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Anthrax lethal toxin and tumor necrosis factor-a synergize on intestinal epithelia to induce mouse death

Protein & Cell 2024年第2期15卷 135-148页

作者： Xinhe Gao Teng Teng Yifei Liu Tingting ai Rui Zhao Yilong Fu Peipei zhang Jiahuai Han Yingying zhang State Key Laboratory of Cellular Stress Biology School of Life SciencesFaculty of Medicine and Life SciencesXiamen UniversityXiamen 361102China Research Unit of Cellular Stress of CAMS Xiang'an Hospital of Xiamen UniversityCancer Research Center of Xiamen UniversitySchool of MedicineFaculty of Medicine and Life SciencesXiamen UniversityXiamen 361102China Laboratory Animal Center Faculty of Medicine and Life SciencesXiamen UniversityXiamen 361102China

Bacillus anthracis lethal toxin(LT)is a determinant of lethal *** function in myeloid cells is required for bacterial dissemination,and LT itself can directly trigger dysfunction of the cardiovascular *** interplay between LT and the host responses is important in the pathogenesis,but our knowledge on this interplay remains *** necrosis factor-a(TNF-a)is a pleiotropic pro-inflammatory cytokine induced by bacterial *** LT accumulates and cytokines,predominantly TNF,amass during *** infection,co-treatment of TNF+LT in mice was used to mimic in vivo conditions for LT to function in inflamed *** marrow transplantation and genetically engineered mice showed unexpectedly that the death of intestinal epithelial cells(IECs)rather than that of hematopoietic cells led to LT+TNF-induced *** of p38a mitogen-activated protein kinase(MAPK)signaling by LT in IECs promoted TNF-induced apoptosis and necroptosis of IECs,leading to intestinal damage and mouse ***,p38a inhibition by LT enhanced TNF-mediated cell death in human colon epithelial HT-29 *** intestinal damage is one of the leading causes of lethality in anthrax patients,the IEC damage caused by LT+TNF would most likely be a mechanism underneath this clinical manifestation and could be a target for interventions.

关键词： lethal toxin TNF p38a intestinal epithelial cell cell death

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Clinical Trials of Respiratory Virus Infections: How to Address Challenges and Prepare for the Future

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Infectious Diseases & Immunity 2024年第3期4卷 101-102页

作者： Jingwen ai Wenhong zhang Department of Infectious Diseases Shanghai Key Laboratory of Infectious Diseases and Biosafety Emergency ResponseNational Medical Center for Infectious DiseasesHuashan HospitalShanghai Medical CollegeFudan UniversityShanghai 200040China Shanghai Sci-Tech InnoCenter for Infection and Immunity Shanghai 20052China Institute of Infection and Health Fudan UniversityShanghai 200040China.

*** Prior to the coronavirus disease 2019(COVID-19)outbreak,the only antiviral treatment widely used in clinical settings was for ***,following the global pandemic,there has been renewed research interest in medications for respiratory viral *** trials of antiviral medications often need to consider multiple dimensions because of the significant differences in disease severity among *** example,during respiratory viral epidemic seasons,the clinical spectrum of diseases is usually complex,including asymptomatic infections,symptomatic infections(mild to moderate without hospitalization),severe cases(requiring hospitalization),and fatalities.

关键词： Clinical respiratory clinical

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Epigenetic silencing schlafen-11 sensitizes esophageal cancer to ATM inhibitor

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World Journal of Gastrointestinal Oncology 2024年第5期16卷 2060-2073页

作者： Jing Zhou Mei-Ying zhang ai-ai Gao Cheng Zhu Tao He James G Herman Ming-Zhou Guo School of Medicine NanKai UniversityTianjin 300071China Department of Gastroenterology and Hepatology The First Medical CenterChinese PLA General HospitalBeijing 100853China Departments of Pathology Characteristic Medical Center of The Chinese People’s Armed Police ForceTianjin 300162China The Hillman Cancer Center University of Pittsburgh Cancer InstitutePittsburghPA 15213United States National Key Laboratory of Kidney Diseases Chinese PLA General HospitalBeijing 100853China

BACKGROUND Targeting DNA damage response(DDR)pathway is a cutting-edge *** has been reported that Schlafen-11(SLFN11)contributes to increase chemosensitivity by participating in ***,the detailed mechanism is *** To investigate the role of SLFN11 in DDR and the application of synthetic lethal in esophageal cancer with SLFN11 *** To reach the purpose,eight esophageal squamous carcinoma cell lines,142 esophageal dysplasia(ED)and 1007 primary esophageal squamous cell carcinoma(ESCC)samples and various techniques were utilized,including methylationspecific polymerase chain reaction,CRISPR/Cas9 technique,Western blot,colony formation assay,and xenograft mouse *** Methylation of SLFN11 was exhibited in 9.15%of(13/142)ED and 25.62%of primary(258/1007)ESCC cases,and its expression was regulated by promoter region ***11 methylation was significantly associated with tumor differentiation and tumor size(both P<0.05).However,no significant associations were observed between promoter region methylation and age,gender,smoking,alcohol consumption,TNM stage,or lymph node *** DNA damaged model induced by low dose cisplatin,SLFN11 was found to activate non-homologous end-joining and ATR/CHK1 signaling pathways,while inhibiting the ATM/CHK2 signaling *** silencing of SLFN11 was found to sensitize the ESCC cells to ATM inhibitor(AZD0156),both in vitro and in *** SLFN11 is frequently methylated in human *** of SLFN11 is sensitive marker of ATM inhibitor in ESCC.

关键词： Schlafen-11 Esophageal squamous cell carcinoma DNA methylation Synthetic lethality AZD0156

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A comparison of statistical learning of naturalistic textures between DCNNs and the human visual hierarchy

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Science China Technological Sciences 2024年第8期67卷 2310-2318页

作者： LU XinCheng YUAN ZiQi zhang YiChi ai HaiLin CHENG SiYuan GE YiRan FANG Fang CHEN NiHong Department of Psychological and Cognitive Sciences Tsinghua University Department of Computer Science and Technology Tsinghua University School of Psychological and Cognitive Sciences and Beijing Key Laboratory of Behavior and Mental Health Peking University Key Laboratory of Machine Perception (Ministry of Education) Peking University Peking-Tsinghua Center for Life Sciences Peking University IDG/McGovern Institute for Brain Research Peking University State Key Laboratory of Brain and Cognitive Science Institute of Psychology Chinese Academy of Sciences IDG/McGovern Institute for Brain Research Tsinghua University

The visual system continuously adapts to the statistical properties of the environment. Existing evidence shows a close resemblance between deep convolutional neural networks(CNNs) and primate visual stream in neural selectivity to naturalistic textures above the primary visual processing stage. This study delves into the mechanisms of perceptual learning in CNNs,focusing on how they assimilate the high-order statistics of natural textures. Our results show that a CNN model achieves a similar performance improvement as humans, as manifested in the learning pattern across different types of high-order image statistics. While L2 was the first stage exhibiting texture selectivity, we found that stages beyond L2 were critically involved in learning. The significant contribution of L4 to learning was manifested both in the modulations of texture-selective responses and in the consequences of training with frozen connection weights. Our findings highlight learning-dependent plasticity in the mid-to-high-level areas of the visual hierarchy. This research introduces an ai-inspired approach for studying learning-induced cortical plasticity, utilizing DCNNs as an experimental framework to formulate testable predictions for empirical brain studies.

关键词： CNN perceptual learning naturalistic texture psychophysics

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A highly selective electrochemical impedimetric sensor for imidacloprid determination based on WO_(3)/MoS_(2)nanosheets/molecularly imprinted polymer composite

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Rare Metals 2024年第3期43卷 1309-1315页

作者： Long-Hua Ding Ya-Wen Wang Qiu-Wen Li Li-Li zhang ai-Zhu Wang Institute for Advanced Interdisciplinary Research School of Chemistry and Chemical EngineeringUniversity of JinanJinan250022China HCA Florida Healthcare Westside/Northwest Hospital Internal Medicine PlantationFL33324USA

In this study,an electrochemical impedimetric sensor was established for imidacloprid(IMI)detection based on WO_(3)/MoS_(2)and molecular imprinted polymer(MIP)*** layer was prepared on electrode surface by electropolymerization of o-phenylenediamine(o-PD)in the presence of IMI template,which ensured the specific rec-ognization toward IMI.

关键词： electrochemical polymer polymerization

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Fasn involved in the nephrotoxicity induced by polystyrene nanoplastics and the intervention of melatonin through intestinal microbiota-mediated lipid metabolism disorder

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Nano Research 2024年第8期17卷 7365-7375页

作者： Huiwen Kang Danyang Huang Jiaru Jing Wei zhang Lei zhang Jingyu Wang Ziyan Liu Lin Han Ziyan Wang Lefeng zhang ai Gao Department of Occupational Health and Environmental Health School of Public HealthCapital Medical UniversityBeijing 100069China Beijing Key Laboratory of Environmental Toxicology Capital Medical UniversityBeijing 100069China

Nanoplastics(NPs)can accumulate in the kidney and cause kidney injury,but the multi-organ interaction mechanism and preventive measures of kidney injury are still *** this study,in vivo(60μg/day,42 days)and in vitro(0.4μg/μL,24 h)exposure models of polystyrene nanoplastics(PS-NPs,80 nm)in mice and human kidney cortex proximal tubule epithelial cells(HK-2 cells)were established,*** study revealed that PS-NPs caused obvious pathological changes and impaired renal function in mice,which were related to lipid metabolism disorders mediated by intestinal ***-fatty acid synthase(Fasn)-docosahexaenoic acid(DHA)pathway may be one of the mechanisms of kidney injury in ***,we also found that melatonin attenuates PS-NPs-induced nephrotoxicity by modulating lipid metabolism disorders(represented by DHA)and affects Fasn *** conclusion,our study revealed the important role of intestinal flora-mediated lipid metabolism in PS-NPs-induced nephrotoxicity and preliminarily provided potential key gene targets and effective preventive measures for PS-NPs-induced nephrotoxicity.

关键词： nanoplastics nephrotoxicity lipid metabolism fatty acid synthase(Fasn) melatonin

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Fabrication of telechelic DNA-bridged food emulsion gel as edible ink for 3D printing

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Food Quality and Safety 2024年第1期8卷 158-165页

作者： Ruyuan zhang Hao Huang Rong ai Dong Li Yanqun Xu Weiwei Jin Zisheng Luo College of Biological Chemical Sciences and Engineering Jiaxing UniversityJiaxingChina College of Biosystems Engineering and Food Science Zhejiang UniversityHangzhouChina College of Ecology Lishui UniversityLishuiChina Ningbo Innovation Center Zhejiang UniversityNingboChina Wenzhou Academy of Agriculture Science Liuhongqiao Road 1000WenzhouChina Key Laboratory of Agro-Products Postharvest Handling of Ministry of Agriculture and Rural Affairs Zhejiang Key Laboratory for Agri-Food ProcessingHangzhouChina

Objectives:Interdroplet interactions affect the properties and textures of *** this study,we creatively introduced telechelic DNA to link oil droplets directly at molecular scale to further improve the viscoelastic properties of *** and Methods:A stable emulsion with 70%oil fraction was prepared by adding 40 mg/mL of whey protein isolate and peach gum polysaccharide complex(WPI–PGP complex).The addition of telechelic DNA(0.125–0.375μmol/L)made the emulsion change from a cream-like state to a self-supporting ***:Rheological experiments confirmed that the telechelic DNA could improve the yield stress,storage modulus/loss modulus(Gʹ/Gʹʹ)and apparent viscosity of the emulsion gel in a concentration-dependent manner(0–0.375μmol/L).Inverted fluorescence images clearly showed the interdroplet network of the emulsion gel linked by telechelic *** 3D printing,the emulsion gel with a higher concentration(0.375μmol/L)of telechelic DNA displayed better surface quality and dimensional resolution,indicating improved ***:This study successfully designed a novel telechelic DNA-bridged emulsion gel,which showed great potential as edible ink for 3D printing.

关键词： Telechelic DNA WPI-PGP complex emulsion gel interdroplet interactions 3D printing.

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Inkjet-Printing Controlled Phase Evolution Boosts the Efficiency of Hole Transport Material Free and Carbon-Based CsPbBr3 Perovskite Solar Cells Exceeding 9%

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Energy & Environmental Materials 2024年第2期7卷 213-224页

作者： Lihua zhang Shi Chen Jie Zeng Zhengyan Jiang Qian ai Xianfu zhang Bihua Hu Xingzhu Wang Shihe Yang Baomin Xu Department of Materials Science and Engineering and Shenzhen Engineering Research and Development Center for Flexible Solar Cells Southern University of Science and Technology Department of Chemistry The Hong Kong University of Science and Technology Henan Key Laboratory of Photovoltaic Materials Henan University Guangdong Key Lab of Nano-Micro Material Research School of Chemical Biology and Biotechnology Shenzhen Graduate School Peking University Key University Laboratory of Highly Efficient Utilization of Solar Energy and Sustainable Development of Guangdong Southern University of Science and Technology Guangdong-Hong Kong-Macao Joint Laboratory for Photonic-Thermal-Electrical Energy Materials and Devices Southern University of Science and Technology

Hole transport material free carbon-based all-inorganic CsPbBr3perovskite solar cells（PSCs） are promising for commercialization due to its low-cost,high open-circuit voltage(Voc) and superior *** to the different solubility of PbBr2and CsBr in conventional solvents,CsPbBr3films are mainly obtained by multi-step spin-coating through the phase evolution from PbBr2to CsPb2Br5and then to *** scalable fabrication of highquality CsPbBr3films has been rarely ***,an inkjet-printing method is developed to prepare high-quality *** formation of long-range crystalline CsPb2Br5phase can effectively improve phase purity and promote regular crystal stacking of ***,the inkjetprinted CsPbBr3C-PSCs realized PCEs up to 9.09%,8.59% and 7.81% with active areas of 0.09,0.25,and 1 cm2,respectively,demonstrating the upscaling potential of our fabrication method and *** high performance is mainly ascribed to the high purity,strong crystal orientation,reduced surface roughness and lower trap states density of the as-printed *** work provides insights into the relationship between the phase evolution mechanisms and crystal growth dynamics of cesium lead bromide halide films.

关键词： all-inorganic perovskite solar cells CsPbBr3 inkjet-printing phase evolution

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Nuciferine alleviates collagen-induced arthritic in rats by inhibiting the proliferation and invasion of human arthritis-derived fibroblast-like synoviocytes and rectifying Th17/Treg imbalance

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Chinese Journal of Natural Medicines 2024年第4期22卷 341-355页

作者： WANG Hao GENG Xiaolong ai Fangbin YU Zhilun zhang Yan zhang Beibei LV Cheng GAO Ruiyang YUE Bei DOU Wei The MOE Key Laboratory of Standardization of Chinese Medicines Shanghai Key Laboratory of Compound Chinese Medicinesand the SATCM Key Laboratory of New Resources and Quality Evaluation of Chinese MedicineInstitute of Chinese Materia MedicaSchool of Traditional Chinese Materia MedicaShanghai University of Traditional Chinese Medicine(SHUTCM)Shanghai 201203China

Rheumatoid arthritis(RA)is a chronic autoimmune disorder marked by persistent synovial inflammation and joint degradation,posing challenges in the development of effective ***,an alkaloid found in lotus leaf,has shown promising anti-inflammatory and anti-tumor effects,yet its efficacy in RA treatment remains *** study investigated the antiproliferative effects of nuciferine on the MH7A cell line,a human RA-derived fibroblast-like synoviocyte,revealing its ability to inhibit cell proliferation,promote apoptosis,induce apoptosis,and cause G1/S phase ***,nuciferine significantly reduced the migration and invasion capabilities of MH7A *** therapeutic potential of nuciferine was further evaluated in a collagen-induced arthritis(CIA)rat model,where it markedly alleviated joint swelling,synovial hyperplasia,cartilage injury,and inflammatory *** also improved collagen-induced bone erosion,decreased pro-inflammatory cytokines and serum immunoglobulins(IgG,IgG1,IgG2a),and restored the balance between T helper(Th)17 and regulatory T cells in the spleen of CIA *** results indicate that nuciferine may offer therapeutic advantages for RA by decreasing the proliferation and invasiveness of FLS cells and correcting the Th17/Treg cell imbalance in CIA rats.

关键词： Rheumatoid arthritis Collagen-induced arthritis Fibroblast-like synoviocyte Immune imbalance Nuciferine

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Photo-responsive functional materials based on light-driven molecular motors

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Light(Science & Applications) 2024年第3期13卷 407-420页

作者： Yanping Deng Guiying Long Yang zhang Wei Zhao Guofu Zhou ben L.Feringa Jiawen Chen SCNU-UG International Joint Laboratory of Molecular Science and Displays National Center for International Research on Green OptoelectronicsSouth China Normal UniversityGuangzhou 510006China Stratingh Institute for Chemistry University of GroningenNijenborgh 49747AG GroningenThe Netherlands

In the past two decades,the research and development of light-triggered molecular machines have mainly focused on developing molecular devices at the nanoscale.A key scientific issue in the field is how to amplify the controlled motion of molecules at the nanoscale along multiple length scales,such as the mesoscopic or the macroscopic scale,or in a more practical perspective,how to convert molecular motion into changes of properties of a macroscopic ***-driven molecular motors are able to perform repetitive unidirectional rotation upon irradiation,which offers unique opportunities for responsive macroscopic *** several reviews that focus on the design,synthesis and operation of the motors at the nanoscale,photo-responsive macroscopic materials based on light-driven molecular motors have not been comprehensively *** the present review,we first discuss the strategy of confining absolute molecular rotation into relative rotation by grafting motors on ***,examples of self-assemble motors in supramolecular polymers with high internal order are ***,we will focus on building of motors in a covalently linked system such as polymeric gels and polymeric liquid crystals to generate complex responsive ***,a perspective toward future developments and opportunities is *** review helps us getting a more and more clear picture and understanding on how complex movement can be programmed in light-responsive systems and how man-made adaptive materials can be invented,which can serve as an important guideline for further design of complex and advanced responsive materials.

关键词： functions materials material

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