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蔡小平治疗肿瘤相关性抑郁的临床经验

中医肿瘤学杂志 2024年第2期6卷 62-67页

作者：晁瑞魏征张俊萍蔡小平河南中医药大学第二临床医学院河南郑州450000 河南省中西医结合医院(河南省中医药研究院) 河南郑州450000

肿瘤相关性抑郁是恶性肿瘤确诊及治疗过程中出现的病理性的抑郁状态,主要表现为恐惧、兴趣减退等,不仅使肿瘤患者更加痛苦,也不利于疾病本身的治疗。西医治疗有一定的局限性,患者病情初期,仅仅服用中药,病情就可以得到明显的改善,若不... 详细信息

肿瘤相关性抑郁是恶性肿瘤确诊及治疗过程中出现的病理性的抑郁状态,主要表现为恐惧、兴趣减退等,不仅使肿瘤患者更加痛苦,也不利于疾病本身的治疗。西医治疗有一定的局限性,患者病情初期,仅仅服用中药,病情就可以得到明显的改善,若不予以重视,则会恶化,甚至进展为难治性抑郁。蔡小平教授通过认为肿瘤相关性抑郁与肿瘤及其伴随的治疗密切相关,初则及气,渐及血分,久则伤及肝肾之阴,可从痰气交阻、肝胃不和、肝郁脾虚、心脾两虚、血虚脏躁及肝肾阴虚6个方面进行辨证论治,治疗以行气化痰、疏肝清肝、疏肝健脾、补益心脾、和中缓急及滋肾养肝为主,取得了良好的临床疗效;本文对其辨证治疗肿瘤相关性抑郁的临床经验进行整理,为临床实践提供参考。

关键词：肿瘤相关抑郁临床经验蔡小平辨证论治

Qishen Yiqi Dripping Pills for Cardiovascular Diseases: Effects and Mechanisms

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Chinese Journal of Integrative Medicine 2023年第9期29卷 857-864页

作者： LU Chun-miao YANG Yu-song LU Yan-min ZHU Ya-ping zhang Ao LYU Shi-chao zhang jun-ping Department of Cardiovascular Medicine First Teaching Hospital of Tianjin University of Traditional Chinese MedicineTianjin300193China Graduate School Tianjin University of Traditional Chinese MedicineTianjin300193China Institute of Acute Abdominal Diseases Nankai HospitalTianjin300100China Epidemiology College of Global Public HealthNew York UniversityNew York10003USA Department of Geriatric Medicine First Teaching Hospital of Tianjin University of Traditional Chinese MedicineTianjin300193China

Qishen Yiqi Dripping Pills(QSYQ) is a compound of Chinese medicine, which has been used to treat coronary heart disease and cardiac dysfunction. Its natural components include astragaloside Ⅳ, flavonoids, danshensu, protocatechualdehyde, salvianolic acid B, salvianolic acid A, ginsenosides Rg1, ginsenosides Rb1, and essential oils, etc. It exerts effects of nourishing qi and promoting blood circulation to relieve pain. In this review, the bioactive components of QSYQ and its effects for treating cardiovascular diseases and possible mechanism were summarized, providing references for further study and clinical application of QSYQ.

关键词： Qishen Yiqi Dripping Pills active ingredient cardiovascular diseases mechanisms review

Shengmai San for Treatment of Cardiotoxicity from Anthracyclines:A Systematic Review and Meta-Analysis

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Chinese Journal of Integrative Medicine 2022年第4期28卷 374-383页

作者： zhang Xiao-nan LI Yan-yang zhang Yuan-hui zhang Wan-qin ZHU Ya-ping zhang jun-ping LV Shi-chao LIU Long-tao National Clinical Research Center for Chinese Medicine Cardiology Xiyuan HospitalChina Academy of Chinese Medical SciencesBeijing100091China Tianjin Medical University Cancer Institute and Hospital Tianjin300060China First Teaching Hospital of Tianjin University of Traditional Chinese Medicine Tianjin300112China

Objective:To systematically evaluate the efficacy of Shengmai San in patients with cardiotoxicity of ***:Randomized controlled trials(RCTs)were identified by searching China National Knowledge Infrastructure(CNKI),Wanfang Database,Chinese Biomedical Literature Database(CBM),Pub Med,Cochrane Library,and Embase Databases from the inceptions until December *** Cochrane Handbook was used to evaluate the risk of bias in the included *** analysis was conducted using Rev Man 5.3 ***:Totally 19 RCTs with 2,331 participants were included in this *** showed that in improving arrhythmia(13 RCTs,n=1,877,RR=0.37,95%CI 0.25 to 0.52,P<0.00001),the treatment group was superior to the control *** terms of reducing left ventricular end-diastolic diameter(LVEDD,2 RCTs,n=128,MD=-0.79,95%CI-0.93 to-0.65,P<0.00001)and left ventricular end systolic diameter(LVESD,2 RCTs,n=128,MD=-0.58,95%CI-0.82 to-0.35,P<0.00001),the treatment group was also better than the control *** reducing myocardial enzymes such as creatine kinase(CK)[(3 RCTs,n=256,SMD=-0.80,95%CI-1.16 to-0.44,P<0.0001),(2 RCTs,n=126,SMD=-0.62,95%CI-0.98 to-0.26,P=0.0007)],the treatment group was superior to the control ***:Shengmai San has a positive effect on the treatment of cardiotoxicity from ***,in the future,it is still necessary to conduct high-quality RCTs to verify its efficacy.

关键词： Shengmai San anthracyclines cardiotoxicity systematic review meta-analysis

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病证结合分阶段辨治冠心病临证思考

中国中西医结合杂志 2024年第5期44卷 603-607页

作者：耿小飞范新彪严志鹏尚文钰张弛李文秀张军平天津中医药大学第一附属医院国家中医针灸临床医学研究中心天津300381

冠心病作为心血管疾病死亡的主要原因,明确中医与西医治疗上的优势与局限对运用中西医结合的方式防治冠心病具有重要意义。笔者以冠心病各阶段病理特点、证候特点为基础,认为冠心病各病理阶段之间具有因果相连、递进发展的特点,中医证... 详细信息

冠心病作为心血管疾病死亡的主要原因,明确中医与西医治疗上的优势与局限对运用中西医结合的方式防治冠心病具有重要意义。笔者以冠心病各阶段病理特点、证候特点为基础,认为冠心病各病理阶段之间具有因果相连、递进发展的特点,中医证候演变上具有时序性的特点,提出冠心病各阶段之间存在“病—时”相应的特点,各证侯之间存在“证—时”相应的特点,凝练形成冠心病“病—证—时”的理念,形成了针对冠心病未病、已病、病瘥等相关的心血管事件链应用中西药联合、分阶段、全时程干预的思路。同时探讨了不同阶段中西医治疗的优势及局限,为中西医结合诊治冠心病提供思考。

关键词：冠心病时序性病证结合临证思考中西医结合

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针灸改善化疗胃肠道不良反应临床研究进展

中医肿瘤学杂志 2024年第2期6卷 86-93页

作者：程碧琳孙士玲张俊萍蔡小平关徐涛唐铮芳河南中医药大学第一附属医院河南郑州450046 河南省中西医结合医院(河南省中医药研究院) 河南郑州450004

检索有关针刺、艾灸及其他相关治疗如温针灸、电针、穴位贴敷、穴位注射等治疗恶性肿瘤化疗相关性胃肠道不良反应的临床研究文献。概述针刺、艾灸及其他相关治疗干预化疗相关性胃肠道不良反应的研究进展,如化疗恶心、呕吐、呃逆、腹胀... 详细信息

检索有关针刺、艾灸及其他相关治疗如温针灸、电针、穴位贴敷、穴位注射等治疗恶性肿瘤化疗相关性胃肠道不良反应的临床研究文献。概述针刺、艾灸及其他相关治疗干预化疗相关性胃肠道不良反应的研究进展,如化疗恶心、呕吐、呃逆、腹胀、腹痛、腹泻、便秘等,临床应用中常使用单纯针刺、艾灸或联合中医外治、中医内治法,以提高疗效,主要选取穴位有足三里、内关、中脘、神阙等穴位。针灸改善化疗相关胃肠道不良反应的应用已较为普遍,较单独西医治疗具有明显优势,常通过减少相关症状发病频率、缓解临床症状、缩短持续时间、提高生活质量的方式起效,值得临床进一步推广。

关键词：针灸化疗胃肠道不良反应研究进展

Feature Matching via Topology-Aware Graph Interaction Model

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IEEE/CAA Journal of Automatica Sinica 2024年第1期11卷 113-130页

作者： Yifan Lu Jiayi Ma Xiaoguang Mei jun Huang Xiao-ping zhang the Electronic Information School Wuhan UniversityWuhan 430072China IEEE Tsinghua Berkeley Shenzhen Institute Shenzhen 518071China the Department of Electrical Computer and Biomedical EngineeringToronto Metropolitan UniversityToronto ON M5B 2K3Canada

Feature matching plays a key role in computer vision. However, due to the limitations of the descriptors, the putative matches are inevitably contaminated by massive *** paper attempts to tackle the outlier filtering problem from two aspects. First, a robust and efficient graph interaction model,is proposed, with the assumption that matches are correlated with each other rather than independently distributed. To this end, we construct a graph based on the local relationships of matches and formulate the outlier filtering task as a binary labeling energy minimization problem, where the pairwise term encodes the interaction between matches. We further show that this formulation can be solved globally by graph cut algorithm. Our new formulation always improves the performance of previous localitybased method without noticeable deterioration in processing time,adding a few milliseconds. Second, to construct a better graph structure, a robust and geometrically meaningful topology-aware relationship is developed to capture the topology relationship between matches. The two components in sum lead to topology interaction matching(TIM), an effective and efficient method for outlier filtering. Extensive experiments on several large and diverse datasets for multiple vision tasks including general feature matching, as well as relative pose estimation, homography and fundamental matrix estimation, loop-closure detection, and multi-modal image matching, demonstrate that our TIM is more competitive than current state-of-the-art methods, in terms of generality, efficiency, and effectiveness. The source code is publicly available at http://***/YifanLu2000/TIM.

关键词： Feature matching graph cut outlier filtering topology preserving

Reinforcement of High Impact Polystyrene by Aramid Nanoparticle Fillers Prepared via an In situ Bottom-up Approach

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Chinese Journal of Polymer Science 2024年第8期42卷 1167-1176页

作者： Xiang-jun Gong Zhi-ping Zhao Chang-Mei Sun Ying zhang Rong-jun Qu Ying Wang School of Chemistry and Materials Science Ludong UniversityYantai 264025China

In this work,aramid nanoparticles(ANPs)were prepared in dimethyl formamide(DMF)solution containing high impact polystyrene(HIPS)via a bottom-up *** electron microscopy(TEM)images showed that the obtained ANPs were evenly distributed in the HIPS matrix without any *** composition of the ANPs,i.e.,poly(p-phenyl-p-phenylenediamine)(PPTA),was confirmed by Fourier transform infrared spectroscopy(FTIR),X-ray photoelectron spectroscopy(XPS)and X-ray diffractometer(XRD).The ANP/HIPS composites,obtained after ethanol precipitation,were added to neat HIPS as fillers to fabricate ANP/HIPS composite *** surface roughness and the glass transition temperature(T_g)of the sheets were characterized by atomic force microscope(AFM)and differential scanning calorimetry(DSC),*** with neat HIPS,the mechanical properties of the composite sheet were significantly improved,and the Young's modulus increased from 246.55 MPa to 2025.12 MPa,the tensile strength increased from 3.07 MPa to 29.76 MPa,and the toughness increased from 0.32 N/mm^2 to 3.92 N/mm^2,with an increase rate of 721%,869%and 1125%,***,the thermal stability of the composites improved with the increase in ANP content.

关键词： High impact polystyrene PPTA nanoparticle Reinforce Mechanical property

Two types of dynamic cool coronal structures observed with STEREO and Hinode

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Research in Astronomy and Astrophysics 2009年第12期9卷 1368-1376页

作者： jun zhang Le-ping Li Key Laboratory of Solar Activity National Astronomical Observatories Chinese Academy of Sciences Beijing 100012 China

Solar coronal loops show significant plasma motions during their formation and eruption stages. Dynamic cool coronal structures, on the other hand, are often observed to propagate along coronal loops. We report on the discovery of two types of dynamic cool coronal structures, and characterize their fundamental properties. Using the EUV 304 A images from the Extreme UltraViolet Imager （EUVI） telescope on the Solar TErrestrial RElation Observatory （STEREO） and the Ca Ⅱ filtergrams from the Solar Optical Telescope （SOT） instrument on Hinode, we study the evolution of an EUV arch and the kinematics of cool coronal structures. The EUV 304A observations show that a missile-like plasmoid moves along an arch-shaped trajectory, with an average velocity of 31 km s^- 1. About three hours later, a plasma arch forms along the trajectory, subsequently the top part of the arch fades away and disappears; meanwhile the plasma belonging to the two legs of the arch flows downward to the arch＇s feet. During the arch formation and disappearance, SOT Ca Ⅱ images explore dynamic cool coronal structures beneath the arch. By tracking these structures, we classify them into two types. Type I is thread- like in shape and flows downward with a greater average velocity of 72 km s-l; finally it combines with a loop fibril at a chromospheric altitude. Type Ⅱ is shape-transformable and sometimes rolling as it flows downward with a smaller velocity of 37 km s-1, then disappears insularly in the chromosphere. It is suggested that the two types of structures are possibly controlled by different magnetic configurations.

关键词： Sun: chromosphere -- Sun: UV radiation -- Sun: activity

FPGA-based position reconstruction method for neutron beam flux spatial distribution measurement in BNCT

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Nuclear Science and Techniques 2024年第3期35卷 96-108页

作者： Wei Jiang ping Cao Yi-Ming Wu Xian-Ke Liu Zhu-jun Fang Zhi-Yong zhang Bin Shi jun Chen State Key Laboratory of Particle Detection and Electronics University of Science and Technology of ChinaHefei 230026China Department of Modern Physics University of Science and Technology of ChinaHefei 230026China School of Nuclear Science and Technology University of Science and Technology of ChinaHefei 230026China National Key Laboratory for Metrology and Calibration Techniques China Institute of Atomic EnergyBeijing 102413China

A new measurement method for the spatial distribution of neutron beam flux in boron neutron capture therapy(BNCT)is being developed based on the two-dimensional Micromegas *** address the issue of long processing times in traditional offline position reconstruction methods,this paper proposes a field programmable gate array based online position reconstruction method utilizing the micro-time projection chamber *** method encapsulates key technical aspects:a self-adaptive serial link technique built upon the dynamical adjustment of the delay chain length,fast sorting,a coordinate-matching technique based on the mapping between signal timestamps and random access memory(RAM)addresses,and a precise start point-merging technique utilizing a circular combined *** performance test of the selfadaptive serial link shows that the bit error rate of the link is better than 10-12 at a confidence level of 99%,ensuring reliable data *** experiment utilizing the readout electronics and Micromegas detector shows a spatial resolution of approximately 1.4 mm,surpassing the current method’s resolution level of 5 *** beam experiment confirms that the readout electronics system can obtain the flux spatial distribution of neutron beams online,thus validating the feasibility of the position reconstruction *** online position reconstruction method avoids traditional methods,such as bubble sorting and traversal searching,simplifies the design of the logic firmware,and reduces the time complexity from O(n2)to O(n).This study contributes to the advancement in measuring neutron beam flux for BNCT.

关键词： Position reconstruction FPGA Readout electronics Neutron flux spatial distribution