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硫酸法钛白粉水洗及水循环膜处理工艺

化工管理 2021年第7期 162-163页

作者：曲波张春洁山东道恩钛业有限公司山东龙口265700

在硫酸法钛白粉生产过程中,保证钛白粉产品质量的一道重要工序为水洗工序,传统水洗工序有着粉体流失严重、废水排放量大等情况,不利于钛白粉行业发展,因此水洗及水循环膜处理工艺就显得尤为重要。实例表明,该工艺浆料单质铁含量低于10 m... 详细信息

在硫酸法钛白粉生产过程中,保证钛白粉产品质量的一道重要工序为水洗工序,传统水洗工序有着粉体流失严重、废水排放量大等情况,不利于钛白粉行业发展,因此水洗及水循环膜处理工艺就显得尤为重要。实例表明,该工艺浆料单质铁含量低于10 mg/kg,固含量为300g/L。

关键词：硫酸法钛白粉水洗水循环膜处理工艺

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煤矿工人眼爆炸伤78例调查分析

眼外伤职业眼病杂志 2005年第8期27卷 586-587页

作者：刘永慧张春杰曹惠肥城矿业集团公司中心医院眼科山东肥城271608

目的探讨煤矿工人眼爆炸伤的特点和处理原则。方法分析78例(120眼)眼爆炸伤的临床资料。结果双眼伤42例(84眼)占70.00%,以角膜、巩膜穿孔伤、外伤性白内障、眼内异物和视网膜视神经损伤为多。34例(52眼)合并其他器官损伤,占43.33%。6眼... 详细信息

目的探讨煤矿工人眼爆炸伤的特点和处理原则。方法分析78例(120眼)眼爆炸伤的临床资料。结果双眼伤42例(84眼)占70.00%,以角膜、巩膜穿孔伤、外伤性白内障、眼内异物和视网膜视神经损伤为多。34例(52眼)合并其他器官损伤,占43.33%。6眼行眼球摘除术(5.00%)。术后致盲率为24.17%(29眼),致残率为40.00%(48眼)。结论眼爆炸伤伤情复杂严重,致盲率高,多合并其他器官损伤。及时正确的治疗是改善预后的关键。

关键词：煤矿爆炸眼外伤

The cGAS-STING-interferon regulatory factor 7 pathway regulates neuroinflammation in Parkinson's disease

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Neural Regeneration Research 2025年第8期20卷 2361-2372页

作者： Shengyang Zhou Ting Li Wei zhang Jian Wu Hui Hong Wei Quan Xinyu Qiao chun Cui Chenmeng Qiao Weijiang Zhao Yanqin Shen Laboratory of Neurodegenerative and Neuroinjury Diseases Wuxi Medicine SchoolJiangnan UniversityWuxiJiangsu ProvinceChina

Interferon regulatory factor 7 plays a crucial role in the innate immune ***,whether interferon regulatory factor 7-mediated signaling contributes to Parkinson's disease remains *** we report that interferon regulatory factor 7 is markedly up-regulated in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced mouse model of Parkinson's disease and co-localizes with microglial *** the selective cyclic guanosine monophosphate adenosine monophosphate synthase inhibitor RU.521 and the stimulator of interferon genes inhibitor H151 effectively suppressed interferon regulatory factor 7 activation in BV2 microglia exposed to 1-methyl-4-phenylpyridinium and inhibited transformation of mouse BV2 microglia into the neurotoxic M1 *** addition,si RNA-mediated knockdown of interferon regulatory factor 7 expression in BV2 microglia reduced the expression of inducible nitric oxide synthase,tumor necrosis factorα,CD16,CD32,and CD86 and increased the expression of the anti-inflammatory markers ARG1 and *** together,our findings indicate that the cyclic guanosine monophosphate adenosine monophosphate synthase-stimulator of interferon genes-interferon regulatory factor 7 pathway plays a crucial role in the pathogenesis of Parkinson's disease.

关键词： cyclic guanosine monophosphate adenosine monophosphate synthase H151 interferon regulatory factor 7 M1 phenotype neurodegenerative disease neuroinflammation Parkinson’s disease RU521 STING type I interferon

免疫组化法检测非小细胞肺癌组织中CD44v6、Ki-67的表达与患者临床病理特征及转移的关系

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内蒙古师范大学学报（自然科学汉文版） 2020年第1期49卷 72-77页

作者：张春节张志远江苏省连云港市第二人民医院病理科江苏连云港222000 南京医科大学基础医学院江苏南京211166

采用免疫组化法检测非小细胞肺癌(NSCLC)组织中CD44v 6、Ki-67的表达情况,探讨其与患者临床病理特征及转移的关系。通过对113例NSCLC患者CD44v 6、Ki-67表达的检测,分析其与患者临床病理特征及转移关系的相关性。结果显示:NSCLC组织中CD... 详细信息

采用免疫组化法检测非小细胞肺癌(NSCLC)组织中CD44v 6、Ki-67的表达情况,探讨其与患者临床病理特征及转移的关系。通过对113例NSCLC患者CD44v 6、Ki-67表达的检测,分析其与患者临床病理特征及转移关系的相关性。结果显示:NSCLC组织中CD44v 6的阳性表达率69.03%,Ki-67的阳性表达率61.06%;CD44v 6、Ki-67的表达与患者年龄、性别、组织学类型及转移方式均无显著关系(P>0.05),与NSCLC转移相关(P<0.05)。其中,CD44v 6阳性表达中NSCLC转移发生率76.92%,阴性表达中NSCLC转移发生率14.29%;Ki-67阳性表达中NSCLC转移发生率71.01%,阴性表达中NSCLC转移发生率36.36%。表明CD44v 6、Ki-67是NSCLC发生转移的重要因素,联合检测有助于判断NSCLC的侵袭、淋巴结转移情况,可作为一个较好预测其转移扩散能力和预后情况的生物学指标,以辅助指导临床对NSCLC的综合治疗。

关键词：非小细胞肺癌 CD44v 6 Ki-67 免疫组化转移

Nanomaterials-mediated lysosomal regulation:a robust protein-clearance approach for the treatment of Alzheimer’s disease

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Neural Regeneration Research 2025年第2期20卷 424-439页

作者： Mengqi Hao Jianjian Chu Tinglin zhang Tong Yin Yuankai Gu Wendanqi Liang Wenbo Ji Jianhua Zhuang Yan Liu jie Gao You Yin Department of Neurology Second Affiliated Hospital of Naval Medical University(Shanghai Changzheng Hospital)ShanghaiChina School of Health Science and Engineering University of Shanghai for Science and TechnologyShanghaiChina Changhai Clinical Research Unit Shanghai Changhai HospitalNaval Medical UniversityShanghaiChina Department of Clinical Pharmacy Xinhua HospitalShanghai Jiao Tong University School of MedicineShanghaiChina Department of Neurology Shanghai East HospitalSchool of MedicineTongji UniversityShanghaiChina

Alzheimer’s disease is a debilitating,progressive neurodegenerative disorder characterized by the progressive accumulation of abnormal proteins,including amyloid plaques and intracellular tau tangles,primarily within the ***,crucial intracellular organelles responsible for protein degradation,play a key role in maintaining cellular *** studies have suggested a link between the dysregulation of the lysosomal system and pathogenesis of neurodegenerative diseases,including Alzheimer’s *** the normal physiological function of lysosomes hold the potential to reduce the pathological burden and improve the symptoms of Alzheimer’s ***,the efficacy of drugs in treating Alzheimer’s disease is limited,with major challenges in drug delivery efficiency and ***,nanomaterials have gained widespread use in Alzheimer’s disease drug research owing to their favorable physical and chemical *** review aims to provide a comprehensive overview of recent advances in using nanomaterials(polymeric nanomaterials,nanoemulsions,and carbon-based nanomaterials)to enhance lysosomal function in treating Alzheimer’s *** review also explores new concepts and potential therapeutic strategies for Alzheimer’s disease through the integration of nanomaterials and modulation of lysosomal *** conclusion,this review emphasizes the potential of nanomaterials in modulating lysosomal function to improve the pathological features of Alzheimer’s *** application of nanotechnology to the development of Alzheimer’s disease drugs brings new ideas and approaches for future treatment of this disease.

关键词： Alzheimer’s disease autophagy dysfunction lysosomal acidification lysosomal system nanomaterials neurodegenerative diseases

Substrate bias effects in p-channel GaN-on-Si transistors

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Science China(Information Sciences) 2025年第1期68卷 404-405页

作者： Mengyao ZHAO jie MA Lanlan YANG Chuanqi PAN Denggui WANG Jianjun ZHOU Sheng LI Jiaxing WEI Long zhang Siyang LIU Weifeng SUN National ASIC System Engineering Research Center School of Integrated Circuits Southeast University National Center of Technology Innovation for Electronic Design Automation Southeast University National Key Laboratory of Solid-State Microwave Devices and Circuits

The drain current （ID） of the n-channel GaN field-effecttransistor （n-FET） is influenced by the substrate-to-source bias voltage (VBS)（substrate bias effect）[1].Actually,nonzero VBSis also likely to occur in p-FET in real application,because the source electrode of p-FET is usually connected to high *** study reports the dependency between IDand VBSin p-FET for the first time,and analyzes the underlying mechanisms from the perspective of vertical electric field （EF） distribution.

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Nanoimprint lithography-assisted block copolymer self-assembly for hyperfine fabrication of magnetic patterns based on L10-FePt nanoparticles

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Science China Chemistry 2025年

作者： jie zhang Yi Chen Guijun Li Zelin Sun Zhengong Meng Wai-Yeung Wong Department of Applied Biology and Chemical Technology and Research Institute for Smart Energy The Hong Kong Polytechnic University The Hong Kong Polytechnic University Shenzhen Research Institute Division of Integrative Systems and Design and Department of Electronic and Computer Engineering The Hong Kong University of Science and Technology School of Flexible Electronics (Future Technology) and Institute of Advanced Materials (IAM) Nanjing Tech University

L10-FePt-type bit-patterned media has provided a promising alternative for ultrahigh-density magnetic recording systems in the current digital era, but rapid fabrication of magnetic patterns with hyperfine bit islands is still challenging, especially with the target for miniaturization and scalable production simultaneously. Herein, Fe,Pt-containing block copolymers were utilized as single-source precursors for solution-processable patterning and subsequent generation of the demanding magnetic FePt dots by in situ pyrolysis. High-throughput nanoimprint lithography was initially employed to fabricate the predefined bit cells precisely,and then the intrinsic self-assembly of phase-separated block copolymers further drove the formation of accurate bit *** from the synergistic effect of top-down lithographic approach and bottom-up self-assembly, the customizable patterns could be achieved for large-scale mass production in targeted areas, but high-density isolated dots could also be accurately aligned along the patterned features after subsequent self-assembly. This reliable strategy would provide a good avenue to precisely construct ultrahigh-density magnetic data storage devices.

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Identification of a dual functional betulinic acid analog for the treatment of osteoarthritis by phenotypic screening

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Science China Life Sciences 2025年第1期68卷 300-302页

作者： Ze-Min Lin Mai Xiang Wen-Hui Wei Shu-Hui Fan Li Chen jie Wang Xiao-Qian Yang chun-Hao Yang Shi-Jun He Jian-Ping Zuo Laboratory of Immunopharmacology State Key Laboratory of Drug ResearchShanghai Institute of Materia MedicaChinese Academy of Sciences School of Pharmacy University of Chinese Academy of Sciences School of Pharmacy Nanjing University of Chinese Medicine State Key Laboratory of Drug Research Department of Medicinal ChemistryShanghai Institute of Materia MedicaChinese Academy of Sciences Innovation Research Institute of Traditional Chinese Medicine Shanghai University of Traditional Chinese Medicine Experiment Center for Science and Technology Shanghai University of Traditional Chinese Medicine

Dear Editor, Phenotypic drug discovery, which observes compound effects on physiology,has given way to targeting specific molecules, but has revived by using modern methods to find drugs based on therapeutic outcomes in disease models(Vincent et al., 2022). Osteoarthritis(OA) is a prevalent chronic joint disorder, primarily affecting knee joints, with osteoclast activation due to low-grade inflammation resulting in increased bone resorption and structural changes in the joint(Katz et al.,2021).

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钢坯库行车作业的辅助驾驶的技术研发与应用

重型机械 2020年第2期 47-52页

作者：张春杰宋征首钢京唐钢铁联合有限责任公司河北唐山066300

某钢厂行车驾驶员和地面指车工不配合的情况下,采录了行车驾驶室视角和指车工视角的钢坯夹持、吊运和码放动作。通过使用行车夹钳全景监控跟踪系统辅助驾驶技术,并配合智能钢坯库管理系统,实现了行车司机在驾驶室通过智能监控的图像识别... 详细信息

某钢厂行车驾驶员和地面指车工不配合的情况下,采录了行车驾驶室视角和指车工视角的钢坯夹持、吊运和码放动作。通过使用行车夹钳全景监控跟踪系统辅助驾驶技术,并配合智能钢坯库管理系统,实现了行车司机在驾驶室通过智能监控的图像识别,获得了全面的视角进行库区作业,达到了取消指车工的目的。本文的辅助驾驶技术采用可自动控制变焦和角度的摄像头,配合钢坯库管理系统进行信息的自动识别与跟踪位置的自动搜索及对焦,将所需信息以监控形式呈现给行车驾驶员,以满足协助行车驾驶员独立完成各种作业的要求。

关键词：行车夹钳图像识别视角自动识别