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Stems and leaves of Aconitum carmichaelii *** potential herbal resources for treating rheumatoid arthritis： Chemical analysis,toxicity and activity evaluation

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Chinese Journal of Natural Medicines 2018年第9期16卷 644-652页

作者： HE Ya-Nan OU Shui-Ping XIONG Xi PAN Yuan PEI Jin XU Run-Chun GENG Fu-Neng HAN Li zhang ding-kun YANG Ming State Key Laboratory Breeding Base of Systematic Research Development and Utilization of Chinese Medicine Resources Chengdu University of Traditional Chinese Medicine Chengdu 611137 China Affiliated Hospital of Zunyi Medical College Zunyi 563000 China Sichuan Good Doctor Panxi Pharmaceutical Co. Ltd. Xiehang 615000 China Jiangxi University of Traditional Chinese Medicine Nanchang 330004 China

According to folk usage of Aconitum carmichaelii Debx., the present study was designed to determine the feasibility of the stems and leaves of Aconitum carmichaelii Debx. as a new medicinal resource. Fourteen alkaloids in mother roots, fibrous roots, stems, and leaves of Aconitum carmichaelii Debx. were measured by HPLC-MS/MS. And multivariate analysis methods, such as clustering analysis and principal component analysis, were applied to analyze the difference among various parts. In addition, the acute toxicity, analgesia, and anti-inflammatory tests were carried out. The results suggested that the contents of alkaloids in mother roots and fibrous roots were approximate, but those of leaves and stems were different from mother roots and fibrous roots. The results of the acute toxicity testing demonstrated the toxicity of fibrous root was strongest, and mother roots were slightly less toxic than fibrous roots. The stems and leaves were far less toxic than mother and fibrous roots. In addition, the analgesia and inflammatory tests showed the effects of the various tissues had no difference each other. These results provided a basis for developing new complementary and alternative treatments for rheumatoid arthritis patients. Simultaneously, the approach may also turn wastes into treasure and promote the development of circular economy.

关键词： Aconitum carmichaelii Debx. New medical parts Alkaloids Toxicity Efficacy

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Emission control status and future perspectives of diesel trucks in China

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Journal of Environmental Sciences 2025年第2期148卷 702-713页

作者： Shihai zhang Mingliang Fu Hefeng zhang Hang Yin Yan ding State Environmental Protection Key Laboratory of Vehicle Emission Control and Simulation Chinese Research Academy of Environmental SciencesBeijing 100012China Vehicle Emission Control Center Chinese Research Academy of Environmental SciencesBeijing 100012China

Chinese diesel trucks are the main contributors to NOx and particulate matter(PM)vehicle *** increase in diesel trucks could aggravate air pollution and damage human *** Chinese government has recently implemented a series of emission control technologies andmeasures for air quality *** paper summarizes recent control technologies and measures for diesel truck emissions in China and introduces the comprehensive application of control technologies and measures in Beijing-Tianjin-Hebei and surrounding *** onlinemonitoring technology has been adopted according to the China VI standard for heavy-duty diesel trucks,and control measures such as transportation structure adjustment and heavy pollution enterprise classification control continue to support the battle action plan for pollution *** and suggestions are provided for promoting pollution control and supervision of diesel truck emissions:adhere to the concept of overall management and control,vigorously promote the application of systematic and technological means in emission monitoring,continuously facilitate cargo transportation structure adjustment and promote new energy freight *** paper aims to accelerate the implementation of control technologies and measures throughout *** is endeavouring to control diesel truck exhaust *** is willing to cooperate with the world to protect the global ecological environment.

关键词： Air quality Diesel truck emissions Emission control technology Control measures

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Establishment of one-step approach to detoxification of hypertoxic aconite based on the evaluation of alkaloids contents and quality

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Chinese Journal of Natural Medicines 2017年第1期15卷 49-61页

作者： zhang ding-kun HAN Xue TAN Peng LI Rui-Yu NIU Ming zhang Cong-En WANG Jia-Bo YANG Ming XIAO Xiao-He Provincial and State Key Laboratory Breeding Base of System Research Development and Utilization of Chinese Herbal Medicine Resources Chengdu University of Traditional Chinese Medicine Chengdu 610075 China China Military Institute of Chinese Medicine 302 Military Hospital Beijing 100039 China Key Laboratory of Modern Preparation of TCM Jiangxi University of Traditional Chinese Medicine Nanchang 330004 China Integrative Medical Center 302 Military Hospital Beijing 100039 China Sichuan Good Doctor Panxi Pharmaceutical Co. Ltd. Xichang 610031 China

Aconite is a valuable drug and also a toxic material, which can be used only after detoxification processing. Although traditional processing methods can achieve detoxification effect as desired, there are some obvious drawbacks, including a significant loss of alkaloids and poor quality consistency. It is thus necessary to develop a new detoxification approach. In the present study, we designed a novel one-step detoxification approach by quickly drying fresh-cut aconite particles. In order to evaluate the technical advantages, the contents of mesaconitine, aconitine, hypaconitine, benzoylmesaconine, benzoylaconine, benzoylhypaconine, neoline, fuziline, songorine, and talatisamine were determined using HPLC and UHPLC/Q-TOF-MS. Multivariate analysis methods, such as Clustering analysis and Principle component analysis, were applied to determine the quality differences between samples. Our results showed that traditional processes could reduce toxicity as desired, but also led to more than 85.2% alkaloids loss. However, our novel one-step method was capable of achieving virtually the same detoxification effect, with only an approximately 30% alkaloids loss. Cluster analysis and Principal component analysis analyses suggested that Shengfupian and the novel products were significantly different from various traditional products. Acute toxicity testing showed that the novel products achieved a good detoxification effect, with its maximum tolerated dose being equivalent to 20 times of adult dosage. And cardiac effect testing also showed that the activity of the novel products was stronger than that of traditional products. Moreover, particles specification greatly improved the quality consistency of the novel products, which was immensely superior to the traditional products. These results would help guide the rational optimization of aconite processing technologies, providing better drugs for clinical treatment.

关键词： Aconite Detoxication methods Quantitative determination Cardiac effect Quality consistency.

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改善与革命──企业变革的理论综述

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中国软科学 2000年第10期 121-124页

作者：张鼎昆清华大学经济管理学院北京100084

本文以跃变和渐变为主线，结合国内外企业变革案例，对近年来有关企业组织变革的研究进行了归纳。最终形成的变革统一体，将跃变和渐变看成是在企业不同发展阶段交替运用的策略，并且二者间在相互转化的内在关系。

关键词：跃变组织变革渐变企业变革理论

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人类绩效技术及其在企业中的应用

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中国管理科学 2001年第2期9卷 75-80页

作者：张鼎昆清华大学经济管理学院北京100084

人类绩效技术 (HumanPerformanceTechnology ,简称HPT)是近几年发展很快的新兴领域。其显著的实践指导价值 ,使人类绩效技术受到管理学界及商业界越来越多的关注。但在国内 ,它还是一个相对陌生的领域。本文重点评论这一学科的基本内容... 详细信息

人类绩效技术 (HumanPerformanceTechnology ,简称HPT)是近几年发展很快的新兴领域。其显著的实践指导价值 ,使人类绩效技术受到管理学界及商业界越来越多的关注。但在国内 ,它还是一个相对陌生的领域。本文重点评论这一学科的基本内容、框架 ,以及在提高企业绩效方面的操作模型 ,并突出绩效技术的系统性原则和实践性原则。

关键词：人类绩效技术绩效改进企业干预方案

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Effects of biological soil crusts on plant growth and nutrient dynamics in the Minqin oasis-desert ecotone,Northwest China

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Journal of Arid Land 2025年第1期17卷 130-143页

作者： KANG Jianjun YANG Fan zhang Dongmei ding Liang Key Laboratory of Ecological Safety and Sustainable Development in Arid Lands Linze Inland River Basin Research StationChinese Ecosystem Research NetworkNorthwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesLanzhou 730000China Minqin National Studies Station for Desert Steppe Ecosystem Gansu Desert Control Research InstituteLanzhou 730070China zhangye Agricultural and Rural Bureau Zhangye 734000China

Biological soil crusts(BSCs)play crucial roles in improving soil fertility and promoting plants settlement and reproduction in arid ***,the specific effects of BSCs on growth status and nutrient accumulation of plants are still unclear in different arid *** study analyzed the effects of three different BSCs treatments(without crust(WC),intact crust(IC),and broken crust(BC))on the growth,inorganic nutrient absorption,and organic solute synthesis of three typical desert plants(Grubovia dasyphylla(Fisch.&***.)Freitag&***,Nitraria tangutorum Bobrov,and Caragana koraiensis Kom.)in the Minqin desert-oasis ecotone of Northwest *** showed that the effects of three BSCs treatments on seed emergence and survival of three plants varied with seed *** IC treatment significantly hindered the emergence and survival of seeds,while the BC treatment was more conducive to seed emergence and survival of *** significantly promoted the growth of three plants,but their effects on plant growth varied at different stages of the ***,the growth of *** was affected by BSCs in early stage,but the effects on the growth of *** significantly weakened in the middle and late ***,the growth of *** and *** only showed differences at the middle and late stages,with a significant enhancement in *** of variance showed that BSCs,plant species,growth period,and their interactions had significant effects on the biomass and root:shoot ratio of three *** significantly affected the nutrients absorption and organic solute synthesis in ***,BSCs significantly promoted nitrogen(N)absorption in plants and increased plant adaptability in N poor desert ecosystems,but had no significant effects on phosphorus(P)*** effects of BSCs on inorganic nutrient absorption and organic solute synthesis in plants varied significantly among different plant *** results su

关键词： biological soil crusts(BSCs) desert oasis desert plants growth nutrient accumulation

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From waste to wealth:Coal tar residue derived carbon materials as low-cost anodes for potassium-ion batteries

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 464-475页

作者： Zhonghua Lu Jun Shen Xin zhang Lingcong Chao Liang Chen ding zhang Tao Wei Shoudong Xu College of Chemical Engineering and Technology Taiyuan University of TechnologyTaiyuan 030024China College of Chemistry Taiyuan University of TechnologyTaiyuan 030024China School of Chemical Engineering and Pharmacy Wuhan Institute of TechnologyWuhan 430205China School of Energy and Power Jiangsu University of Science and TechnologyZhenjiang 212003China

Carbon materials are widely recognized as highly promising electrode materials for various energy storage system *** tar residues(CTR),as a type of carbon-rich solid waste with high value-added utilization,are crucially important for the development of a more sustainable *** this study,we employed a straightforward direct carbonization method within the temperature range of 700-1000℃to convert the worthless solid waste CTR into economically valuable carbon materials as anodes for potassium-ion batteries(PIBs).The effect of carbonization temperature on the microstructure and the potassium ions storage properties of CTR-derived carbons(CTRCs)were systematically explored by structural and morphological characterization,alongside electrochemical performances *** on the co-regulation between the turbine layers,crystal structure,pore structure,functional groups,and electrical conductivity of CTR-derived carbon carbonized at 900℃(CTRC-900H),the electrode material with high reversible capacity of 265.6m Ah·g^(-1)at 50 m A·g^(-1),a desirable cycling stability with 93.8%capacity retention even after 100 cycles,and the remarkable rate performance for PIBs were ***,cyclic voltammetry(CV)at different scan rates and galvanostatic intermittent titration technique(GITT)have been employed to explore the potassium ions storage mechanism and electrochemical kinetics of *** indicate that the electrode behavior is predominantly governed by surface-induced capacitive processes,particularly under high current densities,with the potassium storage mechanism characterized by an“adsorption-weak intercalation”*** work highlights the potential of CTR-based carbon as a promising electrode material category suitable for high-performance PIBs electrodes,while also provides valuable insights into the new avenues for the high value-added utilization of CTR.

关键词： coal tar residue carbon materials anode potassium-ion batteries high value-added

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Correlation between grain size,mechanical properties and deformed microstructure of Fe-20Mn-6Al-0.6C-0.15Si low-density steel

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Journal of Iron and Steel Research International 2025年第1期32卷 282-292页

作者： Qi zhang Guang-hui Chen Zheng-liang Xue Zheng-kun Chen Guang Xu State Key Laboratory of Refractories and Metallurgy Wuhan University of Science and TechnologyWuhan430081HubeiChina Key Laboratory for Ferrous Metallurgy and Resources Utilization of Ministry of Education Wuhan University of Science and TechnologyWuhan430081HubeiChina Red Eagle Novel Refractory Materials Research Institute Zhejiang Red Eagle Group Co.Ltd.Huzhou313000ZhejiangChina

The effects of austenite grain size on the deformed microstructure and mechanical properties of an Fe-20Mn-6Al-0.6C-0.15Si(wt.%)low-density steel were *** microstructure of the experimental steel after solution treatment was single austenitic *** austenite grain size increased with solution temperature and time.A model was established to show the relationship between temperature,time and austenite grain size for the experimental *** addition,as the solution temperature increased,the strength decreased,while the elongation first increased and then *** decrease in elongation after solution treatment at 1100℃ for 90 min is contributed to the over-coarse austenite ***,after solution treatment at 900℃ for 90 min,the strength-elongation product reached the highest value of 44.4 GPa%.As the austenite grain size increased,the intensity of//tensile direction fiber *** was accompanied by a decrease in dislocation density,resulting in a lower fraction of low-angle grain boundaries and a lower work hardening ***,the austenite grain size has a critical influence on the mechanical properties of the low-density *** grains lead to a lower yield strength due to the Hall-Petch effect and a lower tensile strength because of lower dislocation strengthening.

关键词： Austenitic low-density steel Solution treatment Grain size Mechanical property Deformed microstructure

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Lightweight Underwater Target Detection Using YOLOv8 with Multi-Scale Cross-Channel Attention

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Computers, Materials & Continua 2025年第1期82卷 713-727页

作者： Xueyan ding Xiyu Chen Jiaxin Wang Jianxin zhang School of Computer Science and Engineering Dalian Minzu UniversityDalian116600China Research Center of Multimodal Information Perception and Intelligent Processing Dalian Minzu UniversityDalian116600China

Underwater target detection is extensively applied in domains such as underwater search and rescue,environmental monitoring,and marine resource *** is crucial in enabling autonomous underwater robot operations and promoting ocean ***,low imaging quality,harsh underwater environments,and obscured objects considerably increase the difficulty of detecting underwater targets,making it difficult for current detection methods to achieve optimal *** order to enhance underwater object perception and improve target detection precision,we propose a lightweight underwater target detection method using You Only Look Once(YOLO)v8 with multi-scale cross-channel attention(MSCCA),named *** the proposed multiscale cross-channel attention module,multi-scale attention(MSA)augments the variety of attentional perception by extracting information from innately diverse sensory *** cross-channel strategy utilizes RepVGGbased channel shuffling(RCS)and one-shot aggregation(OSA)to rearrange feature map channels according to specific *** aggregates all features only once in the final feature mapping,resulting in the extraction of more comprehensive and valuable feature *** experimental results show that the proposed YOLOv8-UOD achieves a mAP50 of 95.67%and FLOPs of 23.8 G on the Underwater Robot Picking Contest 2017(URPC2017)dataset,outperforming other methods in terms of detection precision and computational cost-efficiency.

关键词： Deep learning underwater target detection attention mechanism

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Subretinal fibrosis secondary to neovascular age-related macular degeneration:mechanisms and potential therapeutic targets

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Neural Regeneration Research 2025年第2期20卷 378-393页

作者： Jingxiang zhang Xia Sheng Quanju ding Yujun Wang Jiwei Zhao Jingfa zhang Department of Ophthalmology People’s Hospital of Huangdao DistrictQingdaoShandong ProvinceChina Department of Urology People’s Hospital of Huangdao DistrictQingdaoShandong ProvinceChina Department of Ophthalmology Shanghai General Hospital(Shanghai First People’s Hospital)Shanghai Jiao Tong University School of MedicineShanghaiChina National Clinical Research Center for Eye Diseases Shanghai Key Laboratory of Ocular Fundus DiseasesShanghai Engineering Center for Visual Science and PhotomedicineShanghai Engineering Center for Precise Diagnosis and Treatment of Eye DiseasesShanghaiChina

Subretinal fibrosis is the end-stage sequelae of neovascular age-related macular *** causes local damage to photoreceptors,retinal pigment epithelium,and choroidal vessels,which leads to permanent central vision loss of patients with neovascular age-related macular *** pathogenesis of subretinal fibrosis is complex,and the underlying mechanisms are largely ***,there are no effective treatment options.A thorough understanding of the pathogenesis of subretinal fibrosis and its related mechanisms is important to elucidate its complications and explore potential *** current article reviews several aspects of subretinal fibrosis,including the current understanding on the relationship between neovascular age-related macular degeneration and subretinal fibrosis;multimodal imaging techniques for subretinal fibrosis;animal models for studying subretinal fibrosis;cellular and non-cellular constituents of subretinal fibrosis;pathophysiological mechanisms involved in subretinal fibrosis,such as aging,infiltration of macrophages,different sources of mesenchymal transition to myofibroblast,and activation of complement system and immune cells;and several key molecules and signaling pathways participating in the pathogenesis of subretinal fibrosis,such as vascular endothelial growth factor,connective tissue growth factor,fibroblast growth factor 2,platelet-derived growth factor and platelet-derived growth factor receptor-β,transforming growth factor-βsignaling pathway,Wnt signaling pathway,and the axis of heat shock protein 70-Toll-like receptors 2/*** review will improve the understanding of the pathogenesis of subretinal fibrosis,allow the discovery of molecular targets,and explore potential treatments for the management of subretinal fibrosis.

关键词： choroidal neovascularization epithelial-mesenchymal transition mesenchymal transition myofibroblast neovascular age-related macular degeneration submacular fibrosis subretinal fibrosis therapeutic targets transforming growth factor-β vascular endothelial growth factor

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