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Nano-Micro Letters 2025年第1期17卷 135-159页

作者： Zhengqing Fan Ruimin Li Xin zhang Wanyu Zhao Zhenghui Pan Xiaowei yang School of Chemistry and Chemical Engineering Shanghai Jiao Tong UniversityShanghai 200240People’s Republic of China School of Chemistry and Chemical Engineering Taiyuan University of TechnologyTaiyuan 030024People’s Republic of China School of Materials Science and Engineering Tongji UniversityShanghai 201804People’s Republic of China

Rechargeable magnesium batteries(RMBs)have been considered a promising“post lithium-ion battery”system to meet the rapidly increasing demand of the emerging electric vehicle and grid energy storage ***,the sluggish diffusion kinetics of bivalent Mg^(2+)in the host material,related to the strong Coulomb effect between Mg^(2+)and host anion lattices,hinders their further development toward practical *** engineering,regarded as an effective strategy to break through the slow migration puzzle,has been validated in various cathode materials for *** this review,we first thoroughly understand the intrinsic mechanism of Mg^(2+)diffusion in cathode materials,from which the key factors affecting ion diffusion are further ***,the positive effects of purposely introduced defects,including vacancy and doping,and the corresponding strategies for introducing various defects are *** applications of defect engineering in cathode materials for RMBs with advanced electrochemical properties are also ***,the existing challenges and future perspectives of defect engineering in cathode materials for the overall high-performance RMBs are described.

关键词： Rechargeable magnesium battery Sluggish diffusion kinetic Defect engineering Cathode materials Ion migration

城市记忆视域下洛阳开展研学旅行的价值意蕴及路径研究

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广州城市职业学院学报 2024年第3期18卷 71-75,95页

作者：张晨阳洛阳职业技术学院文化遗产与传播学院河南洛阳471000

生活在城市中的人们总会对城市文化、城市景观、城市空间等产生情感与精神寄托,构成对城市的物质空间记忆和历史文化记忆,研学旅行增强了中小学生的城市记忆与地方认同。洛阳研学资源丰富,市场潜力巨大,研学旅行为洛阳市文化旅游产业高... 详细信息

生活在城市中的人们总会对城市文化、城市景观、城市空间等产生情感与精神寄托,构成对城市的物质空间记忆和历史文化记忆,研学旅行增强了中小学生的城市记忆与地方认同。洛阳研学资源丰富,市场潜力巨大,研学旅行为洛阳市文化旅游产业高质量发展注入了活力,但也存在研学旅行机构思想认识不足、研学活动重“行”轻“研”等问题。为此,提出基于城市记忆的洛阳研学旅行发展提升路径:依托区域旅游经济;激活研学旅游活力;促进学生“学”“思”“行”并进;打造研学精品课程;设计研学三维育人目标;优化研学教师队伍;健全科学评价体制。

关键词：城市记忆洛阳研学旅行价值意蕴文旅融合高质量发展

A Study of CAID Teaching

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A Study of CAID Teaching

Motivational interviewing in postoperative rehabilitation and chronic disease management: Current findings and future research directions

2008 IEEE 9th International Conference on Computer-Aided Industrial Design & Conceptual Design

作者： Fan zhang chen yang Yuan Zhu Artistic Design& Creative School Zhejiang University City College Zhejiang P.R.China

＜正＞The computer science has been developing rapidly in 21st century;it also brings an innovatory design tool to the field of Industry *** is the"Computer-Aided Industrial Design"（CAID）system. The application of CAID system makes the industrial design standards have a qualitative change in design methodology,design flow,Design performance of the quality and efficiency of all *** in the College of Industrial Design Teaching has gradually become a very important professional *** paper discusses the Development Status and Problems in today’s CAID teaching,and proposed the possible solutions and suggestions of CAID teaching and studying.

关键词： CAID teaching problems Teaching Evaluation System.

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World Journal of Psychiatry 2025年第1期15卷 26-31页

作者： Bing-Ren zhang Xiao yang Affiliated Hospital(School of Clinical Medicine) Hangzhou Normal UniversityHangzhou 311121Zhejiang ProvinceChina Mental Health Education and Counseling Center Hangzhou Normal UniversityHangzhou 311121Zhejiang ProvinceChina

This editorial highlights a recently published study examining the effectiveness of music therapy combined with motivational interviewing(MI)in addressing an-xiety and depression among young and middle-aged patients following percuta-neous coronary *** further explores existing evidence and potential future research directions for MI in postoperative rehabilitation and chronic disease *** aims to facilitate behavioral change and promote healthier lifestyles by fostering a trusting relationship with patients and enhan-cing intrinsic *** has demonstrated its effectiveness in posto-perative recovery for oncological surgery,stroke,organ transplants,and gastroin-testinal procedures,as well as in managing chronic conditions such as diabetes,obesity,and periodontal *** approach is patient-centered,adaptable,cost-effective,and easily replicable,though its limitations include reliance on the therapist’s expertise,variability in individual responses,and insufficient long-term follow-up *** research could focus on developing individualized and precise intervention models,exploring applications in digital health management,and confirming long-term outcomes to provide more compre-hensive support for patient rehabilitation.

关键词： Chronic disease management Motivational interviewing Patient-centered Postoperative rehabilitation Treatment adherence

Comparative proteomic analysis of plasma exosomes reveals the functional contribution of N-acetyl-alpha-glucosaminidase to Parkinson’s disease

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Neural Regeneration Research 2025年第10期20卷 2998-3012页

作者： Yuan Zhao Yidan zhang Xin Liu Jian zhang Ya Gao Shuyue Li Cui Chang Xiang Liu Guofeng yang Department of Geriatrics Second Hospital of Hebei Medical UniversityShijiazhuangHebei ProvinceChina Department of Neurosurgery The Second Hospital of Hebei Medical UniversityShijiazhuangHebei ProvinceChina

Parkinson’s disease is the second most common progressive neurodegenerative disorder,and few reliable biomarkers are available to track disease *** proteins,DNA,mRNA,and lipids carried by exosomes reflect intracellular changes,and thus can serve as biomarkers for a variety of *** this study,we investigated alterations in the protein content of plasma exosomes derived from patients with Parkinson’s disease and the potential therapeutic roles of these proteins in Parkinson’s *** a tandem mass tag-based quantitative proteomics approach,we characterized the proteomes of plasma exosomes derived from individual patients,identified exosomal protein signatures specific to patients with Parkinson’s disease,and identified N-acetyl-alpha-glucosaminidase as a differentially expressed protein.N-acetyl-alpha-glucosaminidase expression levels in exosomes from the plasma of patients and healthy controls were validated by enzyme-linked immunosorbent assay and western *** results demonstrated that the exosomal N-acetyl-alpha-glucosaminidase concentration was not only lower in Parkinson’s disease,but also decreased with increasing Hoehn-Yahr stage,suggesting that N-acetyl-alpha-glucosaminidase could be used to rapidly evaluate Parkinson’s disease ***,western blot and immunohistochemistry analysis showed that N-acetyl-alpha-glucosaminidase levels were markedly reduced both in cells treated with 1-methyl-4-phenylpyridinium and cells overexpressingα-synuclein compared with control ***,N-acetyl-alpha-glucosaminidase overexpression significantly increased cell viability and inhibitedα-synuclein expression in 1-methyl-4-phenylpyridinium-treated *** together,our findings demonstrate for the first time that exosomal N-acetyl-alpha-glucosaminidase may serve as a biomarker for Parkinson’s disease diagnosis,and that N-acetyl-alpha-glucosaminidase may reduceα-synuclein expression and 1-methyl-4-phenylpyridinium-induced n

关键词： biomarker diagnosis exosomes N-acetyl-alpha-glucosaminidase Parkinson’s disease proteomic α-synuclein

重度气道狭窄置放国产镍钛记忆合金支架的方法学研究

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中华结核和呼吸杂志 2010年第1期33卷 25-28页

作者：张杰王娟党斌温徐敏裴迎华张晨阳首都医科大学附属北京天坛医院呼吸内科 100050

目的对重度气道狭窄患者置放国产镍钛记忆合金支架的方法学进行初步评价。方法应用全身麻醉下分别采用经喉罩、气管插管或硬质气管镜的方法对2005年11月至2009年4月收入北京天坛医院呼吸科的40例难以在局部麻醉下操作的重症气道狭窄患... 详细信息

目的对重度气道狭窄患者置放国产镍钛记忆合金支架的方法学进行初步评价。方法应用全身麻醉下分别采用经喉罩、气管插管或硬质气管镜的方法对2005年11月至2009年4月收入北京天坛医院呼吸科的40例难以在局部麻醉下操作的重症气道狭窄患者置入国产镍钛记忆合金气道支架。结果40例患者根据病变部位及病变特点选择经喉罩23例，气管插管11例，硬质气管镜6例，并予全身麻醉及机械通气，共放置了42枚支架：气管支架27枚（其中覆膜支架9枚）、左主支气管支架8枚、右主支气管至右中间段支架2枚、气管至左主支气管楔形支架5枚。在全身麻醉、机械通气维持患者各项生命体征的条件下，所有病例都顺利置入，未出现并发症。支架释放后所有病例气道压力即降至正常，同时其他机械通气参数也恢复正常。大部分患者呼吸困难指数分级由Ⅳ-Ⅴ级改善到0～Ⅱ级。结论对于重度气道狭窄患者，在全身麻醉下经喉罩、气管插管及硬质气管镜的方法可以顺利放置局部麻醉下难以操作的各种高难度气道支架的置放，并且安全、有效、舒适，值得在临床进一步推广。

关键词：气道阻塞支气管狭窄治疗,金属支架

Spatial transcriptomics combined with single-nucleus RNA sequencing reveals glial cell heterogeneity in the human spinal cord

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Neural Regeneration Research 2025年第11期20卷 3302-3316页

作者： Yali chen Yiyong Wei Jin Liu Tao Zhu cheng Zhou Donghang zhang Department of Anesthesiology West China HospitalSichuan UniversityChengduSichuan ProvinceChina Laboratory of Anesthesia and Critical Care Medicine National-Local Joint Engineering Research Center of Translational Medicine of AnesthesiologyWest China HospitalSichuan UniversityChengduSichuan ProvinceChina Department of Anesthesiology Longgang District Maternity&Child Healthcare Hospital of Shenzhen City(Longgang Maternity and Child Institute of Shantou University Medical College)ShenzhenGuangdong ProvinceChina Department of Anesthesiology Affiliated Hospital of Zunyi Medical UniversityZunyiGuizhou ProvinceChina

Glial cells play crucial roles in regulating physiological and pathological functions,including sensation,the response to infection and acute injury,and chronic neurodegenerative *** cells include astrocytes,microglia,and oligodendrocytes in the central nervous system,and satellite glial cells and Schwann cells in the peripheral nervous *** the greater understanding of glial cell types and functional heterogeneity achieved through single-cell and single-nucleus RNA sequencing in animal models,few studies have investigated the transcriptomic profiles of glial cells in the human spinal ***,we used high-throughput single-nucleus RNA sequencing and spatial transcriptomics to map the cellular and molecular heterogeneity of astrocytes,microglia,and oligodendrocytes in the human spinal *** explore the conservation and divergence across species,we compared these findings with those from *** the human spinal cord,astrocytes,microglia,and oligodendrocytes were each divided into six distinct transcriptomic *** the mouse spinal cord,astrocytes,microglia,and oligodendrocytes were divided into five,four,and five distinct transcriptomic subclusters,*** comparative results revealed substantial heterogeneity in all glial cell types between humans and ***,we detected sex differences in gene expression in human spinal cord glial ***,in all astrocyte subtypes,the levels of NEAT1 and CHI3L1 were higher in males than in females,whereas the levels of CST3 were lower in males than in *** all microglial subtypes,all differentially expressed genes were located on the sex *** addition to sex-specific gene differences,the levels of MT-ND4,MT2A,MT-ATP6,MT-CO3,MT-ND2,MT-ND3,and MT-CO_(2) in all spinal cord oligodendrocyte subtypes were higher in females than in ***,the present dataset extensively characterizes glial cell heterogeneity and offers a valuable resource for explo

关键词： astrocyte glial cell human microglia oligodendrocyte sex differentiation single-nucleus RNA sequencing spatial transcriptomics species variation spinal cord

Universal design of three-dimensional porous graphene-iron based promotors for kinetically rationalized lithium-sulfur chemistry

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Journal of Energy Chemistry 2025年第1期100卷 192-200页

作者： Hua Gao Yunfeng zhang Menglei Wang Ruoxuan yang Shuai Feng Xuan Cao Yaping zhang Zhongyuan Lu Yingze Song State Key Laboratory of Environment-Friendly Energy Materials School of Materials and Chemistry Southwest University of Science and Technology School of Material Science and Engineering Henan University of Technology College of Chemistry and Chemical Engineering Taishan University

Lithium-sulfur （Li-S） batteries are widely deemed to be one of the most potential candidates for future secondary batteries because of their remarkable energy ***,notorious polysulfide shuttling and retarded sulfur reaction kinetics pose significant obstacles to the further application of Li-S *** rationally designed highly active electrocatalysts can facilitate polysulfide conversion,the universal and scalable synthesis strategies need to be ***,a universal synthetic strategy to construct a series of three-dimensional （3D） porous graphene-iron （3DGr-Fe） based electrocatalysts involving 3DGr-FeP,3DGr-Fe3C,and 3DGr-Fe3Se4is exploited for manipulating the Li-S redox *** has been observed that the implementation of a 3D porous Gr architecture leads to the well-designed conductive networks,while the uniformly dispersed iron nanoparticles introduce an abundance of active sites,fostering the lithium polysulfide conversion,thereby bolstering the overall electrochemical *** Li-S battery with the 3DGr-Fe based electrocatalyst exhibits remarkable capacity retention of 94.8%upon 100 times at 0.2 ***,the soft-packaged Li-S pouch cell based on such a 3DGr-Fe electrocatalyst delivers superior capacity of 1060.71 mA h g-1and guarantees for the continuous 30 min work of fan *** investigation gives comprehensive insights into the design,synthesis,and mechanism of 3DGr-Fe based electrocatalysts with high activity toward efficient and durable Li-S batteries.

关键词： Lithium-sulfur battery Universal synthesis 3D graphene-iron based promotor Electrocatalysis

小檗碱体内代谢产物对前脂肪细胞分化和脂代谢的影响

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中国临床药理学杂志 2024年第17期40卷 2503-2507页

作者：张晨阳朱娟娟卢晶首都医科大学附属北京同仁医院内分泌科北京100730 北京市糖尿病研究所北京100730

目的探究小檗碱(BBR)体内代谢产物对3T3-L1前脂肪细胞分化和脂代谢的作用。方法将3T3-L1前脂肪细胞分为对照组和BBR代谢产物处理组,用细胞增殖计数法检测细胞存活率。BBR、二氢小檗碱(DHB)、小檗红碱(BRB)、非洲防己碱(COL)、巴马汀(PAL... 详细信息

目的探究小檗碱(BBR)体内代谢产物对3T3-L1前脂肪细胞分化和脂代谢的作用。方法将3T3-L1前脂肪细胞分为对照组和BBR代谢产物处理组,用细胞增殖计数法检测细胞存活率。BBR、二氢小檗碱(DHB)、小檗红碱(BRB)、非洲防己碱(COL)、巴马汀(PAL)、药根碱(JAT)和去亚甲基小檗碱(DEM)组分别给予5μmol·L^(-1)BBR、2.5μmol·L^(-1)DHB、10μmol·L^(-1)BRB、20μmol·L^(-1)COL、25μmol·L^(-1)PAL、50μmol·L^(-1)JAT和50μmol·L^(-1)DEM处理;对照组给予正常培养。用实时荧光定量聚合酶链反应法检测脂蛋白脂肪酶(LPL)、乙酰辅酶A羧化酶A(ACACA)等mRNA的表达水平。结果DHB、COL、PAL、JAT、DEM孵育48 h与对照组相比,均不影响细胞存活率,20μmol·L^(-1)BRB可将细胞活性降至(86.55±1.99)%。培养12 d后,对照组和BBR、DHB、BRB、COL、PAL、JAT、DEM组的LPL mRNA相对表达水平分别为1.00±0.02、0.41±0.04、0.44±0.04、1.40±0.08、1.27±0.10、1.15±0.07、3.06±0.30和1.45±0.07,ACACA mRNA相对表达水平分别为1.01±0.01、0.62±0.04、0.69±0.06、1.78±0.17、4.77±0.19、4.20±0.14、6.38±0.30和1.18±0.08。BBR、DHB、JAT组的LPL mRNA相对表达水平与对照组比较,BRB、COL、PAL、JAT组的ACACA mRNA相对表达水平与对照组比较,在统计学上差异均有统计学意义(均P<0.05)。结论小檗碱体内代谢产物可以抑制脂肪细胞分化和促进脂代谢,从而减少细胞中脂质蓄积。

关键词：小檗碱体内代谢产物 3T3-L1前脂肪细胞细胞分化脂质代谢

THE LIMIT CYCLES OF A KIND OF EXPLOITED PREDATOR-PREY SYSTEM

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Annals of Differential Equations 2006年第3期22卷 442-445页

作者： zhang Cuimei chen Wencheng yang Yu ( College of Information Science and Engineering, Shandong University of Science and Technology, Taian 271019 College of Information Science and Engineering, Shandong Agricultural University, Taian 271018)

In this paper, a kind of exploited predator-prey system is studied. By using the qualitative theory, we obtain some sufficient conditions for the existence and nonexistence of limit cycles of the system.

关键词： predator-prey system constant-rate stocking equilibrium point limit cycles