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Nano-Micro Letters 2025年第3期17卷 455-500页

作者： Lei fang Xiaoqi Lin Ruian Xu Lu Liu Yu zhang Feng Tian Jiao Jiao Li Jiajia Xue Beijing Laboratory of Biomedical Materials Beijing University of Chemical TechnologyBeijing 100029People’s Republic of China State Key Laboratory of Organic‑Inorganic Composites Beijing University of Chemical TechnologyBeijing 100029People’s Republic of China School of Biomedical Engineering Faculty of Engineering and ITUniversity of Technology SydneySydneyNSW 2007Australia

The intricate hierarchical structure of musculoskeletal tissues,including bone and interface tissues,necessitates the use of complex scaffold designs and material structures to serve as tissue-engineered *** has led to growing interest in the development of gradient bone scaffolds with hierarchical structures mimicking the extracellular matrix of native tissues to achieve improved therapeutic *** on the anatomical characteristics of bone and interfacial tissues,this review provides a summary of current strategies used to design and fabricate biomimetic gradient scaffolds for repairing musculoskeletal tissues,specifically focusing on methods used to construct compositional and structural gradients within the *** latest applications of gradient scaffolds for the regeneration of bone,osteochondral,and tendon-to-bone interfaces are ***,the current progress of testing gradient scaffolds in physiologically relevant animal models of skeletal repair is discussed,as well as the challenges and prospects of moving these scaffolds into clinical application for treating musculoskeletal injuries.

关键词： Gradient scaffolds Musculoskeletal tissues Advanced manufacturing Biomaterials Tissue regeneration

Direct Photolithography of WO_(x)Nanoparticles for High‑Resolution Non‑Emissive Displays

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Nano-Micro Letters 2025年第3期17卷 297-309页

作者： Chang Gu Guojian Yang Wenxuan Wang Aiyan Shi Wenjuan fang Lei Qian Xiaofei Hu Ting zhang Chaoyu Xiang Yu‑Mo zhang Laboratory of Optoelectronic Information Technology and Devices Ningbo Institute of Materials Technology and EngineeringChinese Academy of SciencesNingbo 315201People’s Republic of China Hangzhou Bay Laboratory of Advanced Nano‑Optoelectronic Materials and Devices Qianwan Institute of CNITECHNingbo 315336People’s Republic of China Smart Materials for Architecture Research Lab Innovation Center of Yangtze River DeltaZhejiang UniversityJiaxing 314100People’s Republic of China University of Science and Technology of China Hefei 230026People’s Republic of China State Key Lab of Supramolecular Structure and Materials College of ChemistryJilin UniversityChangchun 130012People’s Republic of China

High-resolution non-emissive displays based on electrochromic tungsten oxides(WOx)are crucial for future near-eye virtual/augmented reality interactions,given their impressive attributes such as high environmental stability,ideal outdoor readability,and low energy ***,the limited intrinsic structure of inorganic materials has presented a significant challenge in achieving precise patterning/pixelation at the micron ***,we successfully developed the direct photolithography for WOx nanoparticles based on in situ photo-induced ligand *** strategy enabled us to achieve ultra-high resolution efficiently(line width3600 cycles),as well as promising applications in electronic logos,pixelated displays,flexible electronics,*** success and advancements presented here are expected to inspire and accelerate research and development(R&D)in high-resolution non-emissive displays and other ultra-fine micro-electronics.

关键词： Electrochromic Direct photolithography WOx nanoparticles In situ photo-induced ligand exchange High-resolution displays

他克林和双他克林抗星形孢菌素致凋亡作用的比较

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生物化学与生物物理进展 2002年第4期29卷 615-620页

作者：彭芳芳张百芳章江洲武栋成武汉大学医学院生物化学教研室武汉430071

用星形孢菌素 (STS)诱导NG10 8 15细胞和HeLa细胞凋亡 ,观察他克林和双他克林是否具有抗凋亡作用 .相差显微镜和Hoechst 33342染色观察细胞及胞核形态 ;噻唑蓝 (MTT)测定分析细胞损伤状况 ;DNA提取及琼脂糖凝胶电泳观察凋亡特征性梯带 ... 详细信息

用星形孢菌素 (STS)诱导NG10 8 15细胞和HeLa细胞凋亡 ,观察他克林和双他克林是否具有抗凋亡作用 .相差显微镜和Hoechst 33342染色观察细胞及胞核形态 ;噻唑蓝 (MTT)测定分析细胞损伤状况 ;DNA提取及琼脂糖凝胶电泳观察凋亡特征性梯带 ;蛋白质印迹分析Bcl 2和Bax的表达水平 .结果表明 ,经 0 1mmol/L他克林预处理后 ,由STS诱导的NG10 8 15细胞凋亡受到明显抑制 .双他克林预处理无保护作用 .蛋白质印迹分析表明他克林可显著抑制Bax的表达 ,同时还可促进Bcl 2的表达 .他克林和双他克林预处理对STS诱导的HeLa细胞损伤无明显的保护作用 .结论为 :a 他克林对STS诱导的神经细胞损伤有显著的保护作用 ,但这种保护作用与其AChE抑制作用似乎没有明显关联 .b 他克林对STS损伤的保护作用有细胞选择性 .

关键词：他克林双他克林星形孢菌素 AChE抑制剂细胞凋亡阿尔茨海默病神经细胞损伤抑制作用抗凋亡

Two Second-Order Ecient Numerical Schemes for the Boussinesq Equations

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应用数学 2025年第1期38卷 114-129页

作者： LIU fang WANG Danxia zhang Jianwen School of Mathematics Taiyuan University of TechnologyJinzhong 030600China Shanxi Key Laboratory for Intelligent Optimization Computing and Blockchain Technology Jinzhong 030600China

In this paper,we construct two fully decoupled,second-order semi-discrete numerical schemes for the Boussinesq equations based on the scalar auxiliary variable(SAV)*** introducing a scalar auxiliary variable,the original Boussinesq system is transformed into an equivalent *** we discretize it using the second-order backward di erentiation formula(BDF2)and Crank-Nicolson(CN)to obtain two second-order time-advanced *** both numerical schemes,a pressure-correction method is employed to decouple the velocity and *** two schemes possess the desired property that they can be fully decoupled with satisfying unconditional *** rigorously prove both the unconditional stability and unique solvability of the discrete ***,we provide detailed implementations of the decoupling ***,various 2D numerical simulations are performed to verify the accuracy and energy stability of the proposed schemes.

关键词： Scalar auxiliary variable approach Pressure-correction method Fully decoupled Unconditional stability Boussinesq equations

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含湿氢氧掺混燃烧室动态过程数值分析研究

兵工学报 2015年第2期36卷 313-320页

作者：张方方张振山王晋忠刘佳海军工程大学兵器工程系湖北武汉430033 海军驻874厂军事代表室山西侯马043000

含湿氢氧掺混燃烧室的动态特性直接关系着水下热动力系统的工作安全性。为了研究该型燃烧室的动态过程规律,基于喷管原理推导出工质流入、流出燃烧室的质量流量,利用质量守恒定律和能量守恒定律得到室内气液相质量、温度变化所满足的方... 详细信息

含湿氢氧掺混燃烧室的动态特性直接关系着水下热动力系统的工作安全性。为了研究该型燃烧室的动态过程规律,基于喷管原理推导出工质流入、流出燃烧室的质量流量,利用质量守恒定律和能量守恒定律得到室内气液相质量、温度变化所满足的方程式,利用液滴群蒸发模型考虑气液相的相间作用,进而完成该型燃烧室动态过程详尽模型的建立。利用该模型编写计算程序,完成某含湿氢氧掺混燃烧室动态过程仿真。结果表明:各仿真曲线能够较好地反映对应参数的动态变化规律,验证了模型建立与仿真的正确性;随着掺混冷却水流量的增加,燃烧室温度降低、压力升高,且温度变化是主要方面。

关键词：兵器科学与技术气氢气氧燃烧室动态过程数值分析

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同步荧光法监控人乳脂质替代品氧化过程

分析化学 2018年第4期46卷 543-549页

作者：李雪曹君白新鹏张芳芳海南大学食品学院生物活性物质与功能食品开发重点实验室

以市售大豆油、玉米油、椰子油、葵花籽油和鱼油为原料油脂,通过气相色谱仪检测其脂肪酸含量,并根据原料油脂的脂肪酸特点和GB 10765-2010的相关规定,通过Matlab软件和Excel线性规划求解,设计出6种人乳脂质替代品样品,采用Schaal烘箱加... 详细信息

以市售大豆油、玉米油、椰子油、葵花籽油和鱼油为原料油脂,通过气相色谱仪检测其脂肪酸含量,并根据原料油脂的脂肪酸特点和GB 10765-2010的相关规定,通过Matlab软件和Excel线性规划求解,设计出6种人乳脂质替代品样品,采用Schaal烘箱加速氧化法,研究同步荧光技术结合传统化学试剂法（氧化指标:过氧化值、茴香胺值、总氧化值）监控6种样品的氧化过程,通过统计学分析数据,探索荧光强度和氧化指标之间的统计学关系。结果表明:椰子油的主要脂肪酸为月桂酸和肉豆蔻酸,其饱和脂肪酸含量最高（93.75%±0.06%）;而其余油脂主要由棕榈酸、亚油酸等组成,其中鱼油的不饱和脂肪酸最高。随着氧化时间的延长,荧光强度逐渐减弱,氧化指标数值不断增大;相关分析和回归分析结果表明,6种样品的氧化指标与荧光强度的变化均呈负相关,R;均大于0.9。

关键词：人乳脂质替代品 Schaal烘箱加速氧化法氧化指标同步荧光法

Optimizing electronic structure through point defect engineering for enhanced electrocatalytic energy conversion

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Green Energy & Environment 2025年第1期10卷 109-131页

作者： Wei Ma Jiahao Yao fang Xie Xinqi Wang Hao Wan Xiangjian Shen Lili zhang Menggai Jiao Zhen Zhou Interdisciplinary Research Center for Sustainable Energy Science and Engineering(IRC4SE2) School of Chemical EngineeringZhengzhou UniversityHenan450001China

Point defect engineering endows catalysts with novel physical and chemical properties,elevating their electrocatalytic *** introduction of defects emerges as a promising strategy,effectively modifying the electronic structure of active *** optimization influences the adsorption energy of intermediates,thereby mitigating reaction energy barriers,altering paths,enhancing selectivity,and ultimately improving the catalytic efficiency of *** elucidate the impact of defects on the electrocatalytic process,we comprehensively outline the roles of various point defects,their synthetic methodologies,and characterization ***,we consolidate insights into the relationship between point defects and catalytic activity for hydrogen/oxygen evolution and CO_(2)/O_(2)/N_(2) reduction reactions by integrating mechanisms from diverse *** underscores the pivotal role of point defects in enhancing catalytic *** last,the principal challenges and prospects associated with point defects in current electrocatalysts are proposed,emphasizing their role in advancing the efficiency of electrochemical energy storage and conversion materials.

关键词： Point defect engineering Doping Vacancy Electrocatalysis Electronic structure

Comparison of PDE4 Expression in Different Brain Regions of C57BL/6J and DBA/2J Mice and the Association with Ethanol Drinking Behavior

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神经药理学报 2019年第4期 54-55页

作者： DU Xian WANG Dong zhang fang-fang ZHOU Yan-meng WANG Hao FU Hua-rong zhang Han-ting Institute of Pharmacology Shandong First Medical University & Shandong Academy of Sciences Departments of Behavioral Medicine & Psychiatry Physiology & Pharmacologyand Neurosciencethe Rockefeller Neurosciences InstituteWest Virginia University Health Sciences Center

Background:Alcohol dependence is not only the most common public health problem worldwide,but also the cause of many alcohol-related diseases,yet the mechanisms still remain unclear. Increasing evidence suggests that genetic factors play an important role in alcohol drinking behavior. C57 BL/6 J( B6) mice innately consume larger amounts of alcohol compared to DBA/2 J( DBA) mice,which drink little alcohol. Our recent studies have demonstrated that phosphodiesterase-4( PDE4),an enzyme that catalyzes the hydrolysis of cyclic AMP( cAMP),is an important target for regulating alcohol consumption. However,it is not known which of the four PDE4 subtypes( A-D) is involved. Previous studies demonstrate that lower levels of cAMP signaling are observed in specific brain regions of alcohol-preferring rodents;inhibition of cAMP signaling increases alcohol consumption,while activation of cAMP signaling in the brain decreases alcohol intake,in particularly brain regions such as the striatum and amygdala. Thus,we hypothesized that PDE4 expression in the brain of B6 and DBA mice is different and relevant to alcohol drinking. Objective:To compare the expression of PDE4 subtypes in the ethanol drinking-related brain regions of B6 and DBA mice and their responses to ethanol drinking in the absence or presence of the PDE4 inhibitor. Methods:Adult male and female B6 and DBA mice were tested for ethanol( 7% and 10%,v/v) intake and preference using the twobottle choice. In addition,a separate set of B6 and DBA mice was examined for PDE4 subtype expression levels in the striatum,hippocampus,cerebral cortex,and amygdala of the brain using Western blotting. Further,PDE4 subtype expression in brain regions of B6 mice in response to ethanol drinking was examined. Finally,the PDE4 inhibitor rolipram was administered to B6 mice to detect alcohol drinking behavior changes. Results:1. Differences in ethanol drinking behavior between B6 and DBA mice. Compared to DBA mice,B6 mice did not show signific

关键词： phosphodiesterase-4(PDE4) alcohol drinking C57BL/6J mice DBA/2J mice cAMP

基于耦合法的二维三轴编织复合材料热学性能预测及验证

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材料工程 2020年第4期48卷 151-157页

作者：张芳芳段永川高安娜姚丹燕山大学机械工程学院河北秦皇岛066004 燕山大学先进锻压成形技术与科学教育部重点实验室河北秦皇岛066004

为了改善传统方法建模划分网格繁杂和计算效率低的缺点,利用耦合建模法创建二维三轴编织复合材料的单胞模型,用耦合的思维将增强相单元网格与整体区域单元网格进行耦合处理,协调两者之间的位移场自由度和温度场自由度,通过匹配材料的热... 详细信息

为了改善传统方法建模划分网格繁杂和计算效率低的缺点,利用耦合建模法创建二维三轴编织复合材料的单胞模型,用耦合的思维将增强相单元网格与整体区域单元网格进行耦合处理,协调两者之间的位移场自由度和温度场自由度,通过匹配材料的热学性能,施加温度周期性边界条件,获得单胞模型的等效传热系数和等效热膨胀系数,基于该方法预测并分析编织角和纤维体积含量对各个方向的热传导系数和热膨胀系数的影响程度和规律。

关键词：编织复合材料区域叠合耦合法周期边界条件热学性能

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体育仲裁协议的法律特征思考

体育学刊 2005年第6期12卷 27-29页

作者：张芳芳华南师范大学法学院广东广州510631

体育仲裁协议的法律特征为:主体的法律地位表现为非绝对平等性,双方当事人的意思自治受到一定限制,协议表现形式多样,协议的效力从宽解释。正确认识这些法律特征,有利于完善我国体育仲裁制度、妥善解决体育纠纷。

关键词：体育仲裁仲裁协议体育纠纷法律特征