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Spatial transcriptomics combined with single-nucleus RNA sequencing reveals glial cell heterogeneity in the human spinal cord

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Neural Regeneration Research 2025年第11期20卷 3302-3316页

作者： Yali Chen Yiyong Wei Jin Liu Tao Zhu cheng Zhou Donghang zhang Department of Anesthesiology West China HospitalSichuan UniversityChengduSichuan ProvinceChina Laboratory of Anesthesia and Critical Care Medicine National-Local Joint Engineering Research Center of Translational Medicine of AnesthesiologyWest China HospitalSichuan UniversityChengduSichuan ProvinceChina Department of Anesthesiology Longgang District Maternity&Child Healthcare Hospital of Shenzhen City(Longgang Maternity and Child Institute of Shantou University Medical College)ShenzhenGuangdong ProvinceChina Department of Anesthesiology Affiliated Hospital of Zunyi Medical UniversityZunyiGuizhou ProvinceChina

Glial cells play crucial roles in regulating physiological and pathological functions,including sensation,the response to infection and acute injury,and chronic neurodegenerative *** cells include astrocytes,microglia,and oligodendrocytes in the central nervous system,and satellite glial cells and Schwann cells in the peripheral nervous *** the greater understanding of glial cell types and functional heterogeneity achieved through single-cell and single-nucleus RNA sequencing in animal models,few studies have investigated the transcriptomic profiles of glial cells in the human spinal ***,we used high-throughput single-nucleus RNA sequencing and spatial transcriptomics to map the cellular and molecular heterogeneity of astrocytes,microglia,and oligodendrocytes in the human spinal *** explore the conservation and divergence across species,we compared these findings with those from *** the human spinal cord,astrocytes,microglia,and oligodendrocytes were each divided into six distinct transcriptomic *** the mouse spinal cord,astrocytes,microglia,and oligodendrocytes were divided into five,four,and five distinct transcriptomic subclusters,*** comparative results revealed substantial heterogeneity in all glial cell types between humans and ***,we detected sex differences in gene expression in human spinal cord glial ***,in all astrocyte subtypes,the levels of NEAT1 and CHI3L1 were higher in males than in females,whereas the levels of CST3 were lower in males than in *** all microglial subtypes,all differentially expressed genes were located on the sex *** addition to sex-specific gene differences,the levels of MT-ND4,MT2A,MT-ATP6,MT-CO3,MT-ND2,MT-ND3,and MT-CO_(2) in all spinal cord oligodendrocyte subtypes were higher in females than in ***,the present dataset extensively characterizes glial cell heterogeneity and offers a valuable resource for explo

关键词： astrocyte glial cell human microglia oligodendrocyte sex differentiation single-nucleus RNA sequencing spatial transcriptomics species variation spinal cord

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B型利钠肽短期改变对慢性肺源性心脏病急性加重期患者预后的评估价值

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中国全科医学 2013年第9期16卷 977-979页

作者：王玉宏吴群玫张成森山东省青岛市中心医院急救中心 266042

目的探讨B型利钠肽(BNP)短期改变对慢性肺源性心脏病急性加重期患者预后的评估价值。方法选取2007年2月—2010年2月我院收治的完成2年随访的185例肺源性心脏病急性加重期患者,检测入院时及入院后48 h时BNP水平,利用BNP水平的短期改变(△... 详细信息

目的探讨B型利钠肽(BNP)短期改变对慢性肺源性心脏病急性加重期患者预后的评估价值。方法选取2007年2月—2010年2月我院收治的完成2年随访的185例肺源性心脏病急性加重期患者,检测入院时及入院后48 h时BNP水平,利用BNP水平的短期改变(△BNP)预测患者预后,进行2年的随访。结果入院时患者BNP水平为(718±331)ng/L,入院后48 h为(437±291)ng/L,差异有统计学意义(t=8.672,P<0.05)。27例患者收住ICU治疗,收住ICU治疗的患者△BNP值为(115±62)ng/L,未收住ICU的患者为(269±74)ng/L,差异有统计学意义(t=10.212,P<0.05)。受试者工作特征(ROC)曲线评价△BNP对患者收住ICU的预测,曲线下面积(AUC)为0.82〔标准差(s)=0.04,95%CI(0.74,0.90)〕。10例患者在住院过程中死亡,住院死亡患者△BNP值为(87±36)ng/L,住院生存患者为(315±93)ng/L,差异有统计学意义(t=7.703,P<0.05)。AUC为0.75〔s=0.09,95%CI(0.58,0.92)〕。28例患者在随访6个月过程中死亡,死亡患者△BNP值为(136±54)ng/L,存活患者为(272±93)ng/L,差异有统计学意义(t=13.023,P<0.05);AUC为0.84〔s=0.05,95%CI(0.74,0.94)〕。53例患者在2年随访过程中死亡,死亡患者△BNP值为(167±74)ng/L,存活患者为(296±105)ng/L,差异有统计学意义(t=8.124,P<0.05);AUC为0.82〔s=0.04,95%CI(0.74,0.89)〕。结论对于肺源性心脏病急性加重期的患者,BNP水平的短期改变能预测患者需要收住ICU的危险,并可以预测患者短期、长期病死率。

关键词：肺心病 B型利钠肽预后

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纤维蛋白原β基因-148C/T多态性与脑梗死的关系

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中华医学遗传学杂志 2006年第2期23卷 202-204页

作者：马爱军潘旭东张成森邢岩张雅妮天津医科大学总医院神经内科 300070 青岛大学医学院附属医院神经内科

目的探讨纤维蛋白原(fibrinogen,Fg)β基因启动子区-148C/T多态性、血浆Fg水平与急性动脉粥样硬化性脑梗死的关系。方法用多聚酶链反应-限制性片段长度多态性方法对151例脑梗死患者和101名健康对照进行Fgβ-148C/T基因多态性分析,并应... 详细信息

目的探讨纤维蛋白原(fibrinogen,Fg)β基因启动子区-148C/T多态性、血浆Fg水平与急性动脉粥样硬化性脑梗死的关系。方法用多聚酶链反应-限制性片段长度多态性方法对151例脑梗死患者和101名健康对照进行Fgβ-148C/T基因多态性分析,并应用凝血酶原时间衍生法检测血浆Fg水平。结果脑梗死组血浆Fg水平明显高于对照组(P<0.01);T等位基因携带者较CC基因型者血浆Fg水平明显增高(P<0.01);按性别分组后差异仍有统计学意义;按年龄段分组后,病例组各组T等位基因携带者较CC基因型者血浆Fg水平增高(P<0.05)。中年梗死组较中年对照组T等位基因频率的差异有统计学意义(P<0.05)。结论Fgβ-148C/T基因多态性影响血浆Fg水平,T等位基因可能独立或通过与其它血栓危险因素或环境因素协同作用增高血浆Fg水平,成为脑动脉血栓形成的危险因素。

关键词：纤维蛋白原基因多态性脑梗死

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Lipid droplets in the nervous system:involvement in cell metabolic homeostasis

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Neural Regeneration Research 2025年第3期20卷 740-750页

作者： Yuchen zhang Yiqing Chen cheng Zhuang Jingxuan Qi Robert Chunhua Zhao Jiao Wang School of Life Sciences Shanghai UniversityShanghaiChina School of Medicine Shanghai UniversityShanghaiChina Institute of Basic Medical Sciences Chinese Academy of Medical Sciences School of Basic MedicinePeking Union Medical CollegeBeijingChina Center of Excellence in Tissue Engineering Chinese Academy of Medical SciencesBeijingChina Beijing Key Laboratory of New Drug Development and Clinical Trial of Stem Cell Therapy BeijingChina

Lipid droplets serve as primary storage organelles for neutral lipids in neurons,glial cells,and other cells in the nervous *** droplet formation begins with the synthesis of neutral lipids in the endoplasmic ***,lipid droplets were recognized for their role in maintaining lipid metabolism and energy homeostasis;however,recent research has shown that lipid droplets are highly adaptive organelles with diverse functions in the nervous *** addition to their role in regulating cell metabolism,lipid droplets play a protective role in various cellular stress ***,lipid droplets exhibit specific functions in neurons and glial *** of lipid droplet formation leads to cellular dysfunction,metabolic abnormalities,and nervous system *** review aims to provide an overview of the role of lipid droplets in the nervous system,covering topics such as biogenesis,cellular specificity,and ***,it will explore the association between lipid droplets and neurodegenerative *** the involvement of lipid droplets in cell metabolic homeostasis related to the nervous system is crucial to determine the underlying causes and in exploring potential therapeutic approaches for these diseases.

关键词： Alzheimer's disease lipid droplet biogenesis lipid droplets lipid metabolism nervous system neurodegenerative disorders oxidative stress Parkinson's disease

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Advancements and Challenges in Organic–Inorganic Composite Solid Electrolytes for All‑Solid‑State Lithium Batteries

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Nano-Micro Letters 2025年第1期17卷 46-97页

作者： Xueyan zhang Shichao cheng Chuankai Fu Geping Yin Liguang Wang Yongmin Wu Hua Huo State Key Laboratory of Space Power‑Sources School of Chemistry and Chemical EngineeringHarbin Institute of TechnologyHarbin 150001People’s Republic of China College of Chemical and Biological Engineering Zhejiang UniversityHangzhou 310058People’s Republic of China State Key Laboratory of Space Power-Sources 2965 Dongchuan RoadMinhang DistrictShanghai 200240People’s Republic of China

To address the limitations of contemporary lithium-ion batteries,particularly their low energy density and safety concerns,all-solid-state lithium batteries equipped with solid-state electrolytes have been identified as an up-and-coming *** the various SEs,organic–inorganic composite solid electrolytes(OICSEs)that combine the advantages of both polymer and inorganic materials demonstrate promising potential for large-scale ***,OICSEs still face many challenges in practical applications,such as low ionic conductivity and poor interfacial stability,which severely limit their *** review provides a comprehensive overview of recent research advancements in ***,the influence of inorganic fillers on the main functional parameters of OICSEs,including ionic conductivity,Li+transfer number,mechanical strength,electrochemical stability,electronic conductivity,and thermal stability are systematically *** lithium-ion conduction mechanism of OICSE is thoroughly analyzed and concluded from the microscopic ***,the classic inorganic filler types,including both inert and active fillers,are categorized with special emphasis on the relationship between inorganic filler structure design and the electrochemical performance of ***,the advanced characterization techniques relevant to OICSEs are summarized,and the challenges and perspectives on the future development of OICSEs are also highlighted for constructing superior ASSLBs.

关键词： Composite solid electrolytes Inorganic filler Interfacial stability Li-ion conduction mechanism Characterization techniques

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测井储层描述在塔中I号礁滩体中的应用

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岩性油气藏 2008年第2期20卷 86-90页

作者：赵军海川张承森西南石油大学资源与环境学院中国石油塔里木油田分公司研究院

塔中Ⅰ号坡折带上奥陶统礁滩体储层岩性以碳酸盐岩为主,在测井储层表征与定量评价中,由于储集空间的多样性及其组合的复杂性,给利用测井资料评价碳酸盐岩储层带来了一系列困难。文中以测井资料为基础,结合岩心、实验、试油等资料,划分... 详细信息

塔中Ⅰ号坡折带上奥陶统礁滩体储层岩性以碳酸盐岩为主,在测井储层表征与定量评价中,由于储集空间的多样性及其组合的复杂性,给利用测井资料评价碳酸盐岩储层带来了一系列困难。文中以测井资料为基础,结合岩心、实验、试油等资料,划分出储层储集空间的类型和储层类型。分别建立了不同类型储层的各种测井响应特征及响应模板,并在此基础上建立了礁滩体储层类型的划分标准。根据不同储集类型的孔、渗关系,结合中国石油天然气行业标准,建立了礁滩体不同储层级别的解释图版和解释标准,所划分的储层级别与礁滩体沉积相带具有很好的对比关系,为测井储层评价和完井试油层段的选择提供了可靠的解释依据。

关键词：礁滩储层碳酸盐岩测井响应特征储层类型划分塔里木盆地

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塔中奥陶系碳酸盐岩裂缝的多方法表征及分布规律

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新疆石油地质 2011年第3期32卷 262-266页

作者：琚岩孙雄伟张承森于红枫刘鑫中国石油塔里木油田分公司勘探开发研究院新疆库尔勒841000

奥陶系碳酸盐岩是塔中的主力产层,裂缝是重要的油气储集空间和渗流通道。综合岩心、测井、露头和地震等资料,提出了塔中奥陶系碳酸盐岩裂缝研究的多方法表征适用方案。研究认为,塔中奥陶系碳酸盐岩裂缝的分布规律与岩性、区域应力变化... 详细信息

奥陶系碳酸盐岩是塔中的主力产层,裂缝是重要的油气储集空间和渗流通道。综合岩心、测井、露头和地震等资料,提出了塔中奥陶系碳酸盐岩裂缝研究的多方法表征适用方案。研究认为,塔中奥陶系碳酸盐岩裂缝的分布规律与岩性、区域应力变化、构造部位等因素密切相关,在塔中北斜坡上具有南北分带、东西分块、受断裂控制的分布规律。

关键词：塔里木盆地奥陶系碳酸盐岩油藏裂缝分布

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Spontaneous Orientation Polarization of Anisotropic Equivalent Dipoles Harnessed by Entropy Engineering for Ultra‑Thin Electromagnetic Wave Absorber

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Nano-Micro Letters 2025年第1期17卷 424-438页

作者： Honghan Wang Xinyu Xiao Shangru Zhai Chuang Xue Guangping Zheng Deqing zhang Renchao Che Junye cheng Liaoning Key Lab of Lignocellulose Chemistry and BioMaterials Liaoning Collaborative Innovation Center for Lignocellulosic BiorefinerySchool of Light Industry and Chemical EngineeringDalian Polytechnic UniversityDalian 116034People’s Republic of China School of Life Science and Biotechnology Dalian University of TechnologyDalian 116024People’s Republic of China Department of Mechanical Engineering Hong Kong Polytechnic UniversityHung HomKowloonHong Kong 999077People’s Republic of China School of Materials Science and Engineering Qiqihar UniversityQiqihar 161006People’s Republic of China Laboratory of Advanced Materials Shanghai Key Lab of Molecular Catalysis and Innovative MaterialsAcademy for Engineering&TechnologyFudan UniversityShanghai 200438People’s Republic of China Department of Materials Science Shenzhen MSU-BIT UniversityShenzhen 517182People’s Republic of China

The synthesis of carbon supporter/nanoscale high-entropy alloys(HEAs)electromagnetic response composites by carbothermal shock method has been identified as an advanced strategy for the collaborative competition engineering of conductive/dielectric *** migration modes within HEAs as manipulated by the electronegativity,valence electron configurations and molar proportions of constituent elements determine the steady state and efficiency of equivalent ***,enlightened by skin-like effect,a reformative carbothermal shock method using carbonized cellulose paper(CCP)as carbon supporter is used to preserve the oxygencontaining functional groups(O·)of carbonized cellulose fibers(CCF).Nucleation of HEAs and construction of emblematic shell-core CCF/HEAs heterointerfaces are inextricably linked to carbon metabolism induced by O·.Meanwhile,the electron migration mode of switchable electronrich sites promotes the orientation polarization of anisotropic equivalent *** virtue of the reinforcement strategy,CCP/HEAs composite prepared by 35%molar ratio of Mn element(CCP/HEAs-Mn_(2.15))achieves efficient electromagnetic wave(EMW)absorption of−51.35 dB at an ultra-thin thickness of 1.03 *** mechanisms of the resulting dielectric properties of HEAs-based EMW absorbing materials are elucidated by combining theoretical calculations with experimental characterizations,which provide theoretical bases and feasible strategies for the simulation and practical application of electromagnetic functional devices(e.g.,ultra-wideband bandpass filter).

关键词： High-entropy alloys Carbothermal shock Switchable electron migration modes Emblematic shell-core heterointerfaces Ultra-thin thickness

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A novel flexible nerve guidance conduit promotes nerve regeneration while providing excellent mechanical properties

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Neural Regeneration Research 2025年第7期20卷 2084-2094页

作者： Tong Li Quhan cheng Jingai zhang Boxin Liu Yu Shi Haoxue Wang Lijie Huang Su zhang Ruixin zhang Song Wang Guangxu Lu Peifu Tang Zhongyang Liu Kai Wang Department of Orthopedics the Fourth Medical Center of Chinese PLA General HospitalBeijingChina Department of Training and Sports Medicine Characteristic Medical Center of Chinese People’s Armed Police ForceTianjinChina Medical School of Chinese PLA BeijingChina Key Laboratory of Bioactive Materials for the Ministry of Education College of Life SciencesNankai UniversityTianjinChina Department of Orthopedics Tianjin HospitalTianjinChina Department of Rehabilitation Medicine Er Quan Hospital of PAPWuxiJiangsu ProvinceChina

Autografting is the gold standard for surgical repair of nerve defects>5 mm in length;however,autografting is associated with potential complications at the nerve donor *** an alternative,nerve guidance conduits may be *** ideal conduit should be flexible,resistant to kinks and lumen collapse,and provide physical cues to guide nerve *** designed a novel flexible conduit using electrospinning technology to create fibers on the innermost surface of the nerve guidance conduit and employed melt spinning to align ***,we prepared disordered electrospun fibers outside the aligned fibers and helical melt-spun fibers on the outer wall of the electrospun fiber *** presence of aligned fibers on the inner surface can promote the extension of nerve cells along the *** helical melt-spun fibers on the outer surface can enhance resistance to kinking and compression and provide *** novel conduit promoted nerve regeneration and functional recovery in a rat sciatic nerve defect model,suggesting that it has potential for clinical use in human nerve injuries.

关键词： aligned fibers anti-kinking helical fibers nerve guidance conduit nerve regeneration peripheral nerve injury topological guidance

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远探测声波测井在缝洞型碳酸盐岩储集层评价中的应用

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新疆石油地质 2011年第3期32卷 325-328页

作者：张承森肖承文刘兴礼郭洪波朱登朝王贵清中国石油塔里木油田分公司勘探开发研究院新疆库尔勒841000 中国石油渤海钻探测井公司天津300280

远探测声波反射波测井能够反映井旁3~10 m碳酸盐岩地层或缝洞的声阻抗异常。简述其测量原理,研究不同类型储集层远探测声波反射波成像的典型响应特征。通过在塔里木油田碳酸盐岩地层中的规模化采集和应用实践,与常规测井结合,评价井旁... 详细信息

远探测声波反射波测井能够反映井旁3~10 m碳酸盐岩地层或缝洞的声阻抗异常。简述其测量原理,研究不同类型储集层远探测声波反射波成像的典型响应特征。通过在塔里木油田碳酸盐岩地层中的规模化采集和应用实践,与常规测井结合,评价井旁储集层缝洞发育情况,经酸化压裂测试,有效性评价成功率达到85%以上,取得较好的地质应用效果。

关键词：塔里木盆地碳酸盐岩储集层远探测声波测井测井评价

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