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Impact of corticosteroids on initiation and half-year durability of humoral response in COVID-1. survivors

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Chinese Medical Journal Pulmonary and Critical Care Medicine 2024年第1期2卷 48-55页

作者： Yeming Wang Li Guo Guohui Fan yang Han Qiao {1. Lili Ren Hui {1. Geng Wang Xueyang {1. Tingxuan Huang Weiyang Wang Lan Chen Lixue Huang Xiaoying Gu Xinming Wang Jingchuan Zhong Ying Wang Hui Li Jiapei Yu Zhibo Liu Chaolin Huang Bin Cao Jianwei Wang National Center for Respiratory Medicine State Key Laboratory of Respiratory Health and MultimorbidityNational Clinical Research Center for Respiratory DiseasesInstitute of Respiratory MedicineChinese Academy of Medical SciencesChina-Japan Friendship HospitalBeijing 100029China National Health Commission Key Laboratory of Systems Biology of Pathogens and Christophe Mérieux Laboratory Institute of Pathogen BiologyChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 102629China Key Laboratory of Respiratory Disease Pathogenomics Chinese Academy of Medical SciencesBeijing 100029China School of Population Medicine and Public Health Chinese Academy of Medical Sciences&Peking Union Medical CollegeState Key Laboratory of Respiratory Health and MultimorbidityKey Laboratory of Pathogen Infection Prevention and Control(Peking Union Medical College)Ministry of EducationBeijing 100730China National Center for Respiratory Medicine State Key Laboratory of Respiratory Health and MultimorbidityNational Clinical Research Center for Respiratory DiseasesInstitute of Respiratory MedicineChinese Academy of Medical SciencesDepartment of Clinical research and Data managementCenter of Respiratory MedicineChina-Japan Friendship HospitalBeijing 100029China Jin Yin-tan Hospital WuhanHubei 430023China department of Pulmonary and Critical Care Medicine West China HospitalSichuan UniversityChengduSichuan 610041China department of Rheumatology and Clinical Immunology Chinese Academy of Medical Sciences&Peking Union Medical CollegeNational Clinical Research Center for Dermatologic and Immunologic Diseases(NCRC-DID)Ministry of Science&TechnologyState Key Laboratory of Complex Severe and Rare DiseasesPeking Union Medical College Hospital(PUMCH)Key Laboratory of Rheumatology and Clinical ImmunologyMinistry of EducationBeijing 100730China department of Pulmonary and Critical Care Medicine Center of Respiratory MedicineChina-Japan Friendship HospsitalInstitute of Respiratory MedicineChinese

Background:The impact of corticosteroids on humoral responses in coronavirus disease 201.(COVID-1.)sur-vivors during the acute phase and subsequent 6-month period remains *** study aimed to determine how the use of corticosteroids influences the initiation and duration of humoral responses in COVID-1. survivors 6 months after infection ***:We used kinetic antibody data from the lopinavir-ritonavir trial conducted at Jin Yin-Tan Hospital in January 2020,which involved adults hospitalized with severe COVID-1.(LOTUS,ChiCTR2000029308).Anti-body samples were collected from 1.2 patients during hospitalization,and kinetic antibodies were monitored at all available time points after ***,plasma samples were collected from 1.1.COVID-1. survivors for comprehensive humoral immune measurement at the half-year follow-up *** main focus was comparing the humoral responses between patients treated with systemic corticosteroid therapy and the non-corticosteroid ***:From illness onset to day 30,the median antibody titre areas under the receiver operating characteristic curve(AUCs)of nucleoprotein(N),spike protein(S),and receptor-binding domain(RBD)immunoglobulin G(IgG)were significantly lower in the corticosteroids *** AUCs of N-,S-,and RBD-IgM as well as neutralizing antibodies(NAbs)were numerically lower in the corticosteroids group compared with the non-corticosteroid ***,peak titres of N,S,RBD-IgM and-IgG and NAbs were not influenced by *** 6-month follow-up,we observed a delayed decline for most binding antibodies,except N-IgM(𝛽−0.05,95%CI[−0.1.,0.00])in the corticosteroids group,though not reaching statistical *** significant difference was observed for ***,for the half-year seropositive rate,corticosteroids significantly accelerated the decay of IgA and IgM but made no difference to N-,S-,and RBD-IgG or ***,corticosteroids group showed a trend towards d

关键词： COVID-1. Corticosteroid Immunity Antibody Humoral response

磷酸钠体系中KMnO_4添加剂对LY1.铝合金微弧氧化膜的影响

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材料保护 2018年第9期51卷 80-83,112页

作者：张泽磊苗景国翟大军杨刚四川工程职业技术学院材料工程系四川德阳618000 四川大学制造科学与工程学院四川成都610065

为了提高LY1.铝合金微弧氧化膜的性能,利用扫描电镜(SEM)、X射线衍射仪(XRD)和电化学工作站等,研究了磷酸钠电解液体系中不同浓度的KMnO_4添加剂对微弧氧化膜组织和性能的影响。结果表明:KMnO_4可增加膜层的厚度和显微硬度,当其浓度为2 ... 详细信息

为了提高LY1.铝合金微弧氧化膜的性能,利用扫描电镜(SEM)、X射线衍射仪(XRD)和电化学工作站等,研究了磷酸钠电解液体系中不同浓度的KMnO_4添加剂对微弧氧化膜组织和性能的影响。结果表明:KMnO_4可增加膜层的厚度和显微硬度,当其浓度为2 g/L时,膜层厚度和显微硬度分别达到峰值:23.8μm和602.1.HV;加入KMnO4后,膜层由Al、Al_2O_3和少量的MgAlO_4相组成;膜层的腐蚀电位随KMnO_4浓度的增加而增加,而腐蚀电流密度在其浓度为2 g/L时达到最低值2.455×1.^(-6)A/cm^2。

关键词： LY1.铝合金微弧氧化 KMnO4添加剂 Na3PO4电解液膜层性能

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中药智慧药学服务的实践与技术分析

医药导报 2024年第1期43卷 59-63页

作者：黄永亮吴萍杨婷张敏成都中医药大学附属医院药学部成都610072

目的分析中药智慧药房的发展现状,总结中药智慧药学服务实践经验,概述其技术要求和发展方向。方法成都中医药大学附属医院自201.年1.启动智慧中药房项目,建立中药智慧药房,承担门诊中药饮片调剂、煎药、配送等药学服务业务。结果截... 详细信息

目的分析中药智慧药房的发展现状,总结中药智慧药学服务实践经验,概述其技术要求和发展方向。方法成都中医药大学附属医院自201.年1.启动智慧中药房项目,建立中药智慧药房,承担门诊中药饮片调剂、煎药、配送等药学服务业务。结果截至2023年5月已完成中药饮片代煎配送557.2万副,2022年度共服务患者23.1.万人次。服务环节更简单,无需等候取药,无需二次到院取药,服务效率高,改善了患者就医体验。结论中药智慧药学服务发展迅速,未来将依托技术进步建立全程化智慧服务体系。

关键词：中药药学服务智慧药房人工智能

苦瓜蛋白诱发胃癌细胞SGC7901.亡的研究

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四川肿瘤防治 2001年第1期14卷 1-4页

作者：李春阳贾文祥张雪梅马巨辉张再容刘莉华西医科大学基础医学院微生物学教研室成都生物制品研究所成都610063

目的 :探讨苦瓜蛋白抗肿瘤活性的机制。方法 :从新鲜的苦瓜种子中分离纯化苦瓜蛋白 ,通过MTT比色法分析其对SGC7901.胞以及正常人二倍体细胞2BS增殖的影响 ,并应用光镜、电镜观察及流式细胞术等手段 ,研究苦瓜蛋白诱发胃癌细胞SGC7901...

目的 :探讨苦瓜蛋白抗肿瘤活性的机制。方法 :从新鲜的苦瓜种子中分离纯化苦瓜蛋白 ,通过MTT比色法分析其对SGC7901.胞以及正常人二倍体细胞2BS增殖的影响 ,并应用光镜、电镜观察及流式细胞术等手段 ,研究苦瓜蛋白诱发胃癌细胞SGC7901.形态学、DNA含量变化。结果 :苦瓜蛋白对胃癌细胞SGC7901.IC50约为1.μg/ml,在相同剂量下对2BS细胞的抑制率仅为8 % ;与对照组细胞相比 ,加药后的SGC7901.胞发生典型的凋亡形态学改变及DNA含量变化。结论 :苦瓜蛋白对胃癌细胞SGC7901.增长具有明显的抑制作用。

关键词：苦瓜蛋白胃癌细胞细胞凋亡

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预测典型变形高温合金均匀化动力学的新模型

Transactions of Nonferrous Metals Society of china 2024年第4期34卷 1178-1190页

作者：张献光杨文超周扬闫建昊肖东平税烺付建辉孙飞石鹏陈佳俊裴逸武张健北京科技大学绿色低碳钢铁冶金全国重点实验室北京100083 北京科技大学冶金与生态工程学院北京100083 成都先进金属材料产业技术研究院股份有限公司成都610300 攀钢集团研究院有限公司攀枝花617000 department of Material Design Innovation Engineering Nagoya UniversityFuro-choChikusa-kuNagoya 464-8603Japan

提出一种基于扩散距离概念的变形高温合金均匀化动力学新预测模型。通过定量电子探针(EPMA)分析,系统研究典型镍基变形高温合金(GH41.1.的微观偏析和均匀化动力学。研究发现,基于残余偏析指数模型预测的均匀化动力学与实际测量结果之间... 详细信息

提出一种基于扩散距离概念的变形高温合金均匀化动力学新预测模型。通过定量电子探针(EPMA)分析,系统研究典型镍基变形高温合金(GH41.1.的微观偏析和均匀化动力学。研究发现,基于残余偏析指数模型预测的均匀化动力学与实际测量结果之间存在一定差异。实验和理论分析均表明,考虑了过去通常被忽略的扩散方向因子的一维扩散距离模型可以合理地预测均化动力学。新模型在只需知道原始枝晶臂间距和扩散系数前提下即可完成预测计算,这为变形高温合金均匀化动力学预测提供了一种新的选择。

关键词：变形高温合金微观偏析均匀化动力学预测模型扩散距离

微波消融与手术切除治疗肝细胞癌合并肝硬化效果及安全性的Meta分析

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临床肝胆病杂志 2024年第9期40卷 1807-1815页

作者：骆建兴张扬向讷扈晓宇成都中医药大学附属医院感染科成都610072 成都中医药大学临床医学院成都610072 成都市金牛区驷马桥曹家巷社区卫生服务中心中医科成都610081

目的通过Meta分析系统评价微波消融(MWA)和手术切除(HR)在肝细胞癌(HCC)合并肝硬化中的有效性及安全性。方法本研究根据PRISMA指南完成,PROSPERO注册号:CRD420245091.5。检索Pub Med、Cochrane Library、EMBASE、Web of Science、中国... 详细信息

目的通过Meta分析系统评价微波消融(MWA)和手术切除(HR)在肝细胞癌(HCC)合并肝硬化中的有效性及安全性。方法本研究根据PRISMA指南完成,PROSPERO注册号:CRD420245091.5。检索Pub Med、Cochrane Library、EMBASE、Web of Science、中国知网、维普、万方数据库,时间均为从建库至2023年1.月,搜索MWA对比HR治疗HCC合并肝硬化的随机对照试验(RCT)和队列研究,采用Stata 1..0软件进行Meta分析。结果共纳入3项RCT和5项回顾性队列研究,共953例患者。Meta分析显示:MWA的1.2/3/5年总生存率(OS)与HR相比无统计学差异(P值均>0.05)。MWA的1.2/5年复发率与HR相比无统计学差异(P值均>0.05)。MWA的3年复发率高于HR(RR=1.59,95%CI:1.08~2.33,P=0.01.)。MWA的1.3/5年无复发生存率(DFS)低于HR(RR=0.94,95%CI:0.89~0.99,P=0.01.,I^(2)=0.0%;RR=0.84,95%CI:0.72~0.98,P=0.023,I^(2)=25.4%;RR=0.75,95%CI:0.58~0.98,P=0.032,I^(2)=34.6%)。但亚组分析表明,在RCT组,MWA的1.2/3年OS和1.3年DFS与HR相比无统计学差异(P值均>0.05)。MWA的术中出血量、手术时间、住院时间、不良反应及肝功能均优于HR(SMD=-2.31.95%CI:-2.64~-1.97,P1.I^(2)=3.1.;SMD=-3.38,95%CI:-4.05~-2.71.P1.I^(2)=73.8%;SMD=-2.54,95%CI:-3.27~-1.80,P1.I^(2)=92.8%;RR=0.42,95%CI:0.30~0.59,P1.I^(2)=0.0%;SMD=-1.43,95%CI:-1.89~-0.97,P1.。结论MWA与HR在局部复发、DFS及OS方面无明显差异。MWA术中出血量更少,手术时间更短,不良反应更少,对肝功能影响更小,住院时间更短。

关键词：癌,肝细胞肝硬化 Meta分析

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有限样本下的科技文献语步识别方法探讨

图书情报工作 2024年第3期68卷 117-129页

作者：张鑫许海云杨宁方肖赵爽中国科学院成都文献情报中心成都610213 中国科学院大学信息资源管理系北京100190 山东理工大学管理学院淄博255000

[目的/意义]科技文献语步识别是从非结构化的文献中抽取出研究目的、对象、方法、结果、结论等语义片段,针对摘要语步识别实际应用中常出现的高质量标注样本数量较有限、深度识别模型可解释性差等问题开展研究。[方法/过程]在语步识别... 详细信息

[目的/意义]科技文献语步识别是从非结构化的文献中抽取出研究目的、对象、方法、结果、结论等语义片段,针对摘要语步识别实际应用中常出现的高质量标注样本数量较有限、深度识别模型可解释性差等问题开展研究。[方法/过程]在语步识别中引入提示学习范式,设计对应提示模板和同义词表达器,采用局部线性代理方式生成模型解释,构建可解释的深度学习识别模型,并在生物领域和计算机领域两个数据集随机抽取部分数据中进行模拟实证研究。[结果/结论 ]基于大模型提示学习的范式在语步识别任务上以较少训练代价的取得比精调小模型更高的精度,在Pub Med三个子数据集上训练后,预测精度分别提高2.5%,4.1.和3.9%。结合准确率和解释结果来看,“方法”“结果”语步识别效果较好(F1.约90%),“背景”“对象”语步相对差些(F1.不到70%)。基于提示学习的方式能够以更快捷高效的方式使用预训练语言模型,获得准确性高、可解释性好的识别模型。

关键词：小样本文本增强提示学习模型解释

ERRATUM TO:Cholesterol homeostasis regulated by ABCA1.is critical for retinal ganglion cell survival

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Science china(Life Sciences) 2024年第7期67卷 1548-1548页

作者： Jialiang yang Yuhong Chen Tongdan Zou Bai Xue Fang yang Xiangzhou Wang Yibo Huo Boyun Yan Yuxia Xu Shiyu He Yi Yin Jing Wang Xiong Zhu Lin zhang Yu Zhou Zhengfu Tai Ping Shuai Man Yu Qian Luo Yilian Cheng Bo Gong Xianjun Zhu Jing zhang Xinghuai Sun Ying Lin Houbin zhang Zhenglin yang Key Laboratory for Human Disease Gene Study of sichuan Province and Institute of Laboratory Medicine Sichuan Provincial People’s HospitalUniversity of Electronic Science and Technology of ChinaChengdu 610072China department of Ophthalmology and Visual Science Eye and Ear Nose Throat(ENT)HospitalFudan UniversityShanghai 200032China School of Optoelectronic Science and Engineering University of Electronic Science and Technology of ChinaChengdu 611731China Institute of chengdu Biology Sichuan Translational Medicine HospitalChinese Academy of SciencesChengdu 610093China department of Ophthalmology Sichuan Provincial People’s HospitalUniversity of Electronic Science and Technology of ChinaChengdu 610072China Research Unit for Blindness Prevention of Chinese Academy of Medical Sciences Sichuan Academy of Medical Sciences&Sichuan Provincial People’s HospitalChengdu 610072China

Erratum to:SCIENCE china Life Sciences,Volume 66,Issue 2:21.-225(2022),https://***/1..1.07/s1.427-021.21.6-2 This paper contains an error in Figure 4C,where the representative images of filipin staining of retinal sections from 6-month-old mice were *** provide the correct picture for Figure 4C as *** statistical result in Figure 4D was corrected as *** new Figure 4 does not affect the conclusion of this article.

关键词： Figure critical conclusion

ERRATUM TO: Cholesterol homeostasis regulated by ABCA1.is critical for retinal ganglion cell survival

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Science china Life Sciences 2024年

作者： Jialiang yang Yuhong Chen Tongdan Zou Bai Xue Fang yang Xiangzhou Wang Yibo Huo Boyun Yan Yuxia Xu Shiyu He Yi Yin Jing Wang Xiong Zhu Lin zhang Yu Zhou Zhengfu Tai Ping Shuai Man Yu Qian Luo Yilian Cheng Bo Gong Xianjun Zhu Jing zhang Xinghuai Sun Ying Lin Houbin zhang Zhenglin yang Key Laboratory for Human Disease Gene Study of sichuan Province and Institute of Laboratory Medicine Sichuan Provincial People's Hospital University of Electronic Science and Technology of China department of Ophthalmology Sichuan Provincial People's Hospital University of Electronic Science and Technology of China department of Ophthalmology and Visual Science Eye and Ear Nose Throat (ENT) Hospital Fudan University Institute of chengdu Biology Sichuan Translational Medicine Hospital Chinese Academy of Sciences School of Optoelectronic Science and Engineering University of Electronic Science and Technology of China Research Unit for Blindness Prevention of Chinese Academy of Medical Sciences Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital

Erratum to:SCIENCE china Life Sciences, Volume 66, Issue 2:21.-225 (2022), https://***/1..1.07/s1.427-021.21.6-2This paper contains an error in Figure 4C, where the representative images of filipin staining of retinal sections from 6-month-old mice were *** provide the correct picture for Figure 4C as follows. The statistical result in Figure 4D was corrected as well. This new Figure 4does not affect the conclusion of this article.

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