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SMAD7 expression in CAR-T cells improves persistence and safety for solid tumors

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Cellular & Molecular Immunology 2024年第3期21卷 213-226页

作者： Sixin Liang Rui Zheng Baile Zuo Jia Li Yiyi Wang Yujie Han Hao Dong Xiaojuan Zhao Yiting zhang Pengju Wang Ruotong Meng Lintao Jia angang Yang Bo Yan State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers Department of Biochemistry and Molecular BiologyFourth Military Medical UniversityXi’anShaanxi710032China School of Medicine Technology Xinxiang Medical UniversityXinxiangHenan453003China Department of Obstetrics and Gynecology Xijing Hospital of Fourth Military Medical UniversityXi’anShaanxi710032China College of Life Science Yan’an UniversityYan’anShaanxi716000China Department of Immunology Fourth Military Medical UniversityXi’anShaanxi710032China

Despite the tremendous progress of chimeric antigen receptor T(CAR-T)cell therapy in hematological malignancies,their application in solid tumors has been limited largely due to T-cell exhaustion in the tumor microenvironment(TME)and systemic toxicity caused by excessive cytokine *** a key regulator of the immunosuppressive TME,TGF-βpromotes cytokine synthesis via the NF-κB ***,we coexpressed SMAD7,a suppressor of TGF-βsignaling,with a HER2-targeted CAR in engineered T *** novel CAR-T cells displayed high cytolytic efficacy and were resistant to TGF-β-triggered exhaustion,which enabled sustained tumoricidal capacity after continuous antigen ***,SMAD7 substantially reduced the production of inflammatory cytokines by antigen-primed CAR-T ***,SMAD7 downregulated TGF-βreceptor I and abrogated the interplay between the TGF-βand NF-κB pathways in CAR-T *** a result,these CAR-T cells persistently inhibited tumor growth and promoted the survival of tumor-challenged mice regardless of the hostile tumor microenvironment caused by a high concentration of TGF-β.SMAD7 coexpression also enhanced CAR-T-cell infiltration and persistent activation in patient-derived tumor ***,our study demonstrated the feasibility of SMAD7 coexpression as a novel approach to improve the efficacy and safety of CAR-T-cell therapy for solid tumors.

关键词： TGF-βpathway SMAD7 NF-κB pathway CAR-T-cell therapy Cytokine release syndrome(CRS)

Fuel Tax in Sight to Raise Energy Efficiency

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China Oil & Gas 2007年第2期14卷 22-24页

作者： zhang angang Liaohe Petroleum Exploration Bureau

Policymakers have talked about introducing a fuel tax for more than a decade. Now, the country＇s urgent need to raise energy efficiency makes it the right time to bring the tax into reality. China recently announced its action plan on climate change and the Chinese Government circular urging local governments and companies around the country to implement the General Work Plan for Energy Conservation and Pollutant Discharge Reduction.

关键词：燃油税能源效率石油工业行业标准

Sky-High Emotions—World Champion Parachutists Jump to Marital Bliss

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Women of China 1996年第11期 36-37页

作者： zhang PING zhang angang WANG JIANMING

Bridegroom Wang Yongli, 33, has set three world records to win a like number of world championships. Wang has also won the highest honorary sports medals on five occasions. Bride Sheng Jun, 26, set the world parachute accuracy record and has won three world championships. Wang and Sheng, both of whom have careers spanning lO-odd years, fell in love,

关键词： World Champion Parachutists Jump to Marital Bliss Sky-High Emotions Jun

基于储层动用程度的块状砂体流动单元划分方法及应用研究:以哈萨克斯坦Akshabulak油田为例

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地学前缘 2023年第4期30卷 88-99页

作者：王进财范子菲赵伦陈烨菲张安刚张祥忠郭雪晶李毅中国石油勘探开发研究院北京100083

以南图尔盖盆地Akshabulak油田J-Ⅲ层块状砂体为例,利用油田投产初期生产工作制度相近井的产液剖面资料和单井日产油量划分出“好”“较好”“中等”“差”4类储层动用程度类型。以储层动用程度类型为判别函数,利用岩心分析资料选出与... 详细信息

以南图尔盖盆地Akshabulak油田J-Ⅲ层块状砂体为例,利用油田投产初期生产工作制度相近井的产液剖面资料和单井日产油量划分出“好”“较好”“中等”“差”4类储层动用程度类型。以储层动用程度类型为判别函数,利用岩心分析资料选出与储层动用程度类型响应较好的7类地质参数。以7类地质参数为变量,以测井解释数据为基础,运用神经网络聚类技术将储层划分为“高”“较高”“中等”“低”4类不同级别的流动单元。统计结果表明,4类储层动用程度类型与4种级别流动单元的静态地质参数和动态开发指标界限具有较好的对应性。研究结果表明流动单元的组合样式决定了储层的垂向和平面动用程度:垂向上,流动单元发育种类越多,水体会优先流向高级别流动单元,这导致油藏垂向水驱动用程度不均匀;平面上,高级别流动单元较发育的区域,水体会优先波及,这导致油藏平面水驱前缘推进速度有明显差异。在此基础上提出垂向上高级别流动单元实施调剖堵水、平面上天然水驱协同人工注水开发的开发技术策略,实现了稳产高效开发。

关键词：南图尔盖盆地块状砂体流动单元划分方法储层动用程度类型剩余油特征

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带油环凝析气藏地层压力预测方法

中国石油大学学报（自然科学版） 2014年第5期38卷 124-129页

作者：张安刚范子菲宋珩张慧林中国石油勘探开发研究院北京100083 新疆油田公司勘探开发研究院新疆克拉玛依834000

带油环凝析气藏气顶油环协同开发过程中,地层压力的不断降低导致气顶发生反凝析现象,油环中的溶解气不断逸出,同时还伴随着原生水蒸发、岩石流体膨胀、边底水侵入等变化。综合考虑以上影响因素,在烃类流体物料守恒原理的基础上,建立带... 详细信息

带油环凝析气藏气顶油环协同开发过程中,地层压力的不断降低导致气顶发生反凝析现象,油环中的溶解气不断逸出,同时还伴随着原生水蒸发、岩石流体膨胀、边底水侵入等变化。综合考虑以上影响因素,在烃类流体物料守恒原理的基础上,建立带油环凝析气藏地层压力预测方法。将该方法应用于某实际带油环凝析气藏中。计算结果表明:该方法得到的地层压力与关井实际测压数据吻合较好,具有一定的可靠性;在衰竭开采方式下,气顶采气速度和油环采油速度的增加都会加速地层压力的下降;在气顶孔隙体积大于油环的孔隙体积条件下,气顶采气速度的增加更容易加快地层压力的下降,从而气顶的采气速度不能太大以免地层能量过早枯竭。

关键词：凝析气藏地层压力凝析油溶解气岩石流体膨胀

N-doped graphene quantum dot-decorated N-TiO2/P-doped porous hollow g-C_(3)N_(4) nanotube composite photocatalysts for antibiotic photodegradation and H2 production

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International Journal of Minerals,Metallurgy and Materials 2024年第1期31卷 165-178页

作者： Jingshu Yuan Yao zhang Xiaoyan zhang Junjie zhang Shen’gen zhang Institute for Advanced Materials and Technology University of Science and Technology BeijingBeijing 100083China Xi’an Fanyi University Xi’an 710105China Shunde Graduate School of University of Science and Technology Beijing Foshan 528399China State Key Laboratory of Lunar and Planetary Sciences Macao University of Science and TechnologyMacao SAR 820000China

Exclusive responsiveness to ultraviolet light (~3.2 eV) and high photogenerated charge recombination rate are the two primary drawbacks of pure TiO_(2). We combined N-doped graphene quantum dots (N-GQDs), morphology regulation, and heterojunction construction strategies to synthesize N-GQD/N-doped TiO_(2)/P-doped porous hollow g-C_(3)N_(4) nanotube (PCN) composite photocatalysts (denoted as G-TPCN). The optimal sample (G-TPCN doped with 0.1wt% N-GQD, denoted as 0.1% G-TPCN) exhibits significantly enhanced photoabsorption, which is attributed to the change in bandgap caused by elemental doping (P and N), the improved light-harvesting resulting from the tube structure, and the upconversion effect of N-GQDs. In addition, the internal charge separation and transfer capability of0.1% G-TPCN are dramatically boosted, and its carrier concentration is 3.7, 2.3, and 1.9 times that of N-TiO_(2), PCN, and N-TiO_(2)/PCN(TPCN-1), respectively. This phenomenon is attributed to the formation of Z-scheme heterojunction between N-TiO_(2) and PCNs, the excellent electron conduction ability of N-GQDs, and the short transfer distance caused by the porous nanotube structure. Compared with those of N-TiO_(2), PCNs, and TPCN-1, the H2 production activity of 0.1%G-TPCN under visible light is enhanced by 12.4, 2.3, and 1.4times, respectively, and its ciprofloxacin (CIP) degradation rate is increased by 7.9, 5.7, and 2.9 times, respectively. The optimized performance benefits from excellent photoresponsiveness and improved carrier separation and migration efficiencies. Finally, the photocatalytic mechanism of 0.1% G-TPCN and five possible degradation pathways of CIP are proposed. This study clarifies the mechanism of multiple modification strategies to synergistically improve the photocatalytic performance of 0.1% G-TPCN and provides a potential strategy for rationally designing novel photocatalysts for environmental remediation and solar energy conversion.

关键词： N-doped TiO_(2) N-doped graphene quantum dots P-doped g-C_(3)N_(4) porous hollow nanotube heterojunction photocatalysis

Reversing free-electron transfer of sulfide cocatalyst for exceptional photocatalytic H_(2)evolution

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Journal of Materials Science & Technology 2024年第4期171卷 147-149页

作者： Yanfeng zhang Zhenyi zhang National Experimental Chemistry Teaching Center Hebei Key Laboratory of Inorganic Nano-materialsCollege of Chemistry and Materials ScienceHebei Normal UniversityShijiazhuang 050024China Key Laboratory of New Energy and Rare Earth Resource Utilization of State Ethnic Affairs Commission Key Laboratory of Photosensitive Materials and Devices of Liaoning ProvinceSchool of Physics and Materials EngineeringDalian Minzu UniversityDalian 116600China

Recently,Yu and co-workers deeply explore the potential impact of free electron transfer between co-catalysts and photocatalyst carriers on H_(2)evolution efficiency of active sites over MoS_(2+x).They pro-pose an electron-reversal tactics to evade the unexpected electron transfer and synchronously regulate the above transfer in a beneficial orientation for weakening hydrogen adsorption on S ***,this highlight not only discusses and summarizes the essences of electron reversal and the optimized H ad-sorption/desorption mechanism,but also emphasizes the significance of femtosecond transient absorp-tion spectroscopy(fs-TAS)and in-situ irradiated X-ray photoelectron spectroscopy(ISI-XPS)for revealing charge transfer dynamics and *** anticipate that this highlight can disseminate a new per-spective on the roles of photocatalyst carriers in improving cocatalytic H_(2)-production kinetics.

关键词： Photocatalysis Cocatalyst Electron reversal Antibonding-orbital occupancy S–H bonds

Inter-well internal resonance analysis of rectangular asymmetric cross-ply bistable composite laminated cantilever shell under transverse foundation excitation

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Applied Mathematics and Mechanics(English Edition) 2024年第8期45卷 1353-1370页

作者： Lele REN Wei zhang Yufei zhang State Key Laboratory of Mechanical System and Vibration Shanghai Jiao Tong UniversityShanghai 200240China Department of Mechanics Guangxi UniversityNanning 530004China Beijing Key Laboratory of Nonlinear Vibrations and Strength of Mechanical Structures College of Mechanical EngineeringBeijing University of TechnologyBeijing 100124China

The chaotic dynamic snap-through and complex nonlinear vibrations are investigated in a rectangular asymmetric cross-ply bistable composite laminated cantilever shell,in cases of 1:2 inter-well internal resonance and primary *** transverse foundation excitation is applied to the fixed end of the structure,and the other end is in a free *** first-order approximate multiple scales method is employed to perform the perturbation analysis on the dimensionless two-degree-of-freedom ordinary differential motion control *** four-dimensional averaged equations are derived in both polar and rectangular coordinate *** from the obtained frequency-amplitude and force-amplitude response curves,a detailed analysis is conducted to examine the impacts of excitation amplitude,damping coefficient,and tuning parameter on the nonlinear internal resonance characteristics of the *** nonlinear softening characteristic is exhibited in the upper stable-state,while the lower stable-state demonstrates the softening and linearity *** simulation is carried out using the fourth-order Runge-Kutta method,and a series of nonlinear response curves are *** the excitation amplitude further elucidates the global bifurcation and chaotic dynamic snap-through characteristics of the bistable cantilever shell.

关键词： bistable composite laminated cantilever shell inter-well internal resonance primary resonance chaotic dynamic snap-through complex nonlinear vibration

Deep Guided Attention Network for Joint Denoising and Demosaicing in Real Image

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Chinese Journal of Electronics 2024年第1期33卷 303-312页

作者： Tao zhang Ying FU Jun zhang School of Computer Science and Technology Beijing Institute of Technology Advanced Reasearch Institute of Multidisciplinary Science Beijing Institute of Technology

Denoising(DN) and demosaicing(DM) are the first crucial stages in the image signal processing pipeline. Recently, researches pay more attention to solve DN and DM in a joint manner, which is an extremely undetermined inverse problem. Existing deep learning methods learn the desired prior on synthetic dataset, which limits the generalization of learned network to the real world data. Moreover, existing methods mainly focus on the raw data property of high green information sampling rate for DM, but occasionally exploit the high intensity and signalto-noise(SNR) of green channel. In this work, a deep guided attention network(DGAN) is presented for real image joint DN and DM(JDD), which considers both high SNR and high sampling rate of green information for DN and DM, respectively. To ease the training and fully exploit the data property of green channel, we first train DN and DM sub-networks sequentially and then learn them jointly, which can alleviate the error accumulation. Besides, in order to support the real image JDD, we collect paired raw clean RGB and noisy mosaic images to conduct a realistic dataset. The experimental results on real JDD dataset show the presented approach performs better than the state-of-the-art methods, in terms of both quantitative metrics and qualitative visualization.

关键词： Training Visualization Inverse problems Green products Noise reduction Pipelines Signal processing