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CircTIAM1 overexpression promotes the progression of papillary thyroid cancer by regulating the miR-338-3p/LASP1 axis

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Oncology Research 2024年第11期32卷 1747-1763页

作者： ye zhang YANAN LIANG YAN WU LIWEN SONG ZUWANG zhang School of Medicine and Health Jiuzhou PolytechnicXuzhou221113China Department of Oncology University-Town Hospital of Chongqing Medical UniversityChongqing401331China

Background:Papillary thyroid cancer(PTC)is the most prevalent histological type of differentiated thyroid *** RNAs(circRNAs)have been implicated in the pathogenesis and progression of various ***1(hsa_circ_0061406)is a novel circRNA with aberrant expression in ***,its functional roles in PTC progression remain to be ***:The expression levels of circTIAM1 in the PTC and the matched para-cancerous tissues were detected by quantitative real-time reverse-transcription PCR(qRT-PCR).The subcellular localization of circTIAM1 was examined by fluorescence in-situ hybridization(FISH).Kaplan-Meier plot was used to analyze the association of clinicopathological features with circTIAM1 *** databases were utilized to predict the target miRNAs of circTIAM1 and the downstream target *** pulldown,RIP assay,and dual-luciferase reporter assay were used to confirm the *** experiments,such as CCK-8,EDU staining,and apoptosis assays,as well as in vivo xenograft model were employed to explore the impacts of circTIAM1,miR-338-3p,and LIM/SH3 protein 1(LASP1)on the malignant phenotype of the PTC ***:CircTIAM1 was highly expressed in PTC ***,circTIAM1 silencing suppressed the proliferation and invasion of PTC cells in vitro and impaired tumorigenesis in ***,miR-338-3p was verified as a miRNA target of ***1 was also identified as a downstream target of *** anti-tumorigenic effect of miR-338-3p overexpression and the pro-tumorigenic effect of LASP1 was further explored by functional assays,which demonstrated that circTIAM1 modulated the PTC progression through targeting miR-338-3p/LASP1 ***:The overexpression of circTIAM1 is associated with the malignant progression of PTC.A high level of circTIAM1 promotes the malignancy of PTC cells via the miR-338-3p/LASP1 axis.

关键词： Papillary thyroid cancer Circular RNAs(CircRNAs) LIM/SH3 protein 1(LASP1) CircTIAM1

Characterization and degradation of β-Sn particles in thermal aged Pb-rich solder joint for low-temperature co-fired ceramic(LTCC) applications

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Rare Metals 2024年第10期43卷 5346-5361页

作者： Jin-Hong Liu Zhe Zhu Qiang-Qiang Nie Jun-Fu Liu Peng He Shu-ye zhang State Key Laboratory of Advanced Welding and Joining Harbin Institute of Technology Anhui Key Laboratory of Microsystem East China Research Institute of Microelectronics School of Materials Science and Engineering Hefei University of Technology

High-lead solder joints are still playing an indispensable role in military and space ***, in-depth characterization of high-lead solder joints and the underlying degradation mechanisms remain unexplored. This research first performed aging tests on Sn10Pb90 solder joints, the shear strength at room and elevated temperatures gradually reduced, and the resistance increased. Here, a two-layered Ni–Sn intermetallic compound(IMC) structure was identified using transmission electron microscopy(TEM), which could be attributed to the change of Sn content in the solder. Moreover, the internal annealing twin of a Sn particle was discovered,which could be attributed to creeping induced by thermal expansion coefficient(CTE) difference between Sn and *** analysis of partial and whole annealing twins was conducted through high-resolution TEM(HRTEM).Finally, four degradation mechanisms were *** of the IMC layer would result in increased brittleness and resistivity. For particle coarsening, apart from diminishing the ductility and toughness of the solder joint, it would also accelerate the creeping rate by weakening the phase boundary strength. Regarding voids and cracks induced by phase boundary sliding, wedgeshaped cracking and pore-shaped cracking were discovered and their formation was analyzed. Most importantly, the consumption of Sn resulted in a depletion of wettable layer,leading to the formation of Pb streams and isolated IMC islands, also known as the spalling and delamination of IMCs. Pb diffusion followed a spiral path, which was mutually influenced by orientation misfit and concentration gradient. A technique to prevent cracking was *** research is expected to provide significant technical references for high-lead solder joints.

关键词： Aging Degradation mechanisms High-lead solder joints Properties TEM characterization

Drought-triggered repression of miR166 promotes drought tolerance in soybean

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The Crop Journal 2024年第1期12卷 154-163页

作者： Chen Zhao Jingjing Ma Chen Yan Yu Jiang Yaohua zhang Yudan Lu ye zhang Suxin Yang Xianzhong Feng Jun Yan School of Life Sciences East China Normal UniversityShanghai 200241China Key Laboratory of Soybean Molecular Design Breeding Northeast Institute of Geography and AgroecologyChinese Academy of SciencesChangchun 130102JilinChina

Drought stress limits agricultural productivity *** and characterizing genetic components of drought stress-tolerance networks may improve crop resistance to drought *** show that the regulatory module formed by miR166 and its target gene,ATHB14-LIKE,functions in the regulation of drought tolerance in soybean(Glycine max).Drought stress represses the accumulation of miR166,leading to upregulation of its target *** knockdown of miR166 in the stable transgenic line GmSTTM166 conferred drought tolerance without affecting *** of ABA signaling pathway genes was regulated by the miR166-mediated regulatory pathway,and ATHB14-LIKE directly activates some of these *** is a feedback regulation between ATHB14-LIKE and MIR166 genes,and ATHB14-LIKE inhibits MIR166 *** findings reveal that drought-triggered regulation of the miR166-mediated regulatory pathway increases plants drought resistance,providing new insights into drought stress regulatory network in soybean.

关键词： Soybean Drought stress miRNA ABA signaling

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Unraveling the regulatory network of flower coloration in soybean:Insights into roles of GmMYBA3 and GmMYBR1

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The Crop Journal 2024年第2期12卷 443-455页

作者： Ruifang Gao Yueqing Li Yanan Wang Xiaotong Shan Siqi Yang ye zhang Saiyu Ma Chunbao zhang Jianchun Qin Li Wang Xiang Gao College of Plant Science Jilin UniversityChangchun 130062JilinChina Key Laboratory of Molecular Epigenetics of MOE and Institute of Genetics&Cytology Northeast Normal UniversityChangchun 130024JilinChina Soybean Research Institute National Engineering Research Center for SoybeanJilin Academy of Agricultural SciencesChangchun 130033JilinChina

Anthocyanins play crucial roles in pollen protection and pollinator attraction in flowering ***,the mechanisms underlying flower color determination and whether floral anthocyanin regulators participate in other processes remain largely unresolved in soybeans(Glycine max).In this study,we investigated the genetic components and mechanisms governing anthocyanin biosynthesis in soybean *** and genetic studies have characterized two antagonistic regulators,the positive activator GmMYBA3 and the negative repressor GmMYBR1,that modulate the gene expression of anthocyanin biosynthesis in soybean *** findings revealed a regulatory interplay between GmMYBA3 and GmMYBR1 bridged by GmTT8a,highlighting the complexity of anthocyanin regulation in different soybean *** of additional soybean cultivars demonstrated the universality of GmMYBA3 and GmMYBR1 in regulating floral anthocyanin biosynthesis-related genes,with GmF3’5’H identified as a crucial determinant of white flower *** study provides a molecular mechanism underlying soybean flower color determination,paving the way for the molecular modification of soybean flowers to probably enhance their resistance to abiotic stresses and attractiveness to pollinators.

关键词： Anthocyanin Flower color determination MBW complex MYB repressor Pleiotropic regulator

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Geographically and Temporally Weighted Regression in Assessing Dengue Fever Spread Factors in Yunnan Border Regions

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Biomedical and Environmental Sciences 2024年第5期37卷 511-520页

作者： ZHU Xiao Xiang WANG Song Wang LI Yan Fei zhang ye Wu SU Xue Mei ZHAO Xiao Tao National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases Chinese Center for Disease Control and PreventionBeijing 102211China Yunnan Institute of Parasitic Diseases Pu’er 665000YunnanChina

Objective This study employs the Geographically and Temporally Weighted Regression(GTWR)model to assess the impact of meteorological elements and imported cases on dengue fever outbreaks,emphasizing the spatial-temporal variability of these factors in border *** We conducted a descriptive analysis of dengue fever’s temporal-spatial distribution in Yunnan border *** annual data from 2013 to 2019,with each county in the Yunnan border serving as a spatial unit,we constructed a GTWR model to investigate the determinants of dengue fever and their spatio-temporal heterogeneity in this *** The GTWR model,proving more effective than Ordinary Least Squares(OLS)analysis,identified significant spatial and temporal heterogeneity in factors influencing dengue fever’s spread along the Yunnan ***,the GTWR model revealed a substantial variation in the relationship between indigenous dengue fever incidence,meteorological variables,and imported cases across different *** In the Yunnan border areas,local dengue incidence is affected by temperature,humidity,precipitation,wind speed,and imported cases,with these factors’influence exhibiting notable spatial and temporal variation.

关键词： Dengue fever Meteorological factor Geographically and temporally weighted regression

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Sorely reducing emissions of non-methane short-lived climate forcers will worsen compound flood-heatwave extremes in the Northern Hemisphere

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Advances in Climate Change Research 2024年第4期15卷 737-750页

作者： Ying-Fang LI Zhi-Li WANG Ya-Dong LEI Xiao-Chao YU Lin LIU Hui-Zheng CHE Xiao-ye zhang State Key Laboratory of Severe Weather and Key Laboratory of Atmospheric Chemistry of China Meteorological Administration Chinese Academy of Meteorological SciencesBeijing 100081China University of Chinese Academy of Sciences Beijing 100190China

Non-methane short-lived climate forcer(SLCF)or near-term climate forcer(NTCF)emissions,as a significant driver of climate change,can be reduced to improve air *** reductions may contribute to additional warming of the climate system in the short term,thereby strongly affecting the likelihood of climate ***,there has been no quantitative assessment of the impact of non-methane SLCF mitigation on compound flood-heatwave extremes(CFHEs).This study quantitatively investigates the changes in future(2031-2050 versus 1995-2014)CFHEs and the resulting population exposure in the Northern Hemisphere(NH)due to non-methane SLCF *** used multi-model ensemble simulations under two future scenarios from the Aerosol and Chemistry Model Intercomparison Project(AerChemMIP)in the Coupled Model Intercomparison Project Phase 6(CMIP6).The two future scenarios share the same greenhouse gas(GHG)emissions but have weak(Shared Socioeconomic Pathway(SSP)3-7.0)versus strong(SSP3-7.0-lowNTCF)levels of air quality control *** results show that future non-methane SLCF reductions during 2031-2050 results in about a 7.3%±2.3%increase in grid exposure to CFHEs in the NH relative to the period *** frequency,intensity,and duration of CFHEs increase by varying *** the period 2031-2050,the frequency of CFHEs across the NH increases by 2.9±0.9 events per decade due to non-methane SLCF *** increases in CFHE frequency are more pronounced in East Asia,South Asia,Siberia,and northern and eastern North *** East and South Asia,the in-tensities of both heatwaves and floods corresponding to CFHEs increase markedly,where heatwave magnitude(HWM)increases by 0.3±0.2 K in East Asia and weighted average precipitation(WAP)increases by 18.3%±15.3%and 12.0%±4.5%in East Asia and South Asia,*** other regions,rising temperatures dominate the increase in *** regard to the duration of CFHEs,future reductions in non-methane SLC

关键词： Non-methane SLCFs CHFEs Cleaner air Population exposure

Allergenicity mitigation strategies of seafood allergens for hypoallergen

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Food and Health 2024年第4期6卷 39-40页

作者： Zi-ye zhang State Key Laboratory of Marine Food Processing&Safety Control College of Food Science and EngineeringOcean University of ChinaQingdao 266404China

Introduction Seafood is a widely consumed and nutritionally rich food source,but it ranks among the top allergens,with shellfish and fish being major triggers of allergic *** reactions,primarily caused by proteins such as tropomyosin(TM)in shellfish and parvalbumin(PV)in fish,can lead to life-threatening anaphylaxis in susceptible *** development of hypoallergenic seafood is becoming increasingly important to provide safe alternatives for those with seafood *** comment reviews recent advances in allergenicity mitigation strategies,highlighting the progress made and future potential in producing hypoallergenic seafood products.

关键词： becoming primarily allergen

Identification of serum immunoglobulin M(IgM)of crucian carp(Carassius auratus gibelio)and immune response to cyprinid herpesvirus 2 infection

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Aquaculture and Fisheries 2024年第2期9卷 172-180页

作者： Shuran Wang Haotian Wu Longlong Wang Pinhua Wang Liqun Lu Yousheng Jiang ye zhang Dan Xu National Pathogen Collection Center for Aquatic Animals Shanghai Ocean UniversityShanghai201306China Key Laboratory of Aquatic Genetic Resources of the Ministry of Agriculture Shanghai Ocean UniversityShanghai201306China National Demonstration Center for Experimental Fisheries Science Education Shanghai Ocean UniversityShanghai201306China

Crucian carp(Carassius auratus gibelio),an extensively cultivated freshwater fish,was one of the model species for the study of fish *** antibodies were advantageous molecular tools for studying teleost immune ***,polyclonal antibodies reacting with immunoglobulins(Ig)were used successfully in studies of the teleost *** the present study,we produced polyclonal antibody against CH2 domains of crucian carp IgM,and measured the in vivo dynamics of IgM mRNA caused by CyHV-2 *** recombinant protein IgM with relative molecular weight about 53 KD was correctly expressed in prokaryotic *** specificity of the polyclonal antibody was evaluated by Western blotting and results revealed that the antibody not only specifically recognized crucian carp serum but also cross-reacted with grass carp *** RT-PCR analysis demonstrated the expression of IgM mRNA changed significantly after CyHV-2 *** expression of IgM in the kidney increased and reached a maximum at 6 h post-infection(hpi),while dropped to a low level at 5 days post-infection(dpi).In conclusion,the expression of IgM was significantly upregulated in the kidney of crucian carp infected with CyHV-2,indicating that IgM played a potential role in systemic immunity against viral *** antibody against crucian carp IgM had certain clinical relevance,which might provide insight into the early stage of virus infection and prevention of the disease.

关键词： Immunoglobulin M Crucian carp Polyclonal antibody Cyprinid herpesvirus 2 Immunoprotection

Interleukins in liver disease treatment

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World Journal of Hepatology 2024年第2期16卷 140-145页

作者： Ming Yang Chun-ye zhang Department of Surgery University of MissouriColumbiaMO 65212United States Bond Life Sciences Center University of MissouriColumbiaMO 65212United States

Cytokines play pleiotropic roles in human health and disease by regulating both innate and adaptive immune ***(ILs),a large group of cytokines,can be divided into seven families,including IL-1,IL-2,IL-6,IL-8,IL-10,IL-12,and IL-17 ***,we review the functions of ILs in the pathogenesis and resolution of liver diseases,such as liver inflammation(e.g.,IL-35),alcoholrelated liver disease(e.g.,IL-11),non-alcoholic steatohepatitis(e.g.,IL-22),liver fibrosis(e.g.,Il-17a),and liver cancer(e.g.,IL-8).Overall,IL-1 family members are implicated in liver inflammation induced by different etiologies,such as alcohol consumption,high-fat diet,and hepatitis ***-2 family members mainly regulate T lymphocyte and NK cell proliferation and activation,and the differentiation of T ***-6 family cytokines play important roles in acute phase response in liver infection,liver regeneration,and metabolic regulation,as well as lymphocyte ***-8,also known as CXCL8,is activated in chronic liver diseases,which is associated with the accumulation of neutrophils and ***-10 family members contribute key roles to liver immune tolerance and immunosuppression in liver ***-12 family cytokines influence T-cell differentiation and play an essential role in autoimmune liver ***-17 subfamilies contribute to infection defense,liver inflammation,and Th17 cell *** interact with different type I and type II cytokine receptors to regulate intracellular signaling pathways that mediate their ***,most clinical studies are only performed to evaluate IL-mediated therapies on alcohol and hepatitis virus infection-induced *** pre-clinical and clinical studies are required to evaluate IL-mediated monotherapy and synergistic therapies.

关键词： Interleukins Family members Liver disease Treatment Clinical trials