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Holocene millennial-scale megaflood events point to ENSO-driven extreme climate changes

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Science China Earth Sciences 2023年第11期66卷 2530-2545页

作者： Cong CHEN Yanwei ZHENG Zhuo ZHENG Yongqiang ZONG Kangyou HUANG Barry VROLETT Huanhuan PENG Xiao zhang Yongjie TANG Qiuchi WAN guifang zhang Rachid CHEDADDI Guangdong Key Lab of Geodynamics and Geohazards School of Earth Sciences and EngineeringSun Yat-sen UniversityZhuhai 519082China Key Laboratory of Separation and Comprehensive Utilization of Rare Metals Institute of Resources Utilization and Rare Earth DevelopmentGuangdong Academy of SciencesGuangzhou 510650China Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai) Zhuhai 519082China Key Lab of Guangdong for Utilization of Remote Sensing and Geographical Information System Guangdong Open Laboratory of Geospatial Information Technology and ApplicationGuangzhou Institute of GeographyGuangdong Academy of SciencesGuangzhou 510070China Department of Anthropology University of Hawai’i at ManoaHonoluluHawai’i 96822USA College of Ocean and Meteorology Guangdong Ocean UniversityZhanjiang 524088China Institute of Evolutionary Sciences of Montpellier University of MontpellierCNRSMontpellier 34095France

Reconstructing the Holocene megaflood history is a key component of understanding the mechanism of past climate change and assessing the potential impact of future catastrophic *** Pearl River is the longest watercourse in southern China,and its lower reach has been identified as one of the world's most vulnerable regions for flood ***,there is a complete lack of millennial-scale geological records of paleomegafloods for the future prediction of once-in-a-hundred(even once-in-a-thousand)year floods in southern ***,we identified a series of paleomegaflood deposits interbedded with wood-rich peat layers in the lower West Pearl River *** paleoflood layers have been well dated using AMS~(14)C dating *** to the regional correlation of the flood sequence,sediment characteristics and provenance analysis,there have been at least 7 megafloods corresponding to once-in-a-thousand-year events in the lower reaches of the West Pearl River during the past 6000 years,with an average return period of approximately 855 *** identified paleomegafloods were coeval with periods of strong El Ni?o-Southern Oscillation(ENSO),indicating that weakening of the Asian summer monsoon,associated with enhanced ENSO variability,may have triggered abnormally high precipitation leading to flooding of exceptional magnitude in southern *** addition,the most prominent paleomegafloods identified in the lower Pearl River coincided with intervals of lower precipitation and fewer storms in central-eastern China,indicating the intensification of the meridional“tripole”pattern of precipitation across eastern China during the latter half of the *** land use and deforestation over the last 2000 years have resulted in soil loss and rapid degradation of local primeval forest ecosystems,leading to more catastrophic *** amounts of rice pollen in the uppermost flood layer during the Song Dynasty indicate that this megaflood may have inu

关键词： Holocene megaflood Asian monsoon ENSO Vegetation change Early farming West Pearl River

High strength mullite-bond SiC porous ceramics fabricated by digital light processing

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Journal of Advanced Ceramics 2024年第1期13卷 53-62页

作者： Jian Sun Jingde zhang Xu zhang Zihe Li Jianzhang Li Sijie Wei Weibin zhang Weili Wang guifang Han Key Laboratory for Liquid-Solid Structural Evolution and Processing of Materials(Ministry of Education) School of Materials Science and EngineeringShandong UniversityJinan 250061China Key Laboratory of Special Functional Aggregated Materials Ministry of EducationShandong UniversityJinan 250100China Materials and Structures Research Centre Department of Mechanical EngineeringUniversity of BathBath BA27AYUK National Engineering Research Centre of Ceramic Matrix Composite Manufacture Technology Xi’an Golden Mountain Ceramic Composites Co.Ltd.Xi’an 710118China School of Physics and Materials Science Changji UniversityChangji 831100China

Fabricating SiC ceramics via the digital light processing(DLP)technology is of great challenge due to strong light absorption and high refractive index of deep-colored SiC powders,which highly differ from those of resin,and thus significantly affect the curing performance of the photosensitive SiC *** this paper,a thin silicon oxide(SiO_(2))layer was in-situ formed on the surface of SiC powders by pre-oxidation *** method was proven to effectively improve the curing ability of SiC *** SiC photosensitive slurry was fabricated with solid content of 55 vol%and viscosity of 7.77 Pa·s(shear rate of 30 s^(−1)).The curing thickness was 50μm with exposure time of only 5 ***,a well-designed sintering additive was added to completely convert low-strength SiO_(2) into mullite reinforcement during *** mullite-bond SiC ceramics were successfully *** flexural strength of SiC ceramics sintered at 1550℃in air reached 97.6 MPa with porosity of 39.2 vol%,as high as those prepared by spark plasma sintering(SPS)techniques.

关键词： digital light processing(DLP) SiC ceramics pre-oxidation mullite-bond SiC mechanical properties

外周血液学指标与晚期非小细胞肺癌免疫检查点抑制剂治疗疗效的关系

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现代肿瘤医学 2024年第4期32卷 652-658页

作者：梁嘉欣张桂芳慕竹青黄普超马晓艳李彬新乡医学院河南新乡453000 新乡市中心医院河南新乡453000

目的:观察真实世界免疫检查点抑制剂(ICIs)治疗晚期非小细胞肺癌的疗效及不良反应,探索外周血液学指标与ICIs疗效的关系。方法:回顾性分析我院接受免疫治疗的95例晚期非小细胞肺癌患者的免疫疗效、病例特征及外周血液学指标,并对免疫客... 详细信息

目的:观察真实世界免疫检查点抑制剂(ICIs)治疗晚期非小细胞肺癌的疗效及不良反应,探索外周血液学指标与ICIs疗效的关系。方法:回顾性分析我院接受免疫治疗的95例晚期非小细胞肺癌患者的免疫疗效、病例特征及外周血液学指标,并对免疫客观疗效进行单因素及多因素统计分析。结果:95例入组患者的客观缓解率为32.63%(31/95),疾病控制率为70.53%(67/95);中位无疾病进展生存期为4.1个月,中位总生存期为9.5个月。单因素分析发现治疗线数(P=0.016)、驱动基因(P=0.018)、淋巴细胞百分比(P=0.036)、血红蛋白(P=0.049)、红细胞压积(P=0.039)、凝血酶原时间(P=0.021)、白蛋白(P=0.002)、前体白蛋白(P=0.031)、乳酸脱氢酶(P=0.001)、C反应蛋白(P=0.028)、PNI(P=0.004)与ICIs治疗后疾病是否有效控制相关;多因素分析发现淋巴细胞百分比(P=0.042)、白蛋白(P=0.003)、乳酸脱氢酶(P=0.006)、预后营养指数(P=0.029)、治疗线数(P=0.011)是ICIs疗效的独立影响因素。结论:尽早应用ICIs治疗可提高患者的生存获益,外周血淋巴细胞百分比、白蛋白、乳酸脱氢酶、PNI可作为预测ICIs疗效的潜在生物标志物。

关键词：非小细胞肺癌免疫检查点抑制剂血液学生物标志物

多模态磁共振成像图像中定量特征构建影像组学模型对乳腺癌诊断价值分析

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山西医药杂志 2024年第3期53卷 163-168页

作者：刘琳魏春燕张桂芳夏辉王丙聚郭爱红核工业四一七医院放射科西安710600 延安大学咸阳医院CT/MRI 延安大学咸阳医院神经内科

目的分析多模态磁共振成像(MRI)图像中定量特征构建影像组学模型对乳腺癌诊断价值。方法选择2020年1月至2021年1月乳腺相关疾病患者95例,以病理诊断结果分为良性组(57例)及恶性组(38例);病例纳入时间分为训练组(66例)及验证组(29例)。... 详细信息

目的分析多模态磁共振成像(MRI)图像中定量特征构建影像组学模型对乳腺癌诊断价值。方法选择2020年1月至2021年1月乳腺相关疾病患者95例,以病理诊断结果分为良性组(57例)及恶性组(38例);病例纳入时间分为训练组(66例)及验证组(29例)。均经T_1加权成像(T_1WI)、T_2加权成像(T_2WI)、扩散加权成像(DWI)、动态对比增强(DCE)、表观弥散系数(ADC)多模态MRI检查,比较2组患者临床病理资料,MRI检查结果与病理结果进行对照分析,提取多模态病灶相关影像组学参数,采用支持向量机(SVM)分类器基于训练组患者单一、多影像组学指标构建诊断乳腺癌影像组学模型,通过验证组分析模型诊断效能,诊断效能通过构建受试者工作特征(ROC)曲线进行分析。结果良性乳腺疾病中纤维腺瘤占比49%;恶性乳腺疾病中浸润性导管癌占比74%。恶性组患者年龄、肿块大小高于良性组(P<0.05)。采用四格表法分析发现,T_1WI、T_2WI、ADC、DCE、DWI诊断乳腺癌的灵敏度为61%、67%、71%、79%、86%。从训练组患者病灶感兴趣区(ROI)提取平扫、扩散、增强等MRI检查提取形态特征、一阶特征、纹理特征3种特征。ROC曲线分析发现,T_1WI、T_2WI、DWI、ADC、DCE联合诊断乳腺癌的曲线下面积(AUC)分别为0.715、0.769、0.785、0.835、0.792。平扫、扩散、增强、平扫+扩散、平扫+增强、增强+扩散、平扫+增强+扩散等多影像组学模型诊断乳腺癌的AUC分别为0.746、0.798、0.816、0.839、0.890、0.906、0.927。结论通过多模态MRI图像中定量特征构建影像组学模型在诊断乳腺癌方面具有一定价值,其中平扫+增强+扩散等多影像组学模型诊断乳腺癌的价值更高,可在临床广泛应用。

关键词：磁共振成像定量特征影像组学模型乳腺癌价值

Earthquake deformation field characteristics associated with the 2010 Yushu M_s7.1 earthquake

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Science China Earth Sciences 2011年第4期54卷 571-580页

作者： LIU YunHua SHAN XinJian QU ChunYan zhang guifang State Key Laboratory of Earthquake Dynamics Institute of Geology China Earthquake Administration Beijing 100029 China

The spatial distribution and characterization of a heavily damaged area can be determined by studying surface ruptures of seismogenic *** the distribution of surface ruptures can be obtained shortly after they occur,then areas heavily damaged by an earthquake can be readily *** information can then be used as a guide for earthquake relief *** this paper,an intensity offset-tracking method applied to an ALOS PALSAR image is used to map the Yushu earthquake rupture and to identify the faults activated by the *** displacement analysis indicates that the surface rupture is about 55 km long,running from the epicenter to the southeast,trending N310°W,with a relative displacement of～1 m characterized by sinistral *** result of range displacement observations indicates that the north wall of the fault is dominated by decreases(i.e.,uplift in line of sight observations) ,whereas in the south wall of the fault,the range displacement is dominated by increases(drops in line of sight observations) .Given the position from which the images were recorded,this means that the north wall moves westward,and the south wall move eastward,i.e.,left-lateral slip motion across the ***,an earthquake disaster assessment using computer-assisted image analysis software shows that buildings near the fault rupture have been destroyed most heavily;therefore,the shape of the heavily damage belt is controlled partially by the fault rupture's geometry and the damage degree relates to the magnitude of displacement field.

关键词：地震灾害评估玉树特征形变场地表破裂带 ALOS卫星图像分析软件位移分析

JrATHB-12 mediates JrMYB113 and JrMYB27 to control the anthocyanin levels in different types of red walnut

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Journal of Integrative Agriculture 2024年第8期23卷 2649-2661页

作者： Haifeng Xu guifang Wang Xinying Ji Kun Xiang Tao Wang Meiyong zhang Guangning Shen Rui zhang Junpei zhang Xin Chen Key Laboratory of Huanghuai Protected Horticulture Engineering/National Germplasm Repository of Walnut and Chestnut Shandong Institute of PomologyTai’an 271000China Research Institute of Forestry Chinese Academy of ForestryBeijing 100091China College of Horticulture and Forestry Tarim UniversityAlaer 843300China

Red walnut has broad market prospects because it is richer in anthocyanins than ordinary ***,the mechanism driving anthocyanin biosynthesis in red walnut is still *** studied two types of red walnut,called red walnut 1(R1),with a red pericarp and seed coat,and red walnut 2(R2),with a red seed coat only.R1 mostly contained cyanidin-3-O-galactoside,while R2 contained a various amounts of cyanidin-3-Ogalactoside,cyanidin-3-O-arabinoside,and *** LDOX-2(LOC109007163)and LDOX-3(LOC109010746)genes,which encode leucoanthocyanidin dioxygenase/anthocyanidin synthase(LDOX/ANS),were preliminarily indicated as the crucial genes for anthocyanin biosynthesis in R1 and R2,*** MYB differential genes analysis showed that MYB27 and MYB113 are specifically expressed in the red parts of R1 and R2,respectively,and they are regarded as candidate regulatory *** expression in Arabidopsis and transient injection in walnut showed that both MYB27 and MYB113 were located in the nucleus and promoted anthocyanin accumulation,while MYB27 promoted the expression of LDOX-2,and MYB113 promoted the expression of LDOX-3and *** one-hybrid and electrophoretic mobility shift assays showed that MYB27 could only bind to the LDOX-2 promoter,while MYB113 could bind to the promoters of both LDOX-3 and *** addition,we also identified an HD-Zip transcription factor,ATHB-12,which is specifically expressed in the *** silencing the expression of ATHB-12,the R2 pericarp turned red,and MYB113 expression *** experiments showed that ATHB-12 could specifically interact with MYB113 and bind to its *** suggests that MYB27controls R1 coloration by regulating LDOX-2,while MYB113 controls R2 coloration by regulating LDOX-3 and UAGT-3,but ATHB-12 can specifically bind to and inhibit the MYB113 of the R2 pericarp so that it becomes *** study reveals the anthocyanin biosynthetic mechanisms in two differ

关键词： JrATHB-12 JrMYB113 JrMYB27 red walnut anthocyanin biosynthesis

Impact of Air Pollutants on Lung Function and Inflammatory Response in Asthma in Shanghai

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Biomedical and Environmental Sciences 2024年第8期37卷 811-822页

作者： guifang Wang Youzhi zhang Haiyan Yang Yi Yang Liang Dong Peng zhang Jie Liu Xiaodong Chen Yi Gong Department of Respiratory and Critical Care Medicine Quzhou People's HospitalQuzhou 324000ZhejiangChina Department of Respiratory and Critical Care Medicine Huashan Hospital Affiliated to Fudan UniversityShanghai 200040China Centre of Hydrogen Science Shanghai Jiao Tong University&Key Lab of Hydrogen ScienceShanghai 200240China Department of Respiratory and Critical Care Medicine Shanghai Public Health Clinical CentreFudan UniversityShanghai 201508China

Objective Air pollution is a leading public health *** study investigated the effect of air quality and pollutants on pulmonary function and inflammation in patients with asthma in *** The study monitored 27 asthma outpatients for a year,collecting data on weather,patient self-management[daily asthma diary,peak expiratory flow(PEF)monitoring,medication usage],spirometry and serum *** explore the potential mechanisms of any effects,asthmatic mice induced by ovalbumin(OVA)were exposed to PM_(2.5).Results Statistical and correlational analyses revealed that air pollutants have both acute and chronic effects on *** exposure showed a correlation between PEF and levels of ozone(O_(3))and nitrogen dioxide(NO_(2)).Chronic exposure indicated that interleukin-5(IL-5)and interleukin-13(IL-13)levels correlated with PM_(2.5)and PM_(10)*** asthmatic mouse models,exposure to PM_(2.5)increased cytokine levels and worsened lung ***,PM_(2.5)exposure inhibited cell proliferation by blocking the NF-κB and ERK phosphorylation *** Ambient air pollutants exacerbate asthma by worsening lung function and enhancing Th2-mediated ***,PM_(2.5)significantly contributes to these adverse *** research is needed to elucidate the mechanisms by which PM_(2.5)impacts asthma.

关键词： Ambient air pollutants Acute and chronic effects on asthma PM_(2.5) OVA-induced asthmatic mice

马尾藻岩藻黄素的提取条件优化及抗氧化、抗炎作用

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食品研究与开发 2024年第12期45卷 120-127页

作者：熊海霞皮彩玉叶琬褀张桂芳卢虹玉胡雪琼董晓静广东海洋大学食品科技学院广东省水产品加工与安全重点实验室广东省海洋食品工程技术研究中心广东省海洋生物制品工程实验室水产品深加工广东普通高等学校重点实验室广东湛江524088 海洋食品精深加工关键技术省部共建协同创新中心大连工业大学辽宁大连116034 威海海洋职业学院山东威海264300

以马尾藻为原料,探讨岩藻黄素的提取工艺,并对纯化后的岩藻黄素进行体外抗氧化和抗炎作用研究。结果表明,马尾藻岩藻黄素提取液在4℃避光保存25 d很稳定;通过单因素试验和正交试验确定最佳提取条件:以新鲜冷冻马尾藻为原料,提取溶剂为90... 详细信息

以马尾藻为原料,探讨岩藻黄素的提取工艺,并对纯化后的岩藻黄素进行体外抗氧化和抗炎作用研究。结果表明,马尾藻岩藻黄素提取液在4℃避光保存25 d很稳定;通过单因素试验和正交试验确定最佳提取条件:以新鲜冷冻马尾藻为原料,提取溶剂为90%乙醇∶丙酮=3∶1(体积比),料液比为1∶15(g/mL),提取温度为50℃、100 r/min振荡提取6 h后再超声辅助提取15 min,在此条件下岩藻黄素提取率为0.816 mg/g海藻湿重。抗氧化试验结果显示,马尾藻岩藻黄素的氧化自由基吸收能力(oxygenradicalabsorbancecapacity,ORAC)值为1761μmolTE/g,对DPPH自由基和羟自由基的清除率IC50分别为0.102 mg/mL和0.146 mg/mL。细胞实验结果表明,100μg/mL以下的马尾藻岩藻黄素对小鼠小胶质瘤细胞(BV⁃2)无明显毒性;与脂多糖(lipopolysaccharide,LPS)诱导的模型组相比,60μg/mL的马尾藻岩藻黄素显著降低细胞上清中一氧化氮(nitricoxide,NO)和白细胞介素⁃6(interleukin-6,IL-6)含量。综上所述,马尾藻中岩藻黄素的提取率与很多因素密切相关,并具有显著的抗氧化和抗炎作用。

关键词：马尾藻岩藻黄素条件优化抗氧化抗炎

The Effectiveness of a Multidisciplinary Collaborative Model for the Diagnosis and Treatment of Vertigo

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Proceedings of Anticancer Research 2022年第5期6卷 32-37页

作者： guifang zhang Hui Xia Qi Wang Yuan Wang Zhanning Qi Ruiqing Yan Xianyang Hospital of Yan’an University Xianyang 712000Shaanxi ProvinceChina

Objective:To investigate the effectiveness of applying a multidisciplinary collaborative model for the diagnosis and treatment of patients with ***:The study was carried out in Xianyang Hospital of Yan’an University,in which 100 patients with vertigo were selected from April 2021 to April 2022 and were divided into two groups:the control group was under the single diagnosis and treatment model,whereas the experimental group was under the multidisciplinary collaborative diagnosis and treatment model,with 50 cases in each *** diagnostic effects of the two groups were ***:The diagnostic and therapeutic efficiency of the patients in the experimental group were 94%and 98%,respectively,while those of the patients in the control group were 78%and 82%,respectively,with a significant difference between the two groups(p0.05);after the treatment,the scores improved,with those of the patients in the experimental group being significantly higher than those in the control group(p<0.05).Moreover,the satisfaction rate of patients in the experimental group(98%)was significantly higher than that of the control group(80%)(p<0.05).Conclusion:The application of the multidisciplinary collaborative diagnosis and treatment model in the diagnosis of patients with vertigo is *** multidisciplinary model can improve clinical diagnosis,enhance the treatment effect,improve the clinical symptoms of patients,and increase the satisfaction of patient ***,it is of high clinical application value.

关键词： Multidisciplinary collaborative diagnosis and treatment model Vertigo Diagnostic effect