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Electrochemical sensing of DNA immobilization and hybridization based on carbon nanotubes/nano zinc oxide/chitosan composite film

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Chinese Chemical Letters 2008年第5期19卷 589-591页

作者： Wei zhang Tao Yang da ming Huang Kui Jiao College of Chemistry and Molecular Engineering Qingdao University of Science and Technology Qingdao 266042 China

A novel electrochemical DNA biosensor based on zinc oxide （ZnO） nanoparticles and multi-walled carbon nanotubes （MWNTs） for DNA immobilization and enhanced hybridization detection is presented. The MWNTs/nano ZnO/chitosan composite film modified glassy carbon electrode （MWNTs/ZnO/CHIT/GCE） was fabricated and DNA probes were immobilized on the electrode surface. The hybridization events were monitored by differential pulse voltammetry （DPV） using methylene blue （MB） as an indicator. The sensor can effectively discriminate different DNA sequences related to PAT gene in the transgenic corn, with a detection limit of 2.8× 10^-12 mol/L of target sequence.

关键词： ZnO nanoparticles Multi-walled carbon nanotubes Chitosan DNA sensor PAT gene

External Electro-optic Sampling Utilizing an Asymmetric Fabry-Pérot Film of Poled Electro-optical Polymer

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Chinese Physics Letters 2001年第6期18卷 782-784页

作者： CHEN Kai-Xin YANG Han zhang da-ming zhang Hong-Bo YI Mao-Bin State Key Laboratory on Integrated Optoelectronics Jilin UnversityChangchun 130023

External electro-optic sampling has been first demonstrated using a poled electro-optical polymer asymmetric Fabry-Pérot film,placed freely on the indium-tin oxide coplanar waveguide transmission line and used as electro-optic probe *** one laser beam is required due to the fact that the asymmetric Fabry-Pérot film is utilized to convert the phase modulation to amplitude modulation.A 1.2 GHz microwave signal is sampled,and the voltage sensitivity about 2mV/√Hz is *** results are promising for technical applications in the high-speed electronic devices and monolithic microwave integrated circuits research.

关键词： optical waveguide microwave

Properties of DR1/PMMA-co-GMA for High Speed Electro-optical Switch

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Chemical Research in Chinese Universities 2012年第6期28卷 1091-1094页

作者： CAO Zi-jian JIN Lin WANG Xi-bin CUI Zhan-chen zhang da-ming State Key Laboratory on Integrated Optoelectronics College of Electronic Science and Engineering State Key Laboratory of Superamolecular Structure and Materials Jilin University Changchun 130012 P. R. China

A non-linear optical（NLO） material was synthesized by means of a simple *** material can be applied in electro-optical（EO） devices,such as EO switches and *** Disperse Red 1（DR1） was doped in polymethyl-methacrylate-co-glycidyl methacrylate（PMMA-co-GMA） as the NLO active *** synthesis process and material structure were *** thermal properties,surface morphology and optical characteristics of the material were investigated by means of differential scanning calorimetry（DSC）,thermogravimetric analysis（TGA）,atomic force microscopy（AFM）,and m-lines *** the reflection technique,the value of the electro-optical coefficient γ 33 was measured as 11 pm/V at a wavelength of 1310 *** EO switch with nanosecond response based on this material has been fabricated.

关键词： Disperse Red 1/polymethyl-methacrylate-co-glycidyl methacrylate(DR1/PMMA-co-GMA) Electrooptical switch Thermal stability Optical property

Benefits of Mindfulness Training on the Mental Health of Women During Pregnancy and Early Motherhood:A Randomized Controlled Trial

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Biomedical and Environmental Sciences 2023年第4期36卷 353-366页

作者： WANG Shu Lei SUN Meng Yun HUANG Xing zhang da ming YANG Li XU Tao PAN Xiao Ping ZHENG Rui Min National Center for Women and Children's Health China CDCBeijing 100081China Yantai Center for Disease Control and Prevention Yantai CDCYantai 264003ShandongChina Shanxi Maternal and Child Health Hospital Taiyuan 030001ShanxiChina

Objective This study aimed to evaluate the effects of a mindfulness-based psychosomatic intervention on depression,anxiety,fear of childbirth(FOC),and life satisfaction of pregnant women in *** Women experiencing first-time pregnancy(n=104)were randomly allocated to the intervention group or a parallel active control *** collected data at baseline(T0),postintervention(T1),3 days after delivery(T2),and 42 days after delivery(T3).The participants completed questionnaires for the assessment of the levels of depression,anxiety,FOC,life satisfaction,and *** between the two groups and changes within the same group were analyzed at four time points using repeated-measures analysis of *** Compared with the active control group,the intervention group reported lower depression levels at T2(P=0.038)and T3(P=0.013);reduced anxiety at T1(P=0.001)and T2(P=0.003);reduced FOC at T1(P<0.001)and T2(P=0.04);increased life satisfaction at T1(P<0.001)and T3(P=0.015);and increased mindfulness at T1(P=0.01)and T2(P=0.006).Conclusion The mindfulness-based psychosomatic intervention effectively increased life satisfaction and reduced perinatal depression,anxiety,and FOC.

关键词： Mindfulness Depression Anxiety Fear of childbirth Life satisfaction Randomized controlled trial

Polymer Electro-optic Modulator Linear Bias Using the Thermo-optic Effect

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Chinese Physics Letters 2012年第1期29卷 152-155页

作者： SUN Xiao-Qiang CHEN Chang-ming LI Xiao-Dong WANG Xi-Bin YANG Tian-Fu zhang da-ming WANG Fei XIE Zhi-Yuan Changchun Institute of Applied Chemistry Chinese Academy of SciencesChangchun 130022 State Key Laboratory on Integrated Optoelectronics Jilin UniversityChangchun 130012

A quasi-rectangular waveguide polymer MacH^(-)Zehnder (M-Z) electro-optic (EO) modulator based on an organic/inorganic hybrid material with thermal bias control is fabricated and *** bias for the modulator is obtained through thermo-optic *** optical output is adjusted by changing phase difference between the two arms of the M-Z interferometer.A power consumption of 16.1 m W for π phase change is observed owing to the application of silica *** approach is proved to be effective to suppress direct current drift in polymer EO modulators.

关键词： modulator interferometer waveguide

Optimum design of a polymer electro-optic microring resonator switch

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Optoelectronics Letters 2007年第6期3卷 423-427页

作者： YAN Xin MA Chun-sheng WANG Xian-yin zhang da-ming Liu Shi-yong State Key Laboratory on Integrated Optoelectronics College of Electronic Science and Engineering Jilin UniversityChangchun 130012 China

Novel transfer functions are presented for a polymer electro-optic mieroring resonator switches. The resonating process ot the light in the microring is simulated using the formulas. Then the optimization of the structural parameters is performed, and the characteristics are analyzed, such as the resonance time, output spectrum, operation voltage, insertion loss and crosstalk were analyzed. The simulation results show that the designed device exhibits favorable switching functions.

关键词：集成光学器件聚合物电子光学共振器

Does antecolic reconstruction for duodenojejunostomy improve delayed gastric emptying after pylorus-preserving pancreaticoduodenectomy? A systematic review and meta-analysis

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World Journal of Gastroenterology 2012年第43期18卷 6315-6323页

作者： An-Ping Su Shuang-Shuang Cao Yi zhang Zhao-da zhang Wei-ming Hu Bo-Le Tian Department of Hepatobiliopancreatic Surgery West China Hospital Sichuan University Chengdu 610041 Sichuan Province China

AIM:To evaluate whether antecolic reconstruction for duodenojejunostomy (DJ) can decrease delayed gastric emptying (DGE) rate after pylorus-preserving pancreaticoduodenectomy (PPPD) through literature review and meta-analysis. METHODS:Articles published between January 1991 and April 2012 comparing antecolic and retrocolic reconstruction for DJ after PPPD were retrieved from the databases of MEDLINE (PubMed), EMBASE, OVID and Cochrane Library Central. The primary outcome of interest was DGE. Either fixed effects model or random effects model was used to assess the pooled effect based on the heterogeneity. RESULTS:Five articles were identified for inclusion:two randomized controlled trials and three non-randomized controlled trials. The meta-analysis revealed that antecolic reconstruction for DJ after PPPD was associated with a statistically significant decrease in the incidence of DGE [odds ratio (OR), 0.06; 95% CI, 0.02-0.17; P < 0.00 001] and intra-operative blood loss [mean difference (MD), -317.68; 95% CI, -416.67 to -218.70; P < 0.00 001]. There was no significant difference between the groups of antecolic and retrocolic reconstruction in operative time (MD, 25.23; 95% CI, -14.37 to 64.83; P = 0.21), postoperative mortality, overall morbidity (OR, 0.54; 95% CI, 0.20-1.46; P = 0.22) and length of postoperative hospital stay (MD, -9.08; 95% CI, -21.28 to 3.11; P = 0.14). CONCLUSION:Antecolic reconstruction for DJ can decrease the DGE rate after PPPD.

关键词： Pylorus-preserving pancreaticoduodenectomy Delayed gastric emptying Antecolic reconstruction Retrocolic reconstruction Duodenojejunostomy

Roles of Loss of Chromosome 14q Allele in the Prognosis of Renal Cell Carcinoma with C-reactive Protein Abnormity

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Chinese Medical Journal 2017年第18期130卷 2176-2182页

作者： Gang Wang da-ming zhang Hai-Ying Zhuang Chao Yin Jing Liu Zi-Chun Wang Li-Cheng Cai ming-Hua Ren Wan-Hai Xu Cheng zhang Department of Urology The First Affiliated Hospital of Harbin Medical University Harbin Heilongjiang 150001 China Department of Neurosurgery The First Affiliated Hospital of Harbin Medical University Harbin Heilongjiang 150001 China Department of Pharmacology Harbin Medical University Harbin Heilongjiang 150081 China Department of Pharmacy The First Affiliated Hospital of Harbin Medical University Harbin Heilongjiang 150001 China Department of Urology The Fourth Affiliated Hospital of Harbin Medical University Harbin Heilongjiang 150001 China

Background：Renal cell carcinoma （RCC） is frequently associated with paraneoplastic inflammatory syndrome （PIS）.This study aimed at exploring the connections between the survival rate and specific gene alterations and the potential ***：We retrospectively studied 69 surgical RCC cases from August 2014 to February 2016,including 18 cases of clear cell RCC （ccRCC） demonstrating elevated pretreatment serum C-reactive protein （CRP,Group A）.Twelve of the 18 cases were symptomized with febrile *** also selected 49 cases ofccRCC with normal pretreatment CRP （Group B）.Using 22 microsatellite markers,we compared the incidence of loss of heterozygosity （LOH） between Group A and Group *** statistical tests are ***：The 3p LOH was common in both Group A （89%） and Group B （92%）.The frequency of 14q LOH in Group A （16 of 18） was higher than Group B （4 of 49,χ^2 =40.97 P 〈 0.0001）.The 3p and 14q LOH were the characteristics of ccRCC with elevated acute phase reactants,including PIS,regardless of the presence of *** the contrary,14q LOH was a rare genomic alternation in advanced-staged ccRCC without *** overall survival of patients with elevated CRP （33.3%） was lower than its counterparts （6.1%,hazard ratio=1.852,P 〈 0.0001） in Kaplan-Meier ***：The results imply that the disruption ofa 14q gene（s） might result in not only the inflammatory manifestations in the tumor host but also the poor survival rate as *** isolation of the gene（s） on 14q might be a vital goal in the treatment of PIS-associated RCC.

关键词： C-reactive Protein Gene Alterations Loss of Chromosome Paraneoplastic Inflammatory Syndrome Renal Cell Carcinoma

Contrast-enhanced Ultrasound in Detecting Endoleaks with Failed Computed Tomography Angiography Diagnosis after Endovascular Abdominal Aortic Aneurysm Repair

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Chinese Medical Journal 2015年第18期128卷 2491-2497页

作者： Xiao Yang Yue-Xin Chen Bo zhang Yu-Xin Jiang Chang-Wei Liu Rui-Na Zhao Qiong Wu da-ming zhang Department of Ultrasound Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100730 China Department of Vascular Surgery Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100730 China Department of Radiology Peking Union Medical College Hospital ChineseAcademy of Medical Sciences and Peking Union Medical College Beijing 100730 China

Background： Endovascular aneurysnl repair （EVAR） is one of the first-line therapies of abdominal aortic aneurysms. Postoperative endoleak is the most common complication of EVAR. Computed tomography angiography （CTA）, which is routine for follow-up, has side effects （e.g., radiation） and also has a certain percentage of missed diagnosis. Preliminary studies on contrast-enhanced ultrasound （CEUS） have shown that the sensitivity of CEUS for detecting endoleak is no lower than that of CTA. To investigate the advantages of CEUS, we conducted CEUS examinations of post-EVAR cases in which CTA failed to detect endoleak or could not verify the type of endoleak. Methods： Post-EVAR patients, who were clinically considered to have endoleak and met the inclusion criteria were enrolled between March 2013 and November 2014. All of the patients underwent color Doppler flow imaging （CDFI） and a CEUS examination. Size, location, microbubble dispersion, and hemodynamic characteristics of leaks were recorded. Comparison between the diagnosis of CEUS and CDF1 was conducted using Fisher＇s exact test and clinical outcomes of all patients were followed up. Results： Sixteen patients were enrolled, and 12 （75%） had endoleaks with verified types by CEUS. Among 12 cases of endoleaks were positive by CEUS, 10 were CDFl-positive, and the four CEUS-negative cases were all negative by CDFI. The diagnostic values of CEUS and CDFI were statistically difl＇erent （P = 0,008）. Six patients with high-pressure endoleaks received endovascular re-intervention guided by CEUS results. One patient with type Ⅲ endoleak had open surgery when endovascular repair failed. Conclusions： C EUS is a new, safe, and effective means for detection ofendoleaks post-EVAR. This technique can be used as a supplement for routine CTA follow-up to provide more detailed information on endoleak and its category.

关键词： Abdominal Aortic Aneurysnl: Color Doppler Flow Imaging Contrast-enhanced Ultrasound: Endoleak EndovascularAneurysm Repair