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Chemical Research in Chinese Universities 2019年第2期35卷 261-270页

作者： WANG Wei WANG Tao FAN Xuecheng zhang cuilin HU Jinxing CHEN Hui FANG Zhenxing YAN Jiefeng LIU Bing College of Science & Technology Ningbo UniversityNingbo 315212P.R.China State Key Labomtory of Bio-Fibers and Eco-Textiles Qingdao UniversityQingdao 266071P.R.China

A facile and green freeze-drying-assisted method was proposed to synthesize C0MoO4 mesoporous nano-sheets(MPNSs).The resulting product exhibits a Mgh specific capacity and good rate perfomance when evalimte an anode material for lithium-ion batteries(LIBs).The reversible specific capacity can be kept at 1105.2 mA·h·g^-1 after 100 cycles at a current density of 0.2 A/*** at the current densities of 1 and 4 A/gs the CoMoO4 MPNSs electrode can still retain the reversible capacities of 1148.7 and 540 mA·h·g^-1,***,the full cell(LiPePO4 catliode/CoMoO4 MPNSs anode)displays a stable discharge capacity of 146.7 mA·h·g^-1 at 0.1 C(1 C=170 mA/g)together with an initial coulombic efficiency of 98.2%.In addition,the CoMoO4 crystal structure is destroyed and reduced into Co^0 and Mo^0 in the first discharge *** the subsequent cycles,the attractive Li storage properties come from the reversible conversions between Co/Co^2+and Mo/Mo^6+.The improved electroche-mical performance of CoMoO4 MPNSs is mainly attributed to their unique porous structures,which not only possess a good ion diffusion and electronic conduction pathway,but also provide many cavities to alleviate the volume changes during repeated *** work offers a new perspective to the design of other porous electrode materials with a good energy storage performance.

关键词： Freeze-drying Mesoporous nanosheet CoMoO4 Anode material Lithium storage

Promoting Healthy Longevity Should Start Young: A Life Course Journey

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Maternal-Fetal Medicine 2024年第1期6卷 1-4页

作者： cuilin zhang Claire Guivarch Global Centre for Asian Women's Health Yong Loo Lin School of MedicineNational University of SingaporeSingapore 117549Singapore Department of Obstetrics and Gynaecology Yong Loo Lin School of MedicineNational University of SingaporeSingapore 117549Singapore Bia-Echo Asia Centre for Reproductive Longevity and Equality(ACRLE) Yong Loo Lin School of MedicineNational University of SingaporeSingapore 117549Singapore Department of Nutrition Harvard T.H.Chan School of Public HealthBoston 02115USA

Introduction Throughout a woman’s life,several unique health characteristics are related to an increased risk of later disease morbidity and/or premature mortality(Fig.1).For instance,these include early age at menarche1,2(ie,“short,irregular or long menstrual cycles”)3,4,a history of infertility5,pregnancy loss6,several major pregnancy complications(eg,preeclampsia,gestational hypertension,gestational diabetes mellitus(GDM)and preterm delivery)7–9,and menopause characteristics(eg,long menopause transition period,early age at menopause,and the presence of vasomotor symptoms).

关键词： Population health Longevity Women's health

M1 muscarinic acetylcholine receptor in Alzheimer's disease

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Neuroscience Bulletin 2014年第2期30卷 295-307页

作者： Shangtong Jiang Yanfang Li cuilin zhang Yingjun Zhao Guojun Bu Huaxi Xu Yun-Wu zhang Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research Institute of Neuroscience College of Medicine Xiamen University School of Pharmaceutical Sciences Xiamen University Degenerative Disease Research Program Sanford-Burnham Medical Research Institute

The degeneration of cholinergic neurons and cholinergic hypofunction are pathologies associated with Alzheimer＇s disease （AD）. Muscarinic acetylcholine receptors （mAChRs） mediate acetylcholine-induced neurotransmission and five mAChR subtypes （M1-M5） have been identified. Among them, M1 mAChR is widely expressed in the central nervous system and has been implicated in many physiological and pathological brain functions. In addition, M1 mAChR is postulated to be an important therapeutic target for AD and several other neurodegenerative diseases. In this article, we review recent progress in understanding the functional involvement of M1 mAChR in AD pathology and in developing M1 mAChR agonists forAD treatment.

关键词： agonist Alzheimer's disease amyloid cholinergic hypofunction M1 muscarinic acetylcholinereceptor tau

International Association of Diabetes and Pregnancy Study Group criteria is suitable for gestational diabetes mellitus diagnosis： further evidence from China

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Chinese Medical Journal 2014年第20期127卷 3553-3556页

作者： Wei Yumei Yang Huixia Zhu Weiwei Yang Hongyun Li Haixia Yan Jie zhang cuilin Department of Obstetrics and Gynecology Peking Univesity FirstHospital Beijing 100034 China Department of Clinical Laboratory Peking University First HospitalBeijing 100034 China Division of Epidemiology Statistics and Prevention ResearchNICHD/National Institutes of Health 6100 Executive Blvd Rm7B03 Rockville MD 20852 USA

Background The International Association of Diabetes and Pregnancy Study Group （IADPSG） recommended new diagnostic criteria for gestational diabetes mellitus （GDM） after extensive analyses of the Hyperglycemia and Adverse Pregnancy Outcomes （HAPO） study. Unfortunately, there was no data from mainland of China in this study. We evaluated the feasibility of IADPSG criteria for GDM diagnosis in China. Methods A large prospective study was conducted. We reviewed medical records of a total of 25 674 pregnant women who underwent GDM screening and diagnosis between January 1, 2005 and December 31, 2012 in the Peking University First Hospital. The prevalence of gestational glucose metabolism abnormalities was calculated according to different cut off values defined by the National Diabetes Data Group （NDDG） or the IADPSG, and the incidence of adverse pregnancy outcomes related to GDM was analyzed. Results According to the cut off values of NDDG and IADPSG criteria, the prevalence of gestational glucose metabolism abnormalities was 8.4% and 18.9% （P 〈0.01） respectively, and the prevalence of cesarean section （52.5% vs. 46.0%, P 〈0.01）, macrosomia （7.5% vs. 6.3%, P 〈0.05）, neonatal hypoglycemia （1.6% vs. 1.0%, P 〈0.01）, and perinatal death （0.5% vs. 0.2%, P 〈0.01）; the prevalence was significantly lower when IADPSG criteria were applied. The prevalence of macrosomia, cesarean section, neonatal hypoglycemia, pregnancy induced hypertension, etc. was also higher in the GDM group than in the normal group. The prevalence of cesarean section （62.3%） and macrosomia （14.8%） was the highest in untreated mild GDM patients. Conclusions Our results indicated that treatment/intervention of women with GDM identified by IADPSG criteria was related to significantly lower risk of multiple adverse pregnancy outcomes. Such findings provide support for applying IADPSG criteria in China.

关键词： gestational diabetes mellitus macrosomia cesarean section neonatal hypoglycemia

Near-Infrared Light Activated Thermosensitive Ion Channel to Remotely Control Transgene System for Thrombolysis Therapy

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Near-Infrared Light Activated Thermosensitive Ion Channel to...

基于关系传播链的作业车间调度中最优外协工序辨识

第十一届全国化学生物学学术会议

作者： Peidong Hou Da zhang cuilin zhang Juan Li Xiaolong Liu Huanghao Yang MOE Key Laboratory of Analytical Science of Food Safety and Biology College of ChemistryFuzhou University Mengchao Hepatobiliary Hospital of Fujian Medical University

Aiming at noninvasive,on-demand,and sustained antithrombotic therapy,a new thrombolysis approach based on the transgene system has been developed to remotely and precisely control the expression of urokinase plasminogen activator(uPA) by bioengineered cells for antithrombotic therapy both in vitro and in *** this design,the near-infrared(NIR) light could activate the expression of the thermosensitive transient receptor potential vanilloid-1(TRPV1) channel in response to photothermal responsive nanotransducers to trigger the synthetic signaling pathway to secret *** encapsulating bioengineered cells in injectable hydrogel to ensure long-term survival and convenience for injection,the engineered cells could noninvasively and precisely control the production of uPA protein in situ via an NIR laser to significantly enhance the thrombolysis therapeutic effects by spatiotemporally controlling the local temperature,in both the microfluidic blood circulation mimic and the murine tail thrombus model.

关键词： Antithrombotic therpy near-infrared light thermosensitive ion channels

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计算机集成制造系统 2016年第10期22卷 2333-2347页

作者：张翠林王军强王烁顾强强西安航空学院经济管理学院陕西西安710077 西北工业大学生产与运作系统性能分析中心陕西西安710072 西北工业大学现代设计与集成制造技术教育部重点实验室陕西西安710072

为改变以缓解能力不足为导向的传统外协方式,采用以提升调度性能为导向的新型外协方式,通过辨识最优外协工序,实现以较小的外协代价获得生产系统调度性能的较大提升。首先,建立了最优外协工序辨识模型。其次,以工序与工序间的影响以及... 详细信息

为改变以缓解能力不足为导向的传统外协方式,采用以提升调度性能为导向的新型外协方式,通过辨识最优外协工序,实现以较小的外协代价获得生产系统调度性能的较大提升。首先,建立了最优外协工序辨识模型。其次,以工序与工序间的影响以及工序对调度系统的影响为依据,基于关系传播链揭示了辨识有效候选外协工序的辨识规律,提出了候选外协工序的有效性定理。再次,提出了最优外协工序辨识方法,识别出候选外协工序集并给出对应的重调度方案,基于熵权的逼近理想解法对候选外协工序集进行多属性决策,辨识出最优外协工序及对应的作业调度方案。最后,通过标准算例FT10验证了所提方法的优越性和有效性。

关键词：作业车间调度最优外协工序关系传播链调度性能分析重调度多属性决策

Risk of gestational diabetes recurrence and the development of type 2 diabetes among women with a history of gestational diabetes and risk factors: a study among 18 clinical centers in China

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Chinese Medical Journal 2022年第6期135卷 665-671页

作者： Yumei Wei Juan Juan Rina Su Geng Song Xu Chen Ruiqin Shan Ying Li Shihong Cui Shangrong Fan Ling Feng Zishan You Haixia Meng Yan Cai cuilin zhang Huixia Yang Department of Obstetrics and Gynecology Peking University First HospitalBeijing 100034China Department of Obstetrics Tianjin Central Obstetrics and Gynecology HospitalTianjin 300199China Department of Obstetrics Jinan Maternal and Child Health HospitalJinanShandong 250000China Department of Obstetrics Dalian Maternity HospitalDalianLiaoning 116033China Department of Obstetrics and Gynecology The Third Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan 450052China Department of Obstetrics Shenzhen Peking University HospitalShenzhenGuangdong 518036China Department of Obstetrics and Gynecology Tongji Hospital Affiliated to Huazhong University of Science and TechnologyWuhanHubei 430030China Department of Obstetrics and Gynecology Suzhou Jiulong Hospital Affiliated to Shanghai Jiaotong UniversitySuzhouJiangsu 320571China Department of Obstetrics Affiliated Hospital of Inner Mongolia Medical UniversityHuhhotInner Mongolia 010050China Department of Obstetrics and Gynecology The Fourth Affiliated Hospital of Harbin Medical UniversityHarbinHeilongjiang 150001China Epidemiology Branch Division of Intramural Population Health ResearchEunice Kennedy Shriver National Institute of Child Health and Human DevelopmentNational Institutes of HealthBethesdaMD 20817USA

Background:Gestational diabetes mellitus(GDM)brings health issues for both mothers and offspring,and GDM prevention is as important as GDM *** was shown that a history of GDM was significantly associated with a higher maternal risk for GDM *** incidence of GDM recurrence was unclear because of the incidence of second-child was low before 2016 in *** aim to investigate the prevalence of GDM recurrence and its associated high-risk factors which may be useful for the prediction of GDM recurrence in ***:A retrospective study was conducted which enrolled participants who underwent regular prenatal examination and delivered twice in the same hospital of 18 research *** participants were enrolled from January 2018 to October 2018,where they delivered the second baby during this period.A total of 6204 women were enrolled in this study,and 1002 women with a history of GDM were analyzed *** participants enrolled in the study had an oral glucose tolerance test(OGTT)result at 24 to 28 weeks and were diagnosed as GDM in the first pregnancy according to the OGTT value(when any one of the following values is met or exceeded to the 75-g OGTT:0 h[fasting],≥5.10 mmol/L;1 h,≥10.00 mmol/L;and 2 h,≥8.50 mmol/L).The prevalence of GDM recurrence and development of type 2 diabetes mellitus were calculated,and its related risk factors were ***:In 6204 participants,there are 1002 women(1002/6204,16.15%)with a history of GDM and 5202 women(5202/6204,83.85%)without a history of *** are significant differences in age(32.43±4.03 years vs.33.00±3.34 years vs.32.19±3.37 years,P<0.001),pregnancy interval(4.06±1.44 years vs.3.52±1.43 years vs.3.38±1.35 years,P=0.004),prepregnancy body mass index(BMI)(27.40±4.62 kg/m^(2)vs.23.50±3.52 kg/m^(2)vs.22.55±3.47 kg/m^(2),P<0.001),history of delivered macrosomia(22.7%vs.11.0%vs.6.2%,P<0.001)among the development of diabetes mellitus(DM),recurrence of GDM,and normal ***,it seems

关键词： Gestational diabetes mellitus Recurrence Risk factors Multipara Primipara