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Long-term survival trends of gastric cancer patients between 1972 and 2011 in Qidong

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Chinese Journal of Cancer 2015年第12期34卷 602-607页

作者： Yong-Sheng Chen jian-Guo Chen jian Zhu Yong-Hui zhang Lu-Lu Ding Qidong Liver Cancer Institute Qidong People's Hospital Department of Epidemiology Nantong University Tumor Hospital/Institute

Background:There have been few reports on long-term survival of gastric cancer *** study analyzed the survival data of gastric cancer patients obtained from the population-based Qidong Cancer Registry between 1972 and 2011,providing a basis for evaluation of gastric cancer treatment and ***:The cumulative observed survival rate and relative survival rate of gastric cancer patients were calculated using Hakulinen's method via the SURV3.01 software,which was developed by the Finnish Cancer *** date of the last follow-up for the survival status of the 15,401 registered cases was April 30,***:The 1-,5-,10-,20-,and 30-year observed survival rates were 33.82%,14.18%,10.35%,6.63%,and 4.19%,respectively,and the 1-,5-,10-,20-,and 30-year relative survival rates were 35.43%,18.13%,17.50%,21.96%,and32.84%,*** males,the corresponding observed survival rates were 34.50%,14.40%,10.42%,6.46%,and4.05%,and the corresponding relative survival rates were 36.23%,18.67%,18.28%,23.73%,and 38.61%.For females,the corresponding observed survival rates were 32.62%,13.80%,10.22%,6.95%,and 4.46%,and the corresponding relative survival rates were 34.03%,17.21%,16.28%,19.70%,and 26.78%.Significant differences in relative survival rates were observed between sexes(P=0.003).For the 15-34,35-44,45-54,55-64,65-74,and 75+ age groups,the 5-year relative survival rates were 16.13%,21.77%,18.63%,12.61%,7.99%,and 2.94%,respectively,and the 10-year relative survival rates were 16.49%,22.83%,20.50%,15.97%,15.88%,and 15.73%,*** improvement could be observed for the 5-,10-,and 15-year relative survival rates in Qidong beginning in the 1980 ***:The survival outcome of registered gastric cancer cases in Qidong showed gradual progress over the past two decades.

关键词： Gastric neoplasms, Cancer registration, Survival,Trends, Qidong

Suppression of spermatogenesis by testosterone undecanoate-loaded injectable in situ-forming implants in adult male rats

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Asian Journal of Andrology 2016年第5期18卷 791-797页

作者： Xiao-wei zhang Chong zhang wei zhang Dan Yang Shu Meng Ping Wang Jing Guo Dan-Hua Liu Drug Research Laboratory Liaoning Research Institute of Family Planning Huanggu District Shenyang China

We have investigated the feasibility of administration of testosterone undecanoate （TU）-Ioaded injectable in situ-forming implant （ISFI） for contraception in adult male Sprague-Dawley rats. Male rats were treated with vehicle, TU-Ioaded ISFIs （540, 270 and 135 mg TU kg-1） or TU injections （45 mg TU kg-1 every 30 days） for 120 days. Fertility tests served for determining infertility or restoration of fertility in treated rats. Serum testosterone concentration, epididymal sperm count, motility, morphology, and histology of the testis were monitored. The TU-Ioaded ISFIs increased serum testosterone levels in rats steadily without fluctuation over 3 months. One month after TU administration, the epididymal sperm count decreased significantly in all experimental groups. After 3 months, the animals treated with 270 and 135 mg kg-~ TU-Ioaded ISFIs were 100% infertile, and no implantation sites were produced in the mated females. However, some of males treated with 540 mg kg-~ ISFI or TU injections were still fertile but numbers of implantation sites were also significantly lower than control values. TU-Ioaded ISFI at an appropriate dose has potential as a long-acting male contraceptive drug that suppresses spermatogenesis consistently over a period of 3 months.

关键词： in situ-forming implants male contraception rats spermatogenesis testosterone undecanoate

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镁铝尖晶石纳米前驱体溶胶的制备及表征

华北理工大学学报（自然科学版） 2025年第1期47卷 1-6页

作者：席子建魏军从涂军波马伟平华北理工大学河北省无机非金属材料重点实验室河北唐山063210 河北国亮新材料有限公司河北唐山063009

以六水氯化镁和六水氯化铝为主要原料,氨水为沉淀剂,利用共沉淀法制备了镁铝尖晶石前驱体溶胶。测定了溶胶的固体含量、pH值和密度,对凝胶作用后的粉体进行了综合热分析,红外光谱分析、XRD和TEM。研究表明:使用共沉淀法制备的镁铝尖晶... 详细信息

以六水氯化镁和六水氯化铝为主要原料,氨水为沉淀剂,利用共沉淀法制备了镁铝尖晶石前驱体溶胶。测定了溶胶的固体含量、pH值和密度,对凝胶作用后的粉体进行了综合热分析,红外光谱分析、XRD和TEM。研究表明:使用共沉淀法制备的镁铝尖晶石前驱体溶胶胶粒为水滑石Mg_(2)Al(OH)_(7)和Al(OH)_(3)的无定型混合物,溶胶固体含量为5.8%,密度为1.21 g/cm^(3)。干凝胶粉受热时Mg_(2)Al(OH)_(7)和Al(OH)_(3)发生分解,500℃时开始形成镁铝尖晶石雏晶,700℃时镁铝尖晶石形成的粒径较小,约为15 nm。继续升高煅烧温度,镁铝尖晶石晶格趋于完善,平均晶粒尺寸增大。

关键词：镁铝尖晶石纳米前驱体溶胶共沉淀法纳米晶

The Tiny Zebrafish Keep Swimming Fast in the Developmental Biology Pond

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Journal of Genetics and Genomics 2012年第9期39卷 419-420页

作者： Jinrong Peng jian zhang Anming Meng College of Animal Sciences Zhejiang UniversityHangzhou 310058China Institute of Genetics and Developmental Biology Chinese Academy of SciencesBeijing 100101China School of Life Sciences Tsinghua UniversityBeijing 100084China

In 1996,the journal Development published a special issue on zebrafish solely focusing on characterization of dozens of phenotypic mutants chosen from hundreds of mutants identified through chemical（ENU）mutagenesis by two zebrafish groups in Tubingen and *** milestone formally catapulted zebrafish to a league of genetically tractable model

关键词： life sciences

Ultrathin two-dimensional hybrid perovskites toward flexible electronics and optoelectronics

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National Science Review 2022年第5期9卷 10-12页

作者： Junran zhang Xuefen Song Lin Wang wei Huang Key Laboratory of Flexible Electronics and Institute of Advanced Materials School of Physical and Mathematical Sciences Nanjing Tech University Frontiers Science Center for Flexible Electronics Key Laboratory of Flexible ElectronicsShaanxi Institute of Flexible Electronics Institute of Flexible Electronics Northwestern Polytechnical University

The past decade has witnessed an explosion of research into organic-inorganic hybrid perovskites (OIHPs) due to their outstanding properties,including high flexibility,high absorption/emission efficiency,large defect tolerance and long-distance carrier diffusion [1].Recently,the ultrathin two-dimensional(2D) OIHP (Fig.1),combining the attractive features of hybrid components and 2D morphology,can be considered a rising star among novel flexible materials.

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Explore artificial neural networks for solving complex hydrocarbon chemistry in turbulent reactive flows

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Fundamental Research 2022年第4期2卷 595-603页

作者： jian An Fei Qin jian zhang Zhuyin Ren Institte for Aero Engine Tsinghua UniversitBejing 100084China Seience and Technology on Combustion Internal Flow and Thermal-structure LaboratoryNorthwesterm Polytechnical UniversityXi'an 710072China

Global warming caused by the use of fossil fuels is a common concern of the world *** is of practical importance to conduct in-depth fundamental research and optimal design for modern engine combustors through However,complex hydrocarbon chemistry,an indispensable component for predictive modeling,is computahigh-fidelity computational fluid dynamics(CFD),so as to achieve energy conservation and emission *** demanding,Its application in simulation-based design optimization,although desirable,is quite *** address this challenge,we propose a methodology for representing complex chemistry with artificial neural networks(ANNs),which are trained with a comprehensive sample dataset generated by the Latin hypercube sampling(LHS)*** a given chemical kinetic mechanism,the thermochemical sample data is able to cover the whole accessible pressure/temperature/species space in various turbulent *** ANN-based model consists of two different layers:the self-organizing map(SOM)and the back-propagation neural network(BPNN).The methodology is demonstrated to represent a 30-species methane chemical *** obtained ANN model is applied to simulate both a non-premixed turbulent flame(DLR_A)and a partially premixed turbulent flame(Flame D)to validate its applicability for different *** show that the ANN-based chemical kinetics can reduce the computational cost by about two orders of magnitude without loss of accuracy,The proposed methodology can successfully construct an ANN-based chemical mechanism with significant ffciency gain and a broad scope of applicability,and thus holds a great potential for complex hydrocarbon fuels.

关键词： Chemical kinetics Turbulent combustion Artificial neural network Machine learning Numerical simulation

Realgar(α-As_(4)S_(4))Treats Myelodysplastic Syndromes through Reducing DNA Hypermethylation

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Chinese Journal of Integrative Medicine 2022年第3期28卷 281-288页

作者： zhang Miao zhang Jia-yi SUN Ming-qian LU Peng LIU jian-xun Research Center Xiyuan HospitalChina Academy of Chinese Medical Sciences and Beijing Key Lab of Traditional Chinese Medicine PharmacologyBeijing(100091)China Education Sector Xiyuan HospitalChina Academy ofChinese Medical SciencesBeijing(100091)China MedicalAdministration Division Xiyuan HospitalChina Academy ofChinese Medical SciencesBeijing(100091)China

DNA hypermethylation is an epigenetic modification that plays a critical role in the oncogenesis of myelodysplastic syndromes(MDS).Aberrant DNA methylation represses the transcription of promotors of tumor suppressor genes,inducing gene ***(α-As_(4)S_(4))is a traditional medicine used for the treatment of various diseases in the ancient *** was reported to have efficacy for acute promyelocytic leukemia(APL).It has been demonstrated that realgar could efficiently reduce DNA hypermethylation of *** review discusses the mechanisms of realgar on inhibiting DNA hypermethylation of MDS,as well as the species and metabolisms of arsenic in vivo.

关键词： myelodysplastic syndromes DNA hypermethylation realgar arsenic review

Transport in electron–photon systems

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Frontiers of physics 2023年第4期18卷 129-175页

作者： jian-Sheng Wang Jiebin Peng Zu-Quan zhang Yong-Mei zhang Tao Zhu Department of Physics National University of SingaporeSingapore 117551Republic of Singapore Center for Phononics and Thermal Energy Science China-EU Joint Center for NanophononicsShanghai Key Laboratory of Special Artificial Microstructure Materials and TechnologySchool of Physics Science and EngineeringTongji UniversityShanghai 200092China Department of Physics Zhejiang Normal UniversityJinhua 321004China College of Physics Nanjing University of Aeronautics and AstronauticsNanjing 210016China School of Electronic and Information Engineering Tiangong UniversityTianjin 300387China Beijing National Laboratory for Condensed Matter Physics Institute of PhysicsChinese Academy of SciencesBeijing 100190China

We review the description and modeling of transport phenomena among the electron systems coupled via scalar or vector *** consists of three *** first part is about scalar photons,i.e.,Coulomb *** second part is with transverse photons described by vector *** third part is onϕ=0 or temporal gauge,which is a full theory of the *** use the nonequilibrium Green’s function(NEGF)formalism as a basic tool to study steady-state *** with local equilibrium it is equivalent to the fluctuational electrodynamics(FE),the advantage of NEGF is that it can go beyond FE due to its *** have given a few examples in the review,such as transfer of heat between graphene sheets driven by potential bias,emission of light by a double quantum dot,and emission of energy,momentum,and angular momentum from a graphene *** of these calculations are based on a generalization of the Meir–Wingreen formula commonly used in electronic transport in mesoscopic systems,with materials properties represented by photon self-energy,coupled with the Keldysh equation and the solution to the Dyson equation.

关键词： quantum transport thermal radiation scalar and vector photons nonequilibrium Green's function

Comparison of Abbott and Da-an real-time PCR for quantitating serum HBV DNA

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World Journal of Gastroenterology 2014年第33期20卷 11762-11769页

作者： Ning Qiu Rui Li jian-Guo Yu Wen Yang wei zhang Yong An Tong Li Xue-En Liu Hui Zhuang Department of Microbiology and Infectious Disease Center School of Basic Medical Sciences Peking University Health Science Center Department of Internal Medicine Liver Disease Center No. 88 Hospital of People’s Liberation Army

AIM: To compare the performance of the Da-an real-time hepatitis B virus (HBV) DNA assay and Abbott RealTime HBV assay.

关键词： Hepatitis B virus Hepatitis B virus DNA quantitation Real-time polymerase chain reaction Chronic hepatitis B Antiviral therapy