Energy Convers & Storage Minist EducHubei Key Lab Mat Chem & Serv Failure Wuhan 430074 Peoples R China Huazhong Univ Sci & Technol Hubei Engn Res Ctr Biomat & Med Protect Mat Sch Chem & Chem Engn Wuhan 430074 Peoples R China Wuhan Inst Technol Sch Mat Sci & Engn Wuhan 430205 Peoples R China City Univ Hong Kong Dept Biomed Engn Hong Kong 999077 Peoples R China

Micro-extrusion compression molding and surface modification were proposed for the mass fabrication of a superhydrophobic thermoplastic polyurethane sensor (TCGS).Inspired by scorpions, TCGS features Archimedean spiral crack arrays and micropores, achieving 218.13 sensitivity at 2% strain, a 4300% increase, and over 5000 usage cycles of *** robust superhydrophobicity of TCGS improves sensitivity and stability for detecting small-scale liquid leakage, allowing precise monitoring across various sizes and compositions while providing early warnings in various scenarios. Liquid leakage of pipeline networks not only results in considerable resource wastage but also leads to environmental pollution and ecological imbalance. In response to this global issue, a bioinspired superhydrophobic thermoplastic polyurethane/carbon nanotubes/graphene nanosheets flexible strain sensor (TCGS) has been developed using a combination of micro-extrusion compression molding and surface modification for real-time wireless detection of liquid leakage. The TCGS utilizes the synergistic effects of Archimedean spiral crack arrays and micropores, which are inspired by the remarkable sensory capabilities of scorpions. This design achieves a sensitivity of 218.13 at a strain of 2%, which is an increase of 4300%. Additionally, it demonstrates exceptional durability by withstanding over 5000 usage cycles. The robust superhydrophobicity of the TCGS significantly enhances sensitivity and stability in detecting small-scale liquid leakage, enabling precise monitoring of liquid leakage across a wide range of sizes, velocities, and compositions while issuing prompt alerts. This provides critical early warnings for both industrial pipelines and potential liquid leakage scenarios in everyday life. The development and utilization of bioinspired ultrasensitive flexible strain sensors offer an innovative and effective solution for the early wireless detection of liquid leakage.

关键词： Thermoplastic polyurethane Bioinspired Cracks Liquid leakage Flexible strain sensor

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基于PSA的微型医用制氧机设计

制造业自动化 2013年第16期35卷 106-109页

作者：张东衡侯晓蓓上海医疗器械高等专科学校医疗器械工程系上海200093

通过分析分子筛制氧流程,合理选择设备部件、控制器件及创新的结构设计,研制了一种分子筛变压吸附的微型医用制氧机;从硬件电路设计和软件程序流程设计两方面详细阐述了控制系统的软硬件结构及实现,经运行测试表明,该制氧机出氧浓度和... 详细信息

通过分析分子筛制氧流程,合理选择设备部件、控制器件及创新的结构设计,研制了一种分子筛变压吸附的微型医用制氧机;从硬件电路设计和软件程序流程设计两方面详细阐述了控制系统的软硬件结构及实现,经运行测试表明,该制氧机出氧浓度和压力稳定可靠、噪声低,性价比高,值得推广。

关键词：单片机制氧机 PSA 研制