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Journal of Integrative Agriculture 2022年第6期21卷 1799-1811页

作者： DING Ji-ping LI Jing-han LIU Jia-huan zhang wei-feng JIA Xiang-ping College of Economics&Management Northwest A&F UniversityYangling 712100P.R.China Knowledge Technology and Innovation Group Wageningen UniversityWageningen 6706KNThe Netherlands College of Resources and Environmental Sciences China Agricultural UniversityBeijing 100094P.R.China Agricultural Information Institute Chinese Academy of Agricultural SciencesBeijing 100081P.R.China

Excessive use of nitrogen fertilizer in China and its adverse effects on agricultural production have been a national and global *** addition to massive public initiatives to promote sustainable farm practices,grass-rooted innovations are emerging in the niche,many of which take the forms of information and communication technologies(ICT)and digital *** study examines the effects of ICT-based extension services provided by an entrepreneurial startup on adopting sustainable farming *** found no significant reduction in N-fertilizer use for wheat *** the ICT-based services promoted farmers to adapt N-fertilizer use towards site-specific *** business model of the entrepreneurial venture faces great challenges in becoming participatory and financially sustainable.

关键词： venture capital innovations precision farming private-public partnerships nitrogen management

Microneedle patch loaded with ferritin-nanocaged doxorubicin for locally targeted drug delivery and efficient skin cancer treatment

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Particuology 2024年第5期88卷 282-289页

作者： feng Li Yuan Yang Hua Yue Shuang Wang Xiao zhang wei wei State Key Laboratory of Biochemical Engineering Institute of Process EngineeringChinese Academy of SciencesBeijing100190China Key Laboratory of Biopharmaceutical Preparation and Delivery Chinese Academy of SciencesBeijing100190China School of Chemical Engineering University of Chinese Academy of SciencesBeijing100049China

Ferritin has emerged as a promising nanocarrier for delivering therapeutic agents to ***,the limited drug loading and the off-target impacts after systemic administration remain challenges for cancer treatment with ferritin-based ***,we develop a microneedle patch loaded with ferritin-nanocaged doxorubicin(DoxFe@Fn/MN)for skin cancer ***,doxorubicin(Dox)is encapsulated in ferritin(Fn)using an iron core-assisted strategy,which results in a 3.4-fold increase in Dox loading compared to the direct loading ***,a polyvinyl alcohol-based microneedle(MN)patch is used for the transdermal delivery of DoxFe@Fn,enabling targeted tumour accumulation of DoxFe@Fn and preventing off-target *** released DoxFe@Fn can bind to CD71 highly expressed on skin cancer cells,facilitating its *** a result,the DoxFe@Fn/MN therapy presents a robust antitumour effect in a melanoma tumour model,showing its potential as a promising therapeutic modality for skin cancer treatment.

关键词： Ferritin Microneedle Skin cancer Drug delivery

PEGylated graphene oxide-mediated stimulation of vascular endothelial cells and responsive release of PD-1/PD-L1 inhibitor for efficient chemo-immunotherapy against cancer Author links open overlay panel

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Particuology 2024年第8期91卷 280-290页

作者： Yan Wang feng Li Shuang Wang Jiaqi Meng Xiao zhang wei wei State Key Laboratory of Biochemical Engineering Institute of Process EngineeringChinese Academy of SciencesBeijing100190China Key Laboratory of Biopharmaceutical Preparation and Delivery Chinese Academy of SciencesBeijing100190China School of Chemical Engineering University of Chinese Academy of SciencesBeijing100049China

Immune checkpoint blockade(ICB)has emerged as a promising immunotherapeutic modality against cancer in the ***,only 10-30%of patients respond to ICB,primarily due to poor immunogenicity and insufficient T cell infiltration in solid ***,we presented an approach for high-performance cancer treatment using the programmed cell death protein-1 and programmed cell death ligand-1(PD-1/PD-L1)inhibitor(BMS-202)-loaded PEGylated graphene oxide(GPi).On the one hand,GPi dissociated tight junctions of vascular endothelial cells(VECs)in tumor,thus promoting the extravasation and intratumoral accumulation of liposomal doxorubicin(LipDox),which then effectively induced immunogenic cell death of tumor *** the other hand,GPi also stimulated VECs to upregulate the expression of cell-cell interaction molecules,such as intercellular cell adhesion molecule-1 and vascular cell adhesion molecule-1,which facilitated the infiltration of T cells in *** acting as a stimulator of VECs,GPi could exert responsive release of BMS-202 under the acidic tumor microenvironment and blockade PD-1/PD-L1 axis in ***,the alternating administration of GPi and LipDox effectively inhibited tumor growth in a 4T1 tumor model,providing a novel treatment mode for chemo-immunotherapy.

关键词： PEGylated graphene oxide Vascular endothelial cells Immune checkpoint blockade Immunogenic cell death Chemo-immunotherapy

Ferric ion-triggered surface oxidation of galena for efficient chalcopyrite-galena separation

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International Journal of Minerals,Metallurgy and Materials 2024年第2期31卷 261-267页

作者： Qiancheng zhang Limin zhang feng Jiang Honghu Tang Li Wang wei Sun School of Minerals Processing and Bioengineering Central South UniversityChangsha 410083China Engineering Research Center of Ministry of Education for Carbon Emission Reduction in Metal Resource Exploitation and Utilization Changsha 410083China School of Resource and Environment Hunan University of Technology and BusinessChangsha 410083China

The efficient separation of chalcopyrite(CuFeS2)and galena(PbS)is essential for optimal resource ***,find-ing a selective depressant that is environmentally friendly and cost effective remains a *** various techniques,such as mi-croflotation tests,Fourier transform infrared spectroscopy,scanning electron microscopy(SEM)observation,X-ray photoelectron spec-troscopy(XPS),and Raman spectroscopy measurements,this study explored the use of ferric ions(Fe^(3+))as a selective depressant for *** results of flotation tests revealed the impressive selective inhibition capabilities of Fe^(3+)when used *** analysis showed that Fe^(3+)significantly reduced the adsorption of isopropyl ethyl thionocarbamate(IPETC)on the galena surface while having a minimal impact on *** analysis using SEM,XPS,and Raman spectra revealed that Fe^(3+)can oxidize lead sulfide to form compact lead sulfate nanoparticles on the galena surface,effectively depressing IPETC adsorption and increasing surface *** findings provide a promising solution for the efficient and environmentally responsible separation of chalcopyrite and galena.

关键词： galena chalcopyrite ferric ions flotation separation surface oxidation

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有机肥撒肥机现状分析与展望

林业机械与木工设备 2024年第8期52卷 20-25页

作者：孙同雨张锋伟宋学锋李相周刘禹辰甘肃农业大学机电工程学院甘肃兰州730030

肥料是农业增产最主要的手段,合理利用有机肥,既能提高农业产量,又能避免化肥中不可降解成分对生态环境的污染。面对有机肥撒施的巨大劳动量问题,有机肥撒施机械化的需求日益加剧。通过文献查阅与实物研究,分析了现有的几种撒肥机的结... 详细信息

肥料是农业增产最主要的手段,合理利用有机肥,既能提高农业产量,又能避免化肥中不可降解成分对生态环境的污染。面对有机肥撒施的巨大劳动量问题,有机肥撒施机械化的需求日益加剧。通过文献查阅与实物研究,分析了现有的几种撒肥机的结构类型及其功能的优缺点,结合国内外有机肥撒肥机的发展现状,提出对工作环境单一、物料适应性差、配套设备不足、技术接口不成熟等问题的思考。旨在为我国有机肥撒肥机的发展和优化提供参考。

关键词：撒肥机发展趋势解决方案

Earthquake-triggered landslides affecting a UNESCO Natural Site：the 2017 Jiuzhaigou Earthquake in the World National Park,China

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Journal of Mountain Science 2018年第7期15卷 1412-1428页

作者： WANG Jiao JIN Wen CUI Yi-fei zhang wei-feng WU Chun-hao Alessandro PASUTO Key Laboratory of Mountain Hazards and Earth Surface Process Chinese Academy of SciencesInstitute of Mountain Hazards and Environment Chinese Academy of Sciences Chengdu 610041 China University of ChineseAcademy of Sciences Beijing 100049 China Department of Civil and Environmental Engineering The Hong Kong University of Science and Technology Hong Kong China Sino-Italian Laboratory on Geological and Hydrological Hazards Chengdu 610041 China National Research Council of Italy-Research Institute for Geo-Hydrological Protection Padova Italy

On August 8^(th), 2017, an Ms 7.0 magnitude earthquake occurred in Jiuzhaigou County, northern Sichuan Province, China. The Jiuzhaigou Valley World National Park was the most affected area due to the epicentre being located in the scenic area of the park. Understanding the distribution characteristics of landslides triggered by earthquakes to help protect the natural heritage sites in Jiuzhaigou Valley remains a scientific challenge. In this study, a relatively complete inventory of the coseismic landslides triggered by the earthquake was compiled through the interpretation of high-resolution images combined with a field investigation. The results indicate thatcoseismic landslides not only are concentrated in Rize Gulley, Danzu Gully and Zezhawa Gully in the study area but also occur in the front part of Shuzheng Gully along the road network(from the entrance of Jiuzhaigou Valley to Heye Village). The landslides predominantly occur on the east-and southeastfacing slopes in the study area, which is a result of the integrated action of the valley direction and fault movement direction. The back-slope effect and the slope structure caused the difference in coseismic landslide distribution within the three gullies(Danzu Gully, Rize Gully, and Zezhawa Gully) near the inferred fault. In addition, the topographic position index was used to analyse the impact of microlandforms on earthquake-triggered landslides by considering the effect of the slope angle. The study results reveal a higher concentration of landslides in the slope position class of the middle slope(30°-50°) in Jiuzhaigou Valley. These findings can provide scientific guidance for the protection of natural heritage sites and post-disaster reconstruction in Jiuzhaigou Valley.

关键词： Earthquake-triggered landslides Spatial distribution Landslide area ratio Slope position

Segregation of binary particles in gas-solid fluidized bed

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Frontiers of Chemical Science and Engineering 2024年第6期18卷 113-121页

作者： Yaxiong Yu feng Lu Xuan He Fei wei Chenxi zhang Beijing Key Laboratory of Green Chemical Reaction Engineering and Technology Department of Chemical EngineeringTsinghua UniversityBeijing 100084China School of Chemical Engineering and Technology Xi’an Jiaotong UniversityXi’an 710049China Ordos Laboratory Ordos 017010China Institute for Carbon Neutrality Tsinghua UniversityBeijing 100084China

Particle segregation and mixing behavior play a crucial role in industrial *** study investigates the saturated jetsam fraction,which indicates the maximum capacity of flotsam to entrain jetsam,in an initially separated binary fluidized bed with particle size *** to the value of saturated jetsam fraction,three distinct regimes-segregation,mixing,and an intermediate regime-are ***,intriguing relationships between the saturated jetsam fraction and superficial gas velocity are observed,exhibiting monotonic trends in both the segregation and mixing regimes,while a unique volcano-shaped curve in the intermediate ***,a comprehensive entrainment model based on two-fluid model elucidates the observed phenomena,emphasizing the significance of mixing behavior in fluidized layer on the saturated jetsam *** work offers potential insights for evaluating segregation in industrial applications.

关键词： fluidized bed segregation binary bubbles entrainment

腔镜甲状腺手术与开放手术治疗≤2cm直径甲状腺乳头状癌的效果比较

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吉林医学 2024年第6期45卷 1303-1307页

作者：刘海舟张卫峰张东宝杨帆帆陈亮临海市中医院普外科浙江临海317000

目的:探讨腔镜甲状腺手术与开放手术对≤2 cm直径甲状腺乳头状癌的治疗效果。方法:选取临海市中医院普外科2021年9月~2022年12月收治的160例肿瘤病灶最大直径≤2 cm的甲状腺乳头状癌患者为研究对象,依照手术方式的不同,分为对照组与观... 详细信息

目的:探讨腔镜甲状腺手术与开放手术对≤2 cm直径甲状腺乳头状癌的治疗效果。方法:选取临海市中医院普外科2021年9月~2022年12月收治的160例肿瘤病灶最大直径≤2 cm的甲状腺乳头状癌患者为研究对象,依照手术方式的不同,分为对照组与观察组各80例。对照组患者采取常规开放手术治疗,观察组患者采取腔镜甲状腺手术治疗,对比两组患者围术期指标、术后疼痛程度、美观度与满意度及手术前与手术1 d后的炎性因子表达水平,并对比两组患者术后短期并发症发生率。结果:两组患者术后引流量、淋巴结清扫数目比较,差异无统计学意义(P>0.05),观察组患者手术时间明显高于对照组,观察组患者术中出血量、住院时间明显低于对照组,差异有统计学意义(P0.05),手术后两组患者CRP、IL-2和TNF-α水平均升高,但观察组升高的程度明显小于对照组,差异有统计学意义(P0.05)。结论:腔镜甲状腺手术与开放手术对≤2 cm直径甲状腺乳头状癌均具有良好的治疗效果,但腔镜甲状腺手术与开放手术比较能够进一步减轻手术对患者造成的创伤,淋巴结清扫程度与开放手术相当,能够促进患者术后康复,同时采取腔镜甲状腺手术能够减轻术后炎性因子水平升高现象,安全性较高,并未增加患者短期并发症发生率。

关键词：腔镜甲状腺手术开放手术肿瘤直径甲状腺癌乳头状癌并发症

Study of Cr^(6+) in Water by Surface Enhanced Raman Scattering

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Chinese Physics Letters 1997年第9期14卷 705-707页

作者： HUANG Ya-bin YU Xiao-hong zhang wei-feng MO Yu-jun Department of Physics Henan UniversityKaifeng 475001

Cr_(6+)in K_(2)Cr_(2)O_(7),(NH_(4))_(2)Cr_(2)O_(7),and K_(2)CrO_(4) aqueous solution showed the same new strong band of 794cm^(-1) in surface enhanced Raman scattering(SERS)by using SERS silver *** new feature could be assigned to a surface complex of silver and Cr^(6+),for instance Ag_(2)CrO_(4).The feature of 794cm^(-1) could be a fingerprint band for detecting pollutant Cr^(6+)in water from SERS by using the SERS active substrate of silver.

关键词： silver SERS instance

Blue-Light Emission from Nanocrystalline La_(0.5)Na_(0.5)TiO^(3)

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Chinese Physics Letters 1998年第10期15卷 758-760页

作者： zhang wei-feng zhang Xing-tang YIN Zhen zhang Ming-sheng MA Guo-hong DU Zu-liang Center for Materials Analysis and National Laboratory of Solid State Microstructures Nanjing UniversityNanjing 210093 Department of Physics He’nan UniversityKaifeng 475001

Nanocrystalline La_(0.5)Na_(0.5)TiO^(3) powders were prepared by the stearic acid-gel method,and the grain sizes could be controlled by varying annealing *** sizes were determined to be from 14 to 50nm using Scherrer's formula.A very strong blue-light emission band around 480nm was clearly observed in the nano-sized La_(0.5)Na_(0.5)TiO^(3) with a grain size of 14nm at room ***,nano-size effects on the luminescence properties were *** results could be explained with the aid of a self-trapped exciton model.

关键词： temperature. sizes sized